HK1029790A1 - Processes and intermediates for preparing anti-cancer compounds - Google Patents

Processes and intermediates for preparing anti-cancer compounds

Info

Publication number
HK1029790A1
HK1029790A1 HK01100595A HK01100595A HK1029790A1 HK 1029790 A1 HK1029790 A1 HK 1029790A1 HK 01100595 A HK01100595 A HK 01100595A HK 01100595 A HK01100595 A HK 01100595A HK 1029790 A1 HK1029790 A1 HK 1029790A1
Authority
HK
Hong Kong
Prior art keywords
intermediates
processes
preparing anti
cancer compounds
cancer
Prior art date
Application number
HK01100595A
Other languages
English (en)
Inventor
Richard Shelton Lehner
Timothy Norris
Dinos Paul Santafianos
Original Assignee
Pfizer Prod Inc
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Osi Pharm Inc filed Critical Pfizer Prod Inc
Publication of HK1029790A1 publication Critical patent/HK1029790A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0002—Preliminary treatment
    • C22B15/0004—Preliminary treatment without modification of the copper constituent
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0063—Hydrometallurgy
    • C22B15/0065—Leaching or slurrying
    • C22B15/0067—Leaching or slurrying with acids or salts thereof
    • C22B15/0071—Leaching or slurrying with acids or salts thereof containing sulfur
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK01100595A 1999-03-31 2001-01-27 Processes and intermediates for preparing anti-cancer compounds HK1029790A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12707299P 1999-03-31 1999-03-31

Publications (1)

Publication Number Publication Date
HK1029790A1 true HK1029790A1 (en) 2001-04-12

Family

ID=22428179

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01100595A HK1029790A1 (en) 1999-03-31 2001-01-27 Processes and intermediates for preparing anti-cancer compounds

Country Status (50)

