HK1210659A1 - Humanized il-15 animals il-15 - Google Patents

Humanized il-15 animals il-15

Info

Publication number
HK1210659A1
HK1210659A1 HK15111500.3A HK15111500A HK1210659A1 HK 1210659 A1 HK1210659 A1 HK 1210659A1 HK 15111500 A HK15111500 A HK 15111500A HK 1210659 A1 HK1210659 A1 HK 1210659A1
Authority
HK
Hong Kong
Prior art keywords
humanized
animals
Prior art date
Application number
HK15111500.3A
Other languages
English (en)
Chinese (zh)
Inventor
Jose F Rojas
Ka-Man Venus Lai
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1210659A1 publication Critical patent/HK1210659A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5443IL-15
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0387Animal model for diseases of the immune system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15111500.3A 2013-10-15 2015-11-20 Humanized il-15 animals il-15 HK1210659A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15
PCT/US2014/060568 WO2015057758A1 (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Publications (1)

Publication Number Publication Date
HK1210659A1 true HK1210659A1 (en) 2016-05-06

Family

ID=51830649

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111500.3A HK1210659A1 (en) 2013-10-15 2015-11-20 Humanized il-15 animals il-15

Country Status (28)

Country Link
US (5) US9155290B2 (ru)
EP (3) EP2908626B1 (ru)
JP (3) JP6492095B2 (ru)
KR (1) KR102376041B1 (ru)
CN (2) CN105744829B (ru)
AU (2) AU2014337526B2 (ru)
BR (1) BR112016008175A2 (ru)
CA (1) CA2926090C (ru)
CY (2) CY1118675T1 (ru)
DK (2) DK3138397T3 (ru)
ES (2) ES2613379T3 (ru)
HK (1) HK1210659A1 (ru)
HR (2) HRP20170380T1 (ru)
HU (2) HUE033272T2 (ru)
IL (2) IL244525B (ru)
LT (2) LT2908626T (ru)
MX (1) MX2016004781A (ru)
NZ (1) NZ718655A (ru)
PL (2) PL2908626T3 (ru)
PT (2) PT2908626T (ru)
RS (2) RS58465B1 (ru)
RU (1) RU2674910C2 (ru)
SG (2) SG11201601828XA (ru)
SI (2) SI2908626T1 (ru)
SM (1) SMT201700024B (ru)
TR (1) TR201904342T4 (ru)
WO (1) WO2015057758A1 (ru)
ZA (1) ZA201601676B (ru)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4049535A1 (en) 2009-10-06 2022-08-31 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
PT3375284T (pt) 2011-02-15 2023-06-28 Univ Yale Ratinhos humanizados para m-csf e utilizações dos mesmos
KR20240045263A (ko) 2012-09-07 2024-04-05 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR102649893B1 (ko) 2012-11-05 2024-03-25 리제너론 파마슈티칼스 인코포레이티드 유전자 변형된 비-인간 동물 및 그것의 사용 방법
SG11201601828XA (en) 2013-10-15 2016-04-28 Regeneron Pharma Humanized il-15 animals
MA51519A (fr) 2014-05-05 2020-11-11 Regeneron Pharma Animaux c5 et c3 humanisés
NO2785538T3 (ru) 2014-05-07 2018-08-04
ES2964597T3 (es) 2014-05-19 2024-04-08 Regeneron Pharma Ratones modificados genéticamente que expresan EPO humana
PL3086637T3 (pl) 2014-12-05 2019-09-30 Regeneron Pharmaceuticals, Inc. Zwierzęta nie będące człowiekiem mające humanizowany gen kompleksu różnicowania 47
RU2730599C2 (ru) * 2015-04-13 2020-08-24 Ридженерон Фармасьютикалз, Инк. Гуманизированные мыши с нокином sirpa-il15 и способы их использования
CA3012693C (en) 2016-02-04 2022-08-23 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered angptl8 gene
ES2886958T3 (es) 2016-02-29 2021-12-21 Regeneron Pharma Roedores que tienen un gen TMPRSS humanizado
EP3476865B1 (en) 2016-06-28 2023-09-13 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Method for constructing pd-1 gene-modified humanized animal model and use thereof
WO2018041120A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tigit
CN107815468B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
DK3507373T5 (da) 2016-08-31 2024-09-02 Biocytogen Pharmaceuticals Beijing Co Ltd Genetisk modificeret ikke-menneskeligt dyr med human eller kimær pd-l1
CN107815467B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
WO2018086594A1 (en) 2016-11-11 2018-05-17 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tim-3
CN108070613B (zh) 2016-11-11 2020-03-13 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
CN108239659B (zh) 2016-12-23 2020-03-03 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
