US9404098B2
(en)
|
2008-11-06 |
2016-08-02 |
University Of Georgia Research Foundation, Inc. |
Method for cleaving a target RNA using a Cas6 polypeptide
|
EP2367938B1
(en)
|
2008-12-12 |
2014-06-11 |
DuPont Nutrition Biosciences ApS |
Genetic cluster of strains of streptococcus thermophilus having unique rheological properties for dairy fermentation
|
US9951341B2
(en)
|
2010-10-20 |
2018-04-24 |
Dupont Nutrition Biosciences Aps |
Lactococcus CRISPR-Cas sequences
|
US11951139B2
(en)
|
2015-11-30 |
2024-04-09 |
Seed Health, Inc. |
Method and system for reducing the likelihood of osteoporosis
|
US11844720B2
(en)
|
2011-02-04 |
2023-12-19 |
Seed Health, Inc. |
Method and system to reduce the likelihood of dental caries and halitosis
|
US10111913B2
(en)
|
2011-02-04 |
2018-10-30 |
Joseph E. Kovarik |
Method of reducing the likelihood of skin cancer in an individual human being
|
US10512661B2
(en)
|
2011-02-04 |
2019-12-24 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
|
US9987224B2
(en)
|
2011-02-04 |
2018-06-05 |
Joseph E. Kovarik |
Method and system for preventing migraine headaches, cluster headaches and dizziness
|
US11998479B2
(en)
|
2011-02-04 |
2024-06-04 |
Seed Health, Inc. |
Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
|
US10086018B2
(en)
|
2011-02-04 |
2018-10-02 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of colorectal cancer in a human being
|
US11273187B2
(en)
|
2015-11-30 |
2022-03-15 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of developing depression in an individual
|
US11419903B2
(en)
|
2015-11-30 |
2022-08-23 |
Seed Health, Inc. |
Method and system for reducing the likelihood of osteoporosis
|
US11357722B2
(en)
|
2011-02-04 |
2022-06-14 |
Seed Health, Inc. |
Method and system for preventing sore throat in humans
|
US10835560B2
(en)
|
2013-12-20 |
2020-11-17 |
Joseph E. Kovarik |
Reducing the likelihood of skin cancer in an individual human being
|
US10010568B2
(en)
|
2011-02-04 |
2018-07-03 |
Katherine Rose Kovarik |
Method and system for reducing the likelihood of a spirochetes infection in a human being
|
US11191665B2
(en)
|
2011-02-04 |
2021-12-07 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
|
US10548761B2
(en)
|
2011-02-04 |
2020-02-04 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of colorectal cancer in a human being
|
US10085938B2
(en)
|
2011-02-04 |
2018-10-02 |
Joseph E. Kovarik |
Method and system for preventing sore throat in humans
|
US11523934B2
(en)
|
2011-02-04 |
2022-12-13 |
Seed Health, Inc. |
Method and system to facilitate the growth of desired bacteria in a human's mouth
|
US10687975B2
(en)
|
2011-02-04 |
2020-06-23 |
Joseph E. Kovarik |
Method and system to facilitate the growth of desired bacteria in a human's mouth
|
US10583033B2
(en)
|
2011-02-04 |
2020-03-10 |
Katherine Rose Kovarik |
Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
|
US10245288B2
(en)
|
2011-02-04 |
2019-04-02 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease
|
US10842834B2
(en)
|
2016-01-06 |
2020-11-24 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
|
US11951140B2
(en)
|
2011-02-04 |
2024-04-09 |
Seed Health, Inc. |
Modulation of an individual's gut microbiome to address osteoporosis and bone disease
|
US20140113376A1
(en)
|
2011-06-01 |
2014-04-24 |
Rotem Sorek |
Compositions and methods for downregulating prokaryotic genes
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
US11021737B2
(en)
|
2011-12-22 |
2021-06-01 |
President And Fellows Of Harvard College |
Compositions and methods for analyte detection
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
WO2013141680A1
(en)
*
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
DK3401400T3
(da)
|
2012-05-25 |
2019-06-03 |
