HK1211589A1 - 用於治疗副粘病毒病毒性感染的化合物 - Google Patents

用於治疗副粘病毒病毒性感染的化合物 Download PDF

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HK1211589A1
HK1211589A1 HK15112568.0A HK15112568A HK1211589A1 HK 1211589 A1 HK1211589 A1 HK 1211589A1 HK 15112568 A HK15112568 A HK 15112568A HK 1211589 A1 HK1211589 A1 HK 1211589A1
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Hong Kong
Prior art keywords
paramoxyvirus
compounds
treatment
viral infections
infections
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HK15112568.0A
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English (en)
Chinese (zh)
Inventor
Guangyi Wang
Leonid Beigelman
Anh Truong
Carmela NAPOLITANO
Daniele Andreotti
Haiying He
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Alios Biopharma, Inc.
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Publication of HK1211589A1 publication Critical patent/HK1211589A1/xx

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Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015003376A8 (pt) * 2012-08-23 2018-01-23 Alios Biopharma Inc composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e usos de quantidade eficiente de composto ou sal farmaceuticamente aceitável do mesmo ou composição farmacêutica
EP2935303B1 (en) 2012-12-21 2021-02-17 Janssen BioPharma, Inc. 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效rock1及rock2抑制劑之苯基吡唑衍生物
JP6423372B2 (ja) 2013-02-28 2018-11-14 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 強力なrock1およびrock2阻害剤としてのフェニルピラゾール誘導体
MX2016002199A (es) * 2013-08-21 2016-07-13 Alios Biopharma Inc Compuestos antivirales.
CU24345B1 (es) 2013-09-06 2018-05-08 Aurigene Discovery Tech Ltd Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores
EP3177299A4 (en) * 2014-08-05 2018-04-04 Alios Biopharma, Inc. Combination therapy for treating a paramyxovirus
KR20170068521A (ko) 2014-10-06 2017-06-19 코텍자임, 인코포레이티드 리신 진지페인의 억제제
WO2016132998A1 (ja) * 2015-02-19 2016-08-25 Jnc株式会社 ベンゾチオフェンを有する液晶性化合物、液晶組成物および液晶表示素子
MA41614A (fr) * 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
NZ739226A (en) 2015-07-22 2022-11-25 Enanta Pharm Inc Benzodiazepine derivatives as rsv inhibitors
EP3436434B1 (en) 2016-03-31 2020-07-08 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
MX2019003087A (es) 2016-09-16 2019-08-12 Cortexyme Inc Inhibidores cetónicos de gingipain de lisina.
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
US10881666B2 (en) 2017-09-29 2021-01-05 Enanta Pharmaceuticals, Inc. Combination pharmaceutical agents as RSV inhibitors
CA3084092A1 (en) 2017-12-06 2019-06-13 Ontario Institute For Cancer Research (Oicr) Acyl hydrazone linkers, methods and uses thereof
EP3728273A4 (en) * 2017-12-22 2021-12-29 Ontario Institute for Cancer Research (OICR) Heterocyclic acyl hydrazone linkers, methods and uses thereof
WO2019154949A1 (en) 2018-02-08 2019-08-15 Enyo Pharma Fused thiophene derivatives and their uses
CN108929273A (zh) * 2018-06-27 2018-12-04 合肥医工医药有限公司 一种咪唑乙基香草酸醚钠盐的制备方法
