HRP20010650A2 - Controlled-release compositions of betahistine - Google Patents
Controlled-release compositions of betahistine Download PDFInfo
- Publication number
- HRP20010650A2 HRP20010650A2 HR20010650A HRP20010650A HRP20010650A2 HR P20010650 A2 HRP20010650 A2 HR P20010650A2 HR 20010650 A HR20010650 A HR 20010650A HR P20010650 A HRP20010650 A HR P20010650A HR P20010650 A2 HRP20010650 A2 HR P20010650A2
- Authority
- HR
- Croatia
- Prior art keywords
- tablet
- controlled release
- fatty acid
- release
- betahistine
- Prior art date
Links
- UUQMNUMQCIQDMZ-UHFFFAOYSA-N betahistine Chemical group CNCCC1=CC=CC=N1 UUQMNUMQCIQDMZ-UHFFFAOYSA-N 0.000 title claims description 19
- 229960004536 betahistine Drugs 0.000 title claims description 16
- 238000013270 controlled release Methods 0.000 title claims description 14
- 239000000203 mixture Substances 0.000 title claims description 8
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 13
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 13
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 13
- 238000002844 melting Methods 0.000 claims description 11
- 230000008018 melting Effects 0.000 claims description 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 10
- 239000000194 fatty acid Substances 0.000 claims description 10
- 229930195729 fatty acid Natural products 0.000 claims description 10
- 150000004665 fatty acids Chemical class 0.000 claims description 10
- 239000013543 active substance Substances 0.000 claims description 9
- 238000005469 granulation Methods 0.000 claims description 9
- 230000003179 granulation Effects 0.000 claims description 9
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 6
- 238000007906 compression Methods 0.000 claims description 5
- 230000006835 compression Effects 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- -1 long-chain fatty acid triglycerides Chemical class 0.000 claims description 3
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 239000001993 wax Substances 0.000 claims description 2
- 229920003086 cellulose ether Polymers 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 27
- 238000000338 in vitro Methods 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- 239000000454 talc Substances 0.000 description 14
- 229910052623 talc Inorganic materials 0.000 description 14
- 229910002027 silica gel Inorganic materials 0.000 description 13
- 239000008119 colloidal silica Substances 0.000 description 12
- 229940049654 glyceryl behenate Drugs 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- BXWNKGSJHAJOGX-UHFFFAOYSA-N n-hexadecyl alcohol Natural products CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 8
- 229960000541 cetyl alcohol Drugs 0.000 description 7
- 235000021355 Stearic acid Nutrition 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 6
- 239000008117 stearic acid Substances 0.000 description 6
- 239000001856 Ethyl cellulose Substances 0.000 description 4
- 229920001249 ethyl cellulose Polymers 0.000 description 4
- 235000019325 ethyl cellulose Nutrition 0.000 description 4
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000010512 hydrogenated peanut oil Substances 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000007908 dry granulation Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920003112 high viscosity grade hydroxypropyl cellulose Polymers 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960001021 lactose monohydrate Drugs 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000454A IT1309591B1 (it) | 1999-03-05 | 1999-03-05 | Composizioni a rilascio controllato di betaistina. |
| PCT/EP2000/001642 WO2000053162A1 (en) | 1999-03-05 | 2000-02-28 | Controlled-release compositions of betahistine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20010650A2 true HRP20010650A2 (en) | 2002-10-31 |
Family
ID=11382165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010650A HRP20010650A2 (en) | 1999-03-05 | 2001-09-04 | Controlled-release compositions of betahistine |
Country Status (37)
| Country | Link |
|---|---|
| EP (1) | EP1158963B1 (de) |
| JP (1) | JP2002538197A (de) |
| KR (1) | KR20010102498A (de) |
| CN (1) | CN1165295C (de) |
| AR (1) | AR029154A1 (de) |
| AT (1) | ATE231392T1 (de) |
| AU (1) | AU762532B2 (de) |
| BG (1) | BG105807A (de) |
| BR (1) | BR0008739A (de) |
| CA (1) | CA2364226A1 (de) |
| CO (1) | CO5170438A1 (de) |
| CZ (1) | CZ299510B6 (de) |
| DE (1) | DE60001266T2 (de) |
| DK (1) | DK1158963T3 (de) |
| EE (1) | EE200100453A (de) |
| ES (1) | ES2189739T3 (de) |
| GE (1) | GEP20033078B (de) |
| HK (1) | HK1042246B (de) |
| HR (1) | HRP20010650A2 (de) |
| HU (1) | HUP0200243A2 (de) |
| ID (1) | ID30127A (de) |
| IL (1) | IL145263A0 (de) |
| IT (1) | IT1309591B1 (de) |
| MX (1) | MXPA01008893A (de) |
| NO (1) | NO319135B1 (de) |
| NZ (1) | NZ513949A (de) |
| PE (1) | PE20001547A1 (de) |
| PL (1) | PL196290B1 (de) |
| PT (1) | PT1158963E (de) |