Univ California |
Fremgangsmåder og sammensætninger til rna-styret mål-dna-modifikation og til rna-styret transskriptionsmodulering
|
CN116064532A
(zh)
|
2012-10-23 |
2023-05-05 |
基因工具股份有限公司 |
用于切割靶dna的组合物及其用途
|
KR101844123B1
(ko)
|
2012-12-06 |
2018-04-02 |
시그마-알드리치 컴퍼니., 엘엘씨 |
Crispr-기초된 유전체 변형과 조절
|
ES2883590T3
(es)
|
2012-12-12 |
2021-12-09 |
Broad Inst Inc |
Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
ES2701749T3
(es)
|
2012-12-12 |
2019-02-25 |
Broad Inst Inc |
Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
|
DK2931898T3
(en)
|
2012-12-12 |
2016-06-20 |
Massachusetts Inst Technology |
CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
|
KR20150105634A
(ko)
|
2012-12-12 |
2015-09-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작을 위한 개선된 시스템, 방법 및 효소 조성물의 유전자 조작 및 최적화
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
WO2014093595A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
US20140242664A1
(en)
*
|
2012-12-12 |
2014-08-28 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
ES2741951T3
(es)
|
2012-12-17 |
2020-02-12 |
Harvard College |
Modificación por ingeniería genética del genoma humano guiada por ARN
|
WO2014113493A1
(en)
*
|
2013-01-16 |
2014-07-24 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
US11135273B2
(en)
|
2013-02-07 |
2021-10-05 |
The Rockefeller University |
Sequence specific antimicrobials
|
US10660943B2
(en)
|
2013-02-07 |
2020-05-26 |
The Rockefeller University |
Sequence specific antimicrobials
|
EP3578666A1
(en)
|
2013-03-12 |
2019-12-11 |
President and Fellows of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
RU2018122288A
(ru)
|
2013-03-14 |
2019-03-06 |
Карибо Биосайенсиз, Инк. |
Композиции и способы с участием нуклеиновых кислот, нацеленных на нуклеиновые кислоты
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
EP2970986B1
(en)
|
2013-03-15 |
2020-05-06 |
The General Hospital Corporation |
Rna-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
US9902973B2
(en)
|
2013-04-11 |
2018-02-27 |
Caribou Biosciences, Inc. |
Methods of modifying a target nucleic acid with an argonaute
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
SG10201710030QA
(en)
|
2013-06-04 |
2018-01-30 |
Harvard College |
Rna-guided transcriptional regulation
|
AU2014281027A1
(en)
|
2013-06-17 |
2016-01-28 |
Massachusetts Institute Of Technology |
Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
|
EP3674411A1
(en)
|
2013-06-17 |
2020-07-01 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
RU2716421C2
(ru)
|
2013-06-17 |
2020-03-11 |
Те Брод Инститьют Инк. |
Доставка, применение и применения в терапии систем crispr-cas и композиций для целенаправленного воздействия на нарушения и заболевания с использованием вирусных компонентов
|
CA2915842C
(en)
|
2013-06-17 |
2022-11-29 |
The Broad Institute, Inc. |
Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
AU2014287397B2
(en)
|
2013-07-10 |
2019-10-10 |
President And Fellows Of Harvard College |
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
|
EP2826379A1
(en)
|
2013-07-17 |
2015-01-21 |
Dupont Nutrition Biosciences ApS |
Streptococcus thermophilus strains
|
US10563225B2
(en)
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
CN103388006B
(zh)
*
|
2013-07-26 |
2015-10-28 |
华东师范大学 |
一种基因定点突变的构建方法
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
EP3988649A1
(en)
|
2013-09-18 |
2022-04-27 |
Kymab Limited |
Methods, cells and organisms
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
WO2015070083A1
(en)
|
2013-11-07 |
2015-05-14 |
Editas Medicine,Inc. |
CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
NL2011912C2
(en)
*
|
2013-12-06 |
2015-06-09 |
Univ Delft Tech |
Novel genome alteration system for microorganisms.
