HRP20000740B1 - Water soluble azoles as broad-spectrum antifungals - Google Patents

Water soluble azoles as broad-spectrum antifungals

Info

Publication number
HRP20000740B1
HRP20000740B1 HR20000740A HRP20000740A HRP20000740B1 HR P20000740 B1 HRP20000740 B1 HR P20000740B1 HR 20000740 A HR20000740 A HR 20000740A HR P20000740 A HRP20000740 A HR P20000740A HR P20000740 B1 HRP20000740 B1 HR P20000740B1
Authority
HR
Croatia
Prior art keywords
broad
water soluble
spectrum antifungals
soluble azoles
azoles
Prior art date
Application number
HR20000740A
Other languages
English (en)
Inventor
Lieven Meerpoel
Leo Jacobus Jozef Backx
Louis Jozef Elisabeth Va Veken
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HRP20000740A2 publication Critical patent/HRP20000740A2/hr
Publication of HRP20000740B1 publication Critical patent/HRP20000740B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HR20000740A 1998-05-14 1999-05-06 Water soluble azoles as broad-spectrum antifungals HRP20000740B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201588A EP0957101A1 (en) 1998-05-14 1998-05-14 Water soluble azoles as broad-spectrum antifungals
PCT/EP1999/003242 WO1999058529A1 (en) 1998-05-14 1999-05-06 Water soluble azoles as broad-spectrum antifungals

Publications (2)

Publication Number Publication Date
HRP20000740A2 HRP20000740A2 (en) 2001-10-31
HRP20000740B1 true HRP20000740B1 (en) 2003-12-31

Family

ID=8233724

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20000741A HRP20000741B1 (hr) 1998-05-14 1999-05-06 U vodi topivi azoli kao antifungali širokog spektra
HR20000740A HRP20000740B1 (en) 1998-05-14 1999-05-06 Water soluble azoles as broad-spectrum antifungals

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HR20000741A HRP20000741B1 (hr) 1998-05-14 1999-05-06 U vodi topivi azoli kao antifungali širokog spektra

Country Status (31)

Country Link
US (2) US6448244B1 (cs)
EP (3) EP0957101A1 (cs)
JP (2) JP2002514645A (cs)
KR (2) KR100593395B1 (cs)
CN (2) CN1137118C (cs)
AR (2) AR016480A1 (cs)
AT (2) ATE221884T1 (cs)
AU (2) AU751135B2 (cs)
BG (2) BG64388B1 (cs)
BR (2) BR9910448A (cs)
CA (2) CA2331141C (cs)
CO (1) CO5021227A1 (cs)
CZ (2) CZ298702B6 (cs)
DE (2) DE69902461T2 (cs)
DK (1) DK1077976T3 (cs)
EE (2) EE04346B1 (cs)
ES (2) ES2182531T3 (cs)
HR (2) HRP20000741B1 (cs)
HU (2) HUP0103536A3 (cs)
IL (2) IL139647A0 (cs)
MY (2) MY120248A (cs)
NO (2) NO319760B1 (cs)
NZ (2) NZ507966A (cs)
PL (2) PL194085B1 (cs)
PT (1) PT1077976E (cs)
SI (1) SI1077976T1 (cs)
SK (2) SK286156B6 (cs)
TR (2) TR200003323T2 (cs)
TW (2) TWI259835B (cs)
WO (2) WO1999058529A1 (cs)
ZA (2) ZA200007173B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
WO2001066551A2 (en) * 2000-03-07 2001-09-13 Ranbaxy Laboratories Limited Azole compounds as therapeutic agents for fungal infections
EP1413301A1 (fr) * 2002-10-24 2004-04-28 Bayer CropScience SA Médicaments antifongiques à base de dérivés d'arylamidine
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
BR112012029227B1 (pt) * 2010-05-19 2020-01-07 Sandoz Ag Processo para a preparação de um composto quiral, composto quiral e uso de um composto
WO2013036866A1 (en) * 2011-09-07 2013-03-14 The Johns Hopkins University Itraconazole analogs and use thereof
US11028078B2 (en) * 2011-09-07 2021-06-08 The Johns Hopkins University Itraconazole analogs and use thereof
EP3626242B1 (en) 2013-06-07 2024-08-07 The Scripps Research Institute Itraconazole analogs as inhibitors of fibrosis
PT3227277T (pt) 2014-12-05 2020-04-14 Pulmocide Ltd Composto antimicótico
CN107404878B (zh) 2014-12-10 2021-03-30 斯克利普斯研究所 纤维化的小分子抑制剂
CA2981945C (en) * 2015-05-21 2023-08-29 Pulmocide Limited Antifungal 4-(4-(4-(((3r,5r)-5-((1 h-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-n-(2-hydroxycyclohexyl) benzamide, or a pharmaceutically acceptable salt thereof
CN105237392B (zh) * 2015-11-24 2017-12-12 辽宁渤大化工有限公司 芳烷基水杨酸及其衍生物的制备方法
AU2018321287A1 (en) 2017-08-20 2020-04-02 University Of Connecticut Azole analogues and methods of use thereof
WO2021030174A1 (en) 2019-08-09 2021-02-18 University Of Connecticut Truncated itraconazole analogues and methods of use thereof
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CZ286619B6 (cs) * 1992-03-18 2000-05-17 Janssen Pharmaceutica N. V. Stereoisomerické formy itrakonazolu a saperkonazolu, způsob jejich výroby, jejich komplexy, způsob výroby těchto komplexů, farmaceutické přípravky a způsob jejich výroby
DK0736030T3 (da) * 1993-12-21 2001-10-29 Schering Corp Fungicide tetrahydrofuraner
ES2141329T3 (es) * 1994-01-24 2000-03-16 Janssen Pharmaceutica Nv Antifungicos azolicos solubles en agua.
FI98688C (fi) * 1994-07-20 1997-07-25 Nokia Telecommunications Oy Menetelmä lyhytsanomalähetyksen käynnistämiseksi solukkoradiojärjestelmässä, solukkoradiojärjestelmä sekä solukkoradiojärjestelmän tilaajarekisteri
AR002751A1 (es) * 1995-06-02 1998-04-29 Schering Corp Antifungicos de tetrahidrofurano, composiciones farmaceuticas que los contienen y el uso de los compuestos para preparar composiciones farmaceuticas utiles para el tratamiento de infecciones fungicas
ES2203707T3 (es) * 1995-06-19 2004-04-16 Schering Corporation Antifungicos de tetrahidrofurano.
HU227744B1 (en) * 1997-02-11 2012-02-28 Janssen Pharmaceutica Nv Amino acid ester containing azole antifungals, process for their preparation, pharmaceuticals containing the same and intermediates
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals

Also Published As

Publication number Publication date
HRP20000740A2 (en) 2001-10-31
CZ299481B6 (cs) 2008-08-13
CN1137118C (zh) 2004-02-04
WO1999058530A1 (en) 1999-11-18
NO319760B1 (no) 2005-09-12
WO1999058529A1 (en) 1999-11-18
AR016482A1 (es) 2001-07-04
DK1077976T3 (da) 2002-12-02
KR20010041480A (ko) 2001-05-25
NO20005712L (no) 2000-12-07
JP2002514646A (ja) 2002-05-21
AR016480A1 (es) 2001-07-04
HRP20000741B1 (hr) 2009-02-28
CZ20004108A3 (en) 2001-05-16
CN1300288A (zh) 2001-06-20
DE69902461D1 (de) 2002-09-12
BG64388B1 (bg) 2004-12-30
IL139649A (en) 2004-09-27
CA2331141C (en) 2008-10-28
US6448244B1 (en) 2002-09-10
NO20005712D0 (no) 2000-11-13
SK286156B6 (sk) 2008-04-07
BG104717A (en) 2001-07-31
ES2182531T3 (es) 2003-03-01
EE200000651A (et) 2002-04-15
NZ507966A (en) 2002-10-25
ZA200007459B (en) 2002-09-13
KR100575147B1 (ko) 2006-05-03
SK16812000A3 (sk) 2001-08-06
CN1135229C (zh) 2004-01-21
SK16822000A3 (sk) 2001-07-10
EE04346B1 (et) 2004-08-16
BR9911057A (pt) 2001-02-06
CO5021227A1 (es) 2001-03-27
ATE221884T1 (de) 2002-08-15
NO319851B1 (no) 2005-09-19
EP0957101A1 (en) 1999-11-17
NZ507965A (en) 2002-05-31
TWI259835B (en) 2006-08-11
PL194085B1 (pl) 2007-04-30
DE69907171T2 (de) 2004-02-05
IL139649A0 (en) 2002-02-10
EE04311B1 (et) 2004-06-15
ES2198915T3 (es) 2004-02-01
CA2331187C (en) 2008-11-18
HUP0103536A2 (hu) 2002-07-29
HUP0103536A3 (en) 2002-08-28
BG64954B1 (bg) 2006-10-31
US6384030B1 (en) 2002-05-07
TR200003322T2 (tr) 2001-02-21
EP1077976A1 (en) 2001-02-28
MY122147A (en) 2006-03-31
PT1077976E (pt) 2002-12-31
CZ20004109A3 (en) 2001-05-16
PL344047A1 (en) 2001-09-24
CN1300287A (zh) 2001-06-20
ZA200007173B (en) 2002-03-04
HK1033312A1 (en) 2001-08-24
HUP0102031A2 (hu) 2002-05-29
MY120248A (en) 2005-09-30
KR20010042852A (ko) 2001-05-25
AU758876B2 (en) 2003-04-03
AU751135B2 (en) 2002-08-08
BG104933A (en) 2001-10-31
AU4141799A (en) 1999-11-29
CA2331141A1 (en) 1999-11-18
TW572899B (en) 2004-01-21
EP1077976B1 (en) 2002-08-07
IL139647A0 (en) 2002-02-10
HRP20000741A2 (en) 2001-06-30
DE69907171D1 (de) 2003-05-28
EP1077975B1 (en) 2003-04-23
HUP0102031A3 (en) 2002-10-28
ATE238296T1 (de) 2003-05-15
PL194086B1 (pl) 2007-04-30
KR100593395B1 (ko) 2006-06-28
NO20005713D0 (no) 2000-11-13
AU4361599A (en) 1999-11-29
TR200003323T2 (tr) 2001-02-21
NO20005713L (no) 2001-01-11
HK1032781A1 (en) 2001-08-03
JP2002514645A (ja) 2002-05-21
CZ298702B6 (cs) 2007-12-27
EE200000657A (et) 2002-04-15
PL344037A1 (en) 2001-09-24
CA2331187A1 (en) 1999-11-18
DE69902461T2 (de) 2003-04-10
EP1077975A1 (en) 2001-02-28
SI1077976T1 (en) 2003-02-28
BR9910448A (pt) 2001-01-02
SK285763B6 (sk) 2007-07-06

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Legal Events

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B1PR Patent granted
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Payment date: 20080505

Year of fee payment: 10

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Effective date: 20090507