GB966221A - N-acyl derivatives of 7-aminocephalosporanic acid and related compounds - Google Patents

N-acyl derivatives of 7-aminocephalosporanic acid and related compounds

Info

Publication number
GB966221A
GB966221A GB213560A GB213560A GB966221A GB 966221 A GB966221 A GB 966221A GB 213560 A GB213560 A GB 213560A GB 213560 A GB213560 A GB 213560A GB 966221 A GB966221 A GB 966221A
Authority
GB
United Kingdom
Prior art keywords
cephalosporin
group
nucleus
phenyl group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB213560A
Inventor
Edward Penley Abraham
Guy Geoffrey Frederick Newton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Priority to GB213560A priority Critical patent/GB966221A/en
Priority to SE7511/60A priority patent/SE309986B/xx
Priority to DK307160AA priority patent/DK105027C/en
Priority to CH1418365A priority patent/CH430721A/en
Priority to CH879860A priority patent/CH404860A/en
Priority to NO136915A priority patent/NO122748B/no
Priority to DK24161AA priority patent/DK105590C/en
Priority to SE536/61A priority patent/SE321930B/xx
Priority to FR878632A priority patent/FR89204E/en
Priority to US191213A priority patent/US3219662A/en
Publication of GB966221A publication Critical patent/GB966221A/en
Priority to OA51513A priority patent/OA01264A/en
Priority to NL6608907A priority patent/NL6608907A/xx
Priority to NO16577466A priority patent/NO122750B/no
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Relates to N-acyl derivatives of the nucleus of Cephalosporin C, Cephalosporin CC or a Cephalosporin CA compound, such as Cephalosporin CA (pyridine), having the general formula R1R2. CH.CO.X in which R1, R2 represent a hydrogen atom, an alkyl group, a phenyl group, a substituted phenyl group or a group of structure R3-O-, in which R3 represents an alkyl group, a phenyl group or a substituted phenyl group, and are the same or different, and X represents the residue of the nucleus of Cephalosporin C, Cephalosporin CC or a Cephalosporin CA compound, and to sodium, potassium and ammonium salts thereof. The derivatives may be prepared by treating the nucleus of Cephalosporin C, Cephalosporin CC or a Cephalosporin CA compound with an acylating agent capable of acylating the amino group of the nucleus with the group R1R2.CH. CO, prepared acylating agents being acid chlorides. Examples describe the production of 7-phenylacetamido- and 7-a -phenoxypropionamido-cephalosporamic acid, and of the phenylacetyl derivatives of the nuclei of Cephalosporin CA (pyridine) and Cephalosporin CC. Specification 810,196 also is referred to.
GB213560A 1959-08-04 1960-01-20 N-acyl derivatives of 7-aminocephalosporanic acid and related compounds Expired GB966221A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB213560A GB966221A (en) 1960-01-20 1960-01-20 N-acyl derivatives of 7-aminocephalosporanic acid and related compounds
SE7511/60A SE309986B (en) 1959-08-04 1960-08-03
DK307160AA DK105027C (en) 1959-08-04 1960-08-03 Process for the preparation of derivatives of Cephalosporin C, Cephalosporin Cc or of Cephalosporin CA compounds.
CH1418365A CH430721A (en) 1959-08-04 1960-08-03 Process for the preparation of new antibiotics
CH879860A CH404860A (en) 1959-08-04 1960-08-03 Process for the preparation of cephalosporin C derivatives
NO136915A NO122748B (en) 1959-08-04 1960-08-03
SE536/61A SE321930B (en) 1960-01-20 1961-01-19
DK24161AA DK105590C (en) 1960-01-20 1961-01-19 Process for the preparation of N-acyl derivatives of the nuclei of Cephalosporin C, Cephalosporin CC and Cephalosporin-CA compounds or salts thereof.
FR878632A FR89204E (en) 1960-01-20 1961-11-10 Cephalosporin c derivatives
US191213A US3219662A (en) 1960-01-20 1962-04-30 Transformation products of cephalosporin c and derivatives thereof
OA51513A OA01264A (en) 1959-08-04 1964-12-31 Cephalosporin C derivatives.
NL6608907A NL6608907A (en) 1959-08-04 1966-06-27
NO16577466A NO122750B (en) 1959-08-04 1966-11-28

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB213560A GB966221A (en) 1960-01-20 1960-01-20 N-acyl derivatives of 7-aminocephalosporanic acid and related compounds

Publications (1)

Publication Number Publication Date
GB966221A true GB966221A (en) 1964-08-06

Family

ID=9734213

Family Applications (1)

Application Number Title Priority Date Filing Date
GB213560A Expired GB966221A (en) 1959-08-04 1960-01-20 N-acyl derivatives of 7-aminocephalosporanic acid and related compounds

Country Status (1)

Country Link
GB (1) GB966221A (en)

Similar Documents

Publication Publication Date Title
GB966221A (en) N-acyl derivatives of 7-aminocephalosporanic acid and related compounds
GB1073828A (en) O-desacetyl-o-carbamoyl-7-acylamino-cephalosporanic acids
GB919073A (en) Benzylamine derivatives
ES261390A1 (en) New penicillins
ES269319A1 (en) Methods of destroying nematodes with a pyridine base and its acid addition salts
GB872879A (en) Electrolytic copper-plating baths
GB959993A (en) Camphor derivatives
GB891279A (en) Antibacterial agents
ES446132A1 (en) A procedure for the preparation of new derivatives of 2-alkyl (bottom) -2 or 3-cefem-4-carboxylic acid. (Machine-translation by Google Translate, not legally binding)
ES393554A1 (en) Thiazole derivatives and a process for the manufacture thereof
GB876662A (en) Antibacterial agents
GB894247A (en) Antibacterial agents
GB882335A (en) Improvements in or relating to substances produced from penicillin-producing moulds
GB908787A (en) Penicillins
GB1032641A (en) Cephalosporins
GB920300A (en) Penicillins
GB941998A (en) Method of hardening gelatine
GB874416A (en) Antibacterial agents
ES278857A1 (en) Procedure for preparing new penicillins (Machine-translation by Google Translate, not legally binding)
GB953696A (en) Improvements in and relating to antibiotics
GB943608A (en) Penicillins
GB894457A (en) Improvements in or relating to penicillin derivatives
GB891586A (en) Antibacterial agents
ES228914A3 (en) A procedure for the preparation of non-substitute aminoalquilbenzhydrylic etheries and nioethics (Machine-translation by Google Translate, not legally binding)
GB1017450A (en) 2-amino-4-alkoxy-úË-triazines