Country Link
US (1) US6476040B1 (de)
EP (1) EP1044969B1 (de)
JP (2) JP3420549B2 (de)
KR (2) KR100430210B1 (de)
CN (2) CN1215061C (de)
AP (2) AP1655A (de)
AR (1) AR018705A1 (de)
AT (1) ATE348098T1 (de)
AU (2) AU781402B2 (de)
BG (1) BG65194B1 (de)
BR (1) BRPI0001486B8 (de)
CA (2) CA2427221C (de)
CO (1) CO5160273A1 (de)
CR (1) CR6165A (de)
CZ (1) CZ299426B6 (de)
DE (1) DE60032275T2 (de)
DK (1) DK1044969T3 (de)
DZ (1) DZ3030A1 (de)
EA (3) EA005892B1 (de)
EE (1) EE04589B1 (de)
EG (1) EG22506A (de)
ES (1) ES2278578T3 (de)
GE (1) GEP20022653B (de)
GT (1) GT200000037A (de)
HK (1) HK1029790A1 (de)
HR (1) HRP20000182B1 (de)
HU (1) HU227698B1 (de)
ID (1) ID25427A (de)
IL (2) IL168036A (de)
IS (1) IS2468B (de)
MA (1) MA25087A1 (de)
MY (1) MY136270A (de)
NO (2) NO321952B1 (de)
NZ (2) NZ503683A (de)
OA (1) OA11335A (de)
PA (1) PA8491901A1 (de)
PE (1) PE20001599A1 (de)
PL (1) PL339330A1 (de)
PT (1) PT1044969E (de)
RS (1) RS49836B (de)
SG (2) SG121687A1 (de)
SK (1) SK287339B6 (de)
SV (1) SV2002000047A (de)
TN (1) TNSN00064A1 (de)
TR (1) TR200000837A2 (de)
TW (1) TW553939B (de)
UA (2) UA70928C2 (de)
UY (1) UY26086A1 (de)
YU (1) YU13200A (de)
ZA (1) ZA200001586B (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
KR100600550B1 (ko) 2000-10-20 2006-07-13 에자이 가부시키가이샤 질소 함유 방향환 유도체
EP1408980A4 (de) 2001-06-21 2004-10-20 Ariad Pharma Inc Neue chinazoline und ihre verwendungszwecke
US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
EP1521747B1 (de) 2002-07-15 2018-09-05 Symphony Evolution, Inc. Modulatoren von rezeptor-typ-kinase und anwendungsverfahren
US7148231B2 (en) 2003-02-17 2006-12-12 Hoffmann-La Roche Inc. [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
JPWO2004080462A1 (ja) 2003-03-10 2006-06-08 エーザイ株式会社 ｃ−Ｋｉｔキナーゼ阻害剤
US7618975B2 (en) 2003-07-03 2009-11-17 Myriad Pharmaceuticals, Inc. 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
ATE395346T1 (de) 2003-09-16 2008-05-15 Astrazeneca Ab Chinazolinderivate als tyrosinkinaseinhibitoren
ATE517091T1 (de) 2003-09-26 2011-08-15 Exelixis Inc C-met-modulatoren und verwendungsverfahren
CN101337930B (zh) 2003-11-11 2010-09-08 卫材R&D管理有限公司 脲衍生物的制备方法
JP4205757B2 (ja) 2004-05-06 2009-01-07 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ４−フェニルアミノ−キナゾリン−６−イル−アミド
ATE428421T1 (de) 2004-09-17 2009-05-15 Eisai R&D Man Co Ltd Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US7625911B2 (en) * 2005-01-12 2009-12-01 Mai De Ltd. Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
KR20070108270A (ko) * 2005-02-28 2007-11-08 에자이 알앤드디 매니지먼트 가부시키가이샤 술폰아미드 화합물의 신규 병용
WO2007015569A1 (ja) * 2005-08-01 2007-02-08 Eisai R & D Management Co., Ltd. 血管新生阻害物質の効果を予測する方法
WO2007015578A1 (ja) 2005-08-02 2007-02-08 Eisai R & D Management Co., Ltd. 血管新生阻害物質の効果を検定する方法
WO2007052849A1 (ja) 2005-11-07 2007-05-10 Eisai R & D Management Co., Ltd. 血管新生阻害物質とc-kitキナーゼ阻害物質との併用
US20090247576A1 (en) * 2005-11-22 2009-10-01 Eisai R & D Management Co., Ltd. Anti-tumor agent for multiple myeloma
CN101443009A (zh) * 2006-05-18 2009-05-27 卫材R&D管理有限公司 针对甲状腺癌的抗肿瘤剂
US20090203693A1 (en) * 2006-06-29 2009-08-13 Eisai R & D Management Co., Ltd. Therapeutic agent for liver fibrosis
CA2659307A1 (en) 2006-07-28 2008-01-31 Synthon B.V. Crystalline erlotinib
KR101472600B1 (ko) 2006-08-28 2014-12-15 에자이 알앤드디 매니지먼트 가부시키가이샤 미분화형 위암에 대한 항종양제
US8372856B2 (en) 2006-10-27 2013-02-12 Synthon Bv Hydrates of erlotinib hydrochloride
AU2008205847A1 (en) 2007-01-19 2008-07-24 Eisai R & D Management Co., Ltd. Composition for treatment of pancreatic cancer
WO2008093855A1 (ja) 2007-01-29 2008-08-07 Eisai R & D Management Co., Ltd. 未分化型胃癌治療用組成物
WO2008102369A1 (en) * 2007-02-21 2008-08-28 Natco Pharma Limited Novel polymorphs of erlotinib hydrochloride and method of preparation
JP5524041B2 (ja) 2007-04-04 2014-06-18 シプラ・リミテッド エルロチニブおよびその薬学的に許容可能な塩の製造方法
WO2009002538A2 (en) * 2007-06-25 2008-12-31 Plus Chemicals S.A. Amorphous erlotinib, processes for the preparation thereof, and processes to prepare additional forms of erlotinib
WO2009007984A2 (en) 2007-07-11 2009-01-15 Hetero Drugs Limited An improved process for erlotinib hydrochloride
