HRP20020579B1 - A process for the preparation of quetiapine and intermediates thereof - Google Patents
A process for the preparation of quetiapine and intermediates thereofInfo
- Publication number
- HRP20020579B1 HRP20020579B1 HR20020579A HRP20020579A HRP20020579B1 HR P20020579 B1 HRP20020579 B1 HR P20020579B1 HR 20020579 A HR20020579 A HR 20020579A HR P20020579 A HRP20020579 A HR P20020579A HR P20020579 B1 HRP20020579 B1 HR P20020579B1
- Authority
- HR
- Croatia
- Prior art keywords
- quetiapine
- preparation
- intermediates
- formula
- thiazepine
- Prior art date
Links
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004431 quetiapine Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
- UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0000283A HU227039B1 (en) | 2000-01-25 | 2000-01-25 | New process for the production of quetiapine and intermediates therefor |
PCT/HU2001/000010 WO2001055125A1 (en) | 2000-01-25 | 2001-01-24 | A process for the preparation of quetiapine and intermediates therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20020579A2 HRP20020579A2 (en) | 2004-08-31 |
HRP20020579B1 true HRP20020579B1 (en) | 2005-08-31 |
Family
ID=89978038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20020579A HRP20020579B1 (en) | 2000-01-25 | 2002-07-05 | A process for the preparation of quetiapine and intermediates thereof |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1252151B1 (es) |
CN (2) | CN1177839C (es) |
AT (1) | ATE261949T1 (es) |
AU (1) | AU3214601A (es) |
CZ (1) | CZ301236B6 (es) |
DE (1) | DE60102357T2 (es) |
DK (1) | DK1252151T3 (es) |
ES (1) | ES2217115T3 (es) |
HR (1) | HRP20020579B1 (es) |
HU (1) | HU227039B1 (es) |
PL (1) | PL211338B1 (es) |
RU (1) | RU2258067C2 (es) |
SI (1) | SI1252151T1 (es) |
SK (1) | SK287171B6 (es) |
UA (1) | UA73547C2 (es) |
WO (1) | WO2001055125A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL145430A0 (en) | 1999-03-15 | 2002-06-30 | Axys Pharm Inc | N-cyanomethyl amides, processes for the preparation thereof and pharmaceutical compositions containing the same |
WO2002051983A2 (en) | 2000-12-22 | 2002-07-04 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as cathepsin inhibitors |
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
WO2003024924A1 (en) | 2001-09-14 | 2003-03-27 | Aventis Pharmaceuticals Inc. | Novel compounds and compositions as cathepsin inhibitors |
MXPA04004450A (es) | 2001-11-14 | 2004-08-11 | Aventis Pharma Inc | Nuevos compuestos y composiciones como inhibidores de catepsina s. |
CA2516646A1 (en) * | 2003-02-22 | 2004-09-10 | Teva Pharmaceutical Industries Ltd. | Synthesis of quetiapine and pharmaceutically acceptable salts thereof |
KR100872210B1 (ko) | 2003-04-23 | 2008-12-05 | 메다렉스, 인코포레이티드 | 인터페론 알파 수용체-1 (ifnar-1)에 대한 인체화항체 |
PL195728B1 (pl) * | 2003-07-18 | 2007-10-31 | Helm Ag | Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny |
ES2223294B2 (es) * | 2003-08-08 | 2005-10-01 | Vita Cientifica, S.L. | Procedimiento de preparacion de un compuesto farmaceuticamente activo. |
PT1664007E (pt) * | 2003-09-23 | 2010-02-15 | Fermion Oy | Preparação de quetiapina |
DE602004031129D1 (de) * | 2003-09-23 | 2011-03-03 | Fermion Oy | Verfahren zur herstellung von quetiapin |
KR101038389B1 (ko) * | 2004-06-23 | 2011-06-01 | 에스케이바이오팜 주식회사 | 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[b,f][1,4]티아제핀의 제조방법 |
WO2006035293A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Polymorphic forms of quetiapine hemifumarate |
GB0425729D0 (en) * | 2004-11-23 | 2004-12-22 | Pliva Res & Dev Ltd | Heterocyclic compounds |
WO2006056772A2 (en) * | 2004-11-23 | 2006-06-01 | Pliva Hrvatska D.O.O. | Salts of quetiapine |
