HRP20040781B8 - Process for the preparation of high purity perindopril and intermediates useful in the synthesis - Google Patents
Process for the preparation of high purity perindopril and intermediates useful in the synthesisInfo
- Publication number
- HRP20040781B8 HRP20040781B8 HR20040781A HRP20040781A HRP20040781B8 HR P20040781 B8 HRP20040781 B8 HR P20040781B8 HR 20040781 A HR20040781 A HR 20040781A HR P20040781 A HRP20040781 A HR P20040781A HR P20040781 B8 HRP20040781 B8 HR P20040781B8
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- compound
- preparation
- reacting
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
- 229960002582 perindopril Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- -1 alkyl chloroformate Chemical compound 0.000 abstract 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02290206A EP1333026B1 (en) | 2002-01-30 | 2002-01-30 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
| PCT/IB2003/000691 WO2003064388A2 (en) | 2002-01-30 | 2003-01-29 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| HRP20040781A2 HRP20040781A2 (en) | 2004-12-31 |
| HRP20040781B1 HRP20040781B1 (en) | 2008-12-31 |
| HRP20040781A8 HRP20040781A8 (en) | 2009-01-31 |
| HRP20040781B8 true HRP20040781B8 (en) | 2009-01-31 |
Family
ID=8185713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040781A HRP20040781B8 (en) | 2002-01-30 | 2004-08-27 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US7326794B2 (ko) |
| EP (1) | EP1333026B1 (ko) |
| JP (1) | JP4171423B2 (ko) |
| KR (1) | KR100673701B1 (ko) |
| CN (1) | CN1300111C (ko) |
| AP (1) | AP1741A (ko) |
| AR (1) | AR038340A1 (ko) |
| AT (1) | ATE365714T1 (ko) |
| AU (1) | AU2003206055B2 (ko) |
| BG (1) | BG66126B1 (ko) |
| BR (2) | BRPI0307293B1 (ko) |
| CA (1) | CA2474003C (ko) |
| CY (1) | CY1106721T1 (ko) |
| CZ (1) | CZ305892B6 (ko) |
| DE (1) | DE60220877T2 (ko) |
| DK (1) | DK1333026T3 (ko) |
| EA (1) | EA009277B1 (ko) |
| EE (1) | EE05428B1 (ko) |
| ES (1) | ES2289060T3 (ko) |
| GE (1) | GEP20063899B (ko) |
| HK (1) | HK1076101A1 (ko) |
| HR (1) | HRP20040781B8 (ko) |
| HU (1) | HU227591B1 (ko) |
| ME (1) | ME00444B (ko) |
| MX (1) | MXPA04007444A (ko) |
| NO (1) | NO330223B1 (ko) |
| NZ (1) | NZ534168A (ko) |
| OA (1) | OA12759A (ko) |
| PL (1) | PL212354B1 (ko) |
| PT (1) | PT1333026E (ko) |
| RS (1) | RS52465B (ko) |
| SI (1) | SI1333026T1 (ko) |
| SK (1) | SK287866B6 (ko) |
| UA (1) | UA77756C2 (ko) |
| WO (1) | WO2003064388A2 (ko) |
| ZA (1) | ZA200405548B (ko) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005037788A1 (en) * | 2003-10-21 | 2005-04-28 | Lupin Ltd. | Novel method for preparation of crystalline perindopril erbumine |
| SI21704A (en) * | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
| JP4948392B2 (ja) * | 2004-03-29 | 2012-06-06 | レ ラボラトア セルビエ | 固形薬学的組成物を調製するためのプロセス |
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
| ES2255872B1 (es) * | 2004-12-31 | 2007-08-16 | Quimica Sintetica, S.A. | Procedimiento para la preparacion de perindopril erbumina. |
| SI1679072T1 (sl) | 2005-01-06 | 2009-02-28 | Ipca Lab Ltd | Postopek za sintezo derivatov (2S,3aS,7aS)-1-(S)-alanil-oktahidro-1H-indol-2-karboksilne kisline inuporaba v sintezi perindoprila |
| US7710739B2 (en) | 2005-04-28 | 2010-05-04 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and display device |
| WO2006137082A1 (en) * | 2005-06-23 | 2006-12-28 | Ramesh Babu Potluri | Process for industrially viable preparation of perindopril erbumine |
| US20070032661A1 (en) * | 2005-08-03 | 2007-02-08 | Glenmark Pharmaceuticals Limited | Process for the preparation of intermediates of perindopril |
| AU2006281684B2 (en) * | 2005-08-12 | 2012-08-02 | Lek Pharmaceuticals D.D. | A process for the preparation of perindopril erbumine |
