EA201990951A1 - Комбинации, содержащие ssao/vap-1 ингибитор и sglt2-ингибитор, и их применение - Google Patents

Комбинации, содержащие ssao/vap-1 ингибитор и sglt2-ингибитор, и их применение

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Publication number
EA201990951A1
EA201990951A1 EA201990951A EA201990951A EA201990951A1 EA 201990951 A1 EA201990951 A1 EA 201990951A1 EA 201990951 A EA201990951 A EA 201990951A EA 201990951 A EA201990951 A EA 201990951A EA 201990951 A1 EA201990951 A1 EA 201990951A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitor
vap
application
disorders
ssao
Prior art date
Application number
EA201990951A
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English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of EA201990951A1 publication Critical patent/EA201990951A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Изобретение относится к фармацевтической комбинации в соответствии с изобретением, содержащей SSAO/VAP-1 ингибитор в соответствии с формулой (I)где R-Rи X имеют значения, как определено в настоящей заявке, и SGLT2-ингибитор. Дополнительно настоящее изобретение относится к способам предотвращения, замедления прогрессирования, задержки или лечения фиброзных нарушений, метаболических нарушений, воспалительных нарушений, глазных болезней, нейровоспалительных нарушений или злокачественного новообразования у пациента, который в этом нуждается, характеризующимся тем, что фармацевтическую комбинацию в соответствии с изобретением вводят пациенту.
EA201990951A 2016-10-19 2017-10-16 Комбинации, содержащие ssao/vap-1 ингибитор и sglt2-ингибитор, и их применение EA201990951A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16194572 2016-10-19
PCT/EP2017/076300 WO2018073154A1 (en) 2016-10-19 2017-10-16 Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof

Publications (1)

Publication Number Publication Date
EA201990951A1 true EA201990951A1 (ru) 2019-11-29

Family

ID=57178303

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990951A EA201990951A1 (ru) 2016-10-19 2017-10-16 Комбинации, содержащие ssao/vap-1 ингибитор и sglt2-ингибитор, и их применение

Country Status (14)

Country Link
US (1) US20210212968A1 (ru)
EP (1) EP3528800A1 (ru)
JP (1) JP2019531320A (ru)
KR (1) KR20190070956A (ru)
CN (1) CN109843279A (ru)
AU (1) AU2017344882A1 (ru)
BR (1) BR112019005930A2 (ru)
CA (1) CA3041169A1 (ru)
CL (1) CL2019000935A1 (ru)
EA (1) EA201990951A1 (ru)
IL (1) IL265989A (ru)
MX (1) MX2019004549A (ru)
PH (1) PH12019500845A1 (ru)
WO (1) WO2018073154A1 (ru)

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KR20190110736A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR20190110740A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
BR112021005920A2 (pt) * 2018-09-28 2021-06-29 Acucela Inc. inibidores de vap-1
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JP7414230B2 (ja) * 2018-11-09 2024-01-16 国立大学法人 琉球大学 抗血液悪性腫瘍薬
TW202039486A (zh) * 2018-12-14 2020-11-01 南韓商柳韓洋行股份有限公司 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物
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BR112022007974A2 (pt) 2019-10-29 2022-07-12 Eccogene Shanghai Co Ltd Inibidores de ssao e uso dos mesmos
WO2021195435A1 (en) * 2020-03-25 2021-09-30 Terns, Inc. Treatment of respiratory disorders
IL298145A (en) * 2020-05-13 2023-01-01 Terns Pharmaceuticals Inc Combined treatment of liver disorders
CN113893256A (zh) * 2020-07-06 2022-01-07 诺未科技（北京）有限公司 化合物或其可药用盐、二聚体或三聚体在制备治疗癌症的药物中的应用
US11820754B2 (en) 2020-08-25 2023-11-21 Eli Lilly And Company Polymorphs of an SSAO inhibitor
WO2022183289A1 (en) * 2021-03-04 2022-09-09 The Governors Of The University Of Alberta The use of empagliflozin for the treatment of ulcerative colitis and crohn's disease
TW202333726A (zh) * 2021-11-11 2023-09-01 美商拓臻製藥公司 以ｓｓａｏ抑制劑治療肝病
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Also Published As

Publication number Publication date
JP2019531320A (ja) 2019-10-31
US20210212968A1 (en) 2021-07-15
EP3528800A1 (en) 2019-08-28
IL265989A (en) 2019-06-30
MX2019004549A (es) 2019-06-12
CA3041169A1 (en) 2018-04-26
WO2018073154A1 (en) 2018-04-26
BR112019005930A2 (pt) 2019-06-11
PH12019500845A1 (en) 2019-12-02
CL2019000935A1 (es) 2019-08-09
CN109843279A (zh) 2019-06-04
KR20190070956A (ko) 2019-06-21
AU2017344882A1 (en) 2019-03-28

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