TW224457B - - Google Patents

Info

Publication number
TW224457B
TW224457B TW082103531A TW82103531A TW224457B TW 224457 B TW224457 B TW 224457B TW 082103531 A TW082103531 A TW 082103531A TW 82103531 A TW82103531 A TW 82103531A TW 224457 B TW224457 B TW 224457B
Authority
TW
Taiwan
Application number
TW082103531A
Other languages
Chinese (zh)
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Application granted granted Critical
Publication of TW224457B publication Critical patent/TW224457B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
TW082103531A 1992-04-16 1993-05-06 TW224457B (en, 2012)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
TW224457B true TW224457B (en, 2012) 1994-06-01

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082103531A TW224457B (en, 2012) 1992-04-16 1993-05-06

Country Status (41)

Country Link
US (4) US5374648A (en, 2012)
EP (1) EP0568136A1 (en, 2012)
JP (2) JPH07505407A (en, 2012)
KR (1) KR100264114B1 (en, 2012)
CN (1) CN1042331C (en, 2012)
AP (1) AP480A (en, 2012)
AT (1) AT403917B (en, 2012)
AU (1) AU666927B2 (en, 2012)
BE (1) BE1006343A5 (en, 2012)
BG (1) BG62136B1 (en, 2012)
BR (1) BR1100323A (en, 2012)
CA (3) CA2094076A1 (en, 2012)
CH (1) CH685630A5 (en, 2012)
CY (1) CY2038B1 (en, 2012)
CZ (1) CZ285799B6 (en, 2012)
DK (1) DK169890B1 (en, 2012)
ES (1) ES2105924B1 (en, 2012)
FI (1) FI106198B (en, 2012)
FR (1) FR2690919B1 (en, 2012)
GB (2) GB9208492D0 (en, 2012)
GE (1) GEP19991704B (en, 2012)
GR (1) GR1001619B (en, 2012)
HK (1) HK95797A (en, 2012)
HU (2) HU217964B (en, 2012)
IL (1) IL105412A (en, 2012)
IS (1) IS3994A (en, 2012)
IT (1) IT1265325B1 (en, 2012)
LU (1) LU88248A1 (en, 2012)
MX (1) MX9302195A (en, 2012)
MY (1) MY112232A (en, 2012)
NO (1) NO301879B1 (en, 2012)
NZ (1) NZ247413A (en, 2012)
OA (1) OA10103A (en, 2012)
PL (1) PL176451B1 (en, 2012)
RO (1) RO113242B1 (en, 2012)
RU (1) RU2129544C1 (en, 2012)
SE (1) SE504336C2 (en, 2012)
SK (1) SK281941B6 (en, 2012)
TW (1) TW224457B (en, 2012)
WO (1) WO1993021153A1 (en, 2012)
ZA (1) ZA932642B (en, 2012)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
ES2103590T3 (es) * 1993-05-27 1997-09-16 Merrell Pharma Inc Derivados del acido 3-(indol-3-il) propenoico utilizables como antagonistas nmda.
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (en, 2012) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) * 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
US6030968A (en) * 1996-09-17 2000-02-29 The Regents Of The University Of California Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
CA2266556C (en) * 1996-09-30 2007-11-06 Hoechst Marion Roussel, Inc. Nmda (n-methyl-d-aspartate) antagonists
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
DE69942286D1 (de) * 1998-03-26 2010-06-02 Astellas Pharma Inc Retardpräparat mit Makroliden wie Tacrolimus
HK1054231A1 (en) * 2000-07-31 2003-11-21 Dainippon Sumitomo Pharma Co., Ltd. Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
US7582657B2 (en) * 2001-12-10 2009-09-01 Amgen Inc. Vanilloid receptor ligands and their use in treatments
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
WO2004108733A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
WO2005051919A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
US7488747B2 (en) * 2003-12-29 2009-02-10 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
CA2957667A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
US20070203111A1 (en) 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
JP5438975B2 (ja) * 2006-01-06 2014-03-12 サノビオン ファーマシューティカルズ インク テトラロン系モノアミン再取り込み阻害剤
EP2013835B1 (en) 2006-03-31 2015-11-04 Sunovion Pharmaceuticals Inc. Preparation of chiral amides and amines
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
WO2008089453A2 (en) 2007-01-18 2008-07-24 Sepracor Inc. Inhibitors of d-amino acid oxidase
RU2470011C2 (ru) 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов
US20090247644A1 (en) * 2008-03-28 2009-10-01 Forest Laboratories Holdings Limited Memantine formulations
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
JP2010235597A (ja) * 2009-03-10 2010-10-21 Santen Pharmaceut Co Ltd ４，６−ジクロロ−１ｈ−インドール−２−カルボン酸誘導体又はその塩を有効成分として含有する視神経障害の予防又は治療剤
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
EP3137658B1 (en) 2014-04-30 2022-03-30 Tseng, Yufeng, Jane Use of known compounds as d-amino acid oxidase inhibitors
JP7029129B2 (ja) 2016-09-14 2022-03-03 ユーフェン ジェーン ツェン Ｄ－アミノ酸オキシダーゼ（ｄａａｏ）阻害剤としての新規な置換ベンゾイミダゾール誘導体
CN110996948A (zh) 2017-06-12 2020-04-10 格莱泰施有限责任公司 用nmda拮抗剂和d2/5ht2a或选择性5ht2a拮抗剂治疗抑郁症
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
JPH0347123A (ja) * 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
AU646686B2 (en) * 1990-07-16 1994-03-03 Merrell Pharmaceuticals Inc. Excitatory amino acid antagonistic indole derivatives
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Also Published As

