HK1111999A1 - Spiroketal derivative and use thereof as diabetic medicine - Google Patents
Spiroketal derivative and use thereof as diabetic medicineInfo
- Publication number
- HK1111999A1 HK1111999A1 HK08107008.7A HK08107008A HK1111999A1 HK 1111999 A1 HK1111999 A1 HK 1111999A1 HK 08107008 A HK08107008 A HK 08107008A HK 1111999 A1 HK1111999 A1 HK 1111999A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- optionally substituted
- group
- integer selected
- compound
- diabetic medicine
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/153—Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005020901 | 2005-01-28 | ||
| JP2005176690 | 2005-06-16 | ||
| PCT/JP2006/301284 WO2006080421A1 (fr) | 2005-01-28 | 2006-01-27 | Dérivé de spirocétal et emploi dudit dérivé au titre de médicament contre le diabète |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1111999A1 true HK1111999A1 (en) | 2008-08-22 |
Family
ID=36740445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK08107008.7A HK1111999A1 (en) | 2005-01-28 | 2008-06-24 | Spiroketal derivative and use thereof as diabetic medicine |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7767651B2 (fr) |
| EP (2) | EP1852439B1 (fr) |
| JP (1) | JP4093587B2 (fr) |
| KR (2) | KR101322980B1 (fr) |
| AR (1) | AR054612A1 (fr) |
| AU (1) | AU2006209523B2 (fr) |
| BR (1) | BRPI0606367B1 (fr) |
| CA (1) | CA2596235C (fr) |
| CR (1) | CR9314A (fr) |
| DK (1) | DK1852439T3 (fr) |
| ES (1) | ES2567439T3 (fr) |
| HK (1) | HK1111999A1 (fr) |
| HR (1) | HRP20160333T1 (fr) |
| HU (1) | HUE027078T2 (fr) |
| IL (1) | IL184838A (fr) |
| MA (1) | MA29272B1 (fr) |
| MY (1) | MY140528A (fr) |
| NO (1) | NO341263B1 (fr) |
| NZ (1) | NZ556343A (fr) |
| PL (1) | PL1852439T3 (fr) |
| RU (1) | RU2416617C2 (fr) |
| SI (1) | SI1852439T1 (fr) |
| TW (1) | TW200637869A (fr) |
| WO (1) | WO2006080421A1 (fr) |
Families Citing this family (46)
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| TWI335218B (en) * | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| JP5230613B2 (ja) * | 2006-05-23 | 2013-07-10 | テラコス・インコーポレイテッド | グルコース輸送体阻害剤およびその使用方法 |
| TWI403516B (zh) * | 2006-07-27 | 2013-08-01 | Chugai Pharmaceutical Co Ltd | To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes |
| TWI432446B (zh) * | 2006-07-27 | 2014-04-01 | Chugai Pharmaceutical Co Ltd | 稠環螺酮縮醇衍生物、及其做為糖尿病治療藥之使用 |
| US20100093744A1 (en) | 2006-10-13 | 2010-04-15 | Chugai Seiyaku Kabushiki Kaisha | Thioglucose spiroketal derivative and use thereof as therapeutic agent for diabetes |
| US7795228B2 (en) | 2006-12-28 | 2010-09-14 | Theracos, Inc. | Spiroheterocyclic glycosides and methods of use |
| PE20090938A1 (es) | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
| JP4809931B2 (ja) | 2007-08-23 | 2011-11-09 | セラコス・インコーポレイテッド | ベンジルベンゼン誘導体およびその使用方法 |
| UA101004C2 (en) | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
| WO2009143020A1 (fr) | 2008-05-22 | 2009-11-26 | Bristol-Myers Squibb Company | Procédé de traitement de l'hyperuricémie à l'aide d'un inhibiteur de sglt2 et composition le contenant |
| TW201011043A (en) * | 2008-06-20 | 2010-03-16 | Chugai Pharmaceutical Co Ltd | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives |
| US8283454B2 (en) | 2008-08-22 | 2012-10-09 | Theracos, Inc. | Processes for the preparation of SGLT2 inhibitors |
| ES2380408T3 (es) * | 2008-08-28 | 2012-05-11 | Pfizer Inc. | Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol |
