DK1077976T3 - Vandopløselige azoler som bredspektrede antisvampemidler - Google Patents

Vandopløselige azoler som bredspektrede antisvampemidler

Info

Publication number
DK1077976T3
DK1077976T3 DK99926304T DK99926304T DK1077976T3 DK 1077976 T3 DK1077976 T3 DK 1077976T3 DK 99926304 T DK99926304 T DK 99926304T DK 99926304 T DK99926304 T DK 99926304T DK 1077976 T3 DK1077976 T3 DK 1077976T3
Authority
DK
Denmark
Prior art keywords
broad
water
antifungal agents
spectrum antifungal
soluble azoles
Prior art date
Application number
DK99926304T
Other languages
English (en)
Inventor
Lieven Meerpoel
Leo Jacobus Jozef Backx
Der Veken Louis Jozef Elis Van
Jan Heeres
Frank Christopher Odds
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK1077976T3 publication Critical patent/DK1077976T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK99926304T 1998-05-14 1999-05-06 Vandopløselige azoler som bredspektrede antisvampemidler DK1077976T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201588A EP0957101A1 (en) 1998-05-14 1998-05-14 Water soluble azoles as broad-spectrum antifungals
PCT/EP1999/003243 WO1999058530A1 (en) 1998-05-14 1999-05-06 Water soluble azoles as broad-spectrum antifungals

Publications (1)

Publication Number Publication Date
DK1077976T3 true DK1077976T3 (da) 2002-12-02

Family

ID=8233724

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99926304T DK1077976T3 (da) 1998-05-14 1999-05-06 Vandopløselige azoler som bredspektrede antisvampemidler

Country Status (32)

Country Link
US (2) US6448244B1 (da)
EP (3) EP0957101A1 (da)
JP (2) JP2002514646A (da)
KR (2) KR100593395B1 (da)
CN (2) CN1135229C (da)
AR (2) AR016482A1 (da)
AT (2) ATE221884T1 (da)
AU (2) AU751135B2 (da)
BG (2) BG64388B1 (da)
BR (2) BR9910448A (da)
CA (2) CA2331187C (da)
CO (1) CO5021227A1 (da)
CZ (2) CZ299481B6 (da)
DE (2) DE69902461T2 (da)
DK (1) DK1077976T3 (da)
EE (2) EE04346B1 (da)
ES (2) ES2182531T3 (da)
HK (2) HK1033312A1 (da)
HR (2) HRP20000740B1 (da)
HU (2) HUP0102031A3 (da)
IL (2) IL139647A0 (da)
MY (2) MY120248A (da)
NO (2) NO319760B1 (da)
NZ (2) NZ507966A (da)
PL (2) PL194086B1 (da)
PT (1) PT1077976E (da)
SI (1) SI1077976T1 (da)
SK (2) SK286156B6 (da)
TR (2) TR200003322T2 (da)
TW (2) TW572899B (da)
WO (2) WO1999058530A1 (da)
ZA (2) ZA200007173B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