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
CA2932439A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
SG10201804976YA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for Genome Editing
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
WO2015089351A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
US12005085B2
(en)
|
2013-12-20 |
2024-06-11 |
Seed Health, Inc. |
Probiotic method and composition for maintaining a healthy vaginal microbiome
|
US11839632B2
(en)
|
2013-12-20 |
2023-12-12 |
Seed Health, Inc. |
Topical application of CRISPR-modified bacteria to treat acne vulgaris
|
US11833177B2
(en)
|
2013-12-20 |
2023-12-05 |
Seed Health, Inc. |
Probiotic to enhance an individual's skin microbiome
|
US11998574B2
(en)
|
2013-12-20 |
2024-06-04 |
Seed Health, Inc. |
Method and system for modulating an individual's skin microbiome
|
US11826388B2
(en)
|
2013-12-20 |
2023-11-28 |
Seed Health, Inc. |
Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
|
US11969445B2
(en)
|
2013-12-20 |
2024-04-30 |
Seed Health, Inc. |
Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
|
US11980643B2
(en)
|
2013-12-20 |
2024-05-14 |
Seed Health, Inc. |
Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
EP3116994B1
(en)
|
2014-02-20 |
2019-07-24 |
DSM IP Assets B.V. |
Phage-insensitive streptococcus thermophilus
|
CN111471675A
(zh)
|
2014-03-05 |
2020-07-31 |
国立大学法人神户大学 |
特异性转变靶向dna序列的核酸碱基的基因组序列的修饰方法、及其使用的分子复合体
|
EP3957735A1
(en)
|
2014-03-05 |
2022-02-23 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
DK3116997T3
(da)
|
2014-03-10 |
2019-08-19 |
Editas Medicine Inc |
Crispr/cas-relaterede fremgangsmåder og sammensætninger til behandling af lebers kongenitale amaurose 10 (lca10)
|
EP3981876A1
(en)
|
2014-03-26 |
2022-04-13 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
JP2017512481A
(ja)
|
2014-04-08 |
2017-05-25 |
ノースカロライナ ステート ユニバーシティーNorth Carolina State University |
Crispr関連遺伝子を用いた、rna依存性の転写抑制のための方法および組成物
|
ES2888976T3
(es)
|
2014-06-23 |
2022-01-10 |
Massachusetts Gen Hospital |
Identificación no sesgada pangenómica de DSBs evaluada por secuenciación (GUIDE-Seq.)
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
WO2016033298A1
(en)
|
2014-08-28 |
2016-03-03 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
PL3216867T3
(pl)
|
2014-11-04 |
2020-11-02 |
National University Corporation Kobe University |
Sposób modyfikowania sekwencji genomu w celu wprowadzania swoistej mutacji do docelowej sekwencji DNA poprzez reakcję usuwania zasady i stosowany w nim kompleks cząsteczkowy
|
EP3224353B9
(en)
*
|
2014-11-26 |
2023-08-09 |
Technology Innovation Momentum Fund (Israel) Limited Partnership |
Targeted elimination of bacterial genes
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
KR101761581B1
(ko)
|
2014-12-30 |
2017-07-26 |
주식회사 인트론바이오테크놀로지 |
신규한 장침입성 대장균 박테리오파지 Esc-COP-4 및 이의 장침입성 대장균 증식 억제 용도
|
KR101649851B1
(ko)
*
|
2014-12-30 |
2016-08-30 |
주식회사 인트론바이오테크놀로지 |
신규한 시가독소생산 F18형 대장균 박테리오파지 Esc-COP-1 및 이의 시가독소생산 F18형 대장균 증식 억제 용도
|
KR20170126875A
(ko)
|
2015-01-28 |
2017-11-20 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
Crispr 하이브리드 dna/rna 폴리뉴클레오티드 및 사용 방법
|
EP3265559B1
(en)
|
2015-03-03 |
2021-01-06 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
US11180793B2
(en)
|
2015-04-24 |
2021-11-23 |
Editas Medicine, Inc. |
Evaluation of Cas9 molecule/guide RNA molecule complexes
|
AU2016257306B2
(en)
|
2015-05-06 |
2019-06-27 |
Snipr Technologies Limited |
Altering microbial populations and modifying microbiota
|
EA201792663A1
(ru)
|
2015-05-29 |
2018-04-30 |
Норт Каролина Стейт Юниверсити |
Способы скрининга бактерий, архей, водорослей и дрожжей с использованием нуклеиновых кислот crispr
|
KR20220158846A
(ko)
*
|
2015-06-15 |
2022-12-01 |
노쓰 캐롤라이나 스테이트 유니버시티 |
핵산 및 rna-기반 항미생물제를 효율적으로 전달하기 위한 방법 및 조성물
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
CN109536474A
(zh)
|
2015-06-18 |
2019-03-29 |
布罗德研究所有限公司 |
降低脱靶效应的crispr酶突变
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
CN108350449B
(zh)
|
2015-08-28 |
2022-05-31 |
通用医疗公司 |
工程化的CRISPR-Cas9核酸酶
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
US10767173B2
(en)
|
2015-09-09 |
2020-09-08 |
National University Corporation Kobe University |
Method for converting genome sequence of gram-positive bacterium by specifically converting nucleic acid base of targeted DNA sequence, and molecular complex used in same
|
EP3347467B1
(en)
|
2015-09-11 |
2021-06-23 |
The General Hospital Corporation |
Full interrogation of nuclease dsbs and sequencing (find-seq)
|
US11286480B2
(en)
|
2015-09-28 |
2022-03-29 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
WO2017059313A1
(en)
|
2015-09-30 |
2017-04-06 |
The General Hospital Corporation |
Comprehensive in vitro reporting of cleavage events by sequencing (circle-seq)
|
JP7109784B2
(ja)
|
2015-10-23 |
2022-08-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
遺伝子編集のための進化したCas9蛋白質
|
EP3371329A4
(en)
|
2015-11-03 |
2019-06-19 |
President and Fellows of Harvard College |
METHOD AND DEVICE FOR VOLUMETRIC IMAGING OF A THREE-DIMENSIONAL NUCLEIC ACID-CONTAINING MATRIX
|
BR112018010681A8
(pt)
|
2015-11-27 |
2019-02-26 |
Univ Kobe Nat Univ Corp |
método para modificar um sítio alvejado, complexo de enzima de modificação de ácido nucleico, e, ácido nucleico.
