GB891279A - Antibacterial agents - Google Patents
Antibacterial agentsInfo
- Publication number
- GB891279A GB891279A GB38646/60A GB3864660A GB891279A GB 891279 A GB891279 A GB 891279A GB 38646/60 A GB38646/60 A GB 38646/60A GB 3864660 A GB3864660 A GB 3864660A GB 891279 A GB891279 A GB 891279A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- propionamido
- acids
- nitrophenylthio
- chlorophenylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Relates to acids of the general formula <FORM:0891279/IV (b)/1> and non-toxic salts thereof, wherein R1 is a cyclopentyl, cyclohexyl, benzyl, phenyl or substituted phenyl group or an aliphatic group having from 1 to 20 carbon atoms inclusive and R2 is a cyclopentyl, cyclohexyl or C1-C6 alkyl group. Typical acids of the above formula are 6-(a -methylthiopropionamido), 6-(a -octadecylthiopropionamido), 6-(a -butylthioisovaleramido), 6-(a -allylthiopropionamido), 6-[a -(2-ethylhexyl)thiopropionamido], 6-(a -phenylthiopropionamido), 6-[a -(o-toluenethio)propionamido], 6-[a -(o-nitrophenylthio)propionamido], 6-[a -(p-chlorophenylthio)propionamido], 6-[a -(p-chlorophenylthio)isovaleramido], and 6-[a -(4-nitrophenylthio)caproamido] penicillanic acid. The compounds may be prepared by reacting 6-aminopenicillanic acid or a neutral salt thereof with an acid chloride of the general formula <FORM:0891279/IV (b)/2> or with its functional equivalent as an acylating agent for a primary amino group such as the corresponding carboxylic acid bromides, acid anhydrides and mixed anhydrides with other carboxylic acids.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US891279XA | 1959-11-16 | 1959-11-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB891279A true GB891279A (en) | 1962-03-14 |
Family
ID=22215837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB38646/60A Expired GB891279A (en) | 1959-11-16 | 1960-11-10 | Antibacterial agents |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB891279A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3301849A (en) * | 1963-09-04 | 1967-01-31 | Bristol Myers Co | 6-(alpha-phenoxyalkanoylamino) thiopenicillanic acid |
-
1960
- 1960-11-10 GB GB38646/60A patent/GB891279A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3301849A (en) * | 1963-09-04 | 1967-01-31 | Bristol Myers Co | 6-(alpha-phenoxyalkanoylamino) thiopenicillanic acid |
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