MA29272B1 - Derive de spirocetal et son utilisation comme medicament contre le diabete - Google Patents

Derive de spirocetal et son utilisation comme medicament contre le diabete

Info

Publication number
MA29272B1
MA29272B1 MA30168A MA30168A MA29272B1 MA 29272 B1 MA29272 B1 MA 29272B1 MA 30168 A MA30168 A MA 30168A MA 30168 A MA30168 A MA 30168A MA 29272 B1 MA29272 B1 MA 29272B1
Authority
MA
Morocco
Prior art keywords
substituted
group
compound
possibly
spirocetal
Prior art date
Application number
MA30168A
Other languages
English (en)
Inventor
Takamitsu Kobayashi
Tsutomu Sato
Masahiro Nishimoto
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MA29272B1 publication Critical patent/MA29272B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/153—Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Abstract

LA PRÉSENTE INVENTION A POUR OBJET UN COMPOSÉ DE FORMULE (I) SUIVANTE : [FORMULE CHIMIQUE 1] (I) (DANS LA FORMULE, R1, R2, R3 ET R4 REPRÉSENTENT INDÉPENDAMMENT UN ATOME D'HYDROGÈNE, UN GROUPEMENT ALKYLE EN C1-C6 ÉVENTUELLEMENT SUBSTITUÉ, UN GROUPEMENT ARYLALKYLE EN C7-C14 ÉVENTUELLEMENT SUBSTITUÉ, OU -C(=O)RX ; RX REPRÉSENTE UN GROUPEMENT ALKYLE EN C1-C6 ÉVENTUELLEMENT SUBSTITUÉ, UN GROUPEMENT ARYLE ÉVENTUELLEMENT SUBSTITUÉ, UN GROUPEMENT HÉTÉROARYLE ÉVENTUELLEMENT SUBSTITUÉ, UN GROUPEMENT ALCOXY EN C1-C6 ÉVENTUELLEMENT SUBSTITUÉ OU -NRERF ; AR1 REPRÉSENTE UN CYCLE HYDROCARBONÉ AROMATIQUE ÉVENTUELLEMENT SUBSTITUÉ OU UN HÉTÉROCYCLE AROMATIQUE ÉVENTUELLEMENT SUBSTITUÉ EN POSITION 1 ; Q REPRÉSENTE -(CH2)M-(L)P- OR -(L)P-(CH2)M- ; M REPRÉSENTE UN ENTIER COMPRIS ENTRE 0 ET 2 INCLUS ; N REPRÉSENTE 1 OU 2 ; P REPRÉSENTE 0 OU 1 ; L REPRÉSENTE -O-, -S- OU -NR5- ; ET A REPRÉSENTE UN GROUPEMENT ARYLE ÉVENTUELLEMENT SUBSTITUÉ OU UN GROUPEMENT HÉTÉROARYLE ÉVENTUELLEMENT SUBSTITUÉ.) LA PRÉSENTE INVENTION A ÉGALEMENT POUR OBJET UNE PRODROGUE D'UN TEL COMPOSÉ, UN SEL DE QUALITÉ PHARMACEUTIQUE DUDIT COMPOSÉ OU DE SA PRODROGUE, UN PRODUIT PHARMACEUTIQUE OU UNE PRÉPARATION PHARMACEUTIQUE CONTENANT UN TEL COMPOSÉ, ET SIMILAIRE.
MA30168A 2005-01-28 2007-08-28 Derive de spirocetal et son utilisation comme medicament contre le diabete MA29272B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005020901 2005-01-28
JP2005176690 2005-06-16

Publications (1)

Publication Number Publication Date
MA29272B1 true MA29272B1 (fr) 2008-02-01

Family

ID=36740445

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30168A MA29272B1 (fr) 2005-01-28 2007-08-28 Derive de spirocetal et son utilisation comme medicament contre le diabete

Country Status (24)

Country Link
US (1) US7767651B2 (fr)
EP (2) EP3072897B1 (fr)
JP (1) JP4093587B2 (fr)
KR (2) KR20130102648A (fr)
AR (1) AR054612A1 (fr)
AU (1) AU2006209523B2 (fr)
BR (1) BRPI0606367B1 (fr)
CA (1) CA2596235C (fr)
CR (1) CR9314A (fr)
DK (1) DK1852439T3 (fr)
ES (1) ES2567439T3 (fr)
HK (1) HK1111999A1 (fr)
HR (1) HRP20160333T1 (fr)
HU (1) HUE027078T2 (fr)
IL (1) IL184838A (fr)
MA (1) MA29272B1 (fr)
MY (1) MY140528A (fr)
NO (1) NO341263B1 (fr)
NZ (1) NZ556343A (fr)
PL (1) PL1852439T3 (fr)
RU (1) RU2416617C2 (fr)
SI (1) SI1852439T1 (fr)
TW (1) TW200637869A (fr)
WO (1) WO2006080421A1 (fr)

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TW200637869A (en) 2006-11-01
PL1852439T3 (pl) 2016-10-31
CA2596235A1 (fr) 2006-08-03
KR101322980B1 (ko) 2013-10-29
EP1852439A4 (fr) 2010-01-13
WO2006080421A1 (fr) 2006-08-03
CR9314A (es) 2007-10-04
KR20130102648A (ko) 2013-09-17
TWI377211B (fr) 2012-11-21
HK1111999A1 (en) 2008-08-22
JPWO2006080421A1 (ja) 2008-06-19
AU2006209523B2 (en) 2011-06-02
BRPI0606367A2 (pt) 2009-06-23
MY140528A (en) 2009-12-31
EP3072897B1 (fr) 2019-06-26
KR20070101364A (ko) 2007-10-16
NZ556343A (en) 2010-01-29
RU2416617C2 (ru) 2011-04-20
HRP20160333T1 (hr) 2016-05-06
IL184838A0 (en) 2007-12-03
IL184838A (en) 2012-02-29
CA2596235C (fr) 2014-09-16
AU2006209523A1 (en) 2006-08-03
BRPI0606367B1 (pt) 2023-03-21
DK1852439T3 (en) 2016-05-02
EP1852439A1 (fr) 2007-11-07
US20090030006A1 (en) 2009-01-29
JP4093587B2 (ja) 2008-06-04
NO341263B1 (no) 2017-09-25
EP3072897A1 (fr) 2016-09-28
NO20074310L (no) 2007-10-29
US7767651B2 (en) 2010-08-03
HUE027078T2 (en) 2016-08-29
RU2007132448A (ru) 2009-03-10
SI1852439T1 (sl) 2016-06-30
EP1852439B1 (fr) 2016-03-23
AR054612A1 (es) 2007-07-04

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