HK1045648B - Aplidine treatment of cancers - Google Patents

Aplidine treatment of cancers Download PDF

Info

Publication number
HK1045648B
HK1045648B HK02106981.6A HK02106981A HK1045648B HK 1045648 B HK1045648 B HK 1045648B HK 02106981 A HK02106981 A HK 02106981A HK 1045648 B HK1045648 B HK 1045648B
Authority
HK
Hong Kong
Prior art keywords
aplidine
dose
patients
infusion
mcg
Prior art date
Application number
HK02106981.6A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1045648A1 (en
Inventor
Glynn Thomas Faircloth
Chris Twelves
Luis Paz-Ares
Original Assignee
Pharma Mar, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9927006.8A external-priority patent/GB9927006D0/en
Priority claimed from GB0005701A external-priority patent/GB0005701D0/en
Priority claimed from GB0007639A external-priority patent/GB0007639D0/en
Priority claimed from GB0015496A external-priority patent/GB0015496D0/en
Priority claimed from GB0025209A external-priority patent/GB0025209D0/en
Application filed by Pharma Mar, S.A. filed Critical Pharma Mar, S.A.
Publication of HK1045648A1 publication Critical patent/HK1045648A1/en
Publication of HK1045648B publication Critical patent/HK1045648B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK02106981.6A 1999-11-15 2000-11-15 Aplidine treatment of cancers HK1045648B (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
GB9927006.8 1999-11-15
GBGB9927006.8A GB9927006D0 (en) 1999-11-15 1999-11-15 Aplidine treatment of cancers
GB0005701A GB0005701D0 (en) 2000-03-09 2000-03-09 Antitumor utility of aplidine
GB0005701.8 2000-03-09
GB0007639.8 2000-03-29
GB0007639A GB0007639D0 (en) 2000-03-29 2000-03-29 Antitumour and anti-angiogenic compound
GB0015496A GB0015496D0 (en) 2000-06-23 2000-06-23 Antitumour and anti-angiogenic compound
GB0015496.3 2000-06-23
GB0025209.8 2000-10-13
GB0025209A GB0025209D0 (en) 2000-10-13 2000-10-13 Treatment of cancers
PCT/GB2000/004349 WO2001035974A2 (en) 1999-11-15 2000-11-15 Aplidine treatment of cancers

Publications (2)

Publication Number Publication Date
HK1045648A1 HK1045648A1 (en) 2002-12-06
HK1045648B true HK1045648B (en) 2007-09-21

Family

ID=27515929

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106981.6A HK1045648B (en) 1999-11-15 2000-11-15 Aplidine treatment of cancers

Country Status (27)

Country Link
US (1) US20090298752A1 (enExample)
EP (1) EP1229922B1 (enExample)
JP (1) JP2003514025A (enExample)
KR (1) KR100518986B1 (enExample)
CN (1) CN1423564A (enExample)
AT (1) ATE363910T1 (enExample)
AU (1) AU780417B2 (enExample)
BG (1) BG65381B1 (enExample)
BR (1) BR0015811A (enExample)
CA (1) CA2391502A1 (enExample)
CY (1) CY1106825T1 (enExample)
CZ (1) CZ302498B6 (enExample)
DE (1) DE60035120T2 (enExample)
DK (1) DK1229922T3 (enExample)
ES (1) ES2288486T3 (enExample)
HK (1) HK1045648B (enExample)
HU (1) HUP0203906A2 (enExample)
IL (1) IL149488A0 (enExample)
MX (1) MXPA02004862A (enExample)
NO (1) NO330719B1 (enExample)
NZ (1) NZ518847A (enExample)
PL (1) PL200922B1 (enExample)
PT (1) PT1229922E (enExample)
RU (1) RU2261104C2 (enExample)
SI (1) SI1229922T1 (enExample)
SK (1) SK287762B6 (enExample)
WO (1) WO2001035974A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
NZ525196A (en) 2000-10-12 2004-09-24 Pharma Mar S Treatment of cancers by aplidine in conjunction with a myoprotector
KR20050038578A (ko) * 2001-10-19 2005-04-27 파르마 마르, 에스.에이. 항종양성 화합물의 암치료에 있어서의 향상된 용도
DE60229414D1 (de) * 2001-10-19 2008-11-27 Pharma Mar Sa Verwendung von aplidine in der behandlung von pankreaskrebs
KR20060002778A (ko) 2003-03-12 2006-01-09 파르마 마르, 에스.에이. 개선된 항종양 치료
DK1603584T3 (da) 2003-03-12 2009-01-05 Dana Farber Cancer Inst Inc Aplidine til behandling af multipelt myelom
DK2029155T3 (en) * 2006-02-28 2016-08-01 Pharma Mar Sa IMPROVED treatment of multiple myeloma
ATE479432T1 (de) * 2006-11-03 2010-09-15 Nerviano Medical Sciences Srl Verfahren zur verabreichung einer antitumoralen verbindung
RU2360712C1 (ru) * 2007-10-02 2009-07-10 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ лечения местно-распространенного неоперабельного рака прямой кишки
CA2703024A1 (en) * 2007-10-19 2009-04-23 Giuseppe Longo Sorbello Improved antitumoral treatments
MX2010009697A (es) * 2008-03-07 2010-09-30 Pharm Mar S A Tratamientos anticancerigenos mejorados.
CN103463020B (zh) * 2013-09-23 2015-11-25 李淑兰 Lycojaponicumin A在制备治疗肾癌药物中的应用
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

