GB874416A - Antibacterial agents - Google Patents

Abstract

Relates to penicillins of the formula <FORM:0874416/IV (b)/1> wherein R1, R2 and R3 are the same or different and each is a hydrogen atom or a nitro, amino, lower alkylamino, lower dialkylamino, lower alkanoylamino, lower alkyl, chloro, bromo, iodo, lower alkoxy, hydroxy or sulphamyl group, "lower" referring to radicals containing up to 10 carbon atoms, such as 6-[3-phenylpropionamido], 6-[3-(p-chlorophenyl)propionamido], 6-[3-(p-sulphamylphenyl) propionamido], 6-[3-m,p-dimethoxyphenyl) propionamido] and 6-[3-p-methoxyphenyl propionamido] penicillanic acid and to non-toxic salts thereof. The Specification contains a list of other penicillins of the above formula. The compounds may be prepared by reacting 6-amino-penicillanic acid or a neutral salt thereof with an acid chloride having the general formula <FORM:0874416/IV (b)/2> or its functional equivalent as an acylating agent for a primary amino group, such as the corresponding acid bromides, acid anhydrides and mixed anhydrides with other carboxylic acids, including monoesters of carbonic acid.