HK1151296A1 - Notch1 receptor binding agents and methods of use thereof notch1 - Google Patents

Notch1 receptor binding agents and methods of use thereof notch1

Info

Publication number
HK1151296A1
HK1151296A1 HK11105234.2A HK11105234A HK1151296A1 HK 1151296 A1 HK1151296 A1 HK 1151296A1 HK 11105234 A HK11105234 A HK 11105234A HK 1151296 A1 HK1151296 A1 HK 1151296A1
Authority
HK
Hong Kong
Prior art keywords
notch1
methods
receptor binding
binding agents
notch1 receptor
Prior art date
Application number
HK11105234.2A
Other languages
English (en)
Chinese (zh)
Inventor
Austin L Gurney
Timothy Charles Hoey
Maureen Fitch Bruhns
Fumiko Takada Axelrod
Original Assignee
Oncomed Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharm Inc filed Critical Oncomed Pharm Inc
Publication of HK1151296A1 publication Critical patent/HK1151296A1/xx

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0693—Tumour cells; Cancer cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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  • Medicinal Chemistry (AREA)
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  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Microbiology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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HK11105234.2A 2008-07-08 2011-05-26 Notch1 receptor binding agents and methods of use thereof notch1 HK1151296A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
US11270108P 2008-11-07 2008-11-07
US11269908P 2008-11-07 2008-11-07
PCT/US2009/003995 WO2010005567A2 (en) 2008-07-08 2009-07-08 Notch1 receptor binding agents and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1151296A1 true HK1151296A1 (en) 2012-01-27

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ID=41507637

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11105233.3A HK1151218A1 (en) 2008-07-08 2011-05-26 Notch-binding agents and antagonists and methods of use thereof notch-
HK11105234.2A HK1151296A1 (en) 2008-07-08 2011-05-26 Notch1 receptor binding agents and methods of use thereof notch1

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Application Number Title Priority Date Filing Date
HK11105233.3A HK1151218A1 (en) 2008-07-08 2011-05-26 Notch-binding agents and antagonists and methods of use thereof notch-

Country Status (32)

Country Link
US (11) US8226943B2 (pl)
EP (4) EP2924051A1 (pl)
JP (2) JP5560270B2 (pl)
KR (2) KR101640099B1 (pl)
CN (3) CN102112490B (pl)
AU (2) AU2009269095B2 (pl)
BR (2) BRPI0914007A2 (pl)
CA (2) CA2729602A1 (pl)
CO (2) CO6390041A2 (pl)
CR (1) CR20110069A (pl)
CY (2) CY1116195T1 (pl)
DK (2) DK2307459T3 (pl)
DO (2) DOP2011000004A (pl)
EA (2) EA201170157A1 (pl)
ES (2) ES2531541T3 (pl)
HK (2) HK1151218A1 (pl)
HR (2) HRP20150256T1 (pl)
IL (2) IL210222A (pl)
MA (2) MA32448B1 (pl)
ME (2) ME02148B (pl)
MX (2) MX2011000236A (pl)
MY (2) MY155603A (pl)
NZ (2) NZ590127A (pl)
PL (2) PL2307459T3 (pl)
PT (2) PT2307051E (pl)
RS (2) RS53750B1 (pl)
SG (2) SG192468A1 (pl)
SI (2) SI2307051T1 (pl)
SM (2) SMT201500047B (pl)
UA (1) UA101672C2 (pl)
WO (2) WO2010005567A2 (pl)
ZA (2) ZA201009280B (pl)

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WO2007136856A2 (en) * 2006-05-19 2007-11-29 The Johns Hopkins University Heyl as a therapeutic target and a diagnostic marker for neoplasia and uses therefor
EP2032166B1 (en) 2006-06-13 2013-04-10 OncoMed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
KR20150004933A (ko) 2006-12-18 2015-01-13 제넨테크, 인크. 항-ｎｏｔｃｈ3 길항제 항체 및 ｎｏｔｃｈ3-관련 질환의 예방 및 치료에 있어서 그의 용도
AU2008209482B2 (en) 2007-01-24 2014-05-01 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
JP5560270B2 (ja) 2008-07-08 2014-07-23 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｎｏｔｃｈ結合剤およびアンタゴニストならびにその使用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
KR101712214B1 (ko) * 2008-10-01 2017-03-03 제넨테크, 인크. 항-노치2 항체 및 사용 방법
WO2010146550A1 (en) 2009-06-18 2010-12-23 Pfizer Inc. Anti notch-1 antibodies
RU2012117619A (ru) * 2009-09-30 2013-11-10 Дженентек, Инк. ЛЕЧЕНИЕ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ, УСТОЙЧИВЫХ К ДЕЙСТВИЮ АНТАГОНИСТА Notch1, С ПОМОЩЬЮ АНТАГОНИСТА Notch3
ES2700450T3 (es) 2009-10-16 2019-02-15 Oncomed Pharm Inc Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensores
ES2561102T3 (es) * 2010-01-13 2016-02-24 Oncomed Pharmaceuticals, Inc. Agentes de unión a Notch1 y procedimientos de uso de los mismos
WO2011109262A2 (en) 2010-03-01 2011-09-09 Tau Therapeutics Llc Cancer diagnosis and imaging
KR20130079384A (ko) * 2010-05-03 2013-07-10 제넨테크, 인크. 종양의 진단 및 치료를 위한 조성물 및 방법
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