|
US10086024B2
(en)
|
2015-11-30 |
2018-10-02 |
Joseph E. Kovarik |
Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
|
US10568916B2
(en)
|
2015-11-30 |
2020-02-25 |
Joseph E. Kovarik |
Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
|
US10675347B2
(en)
|
2015-11-30 |
2020-06-09 |
Joseph E. Kovarik |
Method and system for protecting honey bees from fipronil pesticides
|
US11529412B2
(en)
|
2015-11-30 |
2022-12-20 |
Seed Health, Inc. |
Method and system for protecting honey bees from pesticides
|
US10933128B2
(en)
|
2015-11-30 |
2021-03-02 |
Joseph E. Kovarik |
Method and system for protecting honey bees from pesticides
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
CN105567218A
(zh)
*
|
2015-12-25 |
2016-05-11 |
哈尔滨工业大学 |
红色发光材料铕配位聚合物、其制备方法及基于该聚合物的复合光能转换薄膜的制备方法
|
GB201600075D0
(en)
*
|
2016-01-03 |
2016-02-17 |
Glaxosmithkline Biolog Sa |
Immunogenci composition
|
US11512311B2
(en)
|
2016-03-25 |
2022-11-29 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency
|
CN116200465A
(zh)
|
2016-04-25 |
2023-06-02 |
哈佛学院董事及会员团体 |
用于原位分子检测的杂交链反应方法
|
EP3458079A4
(en)
*
|
2016-05-15 |
2020-03-04 |
Regents of the University of California |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACNE
|
US10266851B2
(en)
|
2016-06-02 |
2019-04-23 |
Sigma-Aldrich Co. Llc |
Using programmable DNA binding proteins to enhance targeted genome modification
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
BR112019001887A2
(pt)
|
2016-08-02 |
2019-07-09 |
Editas Medicine Inc |
composições e métodos para o tratamento de doença associada a cep290
|
EP3494215A1
(en)
|
2016-08-03 |
2019-06-12 |
President and Fellows of Harvard College |
Adenosine nucleobase editors and uses thereof
|
JP7201153B2
(ja)
|
2016-08-09 |
2023-01-10 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
プログラム可能cas9-リコンビナーゼ融合タンパク質およびその使用
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
WO2018071868A1
(en)
|
2016-10-14 |
2018-04-19 |
President And Fellows Of Harvard College |
Aav delivery of nucleobase editors
|
US20200172899A1
(en)
|
2016-10-14 |
2020-06-04 |
The General Hospital Corporation |
Epigenetically Regulated Site-Specific Nucleases
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
US11026717B2
(en)
|
2017-03-08 |
2021-06-08 |
Conmed Corporation |
Separable two-part single lumen gas sealed access port for use during endoscopic surgical procedures
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
WO2018165629A1
(en)
|
2017-03-10 |
2018-09-13 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
WO2018174097A1
(ja)
|
2017-03-22 |
2018-09-27 |
国立大学法人神戸大学 |
細胞内在性のdna修飾酵素を利用して標的化したdnaの核酸塩基を特異的に変換する、細胞の核酸配列の変換方法、及びそれに用いる分子複合体
|
IL269458B2
(en)
|
2017-03-23 |
2024-02-01 |
Harvard College |
Nucleic base editors that include nucleic acid programmable DNA binding proteins
|
BR112019021719A2
(pt)
|
2017-04-21 |
2020-06-16 |
The General Hospital Corporation |
Variantes de cpf1 (cas12a) com especificidade para pam alterada
|
BR112019022201A2
(pt)
*
|
2017-04-24 |
2020-05-12 |
Dupont Nutrition Biosciences Aps |
Métodos para modular a atividade de uma endonuclease cas, para aumentar a especificidade de uma endonuclease cas e complexo polinucleotídico guia, para aumentar a frequência de recombinação homóloga e para ativação ou repressão gênica, célula e célula vegetal
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
EP3630198A4
