HK1209739A1 - Pyridazine and pyridine derivatives as nampt inhibitors nampt - Google Patents
Pyridazine and pyridine derivatives as nampt inhibitors namptInfo
- Publication number
- HK1209739A1 HK1209739A1 HK15110586.2A HK15110586A HK1209739A1 HK 1209739 A1 HK1209739 A1 HK 1209739A1 HK 15110586 A HK15110586 A HK 15110586A HK 1209739 A1 HK1209739 A1 HK 1209739A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nampt
- pyridazine
- pyridine derivatives
- inhibitors
- nampt inhibitors
- Prior art date
Links
- 102100033223 Nicotinamide phosphoribosyltransferase Human genes 0.000 title 2
- 108010064862 Nicotinamide phosphoribosyltransferase Proteins 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261645692P | 2012-05-11 | 2012-05-11 | |
US201261719013P | 2012-10-26 | 2012-10-26 | |
US201361779756P | 2013-03-13 | 2013-03-13 | |
PCT/US2013/040481 WO2013170115A1 (en) | 2012-05-11 | 2013-05-10 | Pyridazine and pyridine derivatives as nampt inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1209739A1 true HK1209739A1 (en) | 2016-04-08 |
Family
ID=48539390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15110586.2A HK1209739A1 (en) | 2012-05-11 | 2015-10-28 | Pyridazine and pyridine derivatives as nampt inhibitors nampt |
Country Status (11)
Country | Link |
---|---|
US (4) | US8975398B2 (ja) |
EP (1) | EP2847181A1 (ja) |
JP (1) | JP2015520752A (ja) |
CN (1) | CN104583194A (ja) |
AR (1) | AR091023A1 (ja) |
CA (1) | CA2873097A1 (ja) |
HK (1) | HK1209739A1 (ja) |
MX (1) | MX2014013751A (ja) |
TW (1) | TW201350478A (ja) |
UY (1) | UY34804A (ja) |
WO (1) | WO2013170115A1 (ja) |
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US8975398B2 (en) * | 2012-05-11 | 2015-03-10 | Abbvie Inc. | NAMPT inhibitors |
PE20211798A1 (es) | 2014-03-21 | 2021-09-13 | Abbvie Inc | Anticuerpos y conjugados de anticuerpo y farmaco anti-egfr |
KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
US10144742B2 (en) | 2014-04-18 | 2018-12-04 | Millennium Pharmaceuticals, Inc. | Quinoxaline compounds and uses thereof |
ES2715500T3 (es) | 2014-06-19 | 2019-06-04 | Ariad Pharma Inc | Compuestos de heteroarilo para la inhibición de la quinasa |
CA2974078A1 (en) | 2015-01-20 | 2016-07-28 | Millennium Pharmaceuticals, Inc. | Quinazoline and quinoline compounds and uses thereof |
PL3464336T3 (pl) | 2016-06-01 | 2022-05-16 | Athira Pharma, Inc. | Związki |
CN109562169A (zh) | 2016-06-08 | 2019-04-02 | 艾伯维公司 | 抗cd98抗体及抗体药物偶联物 |
CN116284404A (zh) | 2016-06-08 | 2023-06-23 | 艾伯维公司 | 抗b7-h3抗体和抗体药物偶联物 |
JP2019521973A (ja) | 2016-06-08 | 2019-08-08 | アッヴィ・インコーポレイテッド | 抗bh7−h3抗体及び抗体薬物コンジュゲート |
MX2018015280A (es) | 2016-06-08 | 2019-08-12 | Abbvie Inc | Conjugados de anticuerpo y farmaco anti-egfr. |
BR112018075653A2 (pt) | 2016-06-08 | 2019-08-27 | Abbvie Inc | anticorpos anti-b7-h3 e conjugados anticorpo fármaco |
EP3468615A1 (en) | 2016-06-08 | 2019-04-17 | AbbVie Inc. | Anti-egfr antibody drug conjugates |
CN109561680B (zh) * | 2016-06-23 | 2021-07-13 | 圣朱德儿童研究医院 | 泛酸激酶的小分子调节剂 |
CN109843334A (zh) | 2016-10-18 | 2019-06-04 | 西雅图基因公司 | 烟酰胺腺嘌呤二核苷酸补救途径抑制剂的靶向递送 |
JP7076741B2 (ja) | 2016-12-27 | 2022-05-30 | 国立研究開発法人理化学研究所 | Bmpシグナル阻害化合物 |
WO2018177993A1 (de) | 2017-03-31 | 2018-10-04 | Bayer Cropscience Aktiengesellschaft | Pyrazole zur bekämpfung von arthropoden |
