HK1052501A1 - Preparation of dibenzo [b,f]azepine intermediates - Google Patents

Preparation of dibenzo [b,f]azepine intermediates

Info

Publication number
HK1052501A1
HK1052501A1 HK03103369.4A HK03103369A HK1052501A1 HK 1052501 A1 HK1052501 A1 HK 1052501A1 HK 03103369 A HK03103369 A HK 03103369A HK 1052501 A1 HK1052501 A1 HK 1052501A1
Authority
HK
Hong Kong
Prior art keywords
dibenzo
preparation
azepine
intermediates
azepine intermediates
Prior art date
Application number
HK03103369.4A
Other languages
English (en)
Inventor
Peter Fuenfschilling
Daniel Kaufmann
Olivier Lohse
Ulrich Beutler
Werner Zaugg
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9885081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1052501(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1052501A1 publication Critical patent/HK1052501A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK03103369.4A 2000-02-07 2003-05-13 Preparation of dibenzo [b,f]azepine intermediates HK1052501A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0002740.9A GB0002740D0 (en) 2000-02-07 2000-02-07 Organic compounds
PCT/EP2001/001330 WO2001056992A2 (en) 2000-02-07 2001-02-07 Dibenzo (b,f) azepine intermediates

Publications (1)

Publication Number Publication Date
HK1052501A1 true HK1052501A1 (en) 2003-09-19

Family

ID=9885081

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03103369.4A HK1052501A1 (en) 2000-02-07 2003-05-13 Preparation of dibenzo [b,f]azepine intermediates

Country Status (34)

Country Link
US (1) US7112673B2 (el)
EP (2) EP2067772B1 (el)
JP (1) JP4859322B2 (el)
KR (5) KR101216285B1 (el)
CN (2) CN100455572C (el)
AR (2) AR029442A1 (el)
AT (2) ATE427938T1 (el)
AU (1) AU767724B2 (el)
BR (1) BR0107922A (el)
CA (3) CA2639210C (el)
CO (1) CO5271705A1 (el)
CY (1) CY1111567T1 (el)
CZ (1) CZ301572B6 (el)
DE (2) DE60138271D1 (el)
DK (1) DK2067772T3 (el)
ES (2) ES2363490T3 (el)
GB (1) GB0002740D0 (el)
HK (1) HK1052501A1 (el)
HU (1) HU229420B1 (el)
IL (3) IL150613A0 (el)
MX (1) MXPA02007629A (el)
MY (1) MY136474A (el)
NO (1) NO324949B1 (el)
NZ (1) NZ520329A (el)
PE (1) PE20011078A1 (el)
PL (2) PL217225B1 (el)
PT (2) PT2067772E (el)
RU (1) RU2303591C2 (el)
SI (1) SI2067772T1 (el)
SK (1) SK287217B6 (el)
TR (1) TR200201655T2 (el)
TW (1) TWI284638B (el)
WO (1) WO2001056992A2 (el)
ZA (1) ZA200206219B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302464A1 (en) * 2001-10-09 2003-04-16 Max India Limited Process for preparation of 10-methoxycarbamazepine
US6670472B2 (en) 2001-10-09 2003-12-30 Max India Limited Process for the preparation of 10-methoxycarbamazepine
CA2486560A1 (en) * 2002-06-14 2003-12-24 Taro Pharmaceuticals U.S.A., Inc. Method of preparing a 5h-dibenz[b,f]azepine-5-carboxamide
ITMI20040452A1 (it) 2004-03-09 2004-06-09 Clariant Lsm Italia Spa Processo per la preparazione di oxcarbazepina
RS53599B1 (en) 2005-05-10 2015-02-27 Intermune, Inc. PIRIDON DERIVATIVES FOR STRESS MODULATION OF ACTIVATED PROTEIN KINASE SYSTEMS
MX2008013675A (es) * 2006-04-26 2009-03-06 Supernus Pharmaceuticals Inc Preparaciones de liberacion controlada de oxcarbacepina que tienen perfil de liberacion sigmoidal.
US20090082335A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched oxcarbazepine
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
WO2014049550A1 (en) 2012-09-26 2014-04-03 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
AU2014318748B2 (en) * 2013-09-11 2019-02-28 Duquesne University Of The Holy Ghost Novel anthranilic amides and the use thereof
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847374A (en) * 1987-01-27 1989-07-11 Ciba-Geigy Corporation Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
US6355680B1 (en) * 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
IT1283594B1 (it) * 1996-04-12 1998-04-22 Trifarma Srl Derivati della 5h-dibenz- (b,f)-azepin-5-carbossiammide, loro preparazione e uso come sostanze ad azione medicinale
ATE344791T1 (de) * 1997-07-01 2006-11-15 Warner Lambert Co 2-(4-brom or 4-iod phenylamino)benzoesäurederivate und ihre anwendung als mek-inhibitoren
US6048856A (en) * 1997-12-17 2000-04-11 Novo Nordisk A/S Heterocyclic compounds

