GB2221157B - Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same - Google Patents

Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same

Info

Publication number
GB2221157B
GB2221157B GB8916679A GB8916679A GB2221157B GB 2221157 B GB2221157 B GB 2221157B GB 8916679 A GB8916679 A GB 8916679A GB 8916679 A GB8916679 A GB 8916679A GB 2221157 B GB2221157 B GB 2221157B
Authority
GB
United Kingdom
Prior art keywords
cyclosporin
preparing
same
pharmaceutical composition
intravenous pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8916679A
Other languages
English (en)
Other versions
GB2221157A (en
GB8916679D0 (en
Inventor
Erno Orban
Tibor Balogh
Lajos Ila
Gabor Ambrus
Antonia Jekkel
Sandor Elek
Eva Tomori
Lajos Siklosi
Sarudy Eva Toth
Imre Moravcsik
Istvan Elekkes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of GB8916679D0 publication Critical patent/GB8916679D0/en
Publication of GB2221157A publication Critical patent/GB2221157A/en
Application granted granted Critical
Publication of GB2221157B publication Critical patent/GB2221157B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB8916679A 1988-07-21 1989-07-21 Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same Expired - Lifetime GB2221157B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU883796A HU201567B (en) 1988-07-21 1988-07-21 Process for production of intravenous medical compositions containing cyclosphorin

Publications (3)

Publication Number Publication Date
GB8916679D0 GB8916679D0 (en) 1989-09-06
GB2221157A GB2221157A (en) 1990-01-31
GB2221157B true GB2221157B (en) 1991-12-18

Family

ID=10965544

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8916679A Expired - Lifetime GB2221157B (en) 1988-07-21 1989-07-21 Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same

Country Status (26)

