HRP20040689A2 - Macrocyclic peptides active against the hepatitisc virus - Google Patents
Macrocyclic peptides active against the hepatitisc virus Download PDFInfo
- Publication number
- HRP20040689A2 HRP20040689A2 HR20040689A HRP20040689A HRP20040689A2 HR P20040689 A2 HRP20040689 A2 HR P20040689A2 HR 20040689 A HR20040689 A HR 20040689A HR P20040689 A HRP20040689 A HR P20040689A HR P20040689 A2 HRP20040689 A2 HR P20040689A2
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- hcv
- alkyl
- hepatitis
- acid
- Prior art date
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- 241000700605 Viruses Species 0.000 title description 14
- 108090000765 processed proteins & peptides Proteins 0.000 title description 5
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002369711A CA2369711A1 (en) | 2002-01-30 | 2002-01-30 | Macrocyclic peptides active against the hepatitis c virus |
| PCT/CA2003/000089 WO2003064455A2 (en) | 2002-01-30 | 2003-01-24 | Macrocyclic peptides active against the hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040689A2 true HRP20040689A2 (en) | 2005-06-30 |
Family
ID=27626541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040689A HRP20040689A2 (en) | 2002-01-30 | 2004-07-29 | Macrocyclic peptides active against the hepatitisc virus |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20030181363A1 (de) |
| EP (1) | EP1472278B1 (de) |
| JP (1) | JP4040578B2 (de) |
| KR (1) | KR20040077899A (de) |
| CN (1) | CN1639187A (de) |
| AR (1) | AR038330A1 (de) |
| AT (1) | ATE414098T1 (de) |
| BR (1) | BR0307297A (de) |
| CA (1) | CA2369711A1 (de) |
| DE (1) | DE60324660D1 (de) |
| EA (1) | EA007738B1 (de) |
| EC (1) | ECSP045243A (de) |
| ES (1) | ES2316718T3 (de) |
| HR (1) | HRP20040689A2 (de) |
| MX (1) | MXPA04007462A (de) |
| NO (1) | NO20043591L (de) |
| NZ (1) | NZ534929A (de) |
| PE (1) | PE20030818A1 (de) |
| PL (1) | PL371007A1 (de) |
| RS (1) | RS67004A (de) |
| SA (1) | SA03230569B1 (de) |
| TW (1) | TW200307692A (de) |
| UA (1) | UA78014C2 (de) |
| UY (1) | UY27630A1 (de) |
| WO (1) | WO2003064455A2 (de) |
| ZA (1) | ZA200405639B (de) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL192280B1 (pl) | 1996-10-18 | 2006-09-29 | Vertex Pharma | Inhibitory proteaz serynowych, a zwłaszcza proteazy wirusa NS3 zapalenia wątroby C, kompozycja farmaceutyczna i zastosowania |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| WO2002060926A2 (en) | 2000-11-20 | 2002-08-08 | Bristol-Myers Squibb Company | Hepatitis c tripeptide inhibitors |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| AU2003299519A1 (en) | 2002-05-20 | 2004-05-04 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| EP1505945B1 (de) | 2002-05-20 | 2008-11-05 | Bristol-Myers Squibb Company | Substituierte cycloalkyl p1' hepatitis c virus inhibitoren |
| ES2350201T3 (es) | 2002-05-20 | 2011-01-20 | Bristol-Myers Squibb Company | Sulfamidas heterocíclicas como inhibidores del virus de la hepatitis c. |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| US20050159345A1 (en) * | 2002-10-29 | 2005-07-21 | Boehringer Ingelheim International Gmbh | Composition for the treatment of infection by Flaviviridae viruses |
| US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| CL2004001161A1 (es) | 2003-05-21 | 2005-04-08 | Boehringer Ingelheim Int | Compuestos describe compuestos derivados de quinolina; composicion farmaceutica; y su uso para tratar una enfermedad causada por el virus de la hepatitis c. |
| WO2004111077A1 (en) | 2003-06-18 | 2004-12-23 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor |
| TW201127828A (en) | 2003-09-05 | 2011-08-16 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| EA200600498A1 (ru) * | 2003-09-22 | 2006-10-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Макроциклические пептиды, проявляющие противовирусную активность в отношении вируса гепатита с |
