HK1081969A1 - Pseudopolymorphic forms of a hiv protease inhibitor hiv - Google Patents
Pseudopolymorphic forms of a hiv protease inhibitor hivInfo
- Publication number
- HK1081969A1 HK1081969A1 HK06102443.3A HK06102443A HK1081969A1 HK 1081969 A1 HK1081969 A1 HK 1081969A1 HK 06102443 A HK06102443 A HK 06102443A HK 1081969 A1 HK1081969 A1 HK 1081969A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hiv
- protease inhibitor
- pseudopolymorphic forms
- hiv protease
- pseudopolymorphic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02076929 | 2002-05-16 | ||
| PCT/EP2003/050176 WO2003106461A2 (en) | 2002-05-16 | 2003-05-16 | Pseudopolymorphic forms of a hiv protease inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1081969A1 true HK1081969A1 (en) | 2006-05-26 |
Family
ID=29724454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK06102443.3A HK1081969A1 (en) | 2002-05-16 | 2006-02-23 | Pseudopolymorphic forms of a hiv protease inhibitor hiv |
Country Status (26)
| Country | Link |
|---|---|
| US (8) | US7700645B2 (da) |
| EP (4) | EP1567529B2 (da) |
| JP (1) | JP4864320B2 (da) |
| KR (2) | KR101128370B1 (da) |
| CN (1) | CN100475819C (da) |
| AP (1) | AP2052A (da) |
| AU (2) | AU2003271740B2 (da) |
| BR (1) | BRPI0311176B8 (da) |
| CA (1) | CA2485834C (da) |
| CY (3) | CY1115665T1 (da) |
| DK (3) | DK1567529T4 (da) |
| EA (1) | EA007120B8 (da) |
| ES (4) | ES2638412T3 (da) |
| HK (1) | HK1081969A1 (da) |
| HR (1) | HRP20041061B1 (da) |
| HU (1) | HUE034389T2 (da) |
| IL (1) | IL165140A0 (da) |
| LT (1) | LT2767539T (da) |
| MX (1) | MXPA04011427A (da) |
| NO (1) | NO331477B1 (da) |
| NZ (1) | NZ536497A (da) |
| PL (1) | PL215151B1 (da) |
| PT (3) | PT2767539T (da) |
| SI (3) | SI1567529T2 (da) |
| WO (1) | WO2003106461A2 (da) |
| ZA (1) | ZA200410154B (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2336134B1 (en) | 1998-06-23 | 2016-08-31 | The United States of America, represented by the Secretary, Department of Health and Human Services | Fitness assay and methods for reducing resistance of HIV to therapy |
| PT2767539T (pt) | 2002-05-16 | 2017-08-28 | Janssen Sciences Ireland Uc | Formas pseudopolimórficas de um inibidor de protease de hiv |
| HRP20020614A2 (en) * | 2002-07-22 | 2004-06-30 | PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. | Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a |
| JP4818124B2 (ja) | 2003-12-23 | 2011-11-16 | テイボテク・フアーマシユーチカルズ・リミテツド | （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法 |
| RU2421459C2 (ru) | 2005-02-25 | 2011-06-20 | Тиботек Фармасьютикалз Лтд. | Синтез предшественника ингибитора протеазы |
| DK2089371T3 (da) * | 2006-11-09 | 2011-05-16 | Tibotec Pharm Ltd | Fremstillingsmåde til fremstilling af hexahydrofuro[2,3-b]furan-3-OL |
| TWI482775B (zh) | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法 |
| MX2011007790A (es) * | 2009-01-29 | 2011-11-18 | Mapi Pharma Ltd | Polimorfos de darunavir. |
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| CA2776807C (en) | 2009-09-17 | 2018-10-16 | Mylan Laboratories Limited | An improved process for the preparation of darunavir |
| WO2011051978A2 (en) | 2009-10-30 | 2011-05-05 | Lupin Limited | A novel process for preparation of darunavir and darunavir ethanolate of fine particle size |
| EP2513116B1 (en) * | 2009-12-16 | 2015-08-19 | Hetero Research Foundation | Polymorphs of darunavir |
| JP2013516397A (ja) * | 2010-01-05 | 2013-05-13 | シプラ・リミテッド | ダルナビルの多形及びその製造方法 |
| WO2011092687A1 (en) | 2010-01-28 | 2011-08-04 | Mapi Pharma Hk Limited | Process for the preparation of darunavir and darunavir intermediates |
| WO2011145099A1 (en) * | 2010-05-20 | 2011-11-24 | Hetero Research Foundation | Crystalline hydrochloride salt of darunavir |
