HK1010052A1 - N,n,-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamin] dimaleate salt - Google Patents

N,n,-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamin] dimaleate salt Download PDF

Info

Publication number
HK1010052A1
HK1010052A1 HK98110743A HK98110743A HK1010052A1 HK 1010052 A1 HK1010052 A1 HK 1010052A1 HK 98110743 A HK98110743 A HK 98110743A HK 98110743 A HK98110743 A HK 98110743A HK 1010052 A1 HK1010052 A1 HK 1010052A1
Authority
HK
Hong Kong
Prior art keywords
compound
azaspiro
dipropyl
decane
diethyl
Prior art date
Application number
HK98110743A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1010052B (en
Inventor
E. Dagger Raymond
W. Grady Carolyn
Original Assignee
Anormed Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc. filed Critical Anormed Inc.
Publication of HK1010052B publication Critical patent/HK1010052B/en
Publication of HK1010052A1 publication Critical patent/HK1010052A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
HK98110743A 1995-07-13 1998-09-18 N,n,-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamin] dimaleate salt HK1010052A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US113995P 1995-07-13 1995-07-13
US1139 1995-07-13
US1606596P 1996-04-23 1996-04-23
US16065 1996-04-23

Publications (2)

Publication Number Publication Date
HK1010052B HK1010052B (en) 1999-06-11
HK1010052A1 true HK1010052A1 (en) 1999-06-11

Family

ID=26668617

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98110743A HK1010052A1 (en) 1995-07-13 1998-09-18 N,n,-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamin] dimaleate salt

Country Status (29)

Country Link
EP (1) EP0753512B1 (cs)
JP (1) JP3949750B2 (cs)
KR (1) KR100404832B1 (cs)
CN (1) CN1067378C (cs)
AR (1) AR003452A1 (cs)
AT (1) ATE164154T1 (cs)
AU (1) AU716256B2 (cs)
BG (1) BG62359B1 (cs)
CA (1) CA2181006C (cs)
CZ (1) CZ289617B6 (cs)
DE (1) DE69600189T2 (cs)
DK (1) DK0753512T3 (cs)
EA (1) EA000037B1 (cs)
ES (1) ES2113765T3 (cs)
HK (1) HK1010052A1 (cs)
HU (1) HU226691B1 (cs)
IL (1) IL118815A (cs)
MA (1) MA23936A1 (cs)
MX (1) MX9602767A (cs)
NO (1) NO306672B1 (cs)
NZ (1) NZ286951A (cs)
PL (1) PL191019B1 (cs)
RO (1) RO117376B1 (cs)
SG (1) SG43383A1 (cs)
SK (1) SK281254B6 (cs)
TR (1) TR199600579A2 (cs)
TW (1) TW419462B (cs)
UA (1) UA42749C2 (cs)
UY (1) UY24283A1 (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1293054C (zh) * 2000-08-08 2007-01-03 第一制药株式会社 双环化合物的制备方法和中间体
WO2004080408A2 (en) * 2003-03-10 2004-09-23 Callisto Pharmaceuticals, Inc. Method of treating cancer with azaspirane compositions
CN104119321B (zh) * 2013-04-28 2017-09-08 齐鲁制药有限公司 二氢吲哚酮衍生物的二马来酸盐及其多晶型物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
BG100710A (bg) 1997-03-31
DK0753512T3 (da) 1998-10-19
IL118815A0 (en) 1996-10-31
AU716256B2 (en) 2000-02-24
MA23936A1 (fr) 1997-04-01
ATE164154T1 (de) 1998-04-15
EP0753512A1 (en) 1997-01-15
CA2181006C (en) 2007-04-03
MX9602767A (es) 1998-01-31
AU5945596A (en) 1997-01-23
HUP9601918A2 (en) 1997-09-29
PL315191A1 (en) 1997-01-20
HU226691B1 (en) 2009-06-29
TR199600579A2 (tr) 1997-01-21
EA199600048A3 (ru) 1997-03-31
NO962931L (no) 1997-01-14
IL118815A (en) 2000-06-29
TW419462B (en) 2001-01-21
UA42749C2 (uk) 2001-11-15
SG43383A1 (en) 1997-10-17
KR970069987A (ko) 1997-11-07
EP0753512B1 (en) 1998-03-18
CN1140710A (zh) 1997-01-22
DE69600189D1 (de) 1998-04-23
CZ203696A3 (en) 1997-03-12
CA2181006A1 (en) 1997-01-14
HU9601918D0 (en) 1996-09-30
EA000037B1 (ru) 1998-02-26
EA199600048A2 (ru) 1996-12-30
AR003452A1 (es) 1998-08-05
CZ289617B6 (cs) 2002-03-13
JPH09118618A (ja) 1997-05-06
NO306672B1 (no) 1999-12-06
BG62359B1 (bg) 1999-09-30
SK88696A3 (en) 1997-06-04
HUP9601918A3 (en) 1998-01-28
NZ286951A (en) 1998-02-26
NO962931D0 (no) 1996-07-12
CN1067378C (zh) 2001-06-20
UY24283A1 (es) 2001-10-25
JP3949750B2 (ja) 2007-07-25
RO117376B1 (ro) 2002-02-28
ES2113765T3 (es) 1998-05-01
PL191019B1 (pl) 2006-03-31
KR100404832B1 (ko) 2004-01-13
SK281254B6 (sk) 2001-01-18
DE69600189T2 (de) 1998-10-15