Country Link
US (1) US5047396A (fi)
JP (1) JPH07116051B2 (fi)
KR (1) KR0137674B1 (fi)
AR (1) AR243382A1 (fi)
AT (1) AT402258B (fi)
AU (1) AU614862B2 (fi)
BE (1) BE1004323A4 (fi)
CA (1) CA1332712C (fi)
CH (1) CH679120A5 (fi)
DD (1) DD283934A5 (fi)
DE (1) DE3924207A1 (fi)
DK (1) DK175540B1 (fi)
FI (1) FI92556C (fi)
FR (1) FR2635265B1 (fi)
GB (1) GB2221157B (fi)
GR (1) GR1002184B (fi)
HU (1) HU201567B (fi)
IL (1) IL91069A (fi)
IT (1) IT1231434B (fi)
LU (1) LU87560A1 (fi)
NL (1) NL194578C (fi)
NO (1) NO175287C (fi)
NZ (1) NZ230036A (fi)
PT (1) PT91246B (fi)
SE (1) SE509174C2 (fi)
ZA (1) ZA895588B (fi)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
GB2251186A (en) * 1990-12-04 1992-07-01 Randall Neal Gatz Polypeptide for use in treatment of autoimmune disease
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
ES2098739T3 (es) * 1992-05-13 1997-05-01 Sandoz Ltd Composiciones oftalmicas conteniendo una cyclosporin.
EP0589843B1 (en) 1992-09-25 2001-11-28 Novartis AG Pharmaceutical compositions containing cyclosporins
DE4412201A1 (de) * 1993-04-20 1994-11-10 Rentschler Arzneimittel Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
RU2158601C2 (ru) 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
BR9606603A (pt) * 1995-08-25 1997-09-30 Sangstat Medical Corp Formulação de ciclosporina dispersão aquosa de nanopartículas de ciclosporina kit e processo de preparação de dispersão aquosa de partículas de ciclosporina
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US20050053594A1 (en) * 1995-11-16 2005-03-10 Dario Alessi RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK
DE19549852B4 (de) * 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
DE29824679U1 (de) 1997-01-30 2002-03-28 Novartis Ag, Basel Pharmazeutische Zusammensetzungen
WO1998040094A1 (en) * 1997-03-12 1998-09-17 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
AT408186B (de) * 1998-12-15 2001-09-25 Sanochemia Pharmazeutika Ag Wässerige zubereitung von beta-carotin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE10015814A1 (de) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung
FR2826517B1 (fr) * 2001-06-20 2004-03-12 Somfy Dispositif d'alimentation pour store motorise ou similaire
EP1435910B9 (en) * 2001-10-19 2010-02-03 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) * 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
GB2451811A (en) 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
JP4815418B2 (ja) * 2007-10-19 2011-11-16 カヤバ工業株式会社 空圧緩衝器
EP2334285A1 (en) * 2008-09-12 2011-06-22 Critical Pharmaceuticals Limited Improvements in the absorption of therapeutic agents across mucosal membranes or the skin
FR2948568B1 (fr) * 2009-07-30 2012-08-24 Sanofi Aventis Formulation pharmaceutique
CA2852056C (en) 2011-03-11 2021-08-10 Beth Israel Deaconess Medical Center, Inc. Anti-cd40 antibodies and uses thereof
AU2016315873B2 (en) 2015-09-04 2022-08-18 Primatope Therapeutics Inc. Humanized anti-CD40 antibodies and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3658M (fr) * 1964-02-18 1965-11-02 Michel Marie Andre Guerbet Composition huileuse pour l'injection intravasculaire.
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
CH641356A5 (en) * 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
AU534955B2 (en) * 1980-01-23 1984-02-23 Sandoz Ag Cyclosporin a to treat lymphoproliferative disorders
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE3339235A1 (de) * 1983-10-28 1985-05-09 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von polyurethanen
EP0336976A4 (de) * 1987-10-02 1990-06-27 Vsesojuznyj Kardiologitsches Arzneimittelzubereitung zur behandlung der multiplen sklerose und der seitlichen amyotrophen sklerose.
GB8729153D0 (en) * 1987-12-14 1988-01-27 Efamol Ltd Fatty acid compositions
US4943560A (en) * 1988-04-06 1990-07-24 Regents Of The University Of Minnesota Solvent system for chronic vascular infusion of hydrophobic drugs
DE3832362A1 (de) * 1988-09-23 1990-03-29 Sandoz Ag Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
KR900001364A (ko) 1990-02-27
PT91246B (pt) 1995-05-04
FI893520A0 (fi) 1989-07-21
AT402258B (de) 1997-03-25
DK175540B1 (da) 2004-11-29
IT8921259A0 (it) 1989-07-21
JPH03115227A (ja) 1991-05-16
DK362189D0 (da) 1989-07-21
DE3924207A1 (de) 1990-01-25
SE8902588D0 (sv) 1989-07-21
BE1004323A4 (fr) 1992-11-03
GB2221157A (en) 1990-01-31
NL194578B (nl) 2002-04-02
FR2635265B1 (fr) 1995-03-17
NZ230036A (en) 1991-02-26
FR2635265A1 (fr) 1990-02-16
JPH07116051B2 (ja) 1995-12-13
NL194578C (nl) 2002-08-05
AR243382A1 (es) 1993-08-31
LU87560A1 (fr) 1991-02-18
HU201567B (en) 1990-11-28
CH679120A5 (fi) 1991-12-31
SE509174C2 (sv) 1998-12-14
CA1332712C (en) 1994-10-25
NO892995D0 (no) 1989-07-21
GB8916679D0 (en) 1989-09-06
FI92556B (fi) 1994-08-31
FI92556C (fi) 1994-12-12
ATA176789A (de) 1996-08-15
NL8901902A (nl) 1990-02-16
NO175287C (no) 1994-09-28
KR0137674B1 (ko) 1998-05-15
AU3884589A (en) 1990-02-01
DD283934A5 (de) 1990-10-31
GR890100467A (el) 1990-06-27
HUT50851A (en) 1990-03-28
US5047396A (en) 1991-09-10
GR1002184B (en) 1996-03-12
PT91246A (pt) 1990-02-08
NO892995L (no) 1990-01-22
ZA895588B (en) 1990-07-25
IT1231434B (it) 1991-12-04
FI893520A (fi) 1990-01-22
DE3924207C2 (fi) 1992-07-09
DK362189A (da) 1990-01-22
NO175287B (no) 1994-06-20
SE8902588L (sv) 1990-01-22
IL91069A (en) 1993-07-08
AU614862B2 (en) 1991-09-12

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20090720