| EP1792896A1 (en) * | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
| KR101396899B1 (ko) * | 2006-05-12 | 2014-05-19 | 에지스 지오기스제르기아르 니일바노산 무코도 레스즈베니타르사사그 | Ａｃｅ-억제제의 합성에서의 약학적 중간체 및 이의 용도 |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK144769C (da) | 1979-12-06 | 1982-12-13 | Voelund Vaskerimaskiner | Tromlevaskemaskine med varmeveksler |
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4565819A (en) * | 1979-12-07 | 1986-01-21 | Adir | Substituted imino diacids, their preparation and pharmaceutical compositions which contain them |
| IN156096B (ko) | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| SI9600169A (en) | 1996-05-22 | 1997-12-31 | Krka Tovarna Zdravil | Process for preparation of compounds with ace inhibitory effect |
| FR2807431B1 (fr) | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| AR036187A1 (es) * | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
-
2002
- 2002-01-30 ES ES02290206T patent/ES2289060T3/es not_active Expired - Lifetime
- 2002-01-30 DK DK02290206T patent/DK1333026T3/da active
- 2002-01-30 PT PT02290206T patent/PT1333026E/pt unknown
- 2002-01-30 DE DE60220877T patent/DE60220877T2/de not_active Expired - Lifetime
- 2002-01-30 EP EP02290206A patent/EP1333026B1/en not_active Expired - Lifetime
- 2002-01-30 AT AT02290206T patent/ATE365714T1/de active
- 2002-01-30 SI SI200230586T patent/SI1333026T1/sl unknown
-
2003
- 2003-01-29 KR KR1020047011731A patent/KR100673701B1/ko not_active IP Right Cessation
- 2003-01-29 GE GE5686A patent/GEP20063899B/en unknown
- 2003-01-29 NZ NZ534168A patent/NZ534168A/en not_active IP Right Cessation
- 2003-01-29 CZ CZ2004-906A patent/CZ305892B6/cs not_active IP Right Cessation
- 2003-01-29 AP APAP/P/2004/003091A patent/AP1741A/en active
- 2003-01-29 OA OA1200400196A patent/OA12759A/en unknown
- 2003-01-29 AU AU2003206055A patent/AU2003206055B2/en not_active Ceased
- 2003-01-29 WO PCT/IB2003/000691 patent/WO2003064388A2/en active Application Filing
- 2003-01-29 CN CNB038027143A patent/CN1300111C/zh not_active Expired - Fee Related
- 2003-01-29 CA CA002474003A patent/CA2474003C/en not_active Expired - Fee Related
- 2003-01-29 BR BRPI0307293-2A patent/BRPI0307293B1/pt unknown
- 2003-01-29 EA EA200400929A patent/EA009277B1/ru not_active IP Right Cessation
- 2003-01-29 SK SK329-2004A patent/SK287866B6/sk not_active IP Right Cessation
- 2003-01-29 MX MXPA04007444A patent/MXPA04007444A/es active IP Right Grant
- 2003-01-29 RS YU66704A patent/RS52465B/en unknown
- 2003-01-29 EE EEP200400107A patent/EE05428B1/xx not_active IP Right Cessation
- 2003-01-29 HU HU0300231A patent/HU227591B1/hu not_active IP Right Cessation
- 2003-01-29 UA UA20040807143A patent/UA77756C2/uk unknown
- 2003-01-29 ZA ZA200405548A patent/ZA200405548B/xx unknown
- 2003-01-29 ME MEP-2008-674A patent/ME00444B/me unknown
- 2003-01-29 PL PL358514A patent/PL212354B1/pl unknown
- 2003-01-29 BR BR0307293-2A patent/BR0307293A/pt not_active IP Right Cessation
- 2003-01-29 US US10/503,272 patent/US7326794B2/en not_active Expired - Fee Related
- 2003-01-29 JP JP2003564011A patent/JP4171423B2/ja not_active Expired - Fee Related
- 2003-01-30 AR ARP030100263A patent/AR038340A1/es not_active Application Discontinuation
-
2004
- 2004-08-20 NO NO20043472A patent/NO330223B1/no not_active IP Right Cessation
- 2004-08-27 HR HR20040781A patent/HRP20040781B8/xx not_active IP Right Cessation
- 2004-08-27 BG BG108858A patent/BG66126B1/bg unknown
-
2005
- 2005-09-16 HK HK05108134A patent/HK1076101A1/xx not_active IP Right Cessation
-
2007
- 2007-04-20 US US11/788,454 patent/US7279595B2/en not_active Expired - Fee Related
- 2007-07-12 CY CY20071100925T patent/CY1106721T1/el unknown
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Payment date: 20181210 Year of fee payment: 17 |
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