HK1054038B - 具有抗肿瘤活性的取代n-苄基吲哚-3-基乙醛酸衍生物 - Google Patents

具有抗肿瘤活性的取代n-苄基吲哚-3-基乙醛酸衍生物 Download PDF

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Publication number
HK1054038B
HK1054038B HK03106408.0A HK03106408A HK1054038B HK 1054038 B HK1054038 B HK 1054038B HK 03106408 A HK03106408 A HK 03106408A HK 1054038 B HK1054038 B HK 1054038B
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HK
Hong Kong
Prior art keywords
acid
cooh
substituted
alkyl
mono
Prior art date
Application number
HK03106408.0A
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English (en)
Chinese (zh)
Other versions
HK1054038A1 (en
Inventor
E‧甘瑟尔
E‧甘瑟爾
P‧艾米格
D‧雷彻特
G‧里鲍特
B‧尼科尔
D‧雷徹特
G‧巴施尔
G‧裡鮑特
B‧尼科爾
G‧巴施爾
Original Assignee
赞塔里斯有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 赞塔里斯有限公司 filed Critical 赞塔里斯有限公司
Publication of HK1054038A1 publication Critical patent/HK1054038A1/xx
Publication of HK1054038B publication Critical patent/HK1054038B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
HK03106408.0A 1999-12-23 2000-12-19 具有抗肿瘤活性的取代n-苄基吲哚-3-基乙醛酸衍生物 HK1054038B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
DE19962300.7 1999-12-23
PCT/EP2000/012947 WO2001047913A2 (de) 1999-12-23 2000-12-19 Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung

Publications (2)

Publication Number Publication Date
HK1054038A1 HK1054038A1 (en) 2003-11-14
HK1054038B true HK1054038B (zh) 2007-04-13

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03106408.0A HK1054038B (zh) 1999-12-23 2000-12-19 具有抗肿瘤活性的取代n-苄基吲哚-3-基乙醛酸衍生物

Country Status (31)

Country Link
US (1) US6432987B2 (https=)
EP (1) EP1240157B1 (https=)
JP (1) JP2003519137A (https=)
KR (1) KR100747425B1 (https=)
CN (1) CN1283637C (https=)
AR (1) AR027098A1 (https=)
AT (1) ATE259364T1 (https=)
AU (1) AU772745B2 (https=)
BG (1) BG106924A (https=)
BR (1) BR0016712A (https=)
CA (1) CA2395259A1 (https=)
CO (1) CO5251472A1 (https=)
CZ (1) CZ20022094A3 (https=)
DE (2) DE19962300A1 (https=)
DK (1) DK1240157T3 (https=)
ES (1) ES2215768T3 (https=)
HK (1) HK1054038B (https=)
HU (1) HUP0203716A3 (https=)
IL (1) IL150235A0 (https=)
MX (1) MXPA02006229A (https=)
NO (1) NO324750B1 (https=)
NZ (2) NZ519977A (https=)
PL (1) PL195014B1 (https=)
PT (1) PT1240157E (https=)
RU (1) RU2266280C2 (https=)
SK (1) SK8752002A3 (https=)
TR (1) TR200400601T4 (https=)
TW (1) TWI284128B (https=)
UA (1) UA75060C2 (https=)
WO (1) WO2001047913A2 (https=)
ZA (1) ZA200204896B (https=)

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DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
EP1641777A1 (de) * 2003-06-05 2006-04-05 Zentaris GmbH Indolderivate mit apoptose induzierender wirkung
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
WO2005023761A2 (en) 2003-09-11 2005-03-17 Kemia, Inc. Cytokine inhibitors
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
CA2605214C (en) 2004-12-31 2016-07-12 Reddy Us Therapeutics, Inc. Benzylamine derivatives as cetp inhibitors
EP2363128B1 (en) * 2005-03-11 2016-02-17 Vertex Pharmaceuticals Incorporated Indole modulators of ATP-binding cassette transporters
SG176477A1 (en) * 2006-08-07 2011-12-29 Ironwood Pharmaceuticals Inc Indole compounds
CA2670778A1 (en) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
SG175390A1 (en) 2009-04-29 2011-12-29 Amarin Corp Plc Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
EP2744803A2 (en) 2011-08-18 2014-06-25 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors
MX352074B (es) 2011-09-27 2017-11-08 Dr Reddys Laboratories Ltd Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis.

