GR1001619B - Παράγωγα ινδόλης. - Google Patents

Παράγωγα ινδόλης.

Info

Publication number
GR1001619B
GR1001619B GR930100154A GR930100154A GR1001619B GR 1001619 B GR1001619 B GR 1001619B GR 930100154 A GR930100154 A GR 930100154A GR 930100154 A GR930100154 A GR 930100154A GR 1001619 B GR1001619 B GR 1001619B
Authority
GR
Greece
Prior art keywords
indole derivatives
indole
derivatives
compound
formula
Prior art date
Application number
GR930100154A
Other languages
Greek (el)
English (en)
Inventor
Alfredo Cugola
Giovanni Gaviraghi
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of GR1001619B publication Critical patent/GR1001619B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
GR930100154A 1992-04-16 1993-04-15 Παράγωγα ινδόλης. GR1001619B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
GR1001619B true GR1001619B (el) 1994-07-29

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
GR930100154A GR1001619B (el) 1992-04-16 1993-04-15 Παράγωγα ινδόλης.

Country Status (41)

Country Link
US (4) US5373018A (en, 2012)
EP (1) EP0568136A1 (en, 2012)
JP (2) JPH0649027A (en, 2012)
KR (1) KR100264114B1 (en, 2012)
CN (1) CN1042331C (en, 2012)
AP (1) AP480A (en, 2012)
AT (1) AT403917B (en, 2012)
AU (1) AU666927B2 (en, 2012)
BE (1) BE1006343A5 (en, 2012)
BG (1) BG62136B1 (en, 2012)
BR (1) BR1100323A (en, 2012)
CA (3) CA2094076A1 (en, 2012)
CH (1) CH685630A5 (en, 2012)
CY (1) CY2038B1 (en, 2012)
CZ (1) CZ285799B6 (en, 2012)
DK (1) DK169890B1 (en, 2012)
ES (1) ES2105924B1 (en, 2012)
FI (1) FI106198B (en, 2012)
FR (1) FR2690919B1 (en, 2012)
GB (2) GB9208492D0 (en, 2012)
GE (1) GEP19991704B (en, 2012)
GR (1) GR1001619B (en, 2012)
HK (1) HK95797A (en, 2012)
HU (2) HU217964B (en, 2012)
IL (1) IL105412A (en, 2012)
IS (1) IS3994A (en, 2012)
IT (1) IT1265325B1 (en, 2012)
LU (1) LU88248A1 (en, 2012)
MX (1) MX9302195A (en, 2012)
MY (1) MY112232A (en, 2012)
NO (1) NO301879B1 (en, 2012)
NZ (1) NZ247413A (en, 2012)
OA (1) OA10103A (en, 2012)
PL (1) PL176451B1 (en, 2012)
RO (1) RO113242B1 (en, 2012)
RU (1) RU2129544C1 (en, 2012)
SE (1) SE504336C2 (en, 2012)
SK (1) SK281941B6 (en, 2012)
TW (1) TW224457B (en, 2012)
WO (1) WO1993021153A1 (en, 2012)
ZA (1) ZA932642B (en, 2012)

Families Citing this family (44)

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GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
DK0701551T3 (da) * 1993-05-27 1997-10-20 Merrell Pharma Inc 3-(Indol-3-yl)propensyrederivater som NMDA-antagonister
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (en, 2012) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
AU4416197A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Positive ampa receptor modulation to enhance brain neurotrophic factor expression
IL129187A0 (en) * 1996-09-30 2000-02-17 Hoechst Marion Roussel Inc NMDA (N-methyl-D-aspartate) antagonists
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
PT1064942E (pt) * 1998-03-26 2004-10-29 Fujisawa Pharmaceutical Co Preparacao de libertacao sustentada de um macrolido
US6962921B2 (en) * 2000-07-31 2005-11-08 Dainippon Pharmaceutical Co., Ltd. Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient
WO2003039540A2 (en) * 2001-11-09 2003-05-15 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
JP2005518371A (ja) * 2001-12-10 2005-06-23 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び治療に於けるこれらの使用
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) * 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
BRPI0410936A (pt) * 2003-06-05 2006-06-27 Pfizer Prod Inc pró-fármaco inibidor da beta-lactamase
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
DE602004028150D1 (de) * 2003-11-26 2010-08-26 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
ZA200605383B (en) * 2003-12-29 2008-06-25 Sepracor Inc Pyrrole and pyrazole daao inhibitors
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
MX2008000250A (es) 2005-07-06 2008-03-19 Sepracor Inc Combinaciones de eszopiclona y trans-4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-n-metil-1-naftalenamina o trans 4-(3,4-diclorofenil)-1, 2,3,4-tetrahidro-1-naftalenamina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y
NZ569630A (en) * 2006-01-06 2011-09-30 Sepracor Inc Cycloalkylamines as monoamine reuptake inhibitors
KR101381768B1 (ko) * 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
PT2816024T (pt) 2006-03-31 2017-10-20 Sunovion Pharmaceuticals Inc Aminas quirais
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
WO2008089453A2 (en) 2007-01-18 2008-07-24 Sepracor Inc. Inhibitors of d-amino acid oxidase
CA2688493C (en) 2007-05-31 2016-04-19 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
WO2009151498A2 (en) * 2008-03-28 2009-12-17 Forest Laboratories Holdings Limited Memantine formulations
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
JP2010235597A (ja) * 2009-03-10 2010-10-21 Santen Pharmaceut Co Ltd ４，６−ジクロロ−１ｈ−インドール−２−カルボン酸誘導体又はその塩を有効成分として含有する視神経障害の予防又は治療剤
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
SG10202102125SA (en) 2014-04-30 2021-04-29 Yufeng Tseng Use of known compounds as d-amino acid oxidase inhibitors
US11370775B2 (en) 2016-09-14 2022-06-28 Yufeng Jane Tseng Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors
JP7305560B2 (ja) 2017-06-12 2023-07-10 グリテック， エルエルシー Ｎｍｄａアンタゴニスト及びｄ２／５ｈｔ２ａ又は選択的５ｈｔ２ａアンタゴニストによるうつ病の治療
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

