GB2043639B - 3-optionally substituted methyl-2-penem derivatives - Google Patents

3-optionally substituted methyl-2-penem derivatives

Info

Publication number
GB2043639B
GB2043639B GB8005476A GB8005476A GB2043639B GB 2043639 B GB2043639 B GB 2043639B GB 8005476 A GB8005476 A GB 8005476A GB 8005476 A GB8005476 A GB 8005476A GB 2043639 B GB2043639 B GB 2043639B
Authority
GB
United Kingdom
Prior art keywords
optionally substituted
substituted methyl
penem derivatives
penem
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8005476A
Other versions
GB2043639A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of GB2043639A publication Critical patent/GB2043639A/en
Application granted granted Critical
Publication of GB2043639B publication Critical patent/GB2043639B/en
Priority to MX9203121A priority Critical patent/MX9203121A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
GB8005476A 1979-02-24 1980-02-19 3-optionally substituted methyl-2-penem derivatives Expired GB2043639B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MX9203121A MX9203121A (en) 1979-02-24 1992-06-22 ANTIBACTERIAL AGENTS AND BETA-LACTAMA INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7906634 1979-02-24
GB7932591 1979-09-20

Publications (2)

Publication Number Publication Date
GB2043639A GB2043639A (en) 1980-10-08
GB2043639B true GB2043639B (en) 1983-07-20

Family

ID=26270697

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8005476A Expired GB2043639B (en) 1979-02-24 1980-02-19 3-optionally substituted methyl-2-penem derivatives

Country Status (24)

Country Link
AT (1) AT368506B (en)
AU (1) AU535080B2 (en)
CA (2) CA1154010A (en)
CH (2) CH654831A5 (en)
CS (1) CS226010B2 (en)
DE (1) DE3006273A1 (en)
DK (1) DK159448C (en)
ES (2) ES488886A0 (en)
FI (1) FI75163C (en)
FR (1) FR2449690B1 (en)
GB (1) GB2043639B (en)
GR (1) GR73623B (en)
HK (1) HK74487A (en)
HU (1) HU182664B (en)
IE (1) IE49407B1 (en)
IT (1) IT1193922B (en)
LU (1) LU82192A1 (en)
NL (1) NL192265C (en)
NO (1) NO161000C (en)
NZ (1) NZ192949A (en)
PT (1) PT70849A (en)
SE (1) SE449489B (en)
UA (1) UA6041A1 (en)
YU (1) YU42964B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
DE3121510A1 (en) * 1980-07-04 1982-06-16 Farmitalia Carlo Erba S.p.A., 20159 Milano 6-Alkyl-2-subst. penems and process for their preparation
JPS588084A (en) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd (6r)-substituted-(5r)-penem-3-carboxylic acid derivative and its preparation
EP0180252B1 (en) * 1981-07-15 1989-04-26 Sumitomo Pharmaceuticals Company, Limited Process of preparing azetidinone compounds
NL8204720A (en) * 1981-12-11 1983-07-01 Erba Farmitalia METHOD FOR PREPARING OPTICALLY ACTIVE PENEM COMPOUNDS
NO831160L (en) * 1982-04-08 1983-10-10 Erba Farmitalia PREPARATION OF SUBSTITUTED PENEM DERIVATIVES
PH21930A (en) * 1982-11-16 1988-04-08 Ciba Geigy Ag 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
DE3372968D1 (en) * 1982-11-16 1987-09-17 Ciba Geigy Ag Heterocyclyl-thio compounds, process for their preparation, pharmaceutical compositions containing them and their use
GB8300295D0 (en) * 1983-01-06 1983-02-09 Erba Farmitalia Penem esters
JPS59152387A (en) * 1983-02-10 1984-08-31 Shionogi & Co Ltd Novel penem compound
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4711886A (en) * 1984-07-02 1987-12-08 Merck & Co., Inc. β-lactam derivatives as anti-inflammatory and antidegenerative agents
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
ES2058328T3 (en) * 1987-02-11 1994-11-01 Ciba Geigy Ag BETA-LACTAM ACIDS BICYCLE CARBOXYLICS.
US5364768A (en) * 1987-07-07 1994-11-15 Farmitalia Carlo Erba S.R.L. Process for the preparation of penems
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems
IT1286558B1 (en) * 1996-02-27 1998-07-15 Menarini Farma Ind PROCESS FOR THE PREPARATION OF 2-HALOGENOMETHYL-PENEMS AND THEIR USE FOR THE PREPARATION OF ANTIBACTERIAL PENEMS
JP3866298B2 (en) 1997-12-29 2007-01-10 リサーチ コーポレイション テクノロジーズ，インコーポレイティド 2β-Substituted-6-alkylidenepenicillanic acid derivatives as β-lactamase inhibitors
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6720445B2 (en) 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same
CA2454413A1 (en) 2001-07-24 2003-03-13 Alamx, L.L.C. 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors
JP2005525399A (en) 2002-04-04 2005-08-25 アラムクス エルエルシー Inhibitors of serine and metallo-β-lactamases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77306A1 (en) * 1977-05-09 1979-01-18
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0042026B1 (en) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-disubstituted azetidin-2-on compounds and process for their preparation
EP0010358A1 (en) * 1978-09-20 1980-04-30 Glaxo Group Limited Beta-lactam compounds, processes for their preparation, compositions containing them, intermediates of use in their preparation and methods for the production thereof
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes

Also Published As

Publication number Publication date
YU46180A (en) 1983-02-28
FI800493A (en) 1980-08-25
FI75163B (en) 1988-01-29
ES8107224A1 (en) 1981-10-01
AU535080B2 (en) 1984-03-01
NO161000C (en) 1989-06-21
LU82192A1 (en) 1980-06-06
AT368506B (en) 1982-10-25
ES8200685A1 (en) 1981-11-16
NO800501L (en) 1980-08-25
ES495977A0 (en) 1981-10-01
YU42964B (en) 1989-02-28
NL192265C (en) 1997-04-03
NO161000B (en) 1989-03-13
HK74487A (en) 1987-10-23
PT70849A (en) 1980-03-01
IE800338L (en) 1980-08-24
AU5567080A (en) 1980-09-11
DK159448B (en) 1990-10-15
SE8001424L (en) 1980-08-25
HU182664B (en) 1984-02-28
GB2043639A (en) 1980-10-08
FR2449690B1 (en) 1986-06-13
DK159448C (en) 1991-03-04
CA1154010A (en) 1983-09-20
CA1212665B (en) 1986-10-14
ES488886A0 (en) 1981-11-16
IT8020021A1 (en) 1981-08-19
NL8001012A (en) 1980-08-26
DE3006273A1 (en) 1980-09-04
DK77580A (en) 1980-08-25
IE49407B1 (en) 1985-10-02
NL192265B (en) 1996-12-02
FR2449690A1 (en) 1980-09-19
CH654831A5 (en) 1986-03-14
SE449489B (en) 1987-05-04
ATA91980A (en) 1982-02-15
GR73623B (en) 1984-03-26
IT1193922B (en) 1988-08-31
CS226010B2 (en) 1984-03-19
UA6041A1 (en) 1994-12-29
CH651570A5 (en) 1985-09-30
FI75163C (en) 1988-05-09
IT8020021A0 (en) 1980-02-19
NZ192949A (en) 1984-03-16

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 20000218