GB0412769D0 - Organic compounds - Google Patents

Organic compounds

Info

Publication number
GB0412769D0
GB0412769D0 GBGB0412769.2A GB0412769A GB0412769D0 GB 0412769 D0 GB0412769 D0 GB 0412769D0 GB 0412769 A GB0412769 A GB 0412769A GB 0412769 D0 GB0412769 D0 GB 0412769D0
Authority
GB
United Kingdom
Prior art keywords
organic compounds
salt form
formula
acid addition
present specification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0412769.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32696854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB0412769(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Priority to GBGB0412769.2A priority Critical patent/GB0412769D0/en
Publication of GB0412769D0 publication Critical patent/GB0412769D0/en
Priority to CN200580016187.3A priority patent/CN1956721B/zh
Priority to EP05750584A priority patent/EP1755606B2/en
Priority to NZ551630A priority patent/NZ551630A/en
Priority to CA2567821A priority patent/CA2567821C/en
Priority to KR1020107019024A priority patent/KR20100101017A/ko
Priority to RU2006146632/04A priority patent/RU2396261C2/ru
Priority to SG200903909-0A priority patent/SG153811A1/en
Priority to MXPA06014249A priority patent/MXPA06014249A/es
Priority to HK07107754.4A priority patent/HK1105577C/en
Priority to DK05750584.4T priority patent/DK1755606T4/da
Priority to JP2007526311A priority patent/JP4703650B2/ja
Priority to HR20070577T priority patent/HRP20070577T4/hr
Priority to US11/569,802 priority patent/US7960399B2/en
Priority to KR1020067025788A priority patent/KR101018607B1/ko
Priority to BRPI0511933A priority patent/BRPI0511933B8/pt
Priority to PT05750584T priority patent/PT1755606E/pt
Priority to ES05750584T priority patent/ES2293584T5/es
Priority to SI200530141T priority patent/SI1755606T2/sl
Priority to RU2010112450/04A priority patent/RU2449995C2/ru
Priority to AU2005251476A priority patent/AU2005251476C1/en
Priority to AT05750584T priority patent/ATE376833T1/de
Priority to DE602005003128T priority patent/DE602005003128T3/de
Priority to PL05750584T priority patent/PL1755606T5/pl
Priority to PCT/EP2005/006253 priority patent/WO2005120510A1/en
Priority to ZA200609634A priority patent/ZA200609634B/xx
Priority to IL179532A priority patent/IL179532A/en
Priority to TNP2006000405A priority patent/TNSN06405A1/en
Priority to EC2006007067A priority patent/ECSP067067A/es
Priority to MA29565A priority patent/MA28685B1/fr
Priority to NO20070122A priority patent/NO338181B1/no
Priority to CY20081100014T priority patent/CY1107846T1/el
Priority to AU2009233684A priority patent/AU2009233684A1/en
Priority to JP2011010997A priority patent/JP5400812B2/ja
Priority to US13/089,943 priority patent/US8211902B2/en
Priority to ECSP12007067 priority patent/ECSP12007067A/es
Priority to US13/434,248 priority patent/US8809528B2/en
Priority to US14/322,165 priority patent/US9102653B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cereal-Derived Products (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB0412769.2A 2004-06-08 2004-06-08 Organic compounds Ceased GB0412769D0 (en)

Priority Applications (38)

