EE04589B1 - Vähivastaste ühendite valmistamise protsessid ja vaheühendid - Google Patents

Vähivastaste ühendite valmistamise protsessid ja vaheühendid

Info

Publication number
EE04589B1
EE04589B1 EEP200000255A EEP200000255A EE04589B1 EE 04589 B1 EE04589 B1 EE 04589B1 EE P200000255 A EEP200000255 A EE P200000255A EE P200000255 A EEP200000255 A EE P200000255A EE 04589 B1 EE04589 B1 EE 04589B1
Authority
EE
Estonia
Prior art keywords
intermediates
processes
preparation
anticancer compounds
anticancer
Prior art date
Application number
EEP200000255A
Other languages
English (en)
Estonian (et)
Inventor
Shelton Lehner Richard
Norris Timothy
Paul Santafianos Dinos
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of EE200000255A publication Critical patent/EE200000255A/xx
Publication of EE04589B1 publication Critical patent/EE04589B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0002—Preliminary treatment
    • C22B15/0004—Preliminary treatment without modification of the copper constituent
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0063—Hydrometallurgy
    • C22B15/0065—Leaching or slurrying
    • C22B15/0067—Leaching or slurrying with acids or salts thereof
    • C22B15/0071—Leaching or slurrying with acids or salts thereof containing sulfur
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Metallurgy (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EEP200000255A 1999-03-31 2000-03-30 Vähivastaste ühendite valmistamise protsessid ja vaheühendid EE04589B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12707299P 1999-03-31 1999-03-31

Publications (2)

Publication Number Publication Date
EE200000255A EE200000255A (et) 2000-12-15
EE04589B1 true EE04589B1 (et) 2006-02-15

Family

ID=22428179

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000255A EE04589B1 (et) 1999-03-31 2000-03-30 Vähivastaste ühendite valmistamise protsessid ja vaheühendid

Country Status (50)

Country Link
US (1) US6476040B1 (de)
EP (1) EP1044969B1 (de)
JP (2) JP3420549B2 (de)
KR (2) KR100430210B1 (de)
CN (2) CN100351242C (de)
AP (2) AP1655A (de)
AR (1) AR018705A1 (de)
AT (1) ATE348098T1 (de)
AU (2) AU781402B2 (de)
BG (1) BG65194B1 (de)
BR (1) BRPI0001486B8 (de)
CA (2) CA2302965C (de)
CO (1) CO5160273A1 (de)
CR (1) CR6165A (de)
CZ (1) CZ299426B6 (de)
DE (1) DE60032275T2 (de)
DK (1) DK1044969T3 (de)
DZ (1) DZ3030A1 (de)
EA (3) EA005561B1 (de)
EE (1) EE04589B1 (de)
EG (1) EG22506A (de)
ES (1) ES2278578T3 (de)
GE (1) GEP20022653B (de)
GT (1) GT200000037A (de)
HK (1) HK1029790A1 (de)
HR (1) HRP20000182B1 (de)
HU (1) HU227698B1 (de)
ID (1) ID25427A (de)
IL (2) IL168036A (de)
IS (1) IS2468B (de)
MA (1) MA25087A1 (de)
MY (1) MY136270A (de)
NO (2) NO321952B1 (de)
NZ (2) NZ503683A (de)
OA (1) OA11335A (de)
PA (1) PA8491901A1 (de)
PE (1) PE20001599A1 (de)
PL (1) PL339330A1 (de)
PT (1) PT1044969E (de)
RS (1) RS49836B (de)
SG (2) SG115536A1 (de)
SK (1) SK287339B6 (de)
SV (1) SV2002000047A (de)
TN (1) TNSN00064A1 (de)
TR (1) TR200000837A2 (de)
TW (1) TW553939B (de)
UA (2) UA80955C2 (de)
UY (1) UY26086A1 (de)
YU (1) YU13200A (de)
ZA (1) ZA200001586B (de)

Families Citing this family (68)

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US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
AU2003249212C1 (en) 2002-07-15 2011-10-27 Symphony Evolution, Inc. Receptor-type kinase modulators and methods of use
US7148231B2 (en) * 2003-02-17 2006-12-12 Hoffmann-La Roche Inc. [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
US7994159B2 (en) 2003-03-10 2011-08-09 Eisai R&D Management Co., Ltd. c-Kit kinase inhibitor
US7618975B2 (en) 2003-07-03 2009-11-17 Myriad Pharmaceuticals, Inc. 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
EP1667991B1 (de) 2003-09-16 2008-05-14 Astrazeneca AB Chinazolinderivate als tyrosinkinaseinhibitoren
ES2371383T3 (es) 2003-09-26 2011-12-30 Exelixis, Inc. N-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin-4-ilpropil)oxi]quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida para el tratamiento del cáncer.
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US8969379B2 (en) 2004-09-17 2015-03-03 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
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ES2556173T3 (es) * 2006-05-18 2016-01-13 Eisai R&D Management Co., Ltd. Agente antitumoral para un cáncer de tiroides
EP2044939A1 (de) * 2006-06-29 2009-04-08 Eisai R&D Management Co., Ltd. Therapeutisches mittel gegen leberfibrose
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US8865737B2 (en) 2006-08-28 2014-10-21 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
US8372856B2 (en) * 2006-10-27 2013-02-12 Synthon Bv Hydrates of erlotinib hydrochloride
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UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
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CN103420924B (zh) * 2012-05-25 2016-08-31 浙江九洲药业股份有限公司 一种盐酸埃罗替尼晶型a的制备方法
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KR102204279B1 (ko) 2013-05-14 2021-01-15 에자이 알앤드디 매니지먼트 가부시키가이샤 자궁내막암 대상의 렌바티닙 화합물에 대한 반응성을 예측 및 평가하기 위한 생체표지
CN103333124B (zh) * 2013-05-28 2015-03-25 埃斯特维华义制药有限公司 一种制备盐酸厄洛替尼晶型f的方法
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CA2908441A1 (en) 2014-10-28 2016-04-28 Cerbios-Pharma Sa Process for the preparation of erlotinib
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CN105884653A (zh) * 2016-06-08 2016-08-24 浙江汇能生物股份有限公司 一种埃罗替尼衍生物及其制备方法
CN106279585A (zh) * 2016-08-26 2017-01-04 宁波圣达精工智能科技有限公司 一种阻燃智能密集书架的制备方法