Publication number Publication date
JPH0649027A (ja) 1994-02-22
CZ285799B6 (cs) 1999-11-17
JPH07505407A (ja) 1995-06-15
AT403917B (de) 1998-06-25
DK43193D0 (da) 1993-04-15
IS3994A (is) 1993-10-17
GR1001619B (el) 1994-07-29
LU88248A1 (fr) 1994-03-01
SE9301241L (sv) 1993-10-17
FR2690919B1 (fr) 1995-05-05
GB2266091B (en) 1995-08-09
CH685630A5 (fr) 1995-08-31
GB9208492D0 (en) 1992-06-03
HU9402975D0 (en) 1995-02-28
FI106198B (fi) 2000-12-15
PL176451B1 (pl) 1999-05-31
AU3692393A (en) 1993-10-21
US5374648A (en) 1994-12-20
GB2266091A (en) 1993-10-20
NZ247413A (en) 1995-12-21
BG62136B1 (bg) 1999-03-31
HUT70526A (en) 1995-10-30
GEP19991704B (en) 1999-08-05
CA2094073A1 (en) 1993-10-17
CZ254394A3 (en) 1995-07-12
FR2690919A1 (fr) 1993-11-12
CY2038B1 (en) 1998-04-30
CA2094076A1 (en) 1993-10-17
CA2094075A1 (en) 1993-10-17
ES2105924B1 (es) 1998-07-01
NO943913D0 (no) 1994-10-14
IL105412A0 (en) 1993-08-18
BG99111A (bg) 1995-05-31
FI944800A0 (fi) 1994-10-12
RU94045915A (ru) 1996-09-10
US5510367A (en) 1996-04-23
US5373018A (en) 1994-12-13
AP480A (en) 1996-03-22
MY112232A (en) 2001-05-31
AP9300524A0 (en) 1993-04-30
ES2105924A1 (es) 1997-10-16
OA10103A (en) 1996-12-18
FI944800L (fi) 1994-10-12
NO301879B1 (no) 1997-12-22
RO113242B1 (ro) 1998-05-29
SE9301241D0 (sv) 1993-04-15
ITRM930236A1 (it) 1994-10-15
ZA932642B (en) 1994-01-10
RU2129544C1 (ru) 1999-04-27
WO1993021153A1 (en) 1993-10-28
KR100264114B1 (ko) 2000-11-01
DK43193A (da) 1993-10-17
BR1100323A (pt) 2000-06-27
HU211826A9 (en) 1995-12-28
HU217964B (hu) 2000-05-28
GB9307808D0 (en) 1993-06-02
IT1265325B1 (it) 1996-10-31
SK281941B6 (sk) 2001-09-11
IL105412A (en) 1998-02-22
EP0568136A1 (en) 1993-11-03
AU666927B2 (en) 1996-02-29
DK169890B1 (da) 1995-03-27
SE504336C2 (sv) 1997-01-13
BE1006343A5 (fr) 1994-07-26
CN1042331C (zh) 1999-03-03
ITRM930236A0 (it) 1993-04-15
NO943913L (no) 1994-12-14
SK124194A3 (en) 1995-05-10
CN1085212A (zh) 1994-04-13
HK95797A (en) 1997-08-08
MX9302195A (es) 1994-03-31
ATA75293A (de) 1997-11-15
US5374649A (en) 1994-12-20

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