HK1243369A1 - 用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗 - Google Patents

用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗 Download PDF

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Publication number
HK1243369A1
HK1243369A1 HK18102859.6A HK18102859A HK1243369A1 HK 1243369 A1 HK1243369 A1 HK 1243369A1 HK 18102859 A HK18102859 A HK 18102859A HK 1243369 A1 HK1243369 A1 HK 1243369A1
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Hong Kong
Prior art keywords
inhibitors
membered
independently selected
sulfur
oxygen
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HK18102859.6A
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English (en)
Chinese (zh)
Inventor
Geraldine C. Harriman
Rosana Kapeller-Libermann
William F. Westlin
H. James Harwood
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吉利德阿波罗公司
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Publication of HK1243369A1 publication Critical patent/HK1243369A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18102859.6A 2015-01-09 2016-01-08 用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗 HK1243369A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562101726P 2015-01-09 2015-01-09
US62/101,726 2015-01-09
PCT/US2016/012673 WO2016112305A1 (en) 2015-01-09 2016-01-08 Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease

Publications (1)

Publication Number Publication Date
HK1243369A1 true HK1243369A1 (zh) 2018-07-13

Family

ID=56356482

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18102859.6A HK1243369A1 (zh) 2015-01-09 2016-01-08 用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗
HK18105783.0A HK1246232A1 (zh) 2015-01-09 2016-01-08 用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK18105783.0A HK1246232A1 (zh) 2015-01-09 2016-01-08 用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗

Country Status (13)