Application Number Priority Date Filing Date Title
GBGB0412769.2A GB0412769D0 (en) 2004-06-08 2004-06-08 Organic compounds
PL05750584T PL1755606T5 (pl) 2004-06-08 2005-06-08 Pochodne chinazolinonu użyteczne jako antagoniści receptora waniloidowego
PCT/EP2005/006253 WO2005120510A1 (en) 2004-06-08 2005-06-08 Quinazolinone derivatives useful as vanilloid antagonists
ES05750584T ES2293584T5 (es) 2004-06-08 2005-06-08 Derivados de quinazolinona útiles como antagonistas de vaniloide.
RU2010112450/04A RU2449995C2 (ru) 2004-06-08 2005-06-08 Производные хиназолинона, полезные в качестве ванилоидных антагонистов
NZ551630A NZ551630A (en) 2004-06-08 2005-06-08 Quinazolinone derivatives useful as vanilloid antagonists
CA2567821A CA2567821C (en) 2004-06-08 2005-06-08 Quinazolinone derivatives useful as vanilloid antagonists
KR1020107019024A KR20100101017A (ko) 2004-06-08 2005-06-08 바닐로이드 길항제로서 유용한 퀴나졸리논 유도체
RU2006146632/04A RU2396261C2 (ru) 2004-06-08 2005-06-08 Производные хиназолинона, полезные в качестве ванилоидных антагонистов
SG200903909-0A SG153811A1 (en) 2004-06-08 2005-06-08 Quinazolinone derivatives useful as vanilloid antagonists
MXPA06014249A MXPA06014249A (es) 2004-06-08 2005-06-08 Derivados de quinazolinona utiles como antagonistas vanilloides.
HK07107754.4A HK1105577C (en) 2004-06-08 2005-06-08 Quinazolinone derivatives useful as vanilloid antagonists
AT05750584T ATE376833T1 (de) 2004-06-08 2005-06-08 Chinazolinon-derivate als vanilloid-antagonisten
JP2007526311A JP4703650B2 (ja) 2004-06-08 2005-06-08 バニロイドアンタゴニストとして有用なキナゾリノン誘導体
HR20070577T HRP20070577T4 (hr) 2004-06-08 2005-06-08 Derivati kinazolinona koji se mogu upotrijebiti kao antagonisti vaniloida
US11/569,802 US7960399B2 (en) 2004-06-08 2005-06-08 Quinazolinone derivatives useful as vanilloid antagonists
KR1020067025788A KR101018607B1 (ko) 2004-06-08 2005-06-08 바닐로이드 길항제로서 유용한 퀴나졸리논 유도체
BRPI0511933A BRPI0511933B8 (pt) 2004-06-08 2005-06-08 derivados de quinazolinona, seu uso e seu processo de preparação, e composição farmacêutica
PT05750584T PT1755606E (pt) 2004-06-08 2005-06-08 Derivados de quinazolinona úteis como antagonistas de vanilóide
CN200580016187.3A CN1956721B (zh) 2004-06-08 2005-06-08 用作辣椒素拮抗剂的喹唑啉酮衍生物
SI200530141T SI1755606T2 (sl) 2004-06-08 2005-06-08 Derivati kinazolinona, ki so uporabni kot antagonisti vaniloidnih receptorjev
AU2005251476A AU2005251476C1 (en) 2004-06-08 2005-06-08 Quinazolinone derivatives useful as vanilloid antagonists
EP05750584A EP1755606B2 (en) 2004-06-08 2005-06-08 Quinazolinone derivatives useful as vanilloid antagonists
DK05750584.4T DK1755606T4 (da) 2004-06-08 2005-06-08 Quinazolinonderivater, der er anvendelige som vanilloid-antagonister
DE602005003128T DE602005003128T3 (de) 2004-06-08 2005-06-08 Chinazolinon-derivate als vanilloid-antagonisten
ZA200609634A ZA200609634B (en) 2004-06-08 2006-11-20 Quinazolinone derivatives useful as vanilloid antagonists
IL179532A IL179532A (en) 2004-06-08 2006-11-23 Derivatives of quinazolinone, pharmacological preparations that contain them and their use in the preparation of drugs for the treatment of pain or gastrointestinal disorder
EC2006007067A ECSP067067A (es) 2004-06-08 2006-12-07 Derivados de quinazolinona útiles como antagonistas vanilloides
TNP2006000405A TNSN06405A1 (en) 2004-06-08 2006-12-07 Quinazolinone derivatives useful as vanilloid antagonistes
MA29565A MA28685B1 (fr) 2004-06-08 2006-12-28 Derives de la quinazolinone, antagonistes de la vanilloide
NO20070122A NO338181B1 (no) 2004-06-08 2007-01-08 Kinazolinderivat og farmasøytisk sammensetning omfattende dette
CY20081100014T CY1107846T1 (el) 2004-06-08 2008-01-03 Παραγωγα κιναζολινονης χρησιμα ως βανιλλοειδεις ανταγωνιστες
AU2009233684A AU2009233684A1 (en) 2004-06-08 2009-11-06 Quinazolinone derivatives useful as vanilloid antagonists
JP2011010997A JP5400812B2 (ja) 2004-06-08 2011-01-21 バニロイドアンタゴニストとして有用なキナゾリノン誘導体
US13/089,943 US8211902B2 (en) 2004-06-08 2011-04-19 Quinazolinone derivatives useful as vanilloid antagonists
ECSP12007067 ECSP12007067A (es) 2004-06-08 2012-02-14 Derivados de quinazolinona útiles como antagonistas vanilloides
US13/434,248 US8809528B2 (en) 2004-06-08 2012-03-29 Quinazolinone derivatives useful as vanilloid antagonists
US14/322,165 US9102653B2 (en) 2004-06-08 2014-07-02 Substituted quinazolinones as vanilloid antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0412769.2A GB0412769D0 (en) 2004-06-08 2004-06-08 Organic compounds

