HK1074217A1 - Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase - Google Patents
Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenaseInfo
- Publication number
- HK1074217A1 HK1074217A1 HK05106631A HK05106631A HK1074217A1 HK 1074217 A1 HK1074217 A1 HK 1074217A1 HK 05106631 A HK05106631 A HK 05106631A HK 05106631 A HK05106631 A HK 05106631A HK 1074217 A1 HK1074217 A1 HK 1074217A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- variants
- gdh
- pyrroloquinoline quinone
- dependent glucose
- glucose dehydrogenase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00123512 | 2000-10-27 | ||
EP00127294 | 2000-12-19 | ||
PCT/EP2001/012148 WO2002034919A1 (fr) | 2000-10-27 | 2001-10-20 | Variantes de glucose deshydrogenase soluble, dependante de la pyrroloquinoline quinone |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1074217A1 true HK1074217A1 (en) | 2005-11-04 |
Family
ID=26071553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05106631A HK1074217A1 (en) | 2000-10-27 | 2005-08-02 | Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
Country Status (12)
Country | Link |
---|---|
US (3) | US20030104595A1 (fr) |
EP (1) | EP1332216B1 (fr) |
JP (2) | JP3845618B2 (fr) |
KR (1) | KR100519902B1 (fr) |
CN (1) | CN1288246C (fr) |
AT (1) | ATE520777T1 (fr) |
AU (2) | AU1596602A (fr) |
BR (1) | BRPI0114962B8 (fr) |
CA (1) | CA2427029C (fr) |
HK (1) | HK1074217A1 (fr) |
PL (1) | PL205561B1 (fr) |
WO (1) | WO2002034919A1 (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001059080A1 (fr) | 2000-02-11 | 2001-08-16 | Millennium Pharmaceuticals, Inc. | Proteine kinase 18477 et utilisations de celle-ci |
CN1288246C (zh) * | 2000-10-27 | 2006-12-06 | 霍夫曼-拉罗奇有限公司 | 可溶性吡咯并喹啉醌依赖性葡萄糖脱氢酶变异体 |
JP2003093071A (ja) * | 2001-09-26 | 2003-04-02 | Koji Hayade | グルコース脱水素酵素 |
US6855556B2 (en) * | 2002-01-04 | 2005-02-15 | Becton, Dickinson And Company | Binding protein as biosensors |
EP1367120A3 (fr) * | 2002-05-27 | 2004-06-02 | Toyo Boseki Kabushiki Kaisha | Glucose Déshydrogénase dependante de la Pyrroloquinoline Quinone avec une specifité de substrat et une stabilité supérieures |
EP1544292B1 (fr) * | 2002-07-04 | 2008-09-17 | Ultizyme International Ltd. | Glucose deshydrogenase |
WO2004029235A2 (fr) * | 2002-09-27 | 2004-04-08 | Dsm Ip Assets B.V. | Gene de l'aldehyde deshydrogenase |
EP1584675B1 (fr) | 2002-12-24 | 2010-02-24 | Ikeda Food Research Co. Ltd. | Glucose dehydrogenase de liaison coenzymatique |
JP4415282B2 (ja) * | 2003-03-24 | 2010-02-17 | 東洋紡績株式会社 | 基質特異性または安定性に優れたピロロキノリンキノン(pqq)依存性グルコースデヒドロゲナーゼ改変体 |
DE10320259A1 (de) * | 2003-05-07 | 2004-11-25 | Bayer Technology Services Gmbh | Neuartige Glukose Dehydrogenase und ihre Herstellung |
JP2005328793A (ja) * | 2004-05-21 | 2005-12-02 | Toyobo Co Ltd | 基質特異性に優れたピロロキノリンキノン(pqq)依存性グルコースデヒドロゲナーゼ改変体 |
EP1666586B1 (fr) * | 2003-09-08 | 2009-10-21 | Toyo Boseki Kabushiki Kaisha | Forme modifiée de la glucose déshydrogénase (gdh) pyrroloquinoline quinone (pqq) présentant une excellente spécificité de substrat |
EP1600503A1 (fr) * | 2004-05-14 | 2005-11-30 | Amano Enzyme Inc. | Glucose Déshydrogénase dépendante de la Pyrroloquinoline Quinone |
US7037698B2 (en) | 2004-05-19 | 2006-05-02 | Amano Enzyme Inc. | Pyrroloquinoline quinone-dependent glucose dehydrogenase |
US20060003400A1 (en) * | 2004-06-30 | 2006-01-05 | Byrd Patricia A | Methods and compositions for characterizing a redox reagent system enzyme |
AU2005263591B2 (en) * | 2004-07-20 | 2008-08-14 | F. Hoffmann-La Roche Ag | Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an amino acid insertion |