Country Link
US (2) US20180021341A1 (enExample)
EP (2) EP3597271A1 (enExample)
JP (2) JP2018501276A (enExample)
KR (1) KR20170102299A (enExample)
CN (1) CN107106873A (enExample)
AU (1) AU2016205138A1 (enExample)
BR (1) BR112017014341A2 (enExample)
CA (1) CA2972919A1 (enExample)
EA (2) EA201791258A1 (enExample)
HK (2) HK1243369A1 (enExample)
MX (1) MX2017008844A (enExample)
SG (1) SG11201705361PA (enExample)
WO (1) WO2016112305A1 (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1993360T (pt) 2005-12-28 2017-05-25 Vertex Pharma Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida
TWI625121B (zh) 2009-07-13 2018-06-01 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
US11571431B2 (en) 2013-12-04 2023-02-07 Galmed Research And Development Ltd Aramchol salts
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
CN109879859B (zh) 2015-07-06 2022-01-25 吉利德科学公司 Cot调节剂及其使用方法
US20170166583A1 (en) 2015-11-25 2017-06-15 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
US20170166582A1 (en) * 2015-11-25 2017-06-15 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
IL243707A0 (en) 2016-01-20 2016-05-01 Galmed Res And Dev Ltd Treatment to regulate the microbiota in the intestine
CN112920200A (zh) 2016-03-02 2021-06-08 吉利德阿波罗公司 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
SI3730487T1 (sl) 2016-06-13 2022-08-31 Gilead Sciences, Inc. Azetidinski derivati kot modulatorji FXR (NR1H4)
CA3252823A1 (en) 2016-06-13 2025-02-25 Gilead Sciences Inc Fxr (nr1h4) modulating compounds
EP3534976A4 (en) 2016-11-04 2020-09-16 Children's Hospital Medical Center PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE
US11197870B2 (en) 2016-11-10 2021-12-14 Galmed Research And Development Ltd Treatment for hepatic fibrosis
MA46786A (fr) * 2016-11-10 2019-09-18 Galmed Res And Development Ltd Inhibition de la fibrose chez des patients atteints d'une stéatose hépatique non alcoolique
MA47558A (fr) * 2016-11-10 2019-09-18 Galmed Res And Development Ltd Traitement de la fibrose
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
WO2018134254A1 (en) 2017-01-17 2018-07-26 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
KR102577824B1 (ko) * 2017-01-22 2023-09-13 선샤인 레이크 파르마 컴퍼니 리미티드 티에노피리미딘 유도체 및 의약에서 이의 용도
WO2018171699A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途
TW201900167A (zh) * 2017-03-28 2019-01-01 美商基利科學股份有限公司 治療肝疾病之方法
JP6906626B2 (ja) * 2017-03-28 2021-07-21 ギリアード サイエンシーズ， インコーポレイテッド 肝疾患を処置するための治療的組み合わせ
CA3059883A1 (en) * 2017-04-12 2018-10-18 Gilead Sciences, Inc. Methods of treating liver disease
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
MX2019012535A (es) * 2017-04-18 2020-08-17 Genfit Combinacion que comprende un agonista de ppar tal como elafibranor y un inhibidor de la acetil-coa carboxilasa (acc).
WO2018195727A1 (en) * 2017-04-24 2018-11-01 Tsinghua University Use of autoinducer-related pathway in inducing apoptosis and anti-infective therapy
WO2018236896A1 (en) * 2017-06-19 2018-12-27 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of nafld and nash
WO2019015583A1 (en) 2017-07-17 2019-01-24 Nanjing Ruijie Pharmatech Co., Ltd. NOVEL COMPOUNDS AND THEIR USES AS ACC INHIBITORS
EP3660023B1 (en) * 2017-07-26 2023-03-08 Nanjing Sanhome Pharmaceutical Co., Ltd. Thienopyrimidinedione compounds as acc inhibitors and use thereof
CN109316601B (zh) * 2017-07-31 2021-11-09 武汉朗来科技发展有限公司 药物组合物及其用途
EP3676262A4 (en) 2017-09-03 2021-03-31 Angion Biomedica Corp. VINYLHETEROCYCLENE AS RHO-ASSOCIATED COILED COIL KINASE (ROCK) INHIBITORS
US11033601B2 (en) * 2017-09-14 2021-06-15 The Regents Of The University Of Colorado, A Body Corporate Selective inhibition of V1b for treating fatty liver
JP7479278B2 (ja) * 2017-10-06 2024-05-08 ギリアード サイエンシーズ， インコーポレイテッド Ａｃｃ阻害剤を含む併用療法
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
EP3708577B1 (en) * 2017-11-06 2024-09-04 Shenzhen Turier Biotech Co., Ltd. Treatment of biliary cirrhosis based on oxyntomodulin analogue glp-1r/gcgr dual-target agonist peptide
CN107693514A (zh) * 2017-12-04 2018-02-16 威海贯标信息科技有限公司 一种鲁格列净组合物
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
SG11202007143UA (en) 2018-01-31 2020-08-28 Heparegenix Gmbh Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
AU2019254371A1 (en) * 2018-04-17 2020-10-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
EP3784657A4 (en) * 2018-04-24 2022-02-09 pH Pharma Co., Ltd. USE OF NEUTROPHIL ELASTASE INHIBITORS IN LIVER DISEASE
EP3810139A1 (en) 2018-06-21 2021-04-28 HepaRegeniX GmbH Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
AU2019303986B2 (en) 2018-07-16 2024-02-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
US20210322324A1 (en) * 2018-08-14 2021-10-21 Avolynt Method for treating primary sclerosing cholangitis
US11254660B2 (en) 2018-08-31 2022-02-22 Pfizer Inc. Combinations for treatment of NASH/NAFLD and related diseases
