HRP20000755A2 - Method of increasing bone toughness and stiffness and reducing fractures - Google Patents

Method of increasing bone toughness and stiffness and reducing fractures Download PDF

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Publication number
HRP20000755A2
HRP20000755A2 HR20000755A HRP20000755A HRP20000755A2 HR P20000755 A2 HRP20000755 A2 HR P20000755A2 HR 20000755 A HR20000755 A HR 20000755A HR P20000755 A HRP20000755 A HR P20000755A HR P20000755 A2 HRP20000755 A2 HR P20000755A2
Authority
HR
Croatia
Prior art keywords
bone
pth
months
vertebral
increase
Prior art date
Application number
HR20000755A
Other languages
English (en)
Croatian (hr)
Inventor
Janet M Hock
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26792729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20000755(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HRP20000755A2 publication Critical patent/HRP20000755A2/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
HR20000755A 1998-08-19 1999-08-19 Method of increasing bone toughness and stiffness and reducing fractures HRP20000755A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9715198P 1998-08-19 1998-08-19
US9974698P 1998-09-10 1998-09-10
PCT/US1999/018961 WO2000010596A1 (en) 1998-08-19 1999-08-19 Method of increasing bone toughness and stiffness and reducing fractures

Publications (1)

Publication Number Publication Date
HRP20000755A2 true HRP20000755A2 (en) 2001-02-28

Family

ID=26792729

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000755A HRP20000755A2 (en) 1998-08-19 1999-08-19 Method of increasing bone toughness and stiffness and reducing fractures

Country Status (32)

Country Link
US (2) US6977077B1 (OSRAM)
EP (3) EP1059933B1 (OSRAM)
JP (5) JP2002523375A (OSRAM)
KR (1) KR100454207B1 (OSRAM)
CN (1) CN1205997C (OSRAM)
AR (1) AR033639A1 (OSRAM)
AT (1) ATE231000T1 (OSRAM)
AU (1) AU746277B2 (OSRAM)
BR (1) BR9909445A (OSRAM)
CA (1) CA2325371C (OSRAM)
CO (1) CO5130020A1 (OSRAM)
CY (2) CY1113343T1 (OSRAM)
CZ (1) CZ301017B6 (OSRAM)
DE (2) DE69904918T2 (OSRAM)
DK (4) DK2266598T3 (OSRAM)
DZ (1) DZ2873A1 (OSRAM)
EA (1) EA003362B1 (OSRAM)
ES (4) ES2621653T3 (OSRAM)
HR (1) HRP20000755A2 (OSRAM)
HU (2) HU230697B1 (OSRAM)
ID (1) ID29039A (OSRAM)
IL (2) IL138829A0 (OSRAM)
MY (1) MY129227A (OSRAM)
NO (2) NO323984B1 (OSRAM)
NZ (1) NZ507056A (OSRAM)
PE (1) PE20001089A1 (OSRAM)
PL (1) PL201688B1 (OSRAM)
PT (4) PT1769804E (OSRAM)
TR (1) TR200003455T2 (OSRAM)
TW (1) TW576747B (OSRAM)
UA (1) UA72205C2 (OSRAM)
WO (1) WO2000010596A1 (OSRAM)