| RU (1) | RU2248791C2 (de) |
| SI (1) | SI1158963T1 (de) |
| SK (1) | SK284584B6 (de) |
| TR (1) | TR200102566T2 (de) |
| UA (1) | UA65652C2 (de) |
| WO (1) | WO2000053162A1 (de) |
| YU (1) | YU64001A (de) |
| ZA (1) | ZA200107318B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100712356B1 (ko) * | 2003-01-23 | 2007-05-02 | (주)아모레퍼시픽 | 서방성 제제 및 그의 제조방법 |
| DE60320965D1 (de) * | 2003-07-04 | 2008-06-26 | Formenti Farmaceutici Spa | Betahistinezubereitungen mit kontrollierter Freisetzung |
| US7728015B2 (en) | 2004-04-22 | 2010-06-01 | Mor Research Applications Ltd. | Compositions for weight management |
| EA200601414A1 (ru) | 2004-04-22 | 2007-02-27 | Мор Рисерч Эппликейшнз Лтд. | Способ контроля потребления пищи |
| CA2572928A1 (en) * | 2004-07-22 | 2006-02-26 | Amorepacific Corporation | Sustained-release preparations containing topiramate and the producing method thereof |
| JP2006176461A (ja) * | 2004-12-24 | 2006-07-06 | Dai Ichi Seiyaku Co Ltd | 粒状物 |
| US8642631B2 (en) | 2008-05-27 | 2014-02-04 | University Of Melbourne | Methods of treating mammals with eustachian tube dysfunctions |
| EP2314296A1 (de) * | 2009-10-22 | 2011-04-27 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Im Mund zerfallende Betahistin Tabletten |
| EP2491930A1 (de) * | 2011-02-25 | 2012-08-29 | Deva Holding Anonim Sirketi | Pharmazeutische Kombination von Betahistin mit Trimetazidin |
| DE102012105528A1 (de) | 2012-06-25 | 2014-01-02 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur Freisetzung von Wirkstoffen |
| WO2015053620A1 (en) * | 2013-10-07 | 2015-04-16 | Disphar International B.V. | Betahistine composition |
| LT3431078T (lt) * | 2017-07-20 | 2021-05-10 | Intas Pharmaceuticals Limited | Nepulsatilios prailginto atpalaidavimo betahistino geriamosios kietos kompozicijos |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2432313A1 (fr) * | 1978-08-01 | 1980-02-29 | Foulhoux Pierre | Nouvelle forme galenique de la betahistine et son procede d'obtention |
| GB2280604B (en) * | 1993-07-02 | 1997-04-30 | Resource Medical Limited | Processing of active agents |
| EP0935523B1 (de) * | 1996-10-28 | 2004-09-29 | Inc. General Mills | Einbettung und einkapselung von teilchen zur kontrollierten abgabe |
-
1999
- 1999-03-05 IT IT1999MI000454A patent/IT1309591B1/it active
-
2000
- 2000-02-28 MX MXPA01008893A patent/MXPA01008893A/es unknown
- 2000-02-28 YU YU64001A patent/YU64001A/sh unknown
- 2000-02-28 CN CNB008046190A patent/CN1165295C/zh not_active Expired - Fee Related
- 2000-02-28 WO PCT/EP2000/001642 patent/WO2000053162A1/en active IP Right Grant
- 2000-02-28 UA UA2001085807A patent/UA65652C2/uk unknown
- 2000-02-28 DE DE60001266T patent/DE60001266T2/de not_active Expired - Fee Related
- 2000-02-28 IL IL14526300A patent/IL145263A0/xx unknown
- 2000-02-28 KR KR1020017011271A patent/KR20010102498A/ko not_active Application Discontinuation
- 2000-02-28 SK SK1249-2001A patent/SK284584B6/sk unknown
- 2000-02-28 HU HU0200243A patent/HUP0200243A2/hu unknown
- 2000-02-28 TR TR2001/02566T patent/TR200102566T2/xx unknown
- 2000-02-28 ES ES00910723T patent/ES2189739T3/es not_active Expired - Lifetime
- 2000-02-28 JP JP2000603651A patent/JP2002538197A/ja active Pending
- 2000-02-28 DK DK00910723T patent/DK1158963T3/da active
- 2000-02-28 PL PL350232A patent/PL196290B1/pl unknown
- 2000-02-28 EP EP00910723A patent/EP1158963B1/de not_active Expired - Lifetime
- 2000-02-28 RU RU2001124607/15A patent/RU2248791C2/ru not_active IP Right Cessation
- 2000-02-28 NZ NZ513949A patent/NZ513949A/en unknown
- 2000-02-28 PT PT00910723T patent/PT1158963E/pt unknown
- 2000-02-28 AU AU32831/00A patent/AU762532B2/en not_active Ceased
- 2000-02-28 EE EEP200100453A patent/EE200100453A/xx unknown
- 2000-02-28 CA CA002364226A patent/CA2364226A1/en not_active Abandoned
- 2000-02-28 CZ CZ20013186A patent/CZ299510B6/cs not_active IP Right Cessation
- 2000-02-28 SI SI200030050T patent/SI1158963T1/xx unknown
- 2000-02-28 BR BR0008739-4A patent/BR0008739A/pt not_active Application Discontinuation
- 2000-02-28 AT AT00910723T patent/ATE231392T1/de not_active IP Right Cessation
- 2000-02-28 GE GEAP20006082A patent/GEP20033078B/en unknown
- 2000-02-28 ID IDW00200101790A patent/ID30127A/id unknown
- 2000-03-02 CO CO00015153A patent/CO5170438A1/es not_active Application Discontinuation
- 2000-03-03 PE PE2000000181A patent/PE20001547A1/es not_active Application Discontinuation
- 2000-03-03 AR ARP000100974A patent/AR029154A1/es active IP Right Grant
-
2001
- 2001-08-09 BG BG105807A patent/BG105807A/bg unknown
- 2001-09-04 ZA ZA200107318A patent/ZA200107318B/en unknown
- 2001-09-04 NO NO20014301A patent/NO319135B1/no unknown
- 2001-09-04 HR HR20010650A patent/HRP20010650A2/hr not_active Application Discontinuation
-
2002
- 2002-05-31 HK HK02104045.5A patent/HK1042246B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20050309 Year of fee payment: 6 |
|
| OBST | Application withdrawn |