US7781196B2 (en) | 2004-10-15 | 2010-08-24 | Roche Diagnostics Operations, Inc. | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase |
US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
WO2006085509A1 (fr) * | 2005-02-08 | 2006-08-17 | Toyo Boseki Kabushiki Kaisha | Glucose deshydrogenase modifie dependant de la pyrroloquinolinequinone presentant une excellente specificite a l'egard du substrat |
JP5020070B2 (ja) | 2005-03-25 | 2012-09-05 | 池田食研株式会社 | 補酵素結合型グルコース脱水素酵素をコードするポリヌクレオチド |
WO2006109578A1 (fr) * | 2005-04-05 | 2006-10-19 | Amano Enzyme Inc. | Glucose déshydrogénase pyrroloquinoline-quinone-dépendante altérée et méthode d'amélioration de la spécificité vis-à-vis du substrat de la glucose déshydrogénase pyrroloquinoline-quinone-dépendante altérée |
WO2006137283A1 (fr) | 2005-06-20 | 2006-12-28 | Arkray, Inc. | Glucose déshydrogénase mutante |
JP2007043984A (ja) * | 2005-08-11 | 2007-02-22 | Toyobo Co Ltd | ピロロキノリンキノン依存性グルコース脱水素酵素の基質特異性を向上する方法 |
TW200706650A (en) * | 2005-08-11 | 2007-02-16 | Toyo Boseki | A substrate specificity improved composition for glucose measurement |
US7955484B2 (en) | 2005-12-14 | 2011-06-07 | Nova Biomedical Corporation | Glucose biosensor and method |
PL3246402T3 (pl) * | 2006-04-13 | 2020-10-19 | F. Hoffmann-La Roche Ag | Ulepszone mutanty rozpuszczalnej dehydrogenazy glukozowej zależnej od pirolochinolinochinonu |
KR100973992B1 (ko) * | 2006-05-25 | 2010-08-05 | 삼성전자주식회사 | 시분할 복신 무선통신시스템의 시분할 복신 스위치 |
WO2008001903A1 (fr) | 2006-06-29 | 2008-01-03 | Ikeda Food Research Co., Ltd. | Gène de la glucose-déshydrogénase conjuguée au fad |
US8619038B2 (en) * | 2007-09-04 | 2013-12-31 | Apple Inc. | Editing interface |
DE102008030435A1 (de) * | 2008-06-26 | 2010-01-07 | Bayer Technology Services Gmbh | Neuartige Varianten PQQ-abhängiger Glukosehydrogenase mit verbesserter Substratspezifität |
FR2948680B1 (fr) | 2009-07-28 | 2013-10-04 | Centre Nat Rech Scient | Nouveaux mutants de la pqq s-gdh |
ES2568464T3 (es) * | 2010-07-23 | 2016-04-29 | F. Hoffmann-La Roche Ag | Composiciones que contienen tampón zwiteriónico y usos en dispositivos y métodos electroanalíticos |
EP2465936A1 (fr) | 2010-12-20 | 2012-06-20 | LEK Pharmaceuticals d.d. | Synthèse enzymatique de statines et intermédiaires associés |
AU2011355209B2 (en) | 2010-12-20 | 2015-09-17 | Lek Pharmaceuticals D.D. | Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof |
EP3901624B1 (fr) | 2010-12-22 | 2024-01-31 | Roche Diabetes Care GmbH | Procédés pour compenser des sources d'erreur pendant un essai électrochimique |
CN102559624B (zh) * | 2012-03-05 | 2013-10-16 | 浙江德清汇宁生物科技有限公司 | 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法 |
EP2636750A1 (fr) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Ectoïne en soluté compatible ainsi que ses dérivés pour la stabilisation d'enzymes |
WO2014180939A1 (fr) | 2013-05-08 | 2014-11-13 | Roche Diagnostics Gmbh | Stabilisation d'enzymes à l'aide d'acide nicotinique |
EP3074524B1 (fr) | 2013-11-27 | 2019-11-06 | Roche Diabetes Care GmbH | Composition comprenant des phosphores de conversion ascendante pour détecter un analyte |
EP2927319A1 (fr) | 2014-03-31 | 2015-10-07 | Roche Diagnostics GmbH | Immobilisation d'enzyme à charge élevée par réticulation |
EP3131882B1 (fr) | 2014-04-14 | 2020-07-15 | Roche Diagnostics GmbH | Médiateurs de phénazinium |
CN111848578B (zh) | 2014-08-22 | 2023-10-31 | 豪夫迈·罗氏有限公司 | 氧化还原指示剂 |
CN105331591B (zh) | 2015-10-29 | 2020-02-28 | 英科隆生物技术(杭州)有限公司 | PQQ-sGDH突变体、聚核苷酸及葡萄糖检测装置 |
CN109804240A (zh) | 2016-10-05 | 2019-05-24 | 豪夫迈·罗氏有限公司 | 用于多分析物诊断测试元件的检测试剂和电极布置以及其使用方法 |
