BG64388B1 - Водоразтворими азоли като антифунгали с широк спектър на действие - Google Patents

Водоразтворими азоли като антифунгали с широк спектър на действие Download PDF

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Publication number
BG64388B1
BG64388B1 BG104717A BG10471700A BG64388B1 BG 64388 B1 BG64388 B1 BG 64388B1 BG 104717 A BG104717 A BG 104717A BG 10471700 A BG10471700 A BG 10471700A BG 64388 B1 BG64388 B1 BG 64388B1
Authority
BG
Bulgaria
Prior art keywords
alkyl
formula
radical
amino
aryl
Prior art date
Application number
BG104717A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104717A (en
Inventor
Lieven Meerpoel
Leo Backx
Der Veken Louis Van
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG104717A publication Critical patent/BG104717A/xx
Publication of BG64388B1 publication Critical patent/BG64388B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BG104717A 1998-05-14 2000-08-28 Водоразтворими азоли като антифунгали с широк спектър на действие BG64388B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98201588A EP0957101A1 (en) 1998-05-14 1998-05-14 Water soluble azoles as broad-spectrum antifungals

Publications (2)

Publication Number Publication Date
BG104717A BG104717A (en) 2001-07-31
BG64388B1 true BG64388B1 (bg) 2004-12-30

Family

ID=8233724

Family Applications (2)

Application Number Title Priority Date Filing Date
BG104717A BG64388B1 (bg) 1998-05-14 2000-08-28 Водоразтворими азоли като антифунгали с широк спектър на действие
BG104933A BG64954B1 (bg) 1998-05-14 2000-11-09 Водоразтворими азоли като антифунгали с широк спектър на действие

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG104933A BG64954B1 (bg) 1998-05-14 2000-11-09 Водоразтворими азоли като антифунгали с широк спектър на действие

Country Status (32)

Country Link
US (2) US6384030B1 (cs)
EP (3) EP0957101A1 (cs)
JP (2) JP2002514646A (cs)
KR (2) KR100593395B1 (cs)
CN (2) CN1137118C (cs)
AR (2) AR016482A1 (cs)
AT (2) ATE238296T1 (cs)
AU (2) AU751135B2 (cs)
BG (2) BG64388B1 (cs)
BR (2) BR9911057A (cs)
CA (2) CA2331187C (cs)
CO (1) CO5021227A1 (cs)
CZ (2) CZ298702B6 (cs)
DE (2) DE69902461T2 (cs)
DK (1) DK1077976T3 (cs)
EE (2) EE04311B1 (cs)
ES (2) ES2198915T3 (cs)
HK (2) HK1033312A1 (cs)
HR (2) HRP20000741B1 (cs)
HU (2) HUP0103536A3 (cs)
IL (2) IL139649A (cs)
MY (2) MY122147A (cs)
NO (2) NO319851B1 (cs)
NZ (2) NZ507965A (cs)
PL (2) PL194085B1 (cs)
PT (1) PT1077976E (cs)
SI (1) SI1077976T1 (cs)
SK (2) SK286156B6 (cs)
TR (2) TR200003323T2 (cs)
TW (2) TWI259835B (cs)
WO (2) WO1999058530A1 (cs)
ZA (2) ZA200007173B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
AU3402301A (en) * 2000-03-07 2001-09-17 Ranbaxy Laboratories Limited Azole compounds as therapeutic agents for fungal infections
EP1413301A1 (fr) * 2002-10-24 2004-04-28 Bayer CropScience SA Médicaments antifongiques à base de dérivés d'arylamidine
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
WO2011144653A1 (en) * 2010-05-19 2011-11-24 Sandoz Ag Process for the preparation of chiral triazolones
US11028078B2 (en) * 2011-09-07 2021-06-08 The Johns Hopkins University Itraconazole analogs and use thereof
US9346791B2 (en) 2011-09-07 2016-05-24 The Johns Hopkins University Itraconazole analogs and use thereof
US9663499B2 (en) * 2013-06-07 2017-05-30 The California Institute For Biomedical Research Small molecule inhibitors of fibrosis
WO2016087878A1 (en) 2014-12-05 2016-06-09 Pulmocide Limited Antimycotic compound
WO2016094570A1 (en) * 2014-12-10 2016-06-16 The California Institute For Biomedical Research Small molecule inhibitors of fibrosis
DK3298006T3 (da) 2015-05-21 2020-03-30 Pulmocide Ltd Antifungal 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorphenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-n-(2-hydroxycyclohexyl)benzamid eller et farmaceutisk acceptabelt salt deraf
CN105237392B (zh) * 2015-11-24 2017-12-12 辽宁渤大化工有限公司 芳烷基水杨酸及其衍生物的制备方法
AU2018321287A1 (en) 2017-08-20 2020-04-02 University Of Connecticut Azole analogues and methods of use thereof
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
WO1993019061A1 (en) * 1992-03-18 1993-09-30 Janssen Pharmaceutica N.V. Itraconazole and saperconazole stereoisomers
WO1995017407A1 (en) * 1993-12-21 1995-06-29 Schering Corporation Tetrahydrofuran antifungals
WO1995019983A1 (en) * 1994-01-24 1995-07-27 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
WO1996003843A2 (en) * 1994-07-20 1996-02-08 Nokia Telecommunications Oy Starting a short message transmission in a cellular communication system
WO1997000255A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Tetrahydrofuran antifungals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE240319T1 (de) * 1995-06-02 2003-05-15 Schering Corp Antifungale tetrahydrofurane
DE69824834T2 (de) 1997-02-11 2005-07-21 Janssen Pharmaceutica N.V. Azole enthaltende antifungale aminosäure-ester
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
WO1993019061A1 (en) * 1992-03-18 1993-09-30 Janssen Pharmaceutica N.V. Itraconazole and saperconazole stereoisomers
WO1995017407A1 (en) * 1993-12-21 1995-06-29 Schering Corporation Tetrahydrofuran antifungals
WO1995019983A1 (en) * 1994-01-24 1995-07-27 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
WO1996003843A2 (en) * 1994-07-20 1996-02-08 Nokia Telecommunications Oy Starting a short message transmission in a cellular communication system
WO1997000255A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Tetrahydrofuran antifungals