Also Published As

Publication number Publication date
KR101216285B1 (ko) 2012-12-28
US20030032800A1 (en) 2003-02-13
CA2639210A1 (en) 2001-08-09
PL356404A1 (en) 2004-06-28
AU4237301A (en) 2001-08-14
CZ301572B6 (cs) 2010-04-21
EP1265868B1 (en) 2009-04-08
SK287217B6 (sk) 2010-03-08
CA2724295A1 (en) 2001-08-09
CA2639210C (en) 2011-05-03
ES2324900T3 (es) 2009-08-19
ZA200206219B (en) 2003-04-04
PT2067772E (pt) 2011-07-13
BR0107922A (pt) 2002-10-22
US7112673B2 (en) 2006-09-26
DE60138271D1 (de) 2009-05-20
KR20080003016A (ko) 2008-01-04
AU767724B2 (en) 2003-11-20
KR100931753B1 (ko) 2009-12-14
ATE427938T1 (de) 2009-04-15
PL217225B1 (pl) 2014-06-30
IL188183A (en) 2011-02-28
PL392476A1 (pl) 2010-11-22
HUP0300243A2 (hu) 2003-06-28
EP2067772A2 (en) 2009-06-10
HU229420B1 (en) 2013-12-30
GB0002740D0 (en) 2000-03-29
AR029442A1 (es) 2003-06-25
SI2067772T1 (sl) 2011-08-31
EP2067772B1 (en) 2011-04-13
RU2002123334A (ru) 2004-01-10
CO5271705A1 (es) 2003-04-30
ES2363490T3 (es) 2011-08-05
CY1111567T1 (el) 2015-10-07
WO2001056992A2 (en) 2001-08-09
RU2303591C2 (ru) 2007-07-27
HUP0300243A3 (en) 2005-07-28
SK11262002A3 (sk) 2003-02-04
NO20023575D0 (no) 2002-07-26
AR079237A2 (es) 2012-01-04
WO2001056992A3 (en) 2002-01-24
TWI284638B (en) 2007-08-01
CN1244563C (zh) 2006-03-08
CZ20022676A3 (cs) 2002-11-13
DE60144456D1 (de) 2011-05-26
PE20011078A1 (es) 2001-11-16
MXPA02007629A (es) 2002-12-13
KR20090102882A (ko) 2009-09-30
CN1394204A (zh) 2003-01-29
EP2067772A3 (en) 2009-08-19
NO324949B1 (no) 2008-01-14
EP1265868A2 (en) 2002-12-18
CA2395601C (en) 2010-01-05
JP4859322B2 (ja) 2012-01-25
KR20100018069A (ko) 2010-02-16
IL150613A (en) 2010-05-17
CA2724295C (en) 2011-07-26
TR200201655T2 (tr) 2002-11-21
KR20020071033A (ko) 2002-09-11
PT1265868E (pt) 2009-07-15
CN100455572C (zh) 2009-01-28
CA2395601A1 (en) 2001-08-09
KR20080103608A (ko) 2008-11-27
IL150613A0 (en) 2003-02-12
JP2003521536A (ja) 2003-07-15
MY136474A (en) 2008-10-31
CN1721409A (zh) 2006-01-18
KR100966209B1 (ko) 2010-06-25
PL214039B1 (pl) 2013-06-28
DK2067772T3 (da) 2011-07-18
NO20023575L (no) 2002-07-26
ATE505459T1 (de) 2011-04-15
NZ520329A (en) 2003-11-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190207