| ES2398912T3 (es) | 2003-10-14 | 2013-03-22 | F. Hoffmann-La Roche Ltd. | Ácido carboxílico macrocíclico y compuesto de acilsulfonamida como inhibidor de la replicación del virus de la hepatitis C |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| US7132504B2 (en) | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7135462B2 (en) | 2003-11-20 | 2006-11-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP2007516239A (ja) * | 2003-11-20 | 2007-06-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 特に複分解反応生成物からの、遷移金属の除去方法 |
| US7309708B2 (en) | 2003-11-20 | 2007-12-18 | Birstol-Myers Squibb Company | Hepatitis C virus inhibitors |
| ATE424926T1 (de) * | 2003-12-08 | 2009-03-15 | Boehringer Ingelheim Int | Abtrennung von ruthenium-nebenprodukten durch behandlung mit überkritischen flüssigkeiten |
| WO2005070955A1 (en) * | 2004-01-21 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis c virus |
| SI1713823T1 (sl) | 2004-01-30 | 2010-04-30 | Medivir Ab | Inhibitorji HCV NS-3 serin proteaze |
| WO2005080388A1 (en) | 2004-02-20 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| JP4950026B2 (ja) * | 2004-03-30 | 2012-06-13 | インターミューン・インコーポレーテッド | ウイルス複製阻害剤としての大環状化合物 |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| CA2571984C (en) | 2004-07-16 | 2012-04-10 | Gilead Sciences, Inc. | Antiviral compounds |
| CA2573346C (en) | 2004-07-20 | 2011-09-20 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
| UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
| JP2008513452A (ja) * | 2004-09-17 | 2008-05-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 超臨界流体中の閉環複分解方法 |
| EP1794178A1 (de) * | 2004-09-17 | 2007-06-13 | Boehringer Ingelheim International Gmbh | Verfahren zur herstellung makrocyclischer inhibitoren der hcv-protease |
| WO2006039488A2 (en) | 2004-10-01 | 2006-04-13 | Vertex Pharmaceuticals Incorporated | Hcv ns3-ns4a protease inhibition |
| MX2007004783A (es) * | 2004-10-21 | 2007-05-11 | Pfizer | Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan. |
| MY141025A (en) | 2004-10-29 | 2010-02-25 | Vertex Pharma | Dose forms |
| DE102005002336A1 (de) * | 2005-01-17 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Durchführung von kontinuierlichen Olefin-Ringschluss-Metathesen in komprimiertem Kohlendioxid |
| US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2606195C (en) | 2005-05-02 | 2015-03-31 | Merck And Co., Inc. | Hcv ns3 protease inhibitors |
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| UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
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| UA78014C2 (en) | 2007-02-15 |
| UY27630A1 (es) | 2003-08-29 |
| EA200400886A1 (ru) | 2005-02-24 |
| NZ534929A (en) | 2006-08-31 |
| PL371007A1 (en) | 2005-06-13 |
| BR0307297A (pt) | 2004-12-21 |
| CN1639187A (zh) | 2005-07-13 |
| TW200307692A (en) | 2003-12-16 |
| DE60324660D1 (de) | 2008-12-24 |
| WO2003064455A2 (en) | 2003-08-07 |
| JP4040578B2 (ja) | 2008-01-30 |
| PE20030818A1 (es) | 2003-10-30 |
| WO2003064455A3 (en) | 2004-02-05 |
| EA007738B1 (ru) | 2006-12-29 |
| EP1472278B1 (de) | 2008-11-12 |
| US20030181363A1 (en) | 2003-09-25 |
| ZA200405639B (en) | 2005-07-01 |
| EP1472278A2 (de) | 2004-11-03 |
| SA03230569B1 (ar) | 2007-03-05 |
| RS67004A (en) | 2006-10-27 |
| MXPA04007462A (es) | 2005-07-13 |
| JP2005524632A (ja) | 2005-08-18 |
| AR038330A1 (es) | 2005-01-12 |
| ATE414098T1 (de) | 2008-11-15 |
| CA2369711A1 (en) | 2003-07-30 |
| ES2316718T3 (es) | 2009-04-16 |
| NO20043591L (no) | 2004-08-27 |
| KR20040077899A (ko) | 2004-09-07 |
| ECSP045243A (es) | 2004-09-28 |
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