Also Published As

Publication number Publication date
WO1999058530A1 (en) 1999-11-18
TW572899B (en) 2004-01-21
ATE238296T1 (de) 2003-05-15
NO20005712L (no) 2000-12-07
DE69907171D1 (de) 2003-05-28
CZ20004109A3 (en) 2001-05-16
PL194085B1 (pl) 2007-04-30
ZA200007459B (en) 2002-09-13
HK1032781A1 (en) 2001-08-03
WO1999058529A1 (en) 1999-11-18
HRP20000741A2 (en) 2001-06-30
HRP20000741B1 (en) 2009-02-28
NO319851B1 (no) 2005-09-19
TWI259835B (en) 2006-08-11
EE200000651A (et) 2002-04-15
JP2002514645A (ja) 2002-05-21
MY122147A (en) 2006-03-31
PT1077976E (pt) 2002-12-31
HUP0102031A3 (en) 2002-10-28
NO319760B1 (no) 2005-09-12
EP1077976A1 (en) 2001-02-28
BG104933A (en) 2001-10-31
NZ507965A (en) 2002-05-31
US6384030B1 (en) 2002-05-07
IL139647A0 (en) 2002-02-10
CZ298702B6 (cs) 2007-12-27
MY120248A (en) 2005-09-30
EP1077975A1 (en) 2001-02-28
BR9911057A (pt) 2001-02-06
BG64954B1 (bg) 2006-10-31
ATE221884T1 (de) 2002-08-15
AU758876B2 (en) 2003-04-03
PL344047A1 (en) 2001-09-24
AU4141799A (en) 1999-11-29
KR20010041480A (ko) 2001-05-25
CA2331187C (en) 2008-11-18
AR016480A1 (es) 2001-07-04
NO20005713L (no) 2001-01-11
CN1135229C (zh) 2004-01-21
DE69902461D1 (de) 2002-09-12
EP1077975B1 (en) 2003-04-23
HUP0102031A2 (hu) 2002-05-29
ES2198915T3 (es) 2004-02-01
EE200000657A (et) 2002-04-15
CO5021227A1 (es) 2001-03-27
HK1033312A1 (en) 2001-08-24
SI1077976T1 (en) 2003-02-28
KR100575147B1 (ko) 2006-05-03
NZ507966A (en) 2002-10-25
CN1300287A (zh) 2001-06-20
HUP0103536A3 (en) 2002-08-28
CA2331187A1 (en) 1999-11-18
AU4361599A (en) 1999-11-29
EE04311B1 (et) 2004-06-15
SK16812000A3 (sk) 2001-08-06
PL194086B1 (pl) 2007-04-30
DE69907171T2 (de) 2004-02-05
TR200003323T2 (tr) 2001-02-21
AR016482A1 (es) 2001-07-04
TR200003322T2 (tr) 2001-02-21
PL344037A1 (en) 2001-09-24
DK1077976T3 (da) 2002-12-02
SK16822000A3 (sk) 2001-07-10
EP1077976B1 (en) 2002-08-07
DE69902461T2 (de) 2003-04-10
US6448244B1 (en) 2002-09-10
ZA200007173B (en) 2002-03-04
HRP20000740B1 (en) 2003-12-31
NO20005712D0 (no) 2000-11-13
BR9910448A (pt) 2001-01-02
CN1137118C (zh) 2004-02-04
BG104717A (en) 2001-07-31
ES2182531T3 (es) 2003-03-01
CZ20004108A3 (en) 2001-05-16
HUP0103536A2 (hu) 2002-07-29
KR20010042852A (ko) 2001-05-25
SK285763B6 (sk) 2007-07-06
CZ299481B6 (cs) 2008-08-13
IL139649A0 (en) 2002-02-10
NO20005713D0 (no) 2000-11-13
IL139649A (en) 2004-09-27
SK286156B6 (sk) 2008-04-07
JP2002514646A (ja) 2002-05-21
EP0957101A1 (en) 1999-11-17
EE04346B1 (et) 2004-08-16
AU751135B2 (en) 2002-08-08
CA2331141C (en) 2008-10-28
CN1300288A (zh) 2001-06-20
CA2331141A1 (en) 1999-11-18
KR100593395B1 (ko) 2006-06-28
HRP20000740A2 (en) 2001-10-31

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