HK74487A - ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS - Google Patents

ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS Download PDF

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Publication number
HK74487A
HK74487A HK744/87A HK74487A HK74487A HK 74487 A HK74487 A HK 74487A HK 744/87 A HK744/87 A HK 744/87A HK 74487 A HK74487 A HK 74487A HK 74487 A HK74487 A HK 74487A
Authority
HK
Hong Kong
Prior art keywords
lower alkyl
antibacterial agents
lactamase inhibitors
esters
formula
Prior art date
Application number
HK744/87A
Other languages
English (en)
Inventor
Foqlio Maurizio
Franceschi Giovanni
Scarafile Cosimo
Arcamone Federico
Sanfilippo Aurora
Original Assignee
Farmitalia Carlo Erba S.R.L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba S.R.L filed Critical Farmitalia Carlo Erba S.R.L
Publication of HK74487A publication Critical patent/HK74487A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
HK744/87A 1979-02-24 1987-10-15 ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS HK74487A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7906634 1979-02-24
GB7932591 1979-09-20

Publications (1)

Publication Number Publication Date
HK74487A true HK74487A (en) 1987-10-23

Family

ID=26270697

Family Applications (1)

Application Number Title Priority Date Filing Date
HK744/87A HK74487A (en) 1979-02-24 1987-10-15 ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

Country Status (24)

Country Link
AT (1) AT368506B (enrdf_load_stackoverflow)
AU (1) AU535080B2 (enrdf_load_stackoverflow)
CA (2) CA1154010A (enrdf_load_stackoverflow)
CH (2) CH651570A5 (enrdf_load_stackoverflow)
CS (1) CS226010B2 (enrdf_load_stackoverflow)
DE (1) DE3006273A1 (enrdf_load_stackoverflow)
DK (1) DK159448C (enrdf_load_stackoverflow)
ES (2) ES8200685A1 (enrdf_load_stackoverflow)
FI (1) FI75163C (enrdf_load_stackoverflow)
FR (1) FR2449690B1 (enrdf_load_stackoverflow)
GB (1) GB2043639B (enrdf_load_stackoverflow)
GR (1) GR73623B (enrdf_load_stackoverflow)
HK (1) HK74487A (enrdf_load_stackoverflow)
HU (1) HU182664B (enrdf_load_stackoverflow)
IE (1) IE49407B1 (enrdf_load_stackoverflow)
IT (1) IT1193922B (enrdf_load_stackoverflow)
LU (1) LU82192A1 (enrdf_load_stackoverflow)
NL (1) NL192265C (enrdf_load_stackoverflow)
NO (1) NO161000C (enrdf_load_stackoverflow)
NZ (1) NZ192949A (enrdf_load_stackoverflow)
PT (1) PT70849A (enrdf_load_stackoverflow)
SE (1) SE449489B (enrdf_load_stackoverflow)
UA (1) UA6041A1 (enrdf_load_stackoverflow)
YU (1) YU42964B (enrdf_load_stackoverflow)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
DE3121510A1 (de) * 1980-07-04 1982-06-16 Farmitalia Carlo Erba S.p.A., 20159 Milano 6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
EP0070204B1 (en) * 1981-07-15 1987-11-19 Sumitomo Pharmaceuticals Company, Limited Carboxylic beta-lactam compounds and the preparation thereof
AT379399B (de) * 1981-12-11 1985-12-27 Erba Farmitalia Verfahren zur herstellung von optisch aktiven penemen
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
DE3372968D1 (en) * 1982-11-16 1987-09-17 Ciba Geigy Ag Heterocyclyl-thio compounds, process for their preparation, pharmaceutical compositions containing them and their use
PH21930A (en) * 1982-11-16 1988-04-08 Ciba Geigy Ag 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
GB8300295D0 (en) * 1983-01-06 1983-02-09 Erba Farmitalia Penem esters
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4711886A (en) * 1984-07-02 1987-12-08 Merck & Co., Inc. β-lactam derivatives as anti-inflammatory and antidegenerative agents
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
EP0278911B1 (de) * 1987-02-11 1993-08-04 Ciba-Geigy Ag Bicyclische beta-Lactam-carbonsäuren
US5364768A (en) * 1987-07-07 1994-11-15 Farmitalia Carlo Erba S.R.L. Process for the preparation of penems
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems
IT1286558B1 (it) * 1996-02-27 1998-07-15 Menarini Farma Ind Processo per la preparazione di 2-alogenometil-penems e loro uso per la preparazione di penems antibatterici
ATE219085T1 (de) 1997-12-29 2002-06-15 Res Corp Technologies Inc 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6720445B2 (en) 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same
ATE339424T1 (de) 2001-07-24 2006-10-15 Univ Southern Methodist 3-substituierte 7-alkylidene-3-cephem-4- carbonsäuren als beta-lactamase inhibitoren
WO2003087105A1 (en) 2002-04-04 2003-10-23 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ß-LACTAMASES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77306A1 (enrdf_load_stackoverflow) * 1977-05-09 1979-01-18
EP0000636A1 (en) * 1977-07-13 1979-02-07 Glaxo Group Limited Penem compounds, processes for their preparation, their use in pharmaceutical compositions and azetidinones used in their preparation
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
EP0010358A1 (en) * 1978-09-20 1980-04-30 Glaxo Group Limited Beta-lactam compounds, processes for their preparation, compositions containing them, intermediates of use in their preparation and methods for the production thereof
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes

Also Published As

Publication number Publication date
ES8107224A1 (es) 1981-10-01
IT1193922B (it) 1988-08-31
GB2043639A (en) 1980-10-08
YU46180A (en) 1983-02-28
SE8001424L (sv) 1980-08-25
SE449489B (sv) 1987-05-04
FR2449690B1 (fr) 1986-06-13
LU82192A1 (fr) 1980-06-06
GB2043639B (en) 1983-07-20
DK159448B (da) 1990-10-15
FI800493A7 (fi) 1980-08-25
UA6041A1 (uk) 1994-12-29
NO161000B (no) 1989-03-13
IT8020021A1 (it) 1981-08-19
AT368506B (de) 1982-10-25
NZ192949A (en) 1984-03-16
NL8001012A (nl) 1980-08-26
ES488886A0 (es) 1981-11-16
NO161000C (no) 1989-06-21
HU182664B (en) 1984-02-28
YU42964B (en) 1989-02-28
CH654831A5 (de) 1986-03-14
CA1154010A (en) 1983-09-20
CA1212665B (en) 1986-10-14
AU535080B2 (en) 1984-03-01
IT8020021A0 (it) 1980-02-19
ATA91980A (de) 1982-02-15
DE3006273A1 (de) 1980-09-04
FI75163B (fi) 1988-01-29
FI75163C (fi) 1988-05-09
PT70849A (en) 1980-03-01
CS226010B2 (en) 1984-03-19
NO800501L (no) 1980-08-25
IE49407B1 (en) 1985-10-02
AU5567080A (en) 1980-09-11
NL192265C (nl) 1997-04-03
GR73623B (enrdf_load_stackoverflow) 1984-03-26
NL192265B (nl) 1996-12-02
ES495977A0 (es) 1981-10-01
FR2449690A1 (fr) 1980-09-19
CH651570A5 (de) 1985-09-30
DK77580A (da) 1980-08-25
DK159448C (da) 1991-03-04
IE800338L (en) 1980-08-24
ES8200685A1 (es) 1981-11-16

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PE Patent expired