| WO2012107889A1 (en) | 2011-02-10 | 2012-08-16 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous darunavir |
| SI2729130T1 (en) | 2011-07-07 | 2018-03-30 | Janssen Sciences Ireland Uc | Combined formulations of darunavir |
| US9216990B2 (en) | 2011-12-05 | 2015-12-22 | Mylan Labs Limited | Crystalline Darunavir |
| EP2804869B1 (en) | 2012-01-18 | 2019-06-12 | Aurobindo Pharma Limited | Novel solvates of darunavir |
| CN103509031B (zh) * | 2012-06-20 | 2016-04-27 | 上海迪赛诺药业有限公司 | 制备达芦那韦无定形物的方法 |
| EP2877474B1 (en) * | 2012-07-24 | 2020-11-04 | Laurus Labs Limited | A process for preparation of darunavir |
| AU2013340559B2 (en) | 2012-10-29 | 2018-03-15 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
| US9346820B2 (en) * | 2013-09-11 | 2016-05-24 | Purdue Research Foundation | HIV-1 protease inhibitors having gem-di-fluoro bicyclic P2-ligands |
| WO2016092527A1 (en) * | 2014-12-12 | 2016-06-16 | Sun Pharmaceutical Industries Limited | A process for the preparation of dolutegravir |
| WO2016092525A1 (en) | 2014-12-12 | 2016-06-16 | Lupin Limited | Darunavir n-propanol solvate and process for preparation thereof |
| EP3271347B1 (en) * | 2015-03-19 | 2022-06-22 | Mycovia Pharmaceuticals, Inc. | Antifungal compounds and processes for making |
| BR112019002132A2 (pt) | 2016-08-08 | 2019-05-14 | Hetero Labs Limited | composições anti-retrovirais |
| BR112019002120A2 (pt) | 2016-08-08 | 2019-05-14 | Hetero Labs Limited | composição anti-retroviral de várias classes |
| ES2881949T3 (es) | 2016-10-27 | 2021-11-30 | Gilead Sciences Inc | Forma cristalina de base libre de darunavir |
| CN108727401A (zh) * | 2017-04-20 | 2018-11-02 | 盐城迪赛诺制药有限公司 | 达鲁那韦新晶型及其制备方法和应用 |
| CN109053753A (zh) * | 2018-08-05 | 2018-12-21 | 浙江大学 | 一种制备达卢那韦二水合物晶型的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413999A (en) * | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| JPH05230044A (ja) | 1992-02-21 | 1993-09-07 | Hoechst Japan Ltd | ピレタニドの新規な結晶多形 |
| US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| EP0715618B1 (en) | 1993-08-24 | 1998-12-16 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
| DK0812320T3 (da) * | 1995-02-22 | 2003-04-14 | Aventis Pharma Ltd | Amorft piretanid, polymorfe former deraf, fremgangsmåde til fremstilling deraf og deres anvendelse |
| ZA984514B (en) * | 1997-05-29 | 1998-11-30 | Merck & Co Inc | Hiv protease inhibitor |
| GB9712253D0 (en) | 1997-06-13 | 1997-08-13 | Glaxo Group Ltd | Antiviral compound |
| US6287693B1 (en) * | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
| GB9805898D0 (en) * | 1998-03-20 | 1998-05-13 | Glaxo Group Ltd | Process for the sythesis of hiv protease inhibitors |
| GB9807354D0 (en) | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
| WO1999067254A2 (en) * | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| EP2336134B1 (en) * | 1998-06-23 | 2016-08-31 | The United States of America, represented by the Secretary, Department of Health and Human Services | Fitness assay and methods for reducing resistance of HIV to therapy |
| HRP990358A2 (en) | 1998-11-19 | 2000-08-31 | Du Pont Pharm Co | Crystalline (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-3,4-dihydro-2(1h)-quinazolinone |
| WO2000047551A2 (en) | 1999-02-12 | 2000-08-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of aspartyl protease |
| PT2767539T (pt) | 2002-05-16 | 2017-08-28 | Janssen Sciences Ireland Uc | Formas pseudopolimórficas de um inibidor de protease de hiv |
| JP2013516397A (ja) * | 2010-01-05 | 2013-05-13 | シプラ・リミテッド | ダルナビルの多形及びその製造方法 |
-
2003
- 2003-05-16 PT PT141686865T patent/PT2767539T/pt unknown