Publications (1)

Publication Number Publication Date
GB0412769D0 true GB0412769D0 (en) 2004-07-07

Family

ID=32696854

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0412769.2A Ceased GB0412769D0 (en) 2004-06-08 2004-06-08 Organic compounds

Country Status (29)

Country Link
US (4) US7960399B2 (https=)
EP (1) EP1755606B2 (https=)
JP (2) JP4703650B2 (https=)
KR (2) KR20100101017A (https=)
CN (1) CN1956721B (https=)
AT (1) ATE376833T1 (https=)
AU (2) AU2005251476C1 (https=)
BR (1) BRPI0511933B8 (https=)
CA (1) CA2567821C (https=)
CY (1) CY1107846T1 (https=)
DE (1) DE602005003128T3 (https=)
DK (1) DK1755606T4 (https=)
EC (2) ECSP067067A (https=)
ES (1) ES2293584T5 (https=)
GB (1) GB0412769D0 (https=)
HR (1) HRP20070577T4 (https=)
IL (1) IL179532A (https=)
MA (1) MA28685B1 (https=)
MX (1) MXPA06014249A (https=)
NO (1) NO338181B1 (https=)
NZ (1) NZ551630A (https=)
PL (1) PL1755606T5 (https=)
PT (1) PT1755606E (https=)
RU (2) RU2449995C2 (https=)
SG (1) SG153811A1 (https=)
SI (1) SI1755606T2 (https=)
TN (1) TNSN06405A1 (https=)
WO (1) WO2005120510A1 (https=)
ZA (1) ZA200609634B (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
CA2660957C (en) 2006-08-23 2016-10-11 Neurogen Corporation 2-phenoxy pyrimidinone analogues
CA2668579A1 (en) * 2006-11-06 2008-06-05 Neurogen Corporation Cis-cyclohexyl substituted pyrimidinone derivatives
KR20100039410A (ko) * 2007-07-18 2010-04-15 노파르티스 아게 Ｖｒ－１ 길항제 및 ｃｏｘ－２ 억제제의 상승적 조합물
US8915362B2 (en) 2008-10-08 2014-12-23 Ultimed, Inc. Sharps container
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
UY34094A (es) 2011-05-27 2013-01-03 Novartis Ag Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
CA2867043A1 (en) 2012-05-03 2013-11-07 Novartis Ag L-malate salt of 2,7-diaza-spiro[4.5]dec-7-yle derivatives and crystalline forms thereof as