CU24345B1 - Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores - Google Patents

Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores

Info

Publication number
CU24345B1
CU24345B1 CUP2016000028A CU20160028A CU24345B1 CU 24345 B1 CU24345 B1 CU 24345B1 CU P2016000028 A CUP2016000028 A CU P2016000028A CU 20160028 A CU20160028 A CU 20160028A CU 24345 B1 CU24345 B1 CU 24345B1
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CU
Cuba
Prior art keywords
derivatives
therapeutic agents
tiadiazol
immunomodulators
oxadiazol
Prior art date
Application number
CUP2016000028A
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English (en)
Other versions
CU20160028A7 (es
Inventor
Seetharamaiah Setty Sudarshan Naremaddepalli
Muralidhara Ramachandra
Pottayil Govidan Nair Sasikumar
Original Assignee
Aurigene Discovery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of CU20160028A7 publication Critical patent/CU20160028A7/es
Publication of CU24345B1 publication Critical patent/CU24345B1/es

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/101,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

<p>La presente invención se refiere a compuestos de 1,3,4-oxadiazol y 1,3,4-tiadiazol como agentes terapeúticos capaces de inhibir la vía de señalización de la muerte celular programada 1 (PD1). La invención además se refiere a derivados de los agentes terapeúticos. La invención además abarca el uso de dichos agentes terapeúticos y derivados para el tratamiento de los trastornos a través de inmunopotenciación que comprende la inhibición de la señal inmunosupresiva inducida debido a PD-1, PD-L1 ó PD-L2 y las terapias donde se usan.</p>
CUP2016000028A 2013-09-06 2014-09-05 Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores CU24345B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4012CH2013 2013-09-06
PCT/IB2014/064281 WO2015033301A1 (en) 2013-09-06 2014-09-05 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators

Publications (2)

Publication Number Publication Date
CU20160028A7 CU20160028A7 (es) 2017-02-02
CU24345B1 true CU24345B1 (es) 2018-05-08

Family

ID=52627870

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2016000028A CU24345B1 (es) 2013-09-06 2014-09-05 Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores

Country Status (26)

Country Link
US (3) US20160194295A1 (es)
EP (2) EP3041828B1 (es)
JP (1) JP2016532711A (es)
KR (1) KR20160081898A (es)
CN (1) CN105849092A (es)
AU (1) AU2014316684A1 (es)
CA (1) CA2922655A1 (es)
CU (1) CU24345B1 (es)
CY (1) CY1120769T1 (es)
DK (1) DK3041828T3 (es)
EA (1) EA029661B1 (es)
ES (1) ES2682040T3 (es)
HR (1) HRP20181251T1 (es)
HU (1) HUE039014T2 (es)
IL (1) IL244313A0 (es)
LT (1) LT3041828T (es)
MX (1) MX2016002971A (es)
PH (1) PH12016500405B1 (es)
PL (1) PL3041828T3 (es)
PT (1) PT3041828T (es)
RS (1) RS57559B1 (es)
SG (2) SG10201800508SA (es)
SI (1) SI3041828T1 (es)
SM (1) SMT201800421T1 (es)
TR (1) TR201811077T4 (es)
WO (1) WO2015033301A1 (es)

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RS57559B1 (sr) 2018-10-31
MX2016002971A (es) 2016-10-07
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PL3041828T3 (pl) 2018-10-31
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US9776978B2 (en) 2017-10-03
CY1120769T1 (el) 2019-12-11
PH12016500405B1 (en) 2016-05-16
JP2016532711A (ja) 2016-10-20
EA029661B1 (ru) 2018-04-30
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