ES2234447B1 (es) * | 2005-03-07 | 2006-03-01 | Union Quimico-Farmaceutica S.A. | Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina. |
JP2008502707A (ja) | 2005-04-14 | 2008-01-31 | テバ ファーマシューティカル インダストリーズ リミティド | クエチアピンフマレートの調製方法 |
WO2007036599A1 (en) | 2005-09-30 | 2007-04-05 | Fermion Oy | New crystallization process of quetiapine hemifumarate |
DK2262486T3 (da) | 2008-08-01 | 2013-03-25 | Krka Tovarna Zdravil D D Novo Mesto | Quetiapin sammensætning |
CN101676275B (zh) * | 2008-09-17 | 2014-05-07 | 北京德众万全药物技术开发有限公司 | 一种富马酸喹硫平的制备方法 |
JP2012519683A (ja) | 2009-03-04 | 2012-08-30 | ランバクシー ラボラトリーズ リミテッド | フマル酸クエチアピンの調製方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH422793A (de) * | 1961-07-20 | 1966-10-31 | Wander Ag Dr A | Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine |
CH476753A (de) * | 1962-06-08 | 1969-08-15 | Wander Ag Dr A | Verfahren zur Herstellung von 11-basisch substituierter Dibenzo(b,f)(1,4)thiazepine |
US3539573A (en) * | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
US3560622A (en) * | 1967-10-13 | 1971-02-02 | American Cyanamid Co | Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents |
-
2000
- 2000-01-25 HU HU0000283A patent/HU227039B1/hu not_active IP Right Cessation
-
2001
- 2001-01-24 AU AU32146/01A patent/AU3214601A/en not_active Abandoned
- 2001-01-24 CZ CZ20022463A patent/CZ301236B6/cs not_active IP Right Cessation
- 2001-01-24 SI SI200130107T patent/SI1252151T1/xx unknown
- 2001-01-24 SK SK1060-2002A patent/SK287171B6/sk not_active IP Right Cessation
- 2001-01-24 DK DK01904235T patent/DK1252151T3/da active
- 2001-01-24 UA UA2002086977A patent/UA73547C2/uk unknown
- 2001-01-24 EP EP01904235A patent/EP1252151B1/en not_active Expired - Lifetime
- 2001-01-24 RU RU2002122723/04A patent/RU2258067C2/ru not_active IP Right Cessation
- 2001-01-24 DE DE2001602357 patent/DE60102357T2/de not_active Expired - Lifetime
- 2001-01-24 AT AT01904235T patent/ATE261949T1/de active
- 2001-01-24 PL PL355726A patent/PL211338B1/pl unknown
- 2001-01-24 ES ES01904235T patent/ES2217115T3/es not_active Expired - Lifetime
- 2001-01-24 CN CNB018040993A patent/CN1177839C/zh not_active Expired - Fee Related
- 2001-01-24 CN CNB2004100027829A patent/CN1239487C/zh not_active Expired - Fee Related
- 2001-01-24 WO PCT/HU2001/000010 patent/WO2001055125A1/en active IP Right Grant
-
2002
- 2002-07-05 HR HR20020579A patent/HRP20020579B1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SK287171B6 (sk) | 2010-02-08 |
RU2258067C2 (ru) | 2005-08-10 |
PL211338B1 (pl) | 2012-05-31 |
SK10602002A3 (sk) | 2002-11-06 |
HRP20020579A2 (en) | 2004-08-31 |
UA73547C2 (uk) | 2005-08-15 |
EP1252151B1 (en) | 2004-03-17 |
DK1252151T3 (da) | 2004-07-12 |
ES2217115T3 (es) | 2004-11-01 |
ATE261949T1 (de) | 2004-04-15 |
HU0000283D0 (en) | 2000-03-28 |
DE60102357T2 (de) | 2005-01-13 |
CZ20022463A3 (cs) | 2002-10-16 |
CN1177839C (zh) | 2004-12-01 |
SI1252151T1 (en) | 2004-08-31 |
HU227039B1 (en) | 2010-05-28 |
AU3214601A (en) | 2001-08-07 |
HUP0000283A3 (en) | 2002-11-28 |
CN1239487C (zh) | 2006-02-01 |
HUP0000283A2 (hu) | 2002-04-29 |
EP1252151A1 (en) | 2002-10-30 |
DE60102357D1 (de) | 2004-04-22 |
CN1396916A (zh) | 2003-02-12 |
PL355726A1 (en) | 2004-05-17 |
CZ301236B6 (cs) | 2009-12-16 |
WO2001055125A1 (en) | 2001-08-02 |
RU2002122723A (ru) | 2004-01-10 |
CN1537847A (zh) | 2004-10-20 |
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Legal Events
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A1OB | Publication of a patent application | ||
ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20151230 Year of fee payment: 16 |
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PBON | Lapse due to non-payment of renewal fee |
Effective date: 20170124 |