TW200927732A (en) * 2007-08-23 2009-07-01 Plus Chemicals S A Crystalline forms of erlotinib HCl and formulations thereof
US20090124642A1 (en) * 2007-08-23 2009-05-14 Augusto Canavesi Crystalline forms of Erlotinib HCI and formulations thereof
US20090076042A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched erlotinib
CA2704000C (en) 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
CA2713930A1 (en) * 2008-01-29 2009-08-06 Eisai R & D Management Co., Ltd. Combined use of angiogenesis inhibitor and taxane
WO2009121042A1 (en) * 2008-03-28 2009-10-01 Concert Pharmaceuticals, Inc. Quinazoline derivatives and methods of treatment
US20100004449A1 (en) * 2008-07-07 2010-01-07 Plus Chemicals Sa Crystalline forms of erlotinib base and erlotinib hcl
KR101132937B1 (ko) 2008-10-01 2012-04-06 주식회사종근당 Ｎ-(3-에티닐페닐)-6,7-비스(2-메톡시에톡시)-4-퀴나졸린아민 납실레이트 염
WO2010040212A1 (en) * 2008-10-08 2010-04-15 Apotex Pharmachem Inc. Processes for the preparation of erlotinib hydrochloride
KR102187034B1 (ko) 2009-01-16 2020-12-04 엑셀리시스, 인코포레이티드 암 치료용 ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형
WO2010109443A1 (en) 2009-03-26 2010-09-30 Ranbaxy Laboratories Limited Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
EP2499118A2 (de) 2009-11-12 2012-09-19 Ranbaxy Laboratories Limited Verfahren zur herstellung von erlotinibhydrochlorid form a und erlotinibhydrochlorid form b
WO2011068404A2 (en) 2009-12-02 2011-06-09 Ultimorphix Technologies B.V. Administration of n-(3-ethynylphenylamino)-6,7-bis(2- methoxyethoxy)-4-quinazolinamine mesylate salt by inhalation
KR101677790B1 (ko) 2010-06-25 2016-11-18 에자이 알앤드디 매니지먼트 가부시키가이샤 키나제 저해 작용을 갖는 화합물의 병용에 의한 항종양제
NZ606042A (en) 2010-07-23 2015-05-29 Generics Uk Ltd Process for the preparation of erlotinib and salts thereof
IT1402029B1 (it) * 2010-10-14 2013-08-28 Italiana Sint Spa Procedimento per la preparazione di erlotinib
RU2580609C2 (ru) 2011-04-18 2016-04-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое терапевтическое средство
EP3444363B1 (de) 2011-06-03 2020-11-25 Eisai R&D Management Co., Ltd. Biomarker zur vorhersage und beurteilung des ansprechens von schilddrüsen- und nierenkrebspatienten auf lenvatinibverbindungen
CN102267952B (zh) * 2011-06-21 2013-12-11 天津市汉康医药生物技术有限公司 喹唑啉类化合物、其制备方法和用途
CN103420924B (zh) * 2012-05-25 2016-08-31 浙江九洲药业股份有限公司 一种盐酸埃罗替尼晶型a的制备方法
NZ630289A (en) 2012-09-04 2016-08-26 Shilpa Medicare Ltd Crystalline erlotinib hydrochloride process
KR20150098605A (ko) 2012-12-21 2015-08-28 에자이 알앤드디 매니지먼트 가부시키가이샤 퀴놀린 유도체의 비정질 형태 및 그의 제조방법
WO2014118737A1 (en) 2013-01-31 2014-08-07 Ranbaxy Laboratories Limited Erlotinib salts
SG11201509278XA (en) 2013-05-14 2015-12-30 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN103333124B (zh) * 2013-05-28 2015-03-25 埃斯特维华义制药有限公司 一种制备盐酸厄洛替尼晶型f的方法
SI3524595T1 (sl) 2014-08-28 2022-10-28 Eisai R&D Management Co., Ltd. Derivat kinolina visoke čistosti in postopek njegove proizvodnje
CA2908441A1 (en) 2014-10-28 2016-04-28 Cerbios-Pharma Sa Process for the preparation of erlotinib
WO2016136745A1 (ja) 2015-02-25 2016-09-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体の苦味抑制方法
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
CN105884653A (zh) * 2016-06-08 2016-08-24 浙江汇能生物股份有限公司 一种埃罗替尼衍生物及其制备方法
CN106279585A (zh) * 2016-08-26 2017-01-04 宁波圣达精工智能科技有限公司 一种阻燃智能密集书架的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4747498A (en) * 1986-06-27 1988-05-31 Sunbeam Plastics Corporation Safety dispensing closure-container package
GB9300059D0 (en) * 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
EP1110953B1 (de) * 1995-03-30 2009-10-28 Pfizer Products Inc. Chinazolinone Derivate
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
EP0880508B1 (de) 1996-02-13 2003-04-16 AstraZeneca AB Chinazolinderivate und deren verwendung als vegf hemmer
IL125954A (en) 1996-03-05 2003-06-24 Zeneca Ltd Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US6225499B1 (en) 1997-07-14 2001-05-01 Catalytica Pharmaceuticals, Inc. Process for preparing aminoarylacetylenes
CN101219999A (zh) 1998-04-29 2008-07-16 Osi药物公司 N-(乙炔苯基)-6,7-双(2-甲氧基乙氧基)-4-喹唑啉胺甲磺酸盐无水物和一水合物