RU2002126272A (ru) * 2000-03-07 2004-08-10 Рэнбакси Лабораториз Лимитед (In) Производные азолов в качестве терапевтических агентов против грибковых инфекций
EP1413301A1 (fr) * 2002-10-24 2004-04-28 Bayer CropScience SA Médicaments antifongiques à base de dérivés d'arylamidine
ITMI20032020A1 (it) 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
US9040539B2 (en) * 2010-05-19 2015-05-26 Sandoz Ag Process for the preparation of chiral triazolones
US11028078B2 (en) 2011-09-07 2021-06-08 The Johns Hopkins University Itraconazole analogs and use thereof
US9346791B2 (en) 2011-09-07 2016-05-24 The Johns Hopkins University Itraconazole analogs and use thereof
CN105392364B (zh) 2013-06-07 2018-09-14 加州生物医学研究所 纤维化的小分子抑制剂
EA033736B1 (ru) 2014-12-05 2019-11-20 Pulmocide Ltd Антимикотическое соединение
KR102548066B1 (ko) 2014-12-10 2023-06-26 더 스크립스 리서치 인스티튜트 섬유증의 소분자 억제제
HUE048843T2 (hu) * 2015-05-21 2020-08-28 Pulmocide Ltd Gombaölõ szer 4-(4-(4-(((3R,5R)-5-((1H -1,2,4-triazol-1-YL)metil)-5-(2,4-difluor-fenil)tetra-hidro-furán-3-YL)metoxi)-3 metilfenil)piperazin-1-il)-n -(2-hidroxi-ciklohexil)benzamid, vagy annak gyógyszerészetileg elfogadható sója
CN105237392B (zh) * 2015-11-24 2017-12-12 辽宁渤大化工有限公司 芳烷基水杨酸及其衍生物的制备方法
AU2018321287A1 (en) * 2017-08-20 2020-04-02 University Of Connecticut Azole analogues and methods of use thereof
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
WO1993019061A1 (en) * 1992-03-18 1993-09-30 Janssen Pharmaceutica N.V. Itraconazole and saperconazole stereoisomers
ATE204875T1 (de) * 1993-12-21 2001-09-15 Schering Corp Fungizide tetrahydrofurane
CA2179640C (en) * 1994-01-24 2005-11-15 Jan Heeres Watersoluble azole antifungals
FI98688C (fi) * 1994-07-20 1997-07-25 Nokia Telecommunications Oy Menetelmä lyhytsanomalähetyksen käynnistämiseksi solukkoradiojärjestelmässä, solukkoradiojärjestelmä sekä solukkoradiojärjestelmän tilaajarekisteri
HUP9701690A3 (en) * 1995-06-02 1998-04-28 Schering Corp Kenilwort Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same
EP0837859B1 (en) * 1995-06-19 2003-08-13 Schering Corporation Tetrahydrofuran antifungals
DK0958289T3 (da) 1997-02-11 2004-11-01 Janssen Pharmaceutica Nv Aminosyreester indeholdende azol-antisvampemidler
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals

Also Published As

Publication number Publication date
ATE221884T1 (de) 2002-08-15
EE04346B1 (et) 2004-08-16
DE69907171D1 (de) 2003-05-28
AR016480A1 (es) 2001-07-04
TR200003323T2 (tr) 2001-02-21
BG104717A (en) 2001-07-31
SI1077976T1 (en) 2003-02-28
NO20005713D0 (no) 2000-11-13
MY120248A (en) 2005-09-30
US6448244B1 (en) 2002-09-10
TR200003322T2 (tr) 2001-02-21
HK1033312A1 (en) 2001-08-24
BG64388B1 (bg) 2004-12-30
BR9910448A (pt) 2001-01-02
CA2331187C (en) 2008-11-18
BR9911057A (pt) 2001-02-06
HRP20000741B1 (en) 2009-02-28
SK16822000A3 (sk) 2001-07-10
AU751135B2 (en) 2002-08-08
ES2198915T3 (es) 2004-02-01
NZ507966A (en) 2002-10-25
NO20005713L (no) 2001-01-11
SK286156B6 (sk) 2008-04-07
JP2002514645A (ja) 2002-05-21
HUP0103536A3 (en) 2002-08-28
BG104933A (en) 2001-10-31
CN1300288A (zh) 2001-06-20
CO5021227A1 (es) 2001-03-27
AU758876B2 (en) 2003-04-03
PL194086B1 (pl) 2007-04-30
EP0957101A1 (en) 1999-11-17
CN1300287A (zh) 2001-06-20
CA2331141C (en) 2008-10-28
IL139649A (en) 2004-09-27
DE69902461T2 (de) 2003-04-10
HUP0102031A2 (hu) 2002-05-29
JP2002514646A (ja) 2002-05-21
EE200000651A (et) 2002-04-15
NO319851B1 (no) 2005-09-19
AU4361599A (en) 1999-11-29
TW572899B (en) 2004-01-21
ZA200007459B (en) 2002-09-13
WO1999058530A1 (en) 1999-11-18
HRP20000740B1 (en) 2003-12-31
EP1077976B1 (en) 2002-08-07
PL194085B1 (pl) 2007-04-30
CA2331141A1 (en) 1999-11-18
EE04311B1 (et) 2004-06-15
EP1077975B1 (en) 2003-04-23
CZ20004108A3 (en) 2001-05-16
BG64954B1 (bg) 2006-10-31
KR20010041480A (ko) 2001-05-25
KR100593395B1 (ko) 2006-06-28
MY122147A (en) 2006-03-31
PT1077976E (pt) 2002-12-31
HUP0102031A3 (en) 2002-10-28
NZ507965A (en) 2002-05-31
PL344037A1 (en) 2001-09-24
AR016482A1 (es) 2001-07-04
HK1032781A1 (en) 2001-08-03
HRP20000740A2 (en) 2001-10-31
KR20010042852A (ko) 2001-05-25
CZ20004109A3 (en) 2001-05-16
HUP0103536A2 (hu) 2002-07-29
DE69902461D1 (de) 2002-09-12
SK16812000A3 (sk) 2001-08-06
NO319760B1 (no) 2005-09-12
KR100575147B1 (ko) 2006-05-03
SK285763B6 (sk) 2007-07-06
DE69907171T2 (de) 2004-02-05
US6384030B1 (en) 2002-05-07
CA2331187A1 (en) 1999-11-18
ATE238296T1 (de) 2003-05-15
ES2182531T3 (es) 2003-03-01
NO20005712L (no) 2000-12-07
AU4141799A (en) 1999-11-29
PL344047A1 (en) 2001-09-24
EP1077976A1 (en) 2001-02-28
TWI259835B (en) 2006-08-11
WO1999058529A1 (en) 1999-11-18
CZ299481B6 (cs) 2008-08-13
IL139649A0 (en) 2002-02-10
ZA200007173B (en) 2002-03-04
IL139647A0 (en) 2002-02-10
HRP20000741A2 (en) 2001-06-30
CN1137118C (zh) 2004-02-04
CN1135229C (zh) 2004-01-21
EP1077975A1 (en) 2001-02-28
NO20005712D0 (no) 2000-11-13
CZ298702B6 (cs) 2007-12-27
EE200000657A (et) 2002-04-15

Similar Documents

Publication Publication Date Title
ATE244236T1 (de) Substituierte azole
FR2780857B1 (fr) Agent pesticide
DE60038278D1 (de) Schieberventil
NO20004159L (no) 2-pyridylmetylaminderivater for anvendelse som fungicider
ATE295353T1 (de) Pyrazol-carboxanilide fungizide
FR12C0010I2 (fr) Composition herbicide
DK1028961T5 (da) Pleuromutilinderivater som antimikrobielle midler
FR10C0027I2 (fr) Mélanges fongicides
DK1077976T3 (da) Vandopløselige azoler som bredspektrede antisvampemidler
DE69907062D1 (de) Schlauchhaspel
PT1227724E (pt) Agente herbicida
PT1066291E (pt) (2-halo-4-alcoxifenil)-triazolopirimidinas fungicidas
DK1313370T3 (da) Fungicidformulering
DE59803505D1 (de) Schlauchaufrollsystem
DK1130967T3 (da) Fungicide blandinger
ID25972A (id) Formulasi aerosol pestisida
DE59914148D1 (de) Vorsteuerbares Wegeventil
DK1083792T3 (da) Fungicide blandinger
DK1212332T3 (da) Fungicider
PL340475A1 (en) Diluting agent for chemicals
DE69924266D1 (de) Pestizide tris-oxim-verbindungen
SE9904117D0 (sv) Maskin
FI3993U1 (fi) Letkuventtiili
ITMI990856A0 (it) Composizione erbicida
FI981965A0 (fi) Työteline