| PL2395983T3 (pl) | 2009-02-13 | 2020-09-07 | Boehringer Ingelheim International Gmbh | Kompozycja farmaceutyczna zawierająca inhibitor sglt2, inhibitor dpp-iv i ewentualnie dalszy środek przeciwcukrzycowy oraz jej zastosowania |
| ME02016B (me) | 2009-11-02 | 2015-05-20 | Pfizer | Derivati dioksabiciklo[3.2.1]oktan-2,3,4-triola |
| CN102656177B (zh) * | 2009-12-18 | 2016-01-27 | 中外制药株式会社 | 螺酮缩醇衍生物的制备方法 |
| EP2556056A1 (fr) | 2010-04-06 | 2013-02-13 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur de gpr119 et traitement de troubles associés |
| WO2011153712A1 (fr) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Forme cristalline d'inhibiteur de sglt2 de type benzyl-benzène |
| KR101871011B1 (ko) | 2010-09-22 | 2018-06-25 | 아레나 파마슈티칼스, 인크. | Ｇｐｒ１１９ 수용체의 조절제 및 그와 관련된 장애의 치료 |
| WO2012041898A1 (fr) | 2010-09-29 | 2012-04-05 | Celon Pharma Sp. Z O.O. | Combinaison de l'inhibiteur de sglt2 et d'un composé de sucre pour le traitement du diabète |
| WO2012115249A1 (fr) * | 2011-02-25 | 2012-08-30 | 中外製薬株式会社 | Cristal de dérivé de spirocétal |
| UY33937A (es) | 2011-03-07 | 2012-09-28 | Boehringer Ingelheim Int | Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina |
| WO2012135570A1 (fr) | 2011-04-01 | 2012-10-04 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles qui lui sont associés |
| WO2012145361A1 (fr) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles liés à celui-ci |
| WO2012145603A1 (fr) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles liés à celui-ci |
| WO2012145604A1 (fr) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles liés à celui-ci |
| WO2012170702A1 (fr) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles associés à celui-ci |
| WO2013055910A1 (fr) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles associés |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| WO2013151033A1 (fr) * | 2012-04-03 | 2013-10-10 | 第一三共株式会社 | Dérivé de c-glycoside présentant un cycle spiro |
| US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
| WO2014074668A1 (fr) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulateurs de gpr119 et traitement de troubles associés à ceux-ci |
| CN105611920B (zh) | 2013-10-12 | 2021-07-16 | 泰拉科斯萨普有限责任公司 | 羟基-二苯甲烷衍生物的制备 |
| JP6513030B2 (ja) | 2013-12-27 | 2019-05-15 | 中外製薬株式会社 | トホグリフロジンを含有する固形製剤及びその製造方法 |
| US10346562B2 (en) * | 2014-08-21 | 2019-07-09 | Dassault Systèmes Canada Inc. | Automated curvature modeling of polygonal lines |
| CN106317068A (zh) * | 2015-06-23 | 2017-01-11 | 中国科学院上海药物研究所 | 一种c,o-螺环芳基糖苷类化合物及其制备和应用 |
| CA3041169A1 (fr) | 2016-10-19 | 2018-04-26 | Boehringer Ingelheim International Gmbh | Combinaisons comprenant un inhibiteur de ssao/vap-1 et un inhibiteur de sglt2, leurs utilisations |
| CN110167595A (zh) | 2017-01-11 | 2019-08-23 | 兴和株式会社 | 非酒精性脂肪性肝病的预防及治疗药 |
| CN111989103A (zh) | 2018-04-17 | 2020-11-24 | 勃林格殷格翰国际有限公司 | 药物组合物、其治疗方法和用途 |
| JOP20210009A1 (ar) | 2018-07-19 | 2021-01-12 | Astrazeneca Ab | طرق لعلاج HFpEF باستعمال داباجليفلوزين وتركيبات تشمله |
| WO2020039394A1 (fr) | 2018-08-24 | 2020-02-27 | Novartis Ag | Nouvelles combinaisons de médicaments |
| JP2023515668A (ja) | 2020-03-06 | 2023-04-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｐｏｌ－１依存性巣状分節性糸球体硬化症を治療する方法 |
| WO2022022865A1 (fr) | 2020-07-27 | 2022-02-03 | Astrazeneca Ab | Procédés de traitement d'une maladie rénale chronique avec de la dapagliflozine |