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US4950649A (en) * 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
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FR2698543B1 (fr) * 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
US5462726A (en) * 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
WO1995017901A1 (en) * 1993-12-29 1995-07-06 Matrix Pharmaceutical, Inc. Methods and compositions for the treatment of a host with a cellular proliferative disease
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
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EP0914116B1 (en) * 1996-05-22 2000-10-11 Protarga Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere
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US6156724A (en) * 1996-06-07 2000-12-05 Rinehart; Kenneth L. Uses of didemnins as immunomodulating agents
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UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
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DE60229414D1 (de) * 2001-10-19 2008-11-27 Pharma Mar Sa Verwendung von aplidine in der behandlung von pankreaskrebs
DK1603584T3 (da) * 2003-03-12 2009-01-05 Dana Farber Cancer Inst Inc Aplidine til behandling af multipelt myelom
KR20060002778A (ko) * 2003-03-12 2006-01-09 파르마 마르, 에스.에이. 개선된 항종양 치료
EP1613338A4 (en) * 2003-03-21 2009-06-24 Madeleine M Joullie TAMANDARIN ANALOGUES, FRAGMENTS THEREOF AND METHODS OF MAKING AND USING THE SAME
CA2528669A1 (en) * 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
DK2029155T3 (en) * 2006-02-28 2016-08-01 Pharma Mar Sa IMPROVED treatment of multiple myeloma
CA2703024A1 (en) * 2007-10-19 2009-04-23 Giuseppe Longo Sorbello Improved antitumoral treatments

Also Published As

Publication number Publication date
ATE363910T1 (de) 2007-06-15
AU1402301A (en) 2001-05-30
NZ518847A (en) 2004-02-27
RU2261104C2 (ru) 2005-09-27
DE60035120D1 (de) 2007-07-19
JP2003514025A (ja) 2003-04-15
BG106714A (en) 2003-02-28
EP1229922A2 (en) 2002-08-14
AU780417B2 (en) 2005-03-17
NO20022293D0 (no) 2002-05-14
PL355335A1 (en) 2004-04-19
RU2002115864A (ru) 2004-01-20
ES2288486T3 (es) 2008-01-16
EP1229922B1 (en) 2007-06-06
CY1106825T1 (el) 2012-05-23
WO2001035974A3 (en) 2001-11-01
DK1229922T3 (da) 2007-10-08
NO20022293L (no) 2002-07-05
KR20020064313A (ko) 2002-08-07
SI1229922T1 (sl) 2008-04-30
BR0015811A (pt) 2002-08-06
KR100518986B1 (ko) 2005-10-06
PL200922B1 (pl) 2009-02-27
MXPA02004862A (es) 2003-01-28
BG65381B1 (bg) 2008-05-30
HK1045648A1 (en) 2002-12-06
WO2001035974A2 (en) 2001-05-25
CN1423564A (zh) 2003-06-11
PT1229922E (pt) 2007-09-12
CZ20021697A3 (cs) 2003-02-12
SK6592002A3 (en) 2003-08-05
CZ302498B6 (cs) 2011-06-15
HUP0203906A2 (en) 2003-03-28
NO330719B1 (no) 2011-06-20
DE60035120T2 (de) 2008-01-31
SK287762B6 (sk) 2011-09-05
US20090298752A1 (en) 2009-12-03
IL149488A0 (en) 2002-11-10
CA2391502A1 (en) 2001-05-25

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20111115