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Also Published As

Publication number Publication date
HUP0001353A2 (hu) 2001-05-28
CZ20001155A3 (cs) 2001-03-14
JP2000290262A (ja) 2000-10-17
EA200201245A1 (ru) 2003-04-24
MA25087A1 (fr) 2000-10-01
IS5411A (is) 2000-10-02
NO324745B1 (no) 2007-12-03
TNSN00064A1 (fr) 2005-11-10
JP2003176274A (ja) 2003-06-24
KR100430209B1 (ko) 2004-05-03
IL135245A0 (en) 2001-05-20
HUP0001353A3 (en) 2002-01-28
NO20054715L (no) 2000-10-02
AU2005201494B2 (en) 2008-02-07
NO321952B1 (no) 2006-07-24
HRP20000182B1 (en) 2007-10-31
IL168036A (en) 2006-12-10
AP2000001778A0 (en) 2000-03-31
AU2262000A (en) 2000-10-05
EE200000255A (et) 2000-12-15
BG65194B1 (bg) 2007-06-29
BRPI0001486B8 (pt) 2021-05-25
SK287339B6 (sk) 2010-07-07
TW553939B (en) 2003-09-21
SV2002000047A (es) 2002-01-23
CA2427221C (en) 2008-09-16
DZ3030A1 (fr) 2004-03-27
CA2427221A1 (en) 2000-09-30
BG104278A (en) 2001-08-31
AP1265A (en) 2004-03-26
EA200000274A2 (ru) 2000-10-30
PL339330A1 (en) 2000-10-09
PE20001599A1 (es) 2001-01-18
DK1044969T3 (da) 2007-04-23
EA200201244A1 (ru) 2003-04-24
UA70928C2 (uk) 2004-11-15
HRP20000182A2 (en) 2001-04-30
EG22506A (en) 2003-03-31
EP1044969A2 (de) 2000-10-18
SK4442000A3 (en) 2000-10-09
BR0001486A (pt) 2001-05-02
NZ512818A (en) 2003-01-31
YU13200A (sh) 2002-10-18
EA004654B1 (ru) 2004-06-24
CN100351242C (zh) 2007-11-28
TR200000837A2 (tr) 2000-11-21
CN1276370A (zh) 2000-12-13
RS49836B (sr) 2008-08-07
SG115536A1 (en) 2005-10-28
EP1044969B1 (de) 2006-12-13
SG121687A1 (en) 2006-05-26
UA80955C2 (en) 2007-11-26
IS2468B (is) 2008-12-15
PT1044969E (pt) 2007-05-31
CN1215061C (zh) 2005-08-17
US6476040B1 (en) 2002-11-05
CZ299426B6 (cs) 2008-07-23
CN1699350A (zh) 2005-11-23
PA8491901A1 (es) 2001-12-14
EA005892B1 (ru) 2005-06-30
NO20001648D0 (no) 2000-03-30
KR20010014658A (ko) 2001-02-26
ZA200001586B (en) 2001-10-01
ID25427A (id) 2000-10-05
AU2005201494A1 (en) 2005-05-05
HU0001353D0 (en) 2000-06-28
EA005561B1 (ru) 2005-04-28
KR20020084903A (ko) 2002-11-13
KR100430210B1 (ko) 2004-05-03
BRPI0001486B1 (pt) 2019-01-29
AP1655A (en) 2006-09-01
CA2302965C (en) 2004-02-17
CR6165A (es) 2008-10-10
GEP20022653B (en) 2002-03-25
AR018705A1 (es) 2001-11-28
CA2302965A1 (en) 2000-09-30
DE60032275T2 (de) 2007-07-12
EA200000274A3 (ru) 2003-02-27
DE60032275D1 (de) 2007-01-25
GT200000037A (es) 2001-09-21
AU781402B2 (en) 2005-05-19
UY26086A1 (es) 2000-10-31
MY136270A (en) 2008-09-30
CO5160273A1 (es) 2002-05-30
HK1029790A1 (en) 2001-04-12
NZ503683A (en) 2001-09-28
EP1044969A3 (de) 2000-11-29
HU227698B1 (en) 2011-12-28
ES2278578T3 (es) 2007-08-16
OA11335A (en) 2003-12-10
JP4074509B2 (ja) 2008-04-09
ATE348098T1 (de) 2007-01-15
JP3420549B2 (ja) 2003-06-23
NO20001648L (no) 2000-10-02

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