Also Published As

Publication number Publication date
CN1699350A (zh) 2005-11-23
AU2262000A (en) 2000-10-05
UA80955C2 (en) 2007-11-26
KR100430209B1 (ko) 2004-05-03
ATE348098T1 (de) 2007-01-15
EA005561B1 (ru) 2005-04-28
YU13200A (sh) 2002-10-18
EE200000255A (et) 2000-12-15
CA2427221A1 (en) 2000-09-30
BRPI0001486B8 (pt) 2021-05-25
HUP0001353A3 (en) 2002-01-28
SG121687A1 (en) 2006-05-26
PL339330A1 (en) 2000-10-09
CA2302965C (en) 2004-02-17
US6476040B1 (en) 2002-11-05
HU0001353D0 (en) 2000-06-28
MA25087A1 (fr) 2000-10-01
EA004654B1 (ru) 2004-06-24
DK1044969T3 (da) 2007-04-23
UA70928C2 (uk) 2004-11-15
NZ503683A (en) 2001-09-28
RS49836B (sr) 2008-08-07
ES2278578T3 (es) 2007-08-16
CN1215061C (zh) 2005-08-17
PE20001599A1 (es) 2001-01-18
HU227698B1 (en) 2011-12-28
JP3420549B2 (ja) 2003-06-23
SK287339B6 (sk) 2010-07-07
SK4442000A3 (en) 2000-10-09
CN1276370A (zh) 2000-12-13
ID25427A (id) 2000-10-05
IS2468B (is) 2008-12-15
CN100351242C (zh) 2007-11-28
KR20020084903A (ko) 2002-11-13
PT1044969E (pt) 2007-05-31
CA2427221C (en) 2008-09-16
AP1655A (en) 2006-09-01
EE04589B1 (et) 2006-02-15
EA200000274A3 (ru) 2003-02-27
NZ512818A (en) 2003-01-31
AR018705A1 (es) 2001-11-28
CZ20001155A3 (cs) 2001-03-14
AU2005201494B2 (en) 2008-02-07
IL135245A0 (en) 2001-05-20
MY136270A (en) 2008-09-30
AU781402B2 (en) 2005-05-19
CR6165A (es) 2008-10-10
HUP0001353A2 (hu) 2001-05-28
EG22506A (en) 2003-03-31
EP1044969A2 (de) 2000-10-18
IS5411A (is) 2000-10-02
JP2000290262A (ja) 2000-10-17
EA200201244A1 (ru) 2003-04-24
EA200000274A2 (ru) 2000-10-30
HRP20000182A2 (en) 2001-04-30
JP4074509B2 (ja) 2008-04-09
SV2002000047A (es) 2002-01-23
BRPI0001486B1 (pt) 2019-01-29
GEP20022653B (en) 2002-03-25
EA200201245A1 (ru) 2003-04-24
AP2000001778A0 (en) 2000-03-31
BG104278A (en) 2001-08-31
AP1265A (en) 2004-03-26
JP2003176274A (ja) 2003-06-24
DE60032275T2 (de) 2007-07-12
KR100430210B1 (ko) 2004-05-03
NO321952B1 (no) 2006-07-24
ZA200001586B (en) 2001-10-01
NO20001648L (no) 2000-10-02
BR0001486A (pt) 2001-05-02
CZ299426B6 (cs) 2008-07-23
NO20054715L (no) 2000-10-02
DZ3030A1 (fr) 2004-03-27
TR200000837A2 (tr) 2000-11-21
TW553939B (en) 2003-09-21
AU2005201494A1 (en) 2005-05-05
NO20001648D0 (no) 2000-03-30
HRP20000182B1 (en) 2007-10-31
IL168036A (en) 2006-12-10
CA2302965A1 (en) 2000-09-30
NO324745B1 (no) 2007-12-03
TNSN00064A1 (fr) 2005-11-10
KR20010014658A (ko) 2001-02-26
BG65194B1 (bg) 2007-06-29
EP1044969A3 (de) 2000-11-29
OA11335A (en) 2003-12-10
PA8491901A1 (es) 2001-12-14
EP1044969B1 (de) 2006-12-13
DE60032275D1 (de) 2007-01-25
CO5160273A1 (es) 2002-05-30
EA005892B1 (ru) 2005-06-30
UY26086A1 (es) 2000-10-31
SG115536A1 (en) 2005-10-28
GT200000037A (es) 2001-09-21