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GB1028812A (en) * 1962-08-28 1966-05-11 Ici Ltd Indole derivatives
EP0639567A1 (en) * 1992-05-08 1995-02-22 Otsuka Pharmaceutical Factory, Inc. Indole derivative
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
NZ281431A (en) * 1994-02-22 1997-09-22 Merrell Pharma Inc Alkylamide-substituted indole derivatives
PL180523B1 (pl) * 1994-04-01 2001-02-28 Eli Lilly & Co Nowy zwiazek, pochodna 1H-indolo-3-glioksylamidu i srodek farmaceutyczny PL PL PL PL PL PL PL PL PL PL
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
AU6229298A (en) * 1997-02-20 1998-09-09 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives
US5972988A (en) * 1997-03-26 1999-10-26 Eli Lilly And Company Method for treatment of chronic bronchitis using indole compounds
WO1998047507A1 (en) * 1997-04-24 1998-10-29 Shionogi & Co., Ltd. Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds
TW455581B (en) * 1997-06-26 2001-09-21 Lilly Co Eli Process for preparing 4-substituted-1H-indole-3-glyoxamides
JP2001513555A (ja) * 1997-08-28 2001-09-04 イーライ・リリー・アンド・カンパニー 非リウマチ様関節炎の処置方法
AU9664198A (en) * 1997-09-26 1999-04-23 Eli Lilly And Company Method for the treatment of cystic fibrosis
CA2309135A1 (en) * 1997-10-27 1999-05-06 Michael Lyle Denney N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors
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WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
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SK12752000A3 (sk) * 1998-02-25 2001-03-12 Genetics Institute, Inc. Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DZ2770A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
PL198983B1 (pl) * 1998-04-28 2008-08-29 Elbion Ag Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 oraz sposoby ich wytwarzania
CA2330856A1 (en) * 1998-05-01 1999-11-11 Eli Lilly And Company Spla2 inhibitor compounds for treatment of disease
PL344571A1 (en) * 1998-05-01 2001-11-05 Lilly Co Eli Spla2
WO2000067802A1 (en) * 1999-05-10 2000-11-16 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action

Also Published As

Publication number Publication date
WO2001047913A2 (de) 2001-07-05
ATE259364T1 (de) 2004-02-15
PL355684A1 (en) 2004-05-17
HUP0203716A3 (en) 2004-05-28
CN1283637C (zh) 2006-11-08
ZA200204896B (en) 2002-12-20
HK1054038A1 (en) 2003-11-14
NO324750B1 (no) 2007-12-03
HUP0203716A2 (hu) 2003-03-28
DE50005284D1 (de) 2004-03-18
DK1240157T3 (da) 2004-06-14
ES2215768T3 (es) 2004-10-16
CO5251472A1 (es) 2003-02-28
EP1240157B1 (de) 2004-02-11
EP1240157A2 (de) 2002-09-18
DE19962300A1 (de) 2001-06-28
KR100747425B1 (ko) 2007-08-09
NO20023039L (no) 2002-08-09
CA2395259A1 (en) 2001-07-05
NZ519977A (en) 2004-08-27
PL195014B1 (pl) 2007-07-31
CN1420880A (zh) 2003-05-28
CZ20022094A3 (cs) 2002-10-16
NZ533731A (en) 2005-03-24
TR200400601T4 (tr) 2004-04-21
AR027098A1 (es) 2003-03-12
UA75060C2 (en) 2006-03-15
WO2001047913A3 (de) 2002-04-25
AU2011901A (en) 2001-07-09
IL150235A0 (en) 2002-12-01
US20010014690A1 (en) 2001-08-16
JP2003519137A (ja) 2003-06-17
RU2002120462A (ru) 2004-01-10
NO20023039D0 (no) 2002-06-21
KR20020063245A (ko) 2002-08-01
RU2266280C2 (ru) 2005-12-20
BG106924A (bg) 2003-04-30
MXPA02006229A (es) 2003-01-28
SK8752002A3 (en) 2003-01-09
TWI284128B (en) 2007-07-21
AU772745B2 (en) 2004-05-06
PT1240157E (pt) 2004-06-30
US6432987B2 (en) 2002-08-13
BR0016712A (pt) 2002-09-03

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20101219