KR20210138684A (ko) 2019-03-18 2021-11-19 이난타 파마슈티칼스, 인코포레이티드 Rsv 억제제로서의 벤조디아제핀 유도체
EP4037688A4 (en) 2019-10-04 2023-09-06 Enanta Pharmaceuticals, Inc. ANTIVIRAL HETEROCYCLIC COMPOUNDS
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
CN111004211B (zh) * 2019-12-29 2021-04-02 苏州诚和医药化学有限公司 一种依匹哌唑中间体4-溴苯并[b]噻吩的合成方法
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
CN121021491A (zh) * 2020-10-28 2025-11-28 盐野义制药株式会社 具有抗病毒活性的酰胺衍生物
BR112023016970A2 (pt) 2021-02-26 2023-10-10 Enanta Pharm Inc Compostos heterocíclicos antivirais
JP2024528697A (ja) 2021-07-20 2024-07-30 エイジーエス・セラピューティクス・ソシエテ・パール・アクシオン・サンプリフィエ 微細藻類由来の細胞外小胞、その調製および使用
WO2023052593A1 (en) 2021-10-01 2023-04-06 Janssen Sciences Ireland Unlimited Company Rsv inhibiting spiro bearing derivatives
WO2023144127A1 (en) 2022-01-31 2023-08-03 Ags Therapeutics Sas Extracellular vesicles from microalgae, their biodistribution upon administration, and uses
AR129003A1 (es) 2022-04-07 2024-07-03 Enanta Pharm Inc Compuestos heterocíclicos antivirales
WO2023211997A1 (en) 2022-04-27 2023-11-02 Enanta Pharmaceuticals, Inc. Antiviral compounds
WO2023232976A1 (en) 2022-06-03 2023-12-07 Ags Therapeutics Sas Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses
WO2023237730A1 (en) 2022-06-10 2023-12-14 Janssen Sciences Ireland Unlimited Company Rsv inhibiting triazolo and spiro bearing derivatives
WO2023237732A1 (en) 2022-06-10 2023-12-14 Janssen Sciences Ireland Unlimited Company Rsv inhibiting triazolo bearing derivatives
EP4538258A4 (en) * 2022-06-13 2025-07-30 Hefei Inst Of Pharmaceutical Industry Co Ltd IMIDAZOLIDINYL VANILLIC ACID ETHER DERIVATIVE AND ITS USE
JP2025535944A (ja) 2022-10-24 2025-10-30 エイジーエス・セラピューティクス・ソシエテ・パール・アクシオン・サンプリフィエ 微細藻類由来の細胞外小胞、鼻腔内投与時のそれらの生体内分布、及びそれらの使用
CN116082254B (zh) * 2022-12-28 2025-04-11 浙江永太科技股份有限公司 一种1-烷基-1,2,4-三氮唑-3-甲醇的制备方法
WO2025176847A1 (en) 2024-02-21 2025-08-28 Ags Therapeutics Sas Ocular delivery of active agents via microalgae extracellular vesicles

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2516098A (en) 1949-03-26 1950-07-25 Parke Davis & Co Biphenyl compounds
JPH0615527B2 (ja) 1983-01-21 1994-03-02 アルカロイダ ベギエスゼテイ ギヤル アルキルジアミン誘導体、その製造法および抗不整脈剤
US4876346A (en) 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
IE903957A1 (en) 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5688960A (en) 1995-05-02 1997-11-18 Schering Corporation Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
US5696267A (en) 1995-05-02 1997-12-09 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
MA26487A1 (fr) * 1997-04-29 2004-12-20 Smithkline Beecham Corp Heterocyclecetohydrazides inhibiteurs de proteases, procede pour leur preparation et compositions pharmaceutiques les contenant .
US6410585B1 (en) 1997-08-28 2002-06-25 Scott D. Larsen Inhibitors of protein tyrosine phosphatase
TR200103406T2 (tr) 1998-03-19 2002-06-21 Vertex Pharmaceuticals Incorporated Kaspaz inhibitörleri.