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US6770623B1 (en) * 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
AR033639A1 (es) 1998-08-19 2004-01-07 Lilly Co Eli Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis
US20040033950A1 (en) * 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
EP1222465A1 (en) * 1999-09-20 2002-07-17 Eli Lilly And Company Method for monitoring treatment with a parathyroid hormone
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
US7015195B2 (en) 2002-01-10 2006-03-21 Osteotrophin, Llc Treatment of bone disorders with skeletal anabolic drugs
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
WO2005027915A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
CN101151048A (zh) * 2004-05-10 2008-03-26 纳斯泰克制药公司 增强甲状旁腺激素粘膜递送的组合物和方法
US20060189533A1 (en) * 2004-05-10 2006-08-24 Nastech Pharmaceutical Company Inc. Stable pharmaceutical dosage forms of teriparatide
EP1744683B1 (en) 2004-05-13 2016-03-16 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060069021A1 (en) * 2004-08-13 2006-03-30 Nastech Pharmaceutical Company Inc. Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
CA2608016A1 (en) * 2005-05-11 2006-11-23 Unigene Laboratories, Inc. Improving bone formation and preservation by surgically inducing an increase in osteoblast activity coupled with the effect of administering pthrp or cgrp
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
CN101355959B (zh) * 2005-11-10 2013-02-27 密歇根理工大学管理委员会 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20080119408A1 (en) * 2006-07-07 2008-05-22 Nastech Pharmaceutical Company Inc. Pth formulations for intranasal delivery
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
DK2136850T3 (da) 2007-04-13 2012-04-10 Kuros Biosurgery Ag Polymervævforsegling
US20110137243A1 (en) * 2007-09-06 2011-06-09 Abbott Cardiovascular Systems Inc. Coating On A Balloon Device
US9457056B2 (en) * 2007-12-04 2016-10-04 Ben-Gurion University Of The Negev Research And Development Authority Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis
JP2012512812A (ja) 2007-12-28 2012-06-07 クロス・バイオサージェリー・アクチェンゲゼルシャフト フィブリンフォームに組込まれたｐｄｇｆ融合タンパク質
CN102470164B (zh) 2009-09-09 2014-04-09 旭化成制药株式会社 以每周给药1次每次为100单位～200单位的pth为特征的、含有pth的骨质疏松症治疗/预防剂
WO2011071480A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
WO2012111852A1 (ja) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 椎体骨折治療剤及びその評価方法
ES2882852T3 (es) 2011-03-16 2021-12-02 Kuros Biosurgery Ag Formulación farmacéutica para la utilización en la fusión espinal
KR101891673B1 (ko) 2011-06-07 2018-08-27 아사히 가세이 파마 가부시키가이샤 고순도 ｐｔｈ 함유 동결 건조 제제 및 그의 제조 방법
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
CA3013443C (en) * 2016-02-01 2021-06-15 Eli Lilly And Company Parathyroid hormone - anti-rankl antibody fusion compounds
WO2018144719A1 (en) * 2017-02-01 2018-08-09 The Johns Hopkins University Parathyroid hormone and regeneration of degenerative discs disease
US20200289621A1 (en) * 2017-09-22 2020-09-17 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent stability
WO2020090174A1 (ja) 2018-10-29 2020-05-07 旭化成ファーマ株式会社 週２回の頻度でテリパラチド又はその塩を投与することを特徴とする、骨粗鬆症の予防又は治療方法
WO2021030222A1 (en) 2019-08-09 2021-02-18 Flagship Pioneering Innovations Vi, Llc Modulators of parathyroid hormone receptor (pthr1)
GB2590692A (en) * 2019-12-24 2021-07-07 Corthotec Ltd Composition for improved bone fracture healing

Family Cites Families (18)

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US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
IL78342A (en) * 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
DE3935738A1 (de) 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
CA2126299C (en) 1994-06-20 2000-12-12 Gordon E. Willick Parathyroid hormone analogues for the treatment of osteoporosis
JPH0873376A (ja) * 1994-09-07 1996-03-19 Asahi Chem Ind Co Ltd 骨粗鬆症治療薬
JPH10511095A (ja) * 1994-12-19 1998-10-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド 副甲状腺ホルモン又はその作動薬の低用量継続投与
US5747456A (en) 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
EP0806945B1 (en) * 1994-12-22 2003-04-23 AstraZeneca AB Therapeutic preparation for inhalation containing parathyro d hormone, pth
JPH08310965A (ja) 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
CZ298701B6 (cs) * 1997-09-09 2007-12-27 F. Hoffman-La Roche Ag Lécivo pro hojení kostí a reparaci zlomenin
ZA9811127B (en) 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
AR033639A1 (es) * 1998-08-19 2004-01-07 Lilly Co Eli Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis
US6907597B1 (en) 2000-10-13 2005-06-14 Ati International Srl Method and apparatus for constructing an executable program in memory
US6967759B2 (en) 2001-12-31 2005-11-22 Texas Instruments Incorporated Pulse width modulation sequence generation
JP5796714B2 (ja) 2012-01-13 2015-10-21 株式会社リコー 定着装置及び画像形成装置
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Also Published As