Similar Documents

Publication Publication Date Title
EG22506A (en) Processes and intermediates for preparing anti-cancer compounds
AP2003002757A0 (en) Process and intermediates for preparing anticancer compounds
IL145798A0 (en) Fap-activated anti-tumor compounds
EP1140083A4 (de) Neue verbindungen
HUP0200448A3 (en) Processes for preparing pesticidal intermediates
GB9930390D0 (en) Releasable fasteners
EG24063A (en) Novel compounds
IL149007A0 (en) Pentacyclic taxane compounds
GB9924855D0 (en) Novel processes
GB9911180D0 (en) Processes for preparing pesticidal intermediates
GB0121486D0 (en) Processes for the preparation of Α-Aminoketones
HUP0202865A3 (en) Process for the preparation of 2-cyanopyridines
IL138691A (en) Process for the preparation of 3-acyl-indoles
GB9923024D0 (en) Lap top extension
HUP0000559A3 (en) Process for preparing cyanoaceticacidesters
EP1242378A4 (de) Neue verfahren
TW382910U (en) Structural improvement for the physique of the clog
GB0001064D0 (en) Structure for positioning stationery
IL140300A0 (en) Process for the preparation of amides
HU9904575D0 (en) Process for preparation of n-alkoxy-methyl-acidamides
TW404191U (en) Structure improvement for pendants
TW377550U (en) Improvement for grass-planting brick
HUP0201518A2 (en) Process for the preparation of tetrafluorohalogenbenzenes
TW385647U (en) Structure for ring
PL343301A1 (en) Fastening means

Legal Events

Date Code Title Description
AS Change of ownership

Owner name: PFIZER PRODUCTS INC.

Free format text: FORMER OWNER(S): PFIZER PRODUCTS INC

Owner name: OSI PHARMACEUTICALS, INC.

Free format text: FORMER OWNER(S): PFIZER PRODUCTS INC

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110331