GB876516A - Antibacterial agents - Google Patents

Abstract

Relates to acids having the general formula: <FORM:0876516/IV (b)/1> such as 6-(2-methylbutyramido), 6-(2-ethyl-hexanoamido), 6-(a ,a .-diethylacetamido), 6-(2,3-dimethyl-n-butyramido) and 6-(2-methyl-n-pentanoamido) penicillanic acid, and non-toxic salts thereof, wherein R1 and R2 are the same or different and each is an alkyl group containing from one to ten carbon atoms. The Specification refers to other acids of the above formula. The acids may be made by reacting 6-aminopenicillanic acid or a neutral salt thereof with an acid chloride having the general formula <FORM:0876516/IV (b)/2> where R1 and R2 are as above or with its functional equivalent as an acylating agent for a primary amino group such as the corresponding carboxylic acid anhydrides and mixed anhydrides with other carboxylic acids, including monesters, and particularly lower aliphatic esters, of carbonic acid.