HK1121447A1 - - Google Patents
Info
- Publication number
- HK1121447A1 HK1121447A1 HK09101400.3A HK09101400A HK1121447A1 HK 1121447 A1 HK1121447 A1 HK 1121447A1 HK 09101400 A HK09101400 A HK 09101400A HK 1121447 A1 HK1121447 A1 HK 1121447A1
- Authority
- HK
- Hong Kong
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69622405P | 2005-06-30 | 2005-06-30 | |
PCT/US2006/026210 WO2007005972A1 (en) | 2005-06-30 | 2006-06-29 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1121447A1 true HK1121447A1 (xx) | 2009-04-24 |
Family
ID=37305020
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09101400.3A HK1121447A1 (xx) | 2005-06-30 | 2009-02-13 | |
HK12109557.2A HK1168851A1 (zh) | 2005-06-30 | 2012-09-27 | -氨基- -二氧哌啶- -基 異吲哚啉- -二酮化合物的製備方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12109557.2A HK1168851A1 (zh) | 2005-06-30 | 2012-09-27 | -氨基- -二氧哌啶- -基 異吲哚啉- -二酮化合物的製備方法 |
Country Status (25)
Country | Link |
---|---|
US (5) | US7994327B2 (xx) |
EP (2) | EP2380887B1 (xx) |
JP (2) | JP5366544B2 (xx) |
KR (2) | KR101342241B1 (xx) |
CN (2) | CN102643267B (xx) |
AU (1) | AU2006265019B2 (xx) |
BR (1) | BRPI0612803A2 (xx) |
CA (2) | CA2823088C (xx) |
CR (1) | CR9697A (xx) |
DK (2) | DK1907373T3 (xx) |
EC (1) | ECSP088154A (xx) |
ES (2) | ES2430545T3 (xx) |
HK (2) | HK1121447A1 (xx) |
HR (2) | HRP20130102T1 (xx) |
IL (2) | IL188330A (xx) |
ME (1) | ME01513B (xx) |
MX (1) | MX2007016290A (xx) |
NZ (1) | NZ565309A (xx) |
PE (2) | PE20070103A1 (xx) |
PL (2) | PL2380887T3 (xx) |
PT (2) | PT1907373E (xx) |
RS (2) | RS53030B (xx) |
SI (2) | SI2380887T1 (xx) |
WO (1) | WO2007005972A1 (xx) |
ZA (1) | ZA200800828B (xx) |
Families Citing this family (44)
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JP2008512379A (ja) * | 2004-09-03 | 2008-04-24 | セルジーン・コーポレーション | 置換2−(2,6−ジオキソピペリジン−3−イル)−1−オキソイソインドリン類の調製方法 |
SI2380887T1 (sl) | 2005-06-30 | 2013-12-31 | Celgene Corporation | Postopki priprave spojin 4-amino-2-/2,6-dioksopiperidin-3-il)izoindolin -1,3-diona |
WO2007136640A2 (en) * | 2006-05-16 | 2007-11-29 | Celgene Corporation | Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
PT2076260E (pt) * | 2006-09-15 | 2011-06-07 | Celgene Corp | Compostos de n-metilaminometil-isoindole, composições que os compreendem e seus métodos de utilização |
US8288414B2 (en) | 2007-09-12 | 2012-10-16 | Deuteria Pharmaceuticals, Inc. | Deuterium-enriched lenalidomide |
WO2009111948A1 (zh) * | 2008-03-13 | 2009-09-17 | 天津和美生物技术有限公司 | 3-(4-氨基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮及其衍生物的盐或盐的多晶型物及其制备和应用 |
US20110060010A1 (en) * | 2008-03-13 | 2011-03-10 | Tianjin Hemay Bio-Tech Co., Ltd | Salts of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione and derivatives thereof, or polymorphs of salts, process for preparing same and use thereof |
CN102060746B (zh) * | 2009-06-01 | 2013-02-13 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体 |
CN101580501B (zh) * | 2009-06-01 | 2011-03-09 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体 |
CN101817813B (zh) * | 2010-01-15 | 2013-04-10 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮晶体ⅳ及其药用组合物 |
MX337169B (es) | 2010-02-11 | 2016-02-16 | Celgene Corp | Derivados de arilmetoxi isoindolina y composiciones que los comprenden y metodos para utilizar los mismos. |
CA2867134C (en) | 2011-03-28 | 2019-05-07 | Sheila Dewitt | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
WO2012177678A2 (en) | 2011-06-22 | 2012-12-27 | Celgene Corporation | Isotopologues of pomalidomide |
WO2013126326A1 (en) * | 2012-02-21 | 2013-08-29 | Celgene Corporation | Solid forms of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, compositions and methods of use thereof |
JP2015524811A (ja) * | 2012-07-27 | 2015-08-27 | セルジーン コーポレイション | イソインドリン−1,3−ジオン化合物の調製プロセス |
WO2014025978A1 (en) | 2012-08-09 | 2014-02-13 | Celgene Corporation | Processes for the preparation of (s)-3-4-((4-(morpholinomethyl) benzyl)oxy)-1-oxoisoindolin-2-yl) piperidine-2,6-dione and pharmaceutically acceptable forms thereof |