WO2020049556A1 (en) * 2018-09-06 2020-03-12 Galmed Research And Development Ltd Combination therapy for the treatment of liver disease
WO2020056158A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
CN110950884B (zh) * 2018-09-27 2024-03-26 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
JP2022513101A (ja) * 2018-11-20 2022-02-07 中国医▲薬▼研究▲開▼▲発▼中心有限公司 スピロ環系化合物及びその医薬用途
US11225473B2 (en) 2019-01-15 2022-01-18 Gilead Sciences, Inc. FXR (NR1H4) modulating compounds
EP3927683A1 (en) 2019-02-19 2021-12-29 Gilead Sciences, Inc. Solid forms of fxr agonists
US12458612B2 (en) * 2019-04-10 2025-11-04 Genfit Combination therapy comprising compounds of formula (I) and GLP-1 receptor agonists
SG11202111552YA (en) 2019-05-08 2021-11-29 Aligos Therapeutics Inc MODULATORS OF THR-ß AND METHODS OF USE THEREOF
TWI770527B (zh) 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
JP7374233B2 (ja) * 2019-07-02 2023-11-06 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 立体配置を有するチエノピリミジン誘導体及び薬物におけるその応用
NZ785221A (en) 2019-07-29 2025-08-29 Heparegenix Gmbh Heteroaryl-substituted pyrazolo-pyridine protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
CN110628810B (zh) * 2019-08-13 2022-06-28 浙江大学 一种提高植物光合效率的方法
WO2021040440A1 (ko) * 2019-08-30 2021-03-04 (주)셀트리온 비알콜성 지방간염(nash, nonalcoholic steatohepatitis) 치료 또는 예방을 위한 약학 조성물
US20230105984A1 (en) 2019-12-23 2023-04-06 Svetlana Marukian Compositions and methods for the treatment of liver diseases and disorders
JP7639008B2 (ja) 2020-01-15 2025-03-04 ヘパリジェニックス ゲーエムベーハー 肝再生促進又は肝細胞死の抑制もしくは防止のためのプロテインキナーゼ阻害剤
JP2021134211A (ja) 2020-02-24 2021-09-13 ファイザー・インク Ｎａｆｌｄ／ｎａｓｈおよび関連疾患の処置のための組合せ
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
NZ791393A (en) * 2020-03-11 2025-09-26 Dong A St Co Ltd Pharmaceutical composition for prevention or treatment of nonalcoholic steatohepatitis
EP4126231A1 (en) 2020-03-30 2023-02-08 Gilead Sciences, Inc. Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
CN115397824B (zh) 2020-04-02 2024-10-22 吉利德科学公司 用于制备cot抑制剂化合物的方法
CN111407892A (zh) * 2020-04-08 2020-07-14 中国药科大学 Acsl4及其在nash中的应用
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
CN115666558A (zh) 2020-05-21 2023-01-31 盐野义制药株式会社 脂肪性肝病的治疗用药物
EP4000616A1 (en) * 2020-11-17 2022-05-25 Inventiva Combination therapy for the treatment of a liver disease
US12091404B2 (en) 2021-03-11 2024-09-17 Gilead Sciences, Inc. GLP-1R modulating compounds
WO2022212194A1 (en) 2021-03-29 2022-10-06 Gilead Sciences, Inc. Khk inhibitors
TW202345826A (zh) 2021-06-04 2023-12-01 美商基利科學股份有限公司 治療nash之方法
TW202311256A (zh) 2021-06-18 2023-03-16 美商基利科學股份有限公司 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑
WO2023034381A1 (en) * 2021-08-31 2023-03-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Quantitative systems pharmacology methods for identifying therapeutics for disease states
WO2023047203A1 (en) * 2021-09-25 2023-03-30 Torrent Pharmaceuticals Ltd Combination of omzotirome and antidiabetic agent, antihypertensive agent or anti-dyslipidemic agent
US20250041279A1 (en) 2021-11-19 2025-02-06 Shionogi & Co., Ltd. Therapeutic medicine for heart disease or skeletal muscle disease
US20250017938A1 (en) * 2023-06-20 2025-01-16 Sagimet Biosciences Inc. Combination therapies of fasn inhibitors with thyroid hormone receptor agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155611A1 (en) * 2008-06-20 2009-12-23 Kinemed, Inc. Compositions for the treatment of fibrotic diseases or conditions
US20100113473A1 (en) * 2008-10-30 2010-05-06 Player Mark R Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor
WO2012090219A2 (en) * 2010-12-31 2012-07-05 Jubilant Biosys Ltd. Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors
DK2776038T3 (en) * 2011-11-11 2018-04-23 Gilead Apollo Llc ACC INHIBITORS AND APPLICATIONS THEREOF
EA030958B1 (ru) 2013-05-10 2018-10-31 Джилид Аполло, Ллс Ингибиторы акк и их применение
BR112015028152A2 (pt) * 2013-05-10 2017-07-25 Nimbus Apollo Inc inibidores de acc e usos dos mesmos
EA201591962A1 (ru) * 2013-05-10 2016-06-30 Нимбус Аполло, Инк. Ингибиторы акк и их применение
US9988399B2 (en) 2013-05-10 2018-06-05 Gilead Apollo, Llc Bicyclic compounds as ACC inhibitors and uses thereof

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Publication number Publication date
EP3242722A1 (en) 2017-11-15
EP3242722A4 (en) 2018-07-11
CN107106873A (zh) 2017-08-29
AU2016205138A1 (en) 2017-07-13
US20180021341A1 (en) 2018-01-25
WO2016112305A1 (en) 2016-07-14
CA2972919A1 (en) 2016-07-14
MX2017008844A (es) 2018-03-14
HK1246232A1 (zh) 2018-09-07
EP3597271A1 (en) 2020-01-22
JP2020109130A (ja) 2020-07-16
EA201892625A1 (ru) 2019-07-31
US20190381045A1 (en) 2019-12-19
SG11201705361PA (en) 2017-08-30
BR112017014341A2 (pt) 2018-03-27
EA201791258A1 (ru) 2017-12-29
JP2018501276A (ja) 2018-01-18
KR20170102299A (ko) 2017-09-08

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