Publication number Publication date
KR20010072763A (ko) 2001-07-31
ES2393200T3 (es) 2012-12-19
JP2015028065A (ja) 2015-02-12
PL343595A1 (en) 2001-08-27
IL138829A (en) 2011-01-31
ES2549551T1 (es) 2015-10-29
ES2190244T3 (es) 2003-07-16
PE20001089A1 (es) 2000-11-04
AU5575099A (en) 2000-03-14
HK1102496A1 (en) 2007-11-23
NZ507056A (en) 2003-10-31
CZ20004134A3 (cs) 2001-08-15
MY129227A (en) 2007-03-30
CY1113343T1 (el) 2016-06-22
JP2017190332A (ja) 2017-10-19
DK2266598T3 (en) 2017-05-15
IL138829A0 (en) 2001-10-31
DE15152726T1 (de) 2015-12-10
NO20005947L (no) 2000-11-24
PT1769804E (pt) 2012-11-13
DK1769804T3 (da) 2012-10-15
EA003362B1 (ru) 2003-04-24
TW576747B (en) 2004-02-21
DK2907522T3 (en) 2017-10-23
NO20072983L (no) 2000-11-24
NO323984B1 (no) 2007-07-30
CN1308545A (zh) 2001-08-15
EP1059933B1 (en) 2003-01-15
JP2011021035A (ja) 2011-02-03
PL201688B1 (pl) 2009-04-30
NO20005947D0 (no) 2000-11-24
HU1200430D0 (hu) 2001-11-28
HK1212602A1 (en) 2016-06-17
DK1059933T3 (da) 2003-04-07
WO2000010596A1 (en) 2000-03-02
DK2907522T1 (da) 2015-10-19
ID29039A (id) 2001-07-26
US7163684B2 (en) 2007-01-16
CN1205997C (zh) 2005-06-15
ATE231000T1 (de) 2003-02-15
DE69904918D1 (de) 2003-02-20
DZ2873A1 (fr) 2003-12-15
US6977077B1 (en) 2005-12-20
BR9909445A (pt) 2000-12-12
AR033639A1 (es) 2004-01-07
ES2621653T3 (es) 2017-07-04
TR200003455T2 (tr) 2001-06-21
EP2266598A1 (en) 2010-12-29
PT2907522T (pt) 2017-10-23
EP2907522A1 (en) 2015-08-19
CY1119552T1 (el) 2018-03-07
CA2325371C (en) 2004-08-17
DE69904918T2 (de) 2003-11-13
CZ301017B6 (cs) 2009-10-14
EP1059933A1 (en) 2000-12-20
ES2549551T3 (es) 2017-11-27
EP2907522B1 (en) 2017-08-02
HUP0101594A2 (hu) 2001-11-28
PT1059933E (pt) 2003-06-30
HUP0101594A3 (en) 2002-01-28
HU230697B1 (hu) 2017-09-28
JP6177718B2 (ja) 2017-08-09
KR100454207B1 (ko) 2004-10-26
JP2014139220A (ja) 2014-07-31
UA72205C2 (uk) 2005-02-15
JP2002523375A (ja) 2002-07-30
CA2325371A1 (en) 2000-03-02
PT2266598T (pt) 2017-05-02
AU746277B2 (en) 2002-04-18
EP2266598B1 (en) 2017-02-22
CO5130020A1 (es) 2002-02-27
HK1030545A1 (en) 2001-05-11
US20050197294A1 (en) 2005-09-08
EA200001015A1 (ru) 2001-02-26

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