(en)
|
2017-05-25 |
2021-04-21 |
The General Hospital Corporation |
USE OF CLIVED DESAMINASES TO LIMIT UNWANTED OUT-OF-TARGET DESAMINATION FROM BASE EDITING
|
US11732274B2
(en)
|
2017-07-28 |
2023-08-22 |
President And Fellows Of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
|
US11286468B2
(en)
|
2017-08-23 |
2022-03-29 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
US11725228B2
(en)
|
2017-10-11 |
2023-08-15 |
The General Hospital Corporation |
Methods for detecting site-specific and spurious genomic deamination induced by base editing technologies
|
CN111757937A
(zh)
|
2017-10-16 |
2020-10-09 |
布罗德研究所股份有限公司 |
腺苷碱基编辑器的用途
|
CN107723280B
(zh)
*
|
2017-11-10 |
2019-09-17 |
扬州大学 |
波罗的海希瓦氏菌噬菌体SppYZU01及其用途
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
AU2019256287A1
(en)
|
2018-04-17 |
2020-11-12 |
The General Hospital Corporation |
Sensitive in vitro assays for substrate preferences and sites of nucleic acid binding, modifying, and cleaving agents
|
CN108588245A
(zh)
*
|
2018-04-19 |
2018-09-28 |
上海市质量监督检验技术研究院 |
乳酸菌饮料中嗜酸乳杆菌成分的荧光定量pcr检测方法、检测试剂盒及应用
|
JP2021522857A
(ja)
*
|
2018-05-04 |
2021-09-02 |
ローカス バイオサイエンシーズ,インク. |
標的細菌を死滅させるための方法および組成物
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
US11851663B2
(en)
|
2018-10-14 |
2023-12-26 |
Snipr Biome Aps |
Single-vector type I vectors
|
WO2020160226A1
(en)
*
|
2019-01-31 |
2020-08-06 |
Locus Ip Company, Llc |
Method for treating and/or preventing bacteriophage lysis during fermentation
|
EP3921417A4
(en)
|
2019-02-04 |
2022-11-09 |
The General Hospital Corporation |
ADENINE DNA BASE EDITOR VARIANTS WITH REDUCED OFF-TARGET RNA EDITING
|
CA3132197A1
(en)
*
|
2019-03-07 |
2020-09-10 |
The Trustees Of Columbia University In The City Of New York |
Rna-guided dna integration using tn7-like transposons
|
SG11202109882VA
(en)
|
2019-03-19 |
2021-10-28 |
Broad Inst Inc |
Methods and compositions for editing nucleotide sequences
|
CN110129279B
(zh)
*
|
2019-04-24 |
2022-02-18 |
昆明理工大学 |
一种粪肠球菌噬菌体及其分离、纯化、富集和应用
|
JP2022548735A
(ja)
*
|
2019-09-18 |
2022-11-21 |
アンシリア, インコーポレイテッド |
マイクロバイオーム調節のための組成物及び方法
|
CN110904054A
(zh)
*
|
2019-09-29 |
2020-03-24 |
中国科学院大学 |
一种沙门氏菌噬菌体see-1及其应用
|
EP4097262A1
(en)
*
|
2020-01-30 |
2022-12-07 |
DSM IP Assets B.V. |
Rotation scheme for bacterial cultures in food product fermentation
|
IL295306A
(en)
*
|
2020-02-03 |
2022-10-01 |
Technion Res & Dev Foundation |
A method for isolating a microorganism
|
JP2023525304A
(ja)
|
2020-05-08 |
2023-06-15 |
ザ ブロード インスティテュート,インコーポレーテッド |
標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物
|
CN112063593B
(zh)
*
|
2020-09-17 |
2021-08-31 |
扬州大学 |
一种致病性弧菌噬菌体VmYZU10474及其应用
|
WO2022140630A1
(en)
*
|
2020-12-23 |
2022-06-30 |
Locus Biosciences, Inc. |
Altering the normal balance of microbial populations
|
EP4376627A1
(en)
|
2021-07-29 |
2024-06-05 |
International N&H Denmark ApS |
Compositions and methods for producing fermented plant-based compositions having cream flavor
|
EP4376626A1
(en)
|
2021-07-29 |
2024-06-05 |
International N&H Denmark ApS |
Compositions and methods for producing fermented dairy compositions having cream flavor
|
WO2023082047A1
(en)
|
2021-11-09 |
2023-05-19 |
Dupont Nutrition Biosciences Aps |
Compositions and methods for producing fermented dairy prod-ucts for storage at ambient temperature
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|