CA3064697A1 (en) | 2017-04-19 | 2018-10-25 | Bluefin Biomedicine, Inc. | Anti-vtcn1 antibodies and antibody drug conjugates |
TW201904613A (zh) | 2017-04-27 | 2019-02-01 | 美商西雅圖遺傳學公司 | 季鹼化菸鹼醯胺腺二核苷酸補救合成抑制劑結合物 |
WO2019133632A1 (en) | 2017-12-27 | 2019-07-04 | St. Jude Children's Research Hospital | Methods of treating disorders associated with castor |
SG11202006047RA (en) | 2017-12-27 | 2020-07-29 | St Jude Childrens Res Hospital Inc | Small molecule modulators of pantothenate kinases |
EP3746079A1 (en) * | 2018-01-31 | 2020-12-09 | Bayer Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
AU2019222644B2 (en) | 2018-02-13 | 2021-04-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
JP7105359B2 (ja) | 2018-07-13 | 2022-07-22 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
WO2020072497A1 (en) * | 2018-10-01 | 2020-04-09 | Cornell University | Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof |
AU2019366355B2 (en) | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US20220185815A1 (en) | 2019-03-06 | 2022-06-16 | Daiichi Sankyo Company, Limited | Pyrrolopyrazole derivative |
EP3997209A4 (en) * | 2019-07-08 | 2023-06-07 | Mayo Foundation for Medical Education and Research | WNT ACTIVATORS AND METHODS OF USE |
TW202206422A (zh) | 2020-04-23 | 2022-02-16 | 美商普雷辛肯公司 | 用於cd73調節之化合物及方法及其適應症 |
JP2023529867A (ja) | 2020-06-05 | 2023-07-12 | キネート バイオファーマ インク. | 線維芽細胞増殖因子受容体キナーゼの阻害剤 |
CN114660219A (zh) * | 2020-12-23 | 2022-06-24 | 安徽古特生物科技有限公司 | 一种β-烟酰胺单核苷酸的检测方法 |
AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
CN117285573B (zh) * | 2023-09-26 | 2024-03-26 | 长沙兴嘉生物工程股份有限公司 | 一种β-烟酰胺单核苷酸金属络合物及其制备方法 |
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-
2013
- 2013-05-10 US US13/891,357 patent/US8975398B2/en active Active
- 2013-05-10 AR ARP130101637A patent/AR091023A1/es unknown
- 2013-05-10 CA CA2873097A patent/CA2873097A1/en not_active Abandoned
- 2013-05-10 TW TW102116746A patent/TW201350478A/zh unknown
- 2013-05-10 US US13/891,354 patent/US20130303509A1/en not_active Abandoned
- 2013-05-10 JP JP2015511730A patent/JP2015520752A/ja active Pending
- 2013-05-10 EP EP13726339.8A patent/EP2847181A1/en not_active Withdrawn
- 2013-05-10 MX MX2014013751A patent/MX2014013751A/es unknown
- 2013-05-10 WO PCT/US2013/040481 patent/WO2013170115A1/en active Application Filing
- 2013-05-10 CN CN201380036867.6A patent/CN104583194A/zh active Pending
- 2013-05-10 UY UY0001034804A patent/UY34804A/es not_active Application Discontinuation
-
2015
- 2015-01-23 US US14/603,832 patent/US20150141398A1/en not_active Abandoned
- 2015-10-28 HK HK15110586.2A patent/HK1209739A1/xx unknown
-
2016
- 2016-11-21 US US15/357,383 patent/US20170065575A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2847181A1 (en) | 2015-03-18 |
MX2014013751A (es) | 2015-08-07 |
US20130303510A1 (en) | 2013-11-14 |
US8975398B2 (en) | 2015-03-10 |
US20130303509A1 (en) | 2013-11-14 |
US20150141398A1 (en) | 2015-05-21 |
JP2015520752A (ja) | 2015-07-23 |
CN104583194A (zh) | 2015-04-29 |
AR091023A1 (es) | 2014-12-30 |
CA2873097A1 (en) | 2013-11-14 |
TW201350478A (zh) | 2013-12-16 |
UY34804A (es) | 2013-12-31 |
US20170065575A1 (en) | 2017-03-09 |
WO2013170115A1 (en) | 2013-11-14 |
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