GB900666A - Antibacterial agents - Google Patents
Antibacterial agentsInfo
- Publication number
- GB900666A GB900666A GB1579661A GB1579661A GB900666A GB 900666 A GB900666 A GB 900666A GB 1579661 A GB1579661 A GB 1579661A GB 1579661 A GB1579661 A GB 1579661A GB 900666 A GB900666 A GB 900666A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- chloride
- reacting
- prepared
- propiolactone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Relates to acids of the general formula <FORM:0900666/IV (b)/1> and non-toxic salts thereof, wherein R is a cyclopentyl, cyclohexyl, phenyl, benzyl or phenoxy group or an alkyl group having 1 to 8 carbon atoms inclusive, such as 6-(b -acetoxypropionamido)- or 6-(b -propionyloxypropionamido)-penicillanic acid. The compounds may be prepared by reacting 6-aminopenicillanic acid or a neutral salt thereof with an acid chloride of the general formula R-CO-O-CH2CH2-CO-Cl or with its functional equivalent as an acylating agent for a primary amino group, such as the corresponding carboxylic acid bromides, acid anhydrides and mixed anhydrides with other carboxylic acids. b -acetoxypropionyl chloride is prepared by reacting propiolactone with acetyl chloride. b -propionyloxypropionyl chloride is prepared by the action of thionyl chloride on the corresponding acid, which is obtained by reacting b -propiolactone and propionic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2882860A | 1960-05-13 | 1960-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB900666A true GB900666A (en) | 1962-07-11 |
Family
ID=21845688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1579661A Expired GB900666A (en) | 1960-05-13 | 1961-05-02 | Antibacterial agents |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB900666A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3280111A (en) * | 1961-04-14 | 1966-10-18 | Lepetit Spa | Penicillin derivatives |
| FR2009922A1 (en) * | 1968-05-20 | 1970-02-13 | Laeaeketehdas Orion Oy | METHOD FOR MANUFACTURING NEW PENICILLINS |
| US5091560A (en) * | 1988-03-14 | 1992-02-25 | The Clorox Company | Method for synthesizing acyloxycarboxylic acids |
-
1961
- 1961-05-02 GB GB1579661A patent/GB900666A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3280111A (en) * | 1961-04-14 | 1966-10-18 | Lepetit Spa | Penicillin derivatives |
| FR2009922A1 (en) * | 1968-05-20 | 1970-02-13 | Laeaeketehdas Orion Oy | METHOD FOR MANUFACTURING NEW PENICILLINS |
| US5091560A (en) * | 1988-03-14 | 1992-02-25 | The Clorox Company | Method for synthesizing acyloxycarboxylic acids |
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