HK1045521B - 大环内酯抗生素的新晶形 - Google Patents

大环内酯抗生素的新晶形 Download PDF

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Publication number
HK1045521B
HK1045521B HK02107017.2A HK02107017A HK1045521B HK 1045521 B HK1045521 B HK 1045521B HK 02107017 A HK02107017 A HK 02107017A HK 1045521 B HK1045521 B HK 1045521B
Authority
HK
Hong Kong
Prior art keywords
crystalline form
compound
formula
monohydrate
onset
Prior art date
Application number
HK02107017.2A
Other languages
English (en)
Chinese (zh)
Other versions
HK1045521A1 (en
Inventor
R‧J‧拉夫卡
D‧J‧M‧阿里恩
C‧B‧拉甘
D‧J‧M‧阿裡恩
B‧J‧默顿
B‧J‧默頓
Original Assignee
辉瑞产品公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 辉瑞产品公司 filed Critical 辉瑞产品公司
Publication of HK1045521A1 publication Critical patent/HK1045521A1/xx
Publication of HK1045521B publication Critical patent/HK1045521B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK02107017.2A 1999-05-18 2000-04-14 大环内酯抗生素的新晶形 HK1045521B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13464499P 1999-05-18 1999-05-18
US60/134,644 1999-05-18
PCT/IB2000/000463 WO2000069874A1 (en) 1999-05-18 2000-04-14 Novel crystalline forms of a macrolide antibiotic

Publications (2)

Publication Number Publication Date
HK1045521A1 HK1045521A1 (en) 2002-11-29
HK1045521B true HK1045521B (zh) 2005-12-09

Family

ID=22464300

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107017.2A HK1045521B (zh) 1999-05-18 2000-04-14 大环内酯抗生素的新晶形

Country Status (43)

Country Link
US (1) US6583274B1 (enExample)
EP (1) EP1189912B1 (enExample)
JP (1) JP3897983B2 (enExample)
KR (1) KR100474229B1 (enExample)
CN (1) CN1203084C (enExample)
AP (1) AP2001002325A0 (enExample)
AR (1) AR020030A1 (enExample)
AT (1) ATE392427T1 (enExample)
AU (1) AU772283B2 (enExample)
BG (1) BG106150A (enExample)
BR (1) BR0011300A (enExample)
CA (1) CA2372206C (enExample)
CZ (1) CZ20014120A3 (enExample)
DE (1) DE60038610T2 (enExample)
DK (1) DK1189912T3 (enExample)
DZ (1) DZ3043A1 (enExample)
EA (1) EA003417B1 (enExample)
ES (1) ES2302689T3 (enExample)
GT (1) GT200000072A (enExample)
HK (1) HK1045521B (enExample)
HN (1) HN2000000056A (enExample)
HR (1) HRP20010849A2 (enExample)
HU (1) HUP0201341A3 (enExample)
IL (2) IL145946A0 (enExample)
IS (1) IS6127A (enExample)
MA (1) MA26735A1 (enExample)
MX (1) MXPA01011914A (enExample)
MY (1) MY133397A (enExample)
NO (1) NO320195B1 (enExample)
NZ (1) NZ514765A (enExample)
OA (1) OA11876A (enExample)
PA (1) PA8495001A1 (enExample)
PE (1) PE20010151A1 (enExample)
PL (1) PL353316A1 (enExample)
PT (1) PT1189912E (enExample)
SK (1) SK16472001A3 (enExample)
TN (1) TNSN00103A1 (enExample)
TW (1) TWI225066B (enExample)
UA (1) UA67842C2 (enExample)
UY (1) UY26144A1 (enExample)
WO (1) WO2000069874A1 (enExample)
YU (1) YU76601A (enExample)
ZA (1) ZA200109420B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
BRPI0017013B8 (pt) * 2000-01-27 2022-11-16 Pfizer Prod Inc composição de antibiótico azalídeo e método para sua obtenção
BR0209241A (pt) * 2001-04-27 2004-06-15 Pfizer Prod Inc Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
EP1435359A1 (en) * 2002-12-31 2004-07-07 Alembic Limited A process for the purification of roxithromycin
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
EP2384333B1 (en) * 2009-01-30 2013-04-17 Glaxo Group Limited Anti-inflammatory macrolide
EP2402355A1 (en) * 2010-07-01 2012-01-04 Novartis AG Crystalline anhydrous forms II and III of Tulathromycin
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
CN106008622A (zh) * 2016-08-02 2016-10-12 海门慧聚药业有限公司 泰拉霉素新晶型及其制备
CN109942652B (zh) * 2017-12-21 2022-04-26 洛阳惠中兽药有限公司 一种莱柯霉素晶型ⅰ及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5844105A (en) * 1996-07-29 1998-12-01 Abbott Laboratories Preparation of crystal form II of clarithromycin
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.

Also Published As

Publication number Publication date
US6583274B1 (en) 2003-06-24
EA003417B1 (ru) 2003-04-24
AU772283B2 (en) 2004-04-22
AR020030A1 (es) 2002-03-27
HUP0201341A2 (en) 2002-08-28
ES2302689T3 (es) 2008-08-01
EA200100984A1 (ru) 2002-06-27
CA2372206C (en) 2006-01-10
YU76601A (sh) 2004-09-03
MY133397A (en) 2007-11-30
HUP0201341A3 (en) 2003-03-28
CN1203084C (zh) 2005-05-25
ATE392427T1 (de) 2008-05-15
PL353316A1 (en) 2003-11-17
KR100474229B1 (ko) 2005-03-08
KR20020007415A (ko) 2002-01-26
JP2002544283A (ja) 2002-12-24
EP1189912A1 (en) 2002-03-27
BG106150A (bg) 2002-05-31
ZA200109420B (en) 2002-11-15
UA67842C2 (uk) 2004-07-15
PT1189912E (pt) 2008-05-16
AP2001002325A0 (en) 2001-12-31
JP3897983B2 (ja) 2007-03-28
DE60038610D1 (de) 2008-05-29
MA26735A1 (fr) 2004-12-20
DZ3043A1 (fr) 2004-03-27
DE60038610T2 (de) 2009-06-25
PA8495001A1 (es) 2002-02-21
IS6127A (is) 2001-10-26
CN1351607A (zh) 2002-05-29
TWI225066B (en) 2004-12-11
WO2000069874A1 (en) 2000-11-23
GT200000072A (es) 2001-11-08
HRP20010849A2 (en) 2003-04-30
CA2372206A1 (en) 2000-11-23
DK1189912T3 (da) 2008-06-30
EP1189912B1 (en) 2008-04-16
UY26144A1 (es) 2000-12-29
CZ20014120A3 (cs) 2003-01-15
HK1045521A1 (en) 2002-11-29
NO20015598D0 (no) 2001-11-16
IL145946A (en) 2007-06-17
NO320195B1 (no) 2005-11-14
NO20015598L (no) 2002-01-08
IL145946A0 (en) 2002-07-25
AU3572900A (en) 2000-12-05
PE20010151A1 (es) 2001-02-08
NZ514765A (en) 2004-05-28
TNSN00103A1 (fr) 2005-11-10
OA11876A (en) 2006-03-27
SK16472001A3 (sk) 2003-02-04
HN2000000056A (es) 2001-02-02
MXPA01011914A (es) 2002-05-06
BR0011300A (pt) 2002-02-26

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090414