- 2003-05-16 SI SI200332389T patent/SI1567529T2/sl unknown
- 2003-05-16 EA EA200401503A patent/EA007120B8/ru unknown
- 2003-05-16 ES ES14168686.5T patent/ES2638412T3/es not_active Expired - Lifetime
- 2003-05-16 DK DK03753571.3T patent/DK1567529T4/da active
- 2003-05-16 EP EP03753571.3A patent/EP1567529B2/en not_active Expired - Lifetime
- 2003-05-16 JP JP2004513292A patent/JP4864320B2/ja not_active Expired - Lifetime
- 2003-05-16 PT PT37535713T patent/PT1567529E/pt unknown
- 2003-05-16 WO PCT/EP2003/050176 patent/WO2003106461A2/en active Application Filing
- 2003-05-16 KR KR1020047018426A patent/KR101128370B1/ko active IP Right Grant
- 2003-05-16 EP EP10180831.9A patent/EP2314591B2/en not_active Expired - Lifetime
- 2003-05-16 AP AP2004003191A patent/AP2052A/xx active
- 2003-05-16 MX MXPA04011427A patent/MXPA04011427A/es active IP Right Grant
- 2003-05-16 ES ES16158480T patent/ES2728735T3/es not_active Expired - Lifetime
- 2003-05-16 DK DK14168686.5T patent/DK2767539T3/da active
- 2003-05-16 PT PT101808319T patent/PT2314591E/pt unknown
- 2003-05-16 US US10/514,352 patent/US7700645B2/en active Active
- 2003-05-16 SI SI200332383T patent/SI2314591T2/sl unknown
- 2003-05-16 NZ NZ536497A patent/NZ536497A/en not_active IP Right Cessation
- 2003-05-16 ES ES03753571T patent/ES2498370T5/es not_active Expired - Lifetime
- 2003-05-16 HU HUE14168686A patent/HUE034389T2/en unknown
- 2003-05-16 ES ES10180831T patent/ES2503551T5/es not_active Expired - Lifetime
- 2003-05-16 AU AU2003271740A patent/AU2003271740B2/en not_active Revoked
- 2003-05-16 DK DK10180831.9T patent/DK2314591T4/da active
- 2003-05-16 SI SI200332545T patent/SI2767539T1/sl unknown
- 2003-05-16 BR BRPI0311176A patent/BRPI0311176B8/pt active IP Right Grant
- 2003-05-16 EP EP16158480.0A patent/EP3045460B1/en not_active Expired - Lifetime
- 2003-05-16 CA CA002485834A patent/CA2485834C/en not_active Expired - Lifetime
- 2003-05-16 KR KR1020107024106A patent/KR20100119906A/ko not_active Application Discontinuation
- 2003-05-16 EP EP14168686.5A patent/EP2767539B1/en not_active Expired - Lifetime
- 2003-05-16 CN CNB038164590A patent/CN100475819C/zh not_active Expired - Lifetime
- 2003-05-16 PL PL374321A patent/PL215151B1/pl unknown
- 2003-05-16 LT LTEP14168686.5T patent/LT2767539T/lt unknown
-
2004
- 2004-11-10 IL IL16514004A patent/IL165140A0/xx unknown
- 2004-11-12 HR HRP20041061AA patent/HRP20041061B1/hr not_active IP Right Cessation
- 2004-12-10 NO NO20045409A patent/NO331477B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10154A patent/ZA200410154B/en unknown
-
2006
- 2006-02-23 HK HK06102443.3A patent/HK1081969A1/xx not_active IP Right Cessation
-
2009
- 2009-08-06 US US12/536,807 patent/US8518987B2/en not_active Expired - Lifetime
-
2012
- 2012-07-03 AU AU2012205289A patent/AU2012205289A1/en active Pending
-
2013
- 2013-07-11 US US13/939,494 patent/US20130303790A1/en not_active Abandoned
-
2014
- 2014-02-19 US US14/183,712 patent/US20140171499A1/en not_active Abandoned
- 2014-09-17 CY CY20141100755T patent/CY1115665T1/el unknown
- 2014-09-17 CY CY20141100756T patent/CY1117928T1/el unknown
-
2015
- 2015-08-04 US US14/817,827 patent/US20150336980A1/en not_active Abandoned
-
2017
- 2017-05-22 US US15/600,932 patent/US10000504B2/en not_active Expired - Lifetime
- 2017-08-23 CY CY20171100896T patent/CY1119311T1/el unknown
-
2018
- 2018-05-16 US US15/980,993 patent/US10858369B2/en not_active Expired - Lifetime
-
2020
- 2020-10-30 US US17/085,096 patent/US20210179631A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CHRG | Changes in the register |
Free format text: ADDITION OF INVENTOR: WIGERINCK, PIET BERT PAUL |
|
| PE | Patent expired |
Effective date: 20230511 |