WO1999061437A1 (en) 1998-05-22 1999-12-02 Smithkline Beecham Corporation Novel 2-alkyl substituted imidazole compounds
AR018915A1 (es) * 1998-06-24 2001-12-12 Smithkline Beecham Corp Inhibidores de proteasas diacilhidrazinicos, composicion farmaceutica que la comprenden, usos de los mismos para la manufactura de un medicamento, unprocedimiento de fabricacion de dichos compuestos
EP1105412A1 (en) * 1998-08-17 2001-06-13 Cortech, Inc. Serine protease inhibitors comprising alpha-keto heterocycles
US20100144630A1 (en) * 1999-03-05 2010-06-10 Leland Shapiro Compositions, methods and uses for inhibition and/or treatment of influenza infection
WO2000052034A2 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
EP1169038B9 (en) 1999-04-15 2013-07-10 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
HRP20010934A2 (en) * 1999-06-28 2003-06-30 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors
WO2002059077A1 (en) 2001-01-26 2002-08-01 Takeda Chemical Industries, Ltd. Aminoethanol derivatives
JP2002293764A (ja) 2001-01-26 2002-10-09 Takeda Chem Ind Ltd アミノエタノール誘導体
HUP0304069A2 (hu) 2001-05-11 2004-04-28 Pharmacia Corp. Aromás szulfon-hidroxamátok és proteázgátlókként való alkalmazásuk
US20040024024A1 (en) 2001-05-11 2004-02-05 Freskos John N. Aromatic sulfone hydroxamates and their use as protease inhibitors
US6878743B2 (en) * 2001-09-18 2005-04-12 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
IL160990A0 (en) 2001-10-01 2004-08-31 Bristol Myers Squibb Co Spiro-hydantoin compounds useful as anti-inflammatory agents
HUP0402245A3 (en) 2001-11-01 2010-03-29 Janssen Pharmaceutica Nv Pyrimidinyl-aminobenzamide derivatives as glycogen synthase kinase 3betha inhibitors, their use, pharmaceutical compositions containing them and process for producing them
GB0128415D0 (en) 2001-11-27 2002-01-16 Univ Sheffield Medicaments
DE10224888A1 (de) 2002-06-05 2003-12-24 Merck Patent Gmbh Pyridazinderivate
EA012387B1 (ru) 2002-09-20 2009-10-30 Эрроу Терапьютикс Лимитед Производные бензодиазепина, содержащие их продукт и фармацевтическая композиция и их применение
EP1551809A1 (en) * 2002-10-09 2005-07-13 Pfizer Products Inc. Pyrazole compounds for treatment of neurodegenerative disorders
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
AR045218A1 (es) 2003-08-08 2005-10-19 Schering Corp Aminas ciclicas inhibidoras de bace-1 que poseen una benzamida sustituyente; composiciones farmaceuticas que las contienen y su uso en la fabricacion de medicamentos para tratar enfermedades cognitivas o neurodegenerativas.
CA2534672A1 (en) 2003-08-08 2005-02-17 Schering Corporation Cyclic amine bace-1 inhibitors having a heterocyclic substituent
NZ546365A (en) 2003-10-08 2010-01-29 Vertex Pharma Modulators of ATP-binding cassette transporters containing cycloalkyl or pyranyl groups
DE10348023A1 (de) * 2003-10-15 2005-05-19 Imtm Gmbh Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
JP4769192B2 (ja) * 2003-10-24 2011-09-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド カテプシン阻害剤としての新規な化合物及び組成物
JP2007519735A (ja) 2004-01-30 2007-07-19 メルク エンド カムパニー インコーポレーテッド Hivインテグラーゼ阻害剤として有用であるn−ベンジル−3,4−ジヒドロキシピリジン−2−カルボキサミド及びn−ベンジル−2,3−ジヒドロキシピリジン−4−カルボキサミド化合物
GB0406280D0 (en) 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Chemical compounds
EP1729772B8 (en) 2004-03-24 2017-04-19 Merck Sharp & Dohme Corp. Heteroaryl piperidine glycine transporter inhibitors
WO2006044133A1 (en) * 2004-09-24 2006-04-27 Axys Pharmaceuticals, Inc. Active ketone inhibitors of tryptase
WO2006053109A1 (en) 2004-11-10 2006-05-18 Synta Pharmaceuticals Corp. Heteroaryl compounds
GB0425919D0 (en) 2004-11-25 2004-12-29 Prosidion Ltd Indole-2-carboxylic acid amides
DE102005024245A1 (de) 2005-05-27 2006-11-30 Merck Patent Gmbh Thienopyridine
JP2009507846A (ja) 2005-09-07 2009-02-26 プレキシコン,インコーポレーテッド Ppar活性化合物
TWI435863B (zh) 2006-03-20 2014-05-01 Nihon Nohyaku Co Ltd N-2-(雜)芳基乙基甲醯胺衍生物及含該衍生物之蟲害防治劑
US7939547B2 (en) 2006-05-23 2011-05-10 Irm Llc Compounds and compositions as channel activating protease inhibitors