Similar Documents

Publication Publication Date Title
EP0545194B1 (en) Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof
NO318831B1 (no) Stabilt farmasoytisk preparat inneholdende 4,5-epoksy-morfinan-derivat og metode for stabilisering av dette
US5952365A (en) 2- 2-(Dimethylamino)ethyl!-8,8-dipropyl-2-azaspiro 4.5!decane dimaleate
EP0753512B1 (en) N,N,-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamin] dimaleate salt
US5744495A (en) N, N-diethyl-8, 8-dipropyl-2-azaspiro 4.5! decane-2-propanamine
EP0351561A1 (en) Novel esters of estramustine
HK1010052B (en) N,n,-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamin] dimaleate salt
US5939450A (en) N,N-dimethyl-8,8-dipropyl-2-azaspiro 4.5!decane-2-propanamine dimaleate
MXPA96002767A (en) Dimalate of n, n-dietil-8,8-dipropil-2-azaspiro [4,5] decane-2-propanam
HK1012381A (en) N,n,-diethyl-8,8dipropyl-2-azaspiro(4,5)decane-2-propanamine dimaleate salt
EP0058079B1 (en) 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate, method of preparation thereof, and pharmaceutical composition containing same
US6784315B2 (en) Stilbene derivative crystal and method for producing the same
AU701154B2 (en) Pyrrolidinyl methyl indole salt
KR100765464B1 (ko) 암로디핀 말레이트를 포함하는 약제조성물 및 그 제조 방법
EP0178682A2 (en) 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-fluoro-2-(2,4-difluorophenyl)propane, antifungal composition containing it, and process for preparation of the compound and the composition
CN105367622A (zh) 一种阿加曲班化合物
WO2005023789A1 (en) Phosphoric acid salt of (s)-(+)-2-ethoxy-4-{[3-methyl-1-(2-piperidin-1-yl-phenyl)-butylcarbamoyl]-methyl}-benzoic acid
WO2005023790A1 (en) (s)-(+)-2-ethoxy-4-{[3-methyl-1-(2-piperidin-1-yl-phenyl)-butylcarbamoyl]-methyl}-benzoic acid sodium salt
SE455373B (sv) Anvendning av 1-(4-amino-6,7-dimetoxi-2-kinazolinyl)-4-(2-tetrahydrofuroyl)piperazinhydroklorid-dihydrat for framstellning av ett lekemedel
JPS63295509A (ja) 血管新生抑制剤

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)