AU2016205138A1 - ACC inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease - Google Patents
ACC inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease Download PDFInfo
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- AU2016205138A1 AU2016205138A1 AU2016205138A AU2016205138A AU2016205138A1 AU 2016205138 A1 AU2016205138 A1 AU 2016205138A1 AU 2016205138 A AU2016205138 A AU 2016205138A AU 2016205138 A AU2016205138 A AU 2016205138A AU 2016205138 A1 AU2016205138 A1 AU 2016205138A1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07—ORGANIC CHEMISTRY
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2016/012673 WO2016112305A1 (en) | 2015-01-09 | 2016-01-08 | Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease |
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| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
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| US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法 |
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| WO2018171699A1 (zh) * | 2017-03-24 | 2018-09-27 | 浙江海正药业股份有限公司 | 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
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| TW202345826A (zh) | 2021-06-04 | 2023-12-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
| TW202311256A (zh) | 2021-06-18 | 2023-03-16 | 美商基利科學股份有限公司 | 用於治療fxr誘發之搔癢之il-31調節劑 |
| WO2023034381A1 (en) * | 2021-08-31 | 2023-03-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Quantitative systems pharmacology methods for identifying therapeutics for disease states |
| WO2023047203A1 (en) * | 2021-09-25 | 2023-03-30 | Torrent Pharmaceuticals Ltd | Combination of omzotirome and antidiabetic agent, antihypertensive agent or anti-dyslipidemic agent |
| US20250041279A1 (en) | 2021-11-19 | 2025-02-06 | Shionogi & Co., Ltd. | Therapeutic medicine for heart disease or skeletal muscle disease |
| US20250017938A1 (en) * | 2023-06-20 | 2025-01-16 | Sagimet Biosciences Inc. | Combination therapies of fasn inhibitors with thyroid hormone receptor agonists |
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| WO2009155611A1 (en) * | 2008-06-20 | 2009-12-23 | Kinemed, Inc. | Compositions for the treatment of fibrotic diseases or conditions |
| US20100113473A1 (en) * | 2008-10-30 | 2010-05-06 | Player Mark R | Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor |
| WO2012090219A2 (en) * | 2010-12-31 | 2012-07-05 | Jubilant Biosys Ltd. | Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors |
| DK2776038T3 (en) * | 2011-11-11 | 2018-04-23 | Gilead Apollo Llc | ACC INHIBITORS AND APPLICATIONS THEREOF |
| EA030958B1 (ru) | 2013-05-10 | 2018-10-31 | Джилид Аполло, Ллс | Ингибиторы акк и их применение |
| BR112015028152A2 (pt) * | 2013-05-10 | 2017-07-25 | Nimbus Apollo Inc | inibidores de acc e usos dos mesmos |
| EA201591962A1 (ru) * | 2013-05-10 | 2016-06-30 | Нимбус Аполло, Инк. | Ингибиторы акк и их применение |
| US9988399B2 (en) | 2013-05-10 | 2018-06-05 | Gilead Apollo, Llc | Bicyclic compounds as ACC inhibitors and uses thereof |
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2016
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- 2016-01-08 CN CN201680004801.2A patent/CN107106873A/zh active Pending
- 2016-01-08 EP EP19176040.4A patent/EP3597271A1/en not_active Withdrawn
- 2016-01-08 EA EA201791258A patent/EA201791258A1/ru unknown
- 2016-01-08 AU AU2016205138A patent/AU2016205138A1/en not_active Abandoned
- 2016-01-08 SG SG11201705361PA patent/SG11201705361PA/en unknown
- 2016-01-08 CA CA2972919A patent/CA2972919A1/en not_active Abandoned
- 2016-01-08 EP EP16735485.1A patent/EP3242722A4/en not_active Withdrawn
- 2016-01-08 HK HK18102859.6A patent/HK1243369A1/zh unknown
- 2016-01-08 EA EA201892625A patent/EA201892625A1/ru unknown
- 2016-01-08 WO PCT/US2016/012673 patent/WO2016112305A1/en not_active Ceased
- 2016-01-08 JP JP2017535411A patent/JP2018501276A/ja not_active Withdrawn
- 2016-01-08 HK HK18105783.0A patent/HK1246232A1/zh unknown
- 2016-01-08 KR KR1020177021086A patent/KR20170102299A/ko not_active Withdrawn
- 2016-01-08 US US15/541,008 patent/US20180021341A1/en not_active Abandoned
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2019
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2020
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| EP3242722A4 (en) | 2018-07-11 |
| HK1243369A1 (zh) | 2018-07-13 |
| CN107106873A (zh) | 2017-08-29 |
| US20180021341A1 (en) | 2018-01-25 |
| WO2016112305A1 (en) | 2016-07-14 |
| CA2972919A1 (en) | 2016-07-14 |
| MX2017008844A (es) | 2018-03-14 |
| HK1246232A1 (zh) | 2018-09-07 |
| EP3597271A1 (en) | 2020-01-22 |
| JP2020109130A (ja) | 2020-07-16 |
| EA201892625A1 (ru) | 2019-07-31 |
| US20190381045A1 (en) | 2019-12-19 |
| SG11201705361PA (en) | 2017-08-30 |
| BR112017014341A2 (pt) | 2018-03-27 |
| EA201791258A1 (ru) | 2017-12-29 |
| JP2018501276A (ja) | 2018-01-18 |
| KR20170102299A (ko) | 2017-09-08 |
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