EP2035374A1 (en) 2006-06-08 2009-03-18 Syngeta Participations AG N- (l-alkyl-2- phenylethyl) -carboxamide derivatives and use thereof as fungicides
EP2046794A1 (de) 2006-07-13 2009-04-15 Basf Se Fungizide azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
US7834023B2 (en) 2006-09-20 2010-11-16 Portola Pharmaceuticals, Inc. Substituted dihydroquinazolines as platelet ADP receptor inhibitors
WO2008057599A2 (en) 2006-11-10 2008-05-15 Intra-Cellular Therapies, Inc. Methods for the treatment of abeta related disorders and compositions therefor
EA200901082A1 (ru) * 2007-02-09 2010-02-26 Айрм Ллк Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы
EP2422790A1 (en) 2007-02-09 2012-02-29 Emory University Paramyxovirus family inhibitors and methods of use thereof
EP2594563B1 (en) 2007-05-31 2018-07-18 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
CA2701649C (en) 2007-10-05 2016-05-24 Genzyme Corporation Method of treating polycystic kidney diseases with ceramide derivatives
US20090156509A1 (en) * 2007-12-12 2009-06-18 Accuthera, Inc. Tri-peptide Inhibitors of Serine Elastases
JP5587790B2 (ja) 2008-01-09 2014-09-10 アミュラ セラピューティクス リミティド 化合物
JP2009209090A (ja) 2008-03-04 2009-09-17 Mitsui Chemicals Inc 殺虫剤及び該殺虫剤に含まれる化合物、並びに該化合物の使用方法
WO2009155362A1 (en) 2008-06-19 2009-12-23 Ligand Pharmaceuticals Inc. Small molecule hematopoietic growth factor mimetic compounds and their uses
WO2010018874A1 (en) 2008-08-12 2010-02-18 Takeda Pharmaceutical Company Limited Amide compound
US9173706B2 (en) 2008-08-25 2015-11-03 Covidien Lp Dual-band dipole microwave ablation antenna
WO2010132992A1 (en) * 2009-05-20 2010-11-25 UNIVERSITé LAVAL Compounds for the inhibition of herpesviruses
CN102803224A (zh) 2009-06-26 2012-11-28 万能药生物有限公司 新的氮杂双环己烷类化合物
WO2011005842A1 (en) 2009-07-09 2011-01-13 Gilead Sciences, Inc. Anti-rsv compounds
WO2011046954A1 (en) 2009-10-13 2011-04-21 Ligand Pharmaceuticals Inc. Hematopoietic growth factor mimetic small molecule compounds and their uses
AR078793A1 (es) 2009-10-27 2011-12-07 Orion Corp Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros
ES2360333B1 (es) 2009-10-29 2012-05-04 Consejo Superior De Investigaciones Cientificas (Csic) (70%) Derivados de bis (aralquil) amino y sistemas (hetero) aromaticos de seis miembros y su uso en el tratamiento de patologias neurodegenerativas, incluida la enfermedad de alzheimer
MX2012005994A (es) 2009-12-04 2012-08-08 Taisho Pharmaceutical Co Ltd Compuestos de 2-piridona.
KR101781663B1 (ko) 2010-01-13 2017-09-25 템페로 파마슈티칼즈, 인크. 히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법
WO2011097607A1 (en) * 2010-02-08 2011-08-11 Southern Research Institute Anti-viral treatment and assay to screen for anti-viral agent
EP2542077A4 (en) 2010-03-04 2013-08-21 Merck Sharp & Dohme HEMMER OF CATECHOL-O-METHYL-TRANSFERASE AND ITS USE IN THE TREATMENT OF PSYCHOTIC DISORDER
AU2011305315A1 (en) * 2010-09-24 2013-03-28 The Regents Of The University Of Michigan Deubiquitinase inhibitors and methods for use of the same
WO2012068406A2 (en) 2010-11-18 2012-05-24 Ligand Pharmaceuticals Incorporated Use of hematopoietic growth factor mimetics
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
WO2013055793A1 (en) 2011-10-12 2013-04-18 University Of Pittsburg-Of The Commonwealth System Of Higher Education Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
WO2013059119A1 (en) 2011-10-17 2013-04-25 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
EP2773622A1 (en) 2011-11-04 2014-09-10 Syngenta Participations AG Pesticidal compounds
BR112015003376A8 (pt) * 2012-08-23 2018-01-23 Alios Biopharma Inc composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e usos de quantidade eficiente de composto ou sal farmaceuticamente aceitável do mesmo ou composição farmacêutica
MX2016002199A (es) * 2013-08-21 2016-07-13 Alios Biopharma Inc Compuestos antivirales.
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux

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