HUE038684T2 - Humanizált FC gamma R génnel rendelkezõ egér - Google Patents

Humanizált FC gamma R génnel rendelkezõ egér

Info

Publication number
HUE038684T2
HUE038684T2 HUE10791039A HUE10791039A HUE038684T2 HU E038684 T2 HUE038684 T2 HU E038684T2 HU E10791039 A HUE10791039 A HU E10791039A HU E10791039 A HUE10791039 A HU E10791039A HU E038684 T2 HUE038684 T2 HU E038684T2
Authority
HU
Hungary
Prior art keywords
humanized
mice
gamma
Prior art date
Application number
HUE10791039A
Other languages
English (en)
Inventor
Lynn Macdonald
Naxin Tu
Cagan Gurer
Sean Stevens
Andrew Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43601078&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE038684(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HUE038684T2 publication Critical patent/HUE038684T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
HUE10791039A 2009-12-21 2010-12-17 Humanizált FC gamma R génnel rendelkezõ egér HUE038684T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28856209P 2009-12-21 2009-12-21

Publications (1)

Publication Number Publication Date
HUE038684T2 true HUE038684T2 (hu) 2018-11-28

Family

ID=43601078

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE10791039A HUE038684T2 (hu) 2009-12-21 2010-12-17 Humanizált FC gamma R génnel rendelkezõ egér

Country Status (25)

Country Link
US (8) US8658154B2 (hu)
EP (3) EP3498730A1 (hu)
JP (4) JP5595517B2 (hu)
KR (4) KR102178064B1 (hu)
CN (2) CN104232589B (hu)
AU (3) AU2010339863B2 (hu)
CA (2) CA2784953C (hu)
CY (1) CY1120316T1 (hu)
DK (1) DK2516457T3 (hu)
ES (1) ES2671188T3 (hu)
HK (1) HK1257001A1 (hu)
HR (1) HRP20180911T1 (hu)
HU (1) HUE038684T2 (hu)
IL (4) IL220365A (hu)
LT (1) LT2516457T (hu)
MY (1) MY156743A (hu)
NO (1) NO2516457T3 (hu)
PL (1) PL2516457T3 (hu)
PT (1) PT2516457T (hu)
RS (1) RS57280B1 (hu)
RU (1) RU2549695C2 (hu)
SG (3) SG10202011814TA (hu)
SI (1) SI2516457T1 (hu)
TR (1) TR201808011T4 (hu)
WO (1) WO2011084664A1 (hu)

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JP7131650B1 (ja) 2021-04-28 2022-09-06 井関農機株式会社 脱穀装置

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US20180015185A1 (en) 2018-01-18
IL261257B (en) 2019-12-31
SG181690A1 (en) 2012-07-30
US20140154701A1 (en) 2014-06-05
KR101862277B1 (ko) 2018-06-01
JP2013514778A (ja) 2013-05-02
JP6073840B2 (ja) 2017-02-01
SG10201408415PA (en) 2015-01-29
AU2010339863A1 (en) 2012-07-12
MY156743A (en) 2016-03-31
KR20190045404A (ko) 2019-05-02
KR20180058860A (ko) 2018-06-01
AU2014210646B2 (en) 2016-06-23
JP5891259B2 (ja) 2016-03-22
US9687566B2 (en) 2017-06-27
IL271083A (en) 2020-01-30
CN104232589A (zh) 2014-12-24
US20120260357A1 (en) 2012-10-11
CN102762590B (zh) 2015-11-25
US20140157445A1 (en) 2014-06-05
AU2010339863B2 (en) 2014-07-17
SI2516457T1 (en) 2018-08-31
US10426848B2 (en) 2019-10-01
RS57280B1 (sr) 2018-08-31
AU2014210645A1 (en) 2014-08-28
IL220365A0 (en) 2012-08-30
CA3000246A1 (en) 2011-07-14
WO2011084664A1 (en) 2011-07-14
ES2671188T3 (es) 2018-06-05
EP3336102A2 (en) 2018-06-20
EP3498730A1 (en) 2019-06-19
NO2516457T3 (hu) 2018-08-11
KR102178064B1 (ko) 2020-11-12
EP3336102A3 (en) 2018-08-01
JP2016093201A (ja) 2016-05-26
IL261257A (en) 2018-10-31
US20110154512A1 (en) 2011-06-23
RU2549695C2 (ru) 2015-04-27
US8658853B2 (en) 2014-02-25
DK2516457T3 (en) 2018-06-18
CY1120316T1 (el) 2019-07-10
EP2516457B9 (en) 2021-09-29
US9089599B2 (en) 2015-07-28
US11020495B2 (en) 2021-06-01
AU2014210645B2 (en) 2016-05-19
EP2516457B1 (en) 2018-03-14
US9056130B2 (en) 2015-06-16
CN104232589B (zh) 2018-04-27
US20150313195A1 (en) 2015-11-05
US20210346522A1 (en) 2021-11-11
KR101973524B1 (ko) 2019-09-02
LT2516457T (lt) 2018-06-11
KR20200033981A (ko) 2020-03-30
US8658154B2 (en) 2014-02-25
US20200061213A1 (en) 2020-02-27
CA2784953A1 (en) 2011-07-14
KR20120102138A (ko) 2012-09-17
JP2014209923A (ja) 2014-11-13
IL242719A (en) 2017-09-28
RU2012131296A (ru) 2014-01-27
TR201808011T4 (tr) 2018-06-21
IL220365A (en) 2016-11-30
KR102092744B1 (ko) 2020-03-24
SG10202011814TA (en) 2021-01-28
CN102762590A (zh) 2012-10-31
HK1257001A1 (zh) 2019-10-11
CA2784953C (en) 2018-05-22
EP2516457A1 (en) 2012-10-31
PL2516457T3 (pl) 2018-08-31
HRP20180911T1 (hr) 2018-07-13
JP5595517B2 (ja) 2014-09-24
CA3000246C (en) 2021-05-25
JP2014132909A (ja) 2014-07-24
AU2014210646A1 (en) 2014-08-28
PT2516457T (pt) 2018-06-12

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