CN108424928B (zh) 2016-12-30 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
CN108467873B (zh) 2017-03-17 2020-03-13 百奥赛图江苏基因生物技术有限公司 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用
CN108588126B (zh) 2017-03-31 2020-04-10 北京百奥赛图基因生物技术有限公司 Cd47基因人源化改造动物模型的制备方法及应用
WO2018177441A1 (en) 2017-03-31 2018-10-04 Beijing Biocytogen Co., Ltd GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
CN109136274B (zh) 2017-06-19 2021-04-23 百奥赛图江苏基因生物技术有限公司 人源化cd40基因改造动物模型的制备方法及应用
CN109136275B (zh) 2017-06-19 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化gitr基因改造动物模型的制备方法及应用
CN109136261B (zh) 2017-06-19 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化cd28基因改造动物模型的制备方法及应用
AU2018313892B2 (en) * 2017-08-09 2024-04-18 The Jackson Laboratory Immunodeficient mice expressing human interleukin 15
EP3585162B1 (en) 2017-09-29 2023-08-30 Regeneron Pharmaceuticals, Inc. Rodents comprising a humanized ttr locus and methods of use
WO2019072241A1 (en) 2017-10-13 2019-04-18 Beijing Biocytogen Co., Ltd NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC
CN109913493B (zh) 2017-12-12 2021-03-16 百奥赛图江苏基因生物技术有限公司 人源化cd3基因改造动物模型的制备方法及应用
LT3823443T (lt) 2018-07-16 2024-08-12 Regeneron Pharmaceuticals, Inc. Ditra ligos graužikų modeliai ir jų naudojimas
CN111057721B (zh) 2018-10-12 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用
CN111304247B (zh) 2018-12-20 2021-03-16 百奥赛图江苏基因生物技术有限公司 人源化lag-3基因改造动物模型的制备方法及应用
CN111304248B (zh) * 2018-12-25 2021-08-24 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il15基因改造非人动物的构建方法及应用
CN114107385A (zh) * 2019-01-17 2022-03-01 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
EP3772929B1 (en) 2019-04-04 2023-11-15 Regeneron Pharmaceuticals, Inc. Rodents comprising a humanized coagulation factor 12 locus
WO2020247452A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
WO2020247812A1 (en) 2019-06-07 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized albumin locus
CN114786479B (zh) * 2019-12-25 2023-12-15 江苏集萃药康生物科技股份有限公司 一种il-15人源化小鼠模型及其用途
JP2023511626A (ja) * 2020-01-28 2023-03-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化pnpla3遺伝子座を含む非ヒト動物および使用方法
CN111485001A (zh) * 2020-04-14 2020-08-04 澎立生物医药技术(上海)有限公司 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法
CN112481303B (zh) * 2021-02-09 2021-05-25 百奥赛图(北京)医药科技股份有限公司 Il15ra基因人源化非人动物及其构建方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001239750A1 (en) 2000-02-08 2001-08-20 Genaissance Pharmaceuticals, Inc. Haplotypes of the interleukin 15 gene
US7759541B2 (en) * 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
PT1899364T (pt) * 2005-05-17 2020-05-20 Univ Connecticut Composições e métodos para imunomodulação num organismo
RU2559524C2 (ru) * 2008-06-27 2015-08-10 Мерюс Б.В. Продуцирующие антитела млекопитающие, не являющиеся человеком
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
EP4049535A1 (en) 2009-10-06 2022-08-31 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
HUE038684T2 (hu) * 2009-12-21 2018-11-28 Regeneron Pharma Humanizált FC gamma R génnel rendelkezõ egér
PT3375284T (pt) 2011-02-15 2023-06-28 Univ Yale Ratinhos humanizados para m-csf e utilizações dos mesmos
US9043996B2 (en) * 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
ES2525368T3 (es) * 2011-10-28 2014-12-23 Regeneron Pharmaceuticals, Inc. IL-6 y receptor de IL-6 humanizados
CN104039133B (zh) * 2011-10-28 2018-05-04 瑞泽恩制药公司 表达嵌合主要组织相容性复合物(mhc)ii类分子的基因修饰小鼠
ES2962287T3 (es) 2011-10-28 2024-03-18 Regeneron Pharma Ratones con complejo principal de histocompatibilidad genéticamente modificados
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
KR20240045263A (ko) 2012-09-07 2024-04-05 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR102649893B1 (ko) 2012-11-05 2024-03-25 리제너론 파마슈티칼스 인코포레이티드 유전자 변형된 비-인간 동물 및 그것의 사용 방법
CN110192541B (zh) 2013-02-22 2022-02-18 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠
HUE063376T2 (hu) 2013-09-23 2024-01-28 Regeneron Pharma Humanizált szignál-szabályozó fehérje gént tartalmazó nem humán állatok
SG11201601828XA (en) 2013-10-15 2016-04-28 Regeneron Pharma Humanized il-15 animals