| US20240212818A1 (en) | 2021-04-01 | 2024-06-27 | Astrazeneca Uk Limited | Systems and methods for managing prediabetes with a gliflozin sodiumglucose cotransport 2 inhibitor pharmaceutical composition |
| WO2023144722A1 (fr) | 2022-01-26 | 2023-08-03 | Astrazeneca Ab | Dapagliflozine destinée à être utilisée dans le traitement du prédiabète ou pour réduire le risque de développer un diabète de type 2 |
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| EP1679966A4 (fr) | 2003-08-01 | 2009-05-27 | Janssen Pharmaceutica Nv | Benzimidazole-, benztriazole- et benzimidazolone-o-glucosides substitues |
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| EP1687410A4 (fr) | 2003-10-07 | 2008-04-09 | Isis Pharmaceuticals Inc | Oligonucleotides antisens optimises pour cibler le rein |
| US20050191653A1 (en) | 2003-11-03 | 2005-09-01 | Freier Susan M. | Modulation of SGLT2 expression |
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| CN103030617A (zh) | 2004-03-16 | 2013-04-10 | 贝林格尔.英格海姆国际有限公司 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
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| DE102004028241B4 (de) | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
| US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| DE102004034690A1 (de) | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
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2006
- 2006-01-25 TW TW095102876A patent/TW200637869A/zh unknown
- 2006-01-26 MY MYPI20060375A patent/MY140528A/en unknown
- 2006-01-27 AR ARP060100301A patent/AR054612A1/es not_active Application Discontinuation
- 2006-01-27 JP JP2007500586A patent/JP4093587B2/ja active Active
- 2006-01-27 EP EP06712450.3A patent/EP1852439B1/fr active Active
- 2006-01-27 ES ES06712450.3T patent/ES2567439T3/es active Active
- 2006-01-27 BR BRPI0606367-5A patent/BRPI0606367B1/pt active IP Right Grant
- 2006-01-27 US US11/815,074 patent/US7767651B2/en active Active
- 2006-01-27 NZ NZ556343A patent/NZ556343A/en unknown
- 2006-01-27 RU RU2007132448/04A patent/RU2416617C2/ru active
- 2006-01-27 CA CA2596235A patent/CA2596235C/fr active Active
- 2006-01-27 EP EP16161071.2A patent/EP3072897B1/fr active Active
- 2006-01-27 WO PCT/JP2006/301284 patent/WO2006080421A1/fr active Application Filing
- 2006-01-27 HU HUE06712450A patent/HUE027078T2/en unknown
- 2006-01-27 SI SI200632049A patent/SI1852439T1/sl unknown
- 2006-01-27 DK DK06712450.3T patent/DK1852439T3/en active
- 2006-01-27 KR KR1020077019678A patent/KR101322980B1/ko active IP Right Grant
- 2006-01-27 AU AU2006209523A patent/AU2006209523B2/en active Active
- 2006-01-27 KR KR1020137020138A patent/KR20130102648A/ko not_active Application Discontinuation
- 2006-01-27 PL PL06712450.3T patent/PL1852439T3/pl unknown
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2007
- 2007-07-25 IL IL184838A patent/IL184838A/en active IP Right Grant
- 2007-08-15 CR CR9314A patent/CR9314A/es unknown
- 2007-08-23 NO NO20074310A patent/NO341263B1/no unknown
- 2007-08-28 MA MA30168A patent/MA29272B1/fr unknown
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2008
- 2008-06-24 HK HK08107008.7A patent/HK1111999A1/xx unknown
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2016
- 2016-04-04 HR HRP20160333TT patent/HRP20160333T1/hr unknown
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