CN113234697B (zh) * | 2021-04-28 | 2022-09-02 | 遵义医科大学珠海校区 | 一种葡萄糖脱氢酶变体及其制备方法与应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6190906B1 (en) | 1987-05-20 | 2001-02-20 | Roche Diagnostics Gmbh | Expression vector for the regulatable expression of foreign genes in prokaryotes |
DE3716957A1 (de) | 1987-05-20 | 1988-12-01 | Boehringer Mannheim Gmbh | Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten |
FI905324A (fi) | 1990-10-29 | 1992-04-30 | Valtion Teknillinen | Enzymatiskt bestaemningsfoerfarande foer aldoser. |
DE4311464A1 (de) | 1993-04-08 | 1994-10-13 | Boehringer Mannheim Gmbh | Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase |
DE19639169A1 (de) * | 1996-09-24 | 1998-04-02 | Boehringer Mannheim Gmbh | Redoxaktive Verbindungen und deren Anwendung |
JPH10243786A (ja) * | 1997-03-03 | 1998-09-14 | Koji Hayade | 改変型グルコース脱水素酵素 |
CZ291059B6 (cs) * | 1997-03-12 | 2002-12-11 | Lonza Ag | Způsob výroby esterů 2,6-pyridindikarboxylových kyselin |
US5997817A (en) * | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
JP2000350588A (ja) | 1999-04-08 | 2000-12-19 | Koji Hayade | グルコース脱水素酵素 |
TWI224136B (en) * | 1999-04-30 | 2004-11-21 | Koji Sode | Glucose dehydrogenase |
CN1288246C (zh) * | 2000-10-27 | 2006-12-06 | 霍夫曼-拉罗奇有限公司 | 可溶性吡咯并喹啉醌依赖性葡萄糖脱氢酶变异体 |
JP2003093071A (ja) | 2001-09-26 | 2003-04-02 | Koji Hayade | グルコース脱水素酵素 |
-
2001
- 2001-10-20 CN CNB018212158A patent/CN1288246C/zh not_active Expired - Lifetime
- 2001-10-20 AU AU1596602A patent/AU1596602A/xx active Pending
- 2001-10-20 KR KR10-2003-7005783A patent/KR100519902B1/ko active IP Right Grant
- 2001-10-20 PL PL362548A patent/PL205561B1/pl unknown
- 2001-10-20 AT AT01988775T patent/ATE520777T1/de not_active IP Right Cessation
- 2001-10-20 BR BRPI0114962A patent/BRPI0114962B8/pt not_active IP Right Cessation
- 2001-10-20 JP JP2002537889A patent/JP3845618B2/ja not_active Expired - Lifetime
- 2001-10-20 WO PCT/EP2001/012148 patent/WO2002034919A1/fr active IP Right Grant
- 2001-10-20 EP EP01988775A patent/EP1332216B1/fr not_active Expired - Lifetime
- 2001-10-20 AU AU2002215966A patent/AU2002215966B2/en not_active Expired
- 2001-10-20 CA CA002427029A patent/CA2427029C/fr not_active Expired - Lifetime
- 2001-10-29 US US10/082,627 patent/US20030104595A1/en not_active Abandoned
-
2002
- 2002-12-13 US US10/319,147 patent/US7132270B2/en not_active Expired - Lifetime
-
2005
- 2005-08-02 HK HK05106631A patent/HK1074217A1/xx not_active IP Right Cessation
- 2005-12-09 US US11/298,778 patent/US7547535B2/en not_active Expired - Fee Related
-
2006
- 2006-06-05 JP JP2006156710A patent/JP3889434B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2004512047A (ja) | 2004-04-22 |
US20030104595A1 (en) | 2003-06-05 |
US20040005683A1 (en) | 2004-01-08 |
PL362548A1 (en) | 2004-11-02 |
KR20030048447A (ko) | 2003-06-19 |
CA2427029A1 (fr) | 2002-05-02 |
BRPI0114962B8 (pt) | 2021-07-27 |
CN1288246C (zh) | 2006-12-06 |
EP1332216B1 (fr) | 2011-08-17 |
EP1332216A1 (fr) | 2003-08-06 |
WO2002034919A1 (fr) | 2002-05-02 |
ATE520777T1 (de) | 2011-09-15 |
CN1578836A (zh) | 2005-02-09 |
JP2006314322A (ja) | 2006-11-24 |
US7547535B2 (en) | 2009-06-16 |
BR0114962A (pt) | 2003-10-28 |
AU1596602A (en) | 2002-05-06 |
AU2002215966B2 (en) | 2006-05-04 |
JP3889434B2 (ja) | 2007-03-07 |
PL205561B1 (pl) | 2010-05-31 |
CA2427029C (fr) | 2010-02-02 |
US7132270B2 (en) | 2006-11-07 |
US20060148056A1 (en) | 2006-07-06 |
KR100519902B1 (ko) | 2005-10-10 |
BRPI0114962B1 (pt) | 2016-07-12 |
JP3845618B2 (ja) | 2006-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20211019 |