Family Cites Families (7)

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
PT93943A (pt) * 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
ES2088011T3 (es) * 1990-07-16 1996-08-01 Merrell Pharma Inc Antagonistas de aminoacidos excitadores.
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Also Published As

Publication number Publication date
FI944800L (fi) 1994-10-12
DK169890B1 (da) 1995-03-27
NZ247413A (en) 1995-12-21
ATA75293A (de) 1997-11-15
GB9208492D0 (en) 1992-06-03
ES2105924B1 (es) 1998-07-01
AT403917B (de) 1998-06-25
EP0568136A1 (en) 1993-11-03
MX9302195A (es) 1994-03-31
KR100264114B1 (ko) 2000-11-01
US5374648A (en) 1994-12-20
SE504336C2 (sv) 1997-01-13
IL105412A0 (en) 1993-08-18
CA2094076A1 (en) 1993-10-17
GEP19991704B (en) 1999-08-05
DK43193A (da) 1993-10-17
RU2129544C1 (ru) 1999-04-27
IS3994A (is) 1993-10-17
CN1042331C (zh) 1999-03-03
SK124194A3 (en) 1995-05-10
HU9402975D0 (en) 1995-02-28
NO943913D0 (no) 1994-10-14
DK43193D0 (da) 1993-04-15
IL105412A (en) 1998-02-22
FR2690919A1 (fr) 1993-11-12
HUT70526A (en) 1995-10-30
RU94045915A (ru) 1996-09-10
ES2105924A1 (es) 1997-10-16
BG62136B1 (bg) 1999-03-31
AP9300524A0 (en) 1993-04-30
BG99111A (bg) 1995-05-31
GB9307808D0 (en) 1993-06-02
OA10103A (en) 1996-12-18
JPH0649027A (ja) 1994-02-22
NO301879B1 (no) 1997-12-22
HU217964B (hu) 2000-05-28
CA2094075A1 (en) 1993-10-17
FI106198B (fi) 2000-12-15
GB2266091A (en) 1993-10-20
SK281941B6 (sk) 2001-09-11
CZ254394A3 (en) 1995-07-12
ZA932642B (en) 1994-01-10
ITRM930236A0 (it) 1993-04-15
CA2094073A1 (en) 1993-10-17
ITRM930236A1 (it) 1994-10-15
FI944800A0 (fi) 1994-10-12
CN1085212A (zh) 1994-04-13
HK95797A (en) 1997-08-08
CH685630A5 (fr) 1995-08-31
MY112232A (en) 2001-05-31
HU211826A9 (en) 1995-12-28
PL176451B1 (pl) 1999-05-31
BR1100323A (pt) 2000-06-27
BE1006343A5 (fr) 1994-07-26
GB2266091B (en) 1995-08-09
CZ285799B6 (cs) 1999-11-17
AP480A (en) 1996-03-22
SE9301241D0 (sv) 1993-04-15
AU666927B2 (en) 1996-02-29
IT1265325B1 (it) 1996-10-31
CY2038B1 (en) 1998-04-30
TW224457B (en, 2012) 1994-06-01
AU3692393A (en) 1993-10-21
US5373018A (en) 1994-12-13
US5510367A (en) 1996-04-23
JPH07505407A (ja) 1995-06-15
NO943913L (no) 1994-12-14
US5374649A (en) 1994-12-20
RO113242B1 (ro) 1998-05-29
SE9301241L (sv) 1993-10-17
FR2690919B1 (fr) 1995-05-05
LU88248A1 (fr) 1994-03-01
WO1993021153A1 (en) 1993-10-28

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