Also Published As

Publication number Publication date
RS55472B1 (sr) 2017-04-28
JP6492095B2 (ja) 2019-03-27
RU2016116847A3 (ru) 2018-06-07
AU2020286186B2 (en) 2024-05-23
RS58465B1 (sr) 2019-04-30
JP6600061B2 (ja) 2019-10-30
MX2016004781A (es) 2016-07-26
SMT201700024B (it) 2017-03-08
US9155290B2 (en) 2015-10-13
US20150366175A1 (en) 2015-12-24
LT3138397T (lt) 2019-04-10
US20200178508A1 (en) 2020-06-11
AU2020286186A1 (en) 2021-01-07
PT2908626T (pt) 2017-01-09
EP3138397A1 (en) 2017-03-08
LT2908626T (lt) 2017-01-25
HRP20190542T1 (hr) 2019-07-26
SI2908626T1 (sl) 2017-02-28
BR112016008175A2 (pt) 2017-10-03
CY1121405T1 (el) 2020-05-29
EP3138397B1 (en) 2018-12-26
AU2014337526A1 (en) 2016-04-28
ES2613379T3 (es) 2017-05-24
JP2019216750A (ja) 2019-12-26
RU2674910C2 (ru) 2018-12-13
DK2908626T3 (en) 2017-03-20
HRP20170380T1 (hr) 2017-05-19
CN109090037A (zh) 2018-12-28
EP3461331A1 (en) 2019-04-03
CA2926090C (en) 2022-07-05
IL244525A0 (en) 2016-04-21
CN105744829A (zh) 2016-07-06
US20180116192A1 (en) 2018-05-03
EP2908626B1 (en) 2016-12-07
SI3138397T1 (sl) 2019-04-30
SG10201607768YA (en) 2016-11-29
HUE043969T2 (hu) 2019-09-30
PL2908626T3 (pl) 2017-05-31
HUE033272T2 (en) 2017-11-28
CN105744829B (zh) 2018-08-07
ZA201601676B (en) 2019-12-18
KR20160068774A (ko) 2016-06-15
JP2016533192A (ja) 2016-10-27
CN109090037B (zh) 2021-05-28
US20230189772A1 (en) 2023-06-22
US20150106961A1 (en) 2015-04-16
AU2014337526B2 (en) 2020-09-10
CY1118675T1 (el) 2018-03-07
TR201904342T4 (tr) 2019-05-21
RU2016116847A (ru) 2017-11-21
US11503813B2 (en) 2022-11-22
KR102376041B1 (ko) 2022-03-18
IL269907B (en) 2020-09-30
SG11201601828XA (en) 2016-04-28
DK3138397T3 (en) 2019-04-15
PT3138397T (pt) 2019-03-26
NZ718655A (en) 2022-08-26
CA2926090A1 (en) 2015-04-23
US10561125B2 (en) 2020-02-18
IL244525B (en) 2019-10-31
PL3138397T3 (pl) 2019-06-28
JP2019022518A (ja) 2019-02-14
EP2908626A1 (en) 2015-08-26
WO2015057758A1 (en) 2015-04-23
ES2715949T3 (es) 2019-06-07

Similar Documents

Publication Publication Date Title
IL269907B (en) Humanized animals for – il–15
IL269528A (en) Anti- FCRH5 antibodies
GB201322583D0 (en) Antibodies
GB201305935D0 (en) Scheduling
HK1220142A1 (zh) 抗體
GB201308658D0 (en) Antibodies
IL243581A0 (en) Non-human animals with lincrna deficiency
GB201315486D0 (en) Antibodies
IL245488A0 (en) Anti- ccl17 antibodies
GB201312226D0 (en) Improved antibodies
GB201306076D0 (en) Animal trap
GB2516488B (en) Animal harness
AU356315S (en) Lure
AU356313S (en) Bibbed lure
GB201318283D0 (en) Antibodies