JP6359563B2 (ja) | 2013-01-14 | 2018-07-18 | デュートルクス・リミテッド・ライアビリティ・カンパニーDeuteRx, LLC | 3−(5置換−4−オキソキナゾリン−3(4h)−イル)−3−ジュウテロピペリジン−2,6−ジオン誘導体 |
WO2014152833A1 (en) | 2013-03-14 | 2014-09-25 | Deuterx, Llc | 3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
EP2981532A4 (en) * | 2013-04-01 | 2016-12-14 | Hetero Research Foundation | PROCESS FOR THE PREPARATION OF POMALIDOMIDE |
KR20150136078A (ko) | 2013-04-02 | 2015-12-04 | 셀진 코포레이션 | 중추신경계 암의 치료 및 관리를 위한 4-아미노-2-(2,6-디옥소-피페리딘-3-일)-이소인돌린-1,3-디온을 사용한 방법 및 조성물 |
CN103232380A (zh) * | 2013-05-08 | 2013-08-07 | 中国药科大学 | 一种泊马度胺关键中间体的制备方法 |
CN103275062B (zh) * | 2013-05-17 | 2016-04-13 | 宁波百思佳医药科技有限公司 | 一种Pomalidomide的纯化方法 |
CN103288797B (zh) * | 2013-05-17 | 2016-03-02 | 宁波百思佳医药科技有限公司 | 一种用亚砜类溶剂纯化Pomalidomide的方法 |
EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
UA117141C2 (uk) | 2013-10-08 | 2018-06-25 | Селджин Корпорейшн | Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону |
CN104557858B (zh) * | 2013-10-29 | 2018-06-01 | 上海医药工业研究院 | 一种泊利度胺的制备方法 |
US20160362391A1 (en) * | 2013-11-25 | 2016-12-15 | Mylan Laboratories Ltd. | Improved Process for the Preparation of Pomalidomide and its Purification |
CN103724323B (zh) * | 2014-01-20 | 2016-08-17 | 上海医药工业研究院 | 泊马度胺的制备方法 |
CN104016967A (zh) * | 2014-04-04 | 2014-09-03 | 南京工业大学 | 一种泊利度胺的合成方法 |
CN105440013B (zh) * | 2014-08-29 | 2018-10-09 | 杭州和泽医药科技有限公司 | 一种泊马度胺的制备方法 |
EP3265418B1 (en) | 2015-03-05 | 2020-10-14 | Otis Elevator Company | Elevator car |
US9809603B1 (en) | 2015-08-18 | 2017-11-07 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same |
ITUB20169994A1 (it) | 2016-01-14 | 2017-07-14 | Phf Sa | Nuove forme cristalline di farmaci immunomodulatori |
HU231259B1 (hu) | 2016-02-04 | 2022-06-28 | Egyt Gyogyszervegyeszeti Gyar | Eljárás pomalidomide elõállítására |
CN106432045B (zh) * | 2016-06-29 | 2018-12-18 | 深圳海王医药科技研究院有限公司 | 一种泊马度胺杂质的合成方法 |
WO2018013689A1 (en) | 2016-07-13 | 2018-01-18 | Celgene Corporation | Solid dispersions and solid forms comprising 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, method of preparation and use thereof |
WO2018154516A1 (en) * | 2017-02-23 | 2018-08-30 | Sun Pharmaceutical Industries Limited | Process for the preparation of pomalidomide |
US10093647B1 (en) | 2017-05-26 | 2018-10-09 | Celgene Corporation | Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate, compositions and methods of use thereof |
MD4802C1 (ro) * | 2017-09-07 | 2022-11-30 | Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises" | Utilizarea derivatului de glutaramidă pentru tratarea afecţiunilor, asociate cu activitatea aberantă a citokinelor |
US10093649B1 (en) | 2017-09-22 | 2018-10-09 | Celgene Corporation | Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof |
US10093648B1 (en) | 2017-09-22 | 2018-10-09 | Celgene Corporation | Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof |
AR114803A1 (es) | 2018-04-23 | 2020-10-14 | Celgene Corp | Compuestos de 4-aminoisoindolin-1,3-diona sustituida, composiciones de estos y métodos de tratamiento con dichos compuestos |
CN110343063A (zh) * | 2019-08-09 | 2019-10-18 | 新乡双鹭药业有限公司 | 一种泊马度胺合成中杂质的制备方法 |
CN114605381A (zh) * | 2020-12-03 | 2022-06-10 | 南京海辰药业股份有限公司 | 一种泊马度胺的制备方法 |
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JP2008512379A (ja) | 2004-09-03 | 2008-04-24 | セルジーン・コーポレーション | 置換2−(2,6−ジオキソピペリジン−3−イル)−1−オキソイソインドリン類の調製方法 |
SI2380887T1 (sl) * | 2005-06-30 | 2013-12-31 | Celgene Corporation | Postopki priprave spojin 4-amino-2-/2,6-dioksopiperidin-3-il)izoindolin -1,3-diona |
KR20080042158A (ko) | 2005-08-31 | 2008-05-14 | 셀진 코포레이션 | 이소인돌-이미드 화합물과 이를 포함하는 조성물 및 이를이용한 방법 |
PT2076260E (pt) | 2006-09-15 | 2011-06-07 | Celgene Corp | Compostos de n-metilaminometil-isoindole, composições que os compreendem e seus métodos de utilização |
KR20100124710A (ko) | 2008-03-11 | 2010-11-29 | 닥터 레디스 레보러터리즈 리미티드 | 레날리도미드의 제조 |
WO2009111948A1 (zh) | 2008-03-13 | 2009-09-17 | 天津和美生物技术有限公司 | 3-(4-氨基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮及其衍生物的盐或盐的多晶型物及其制备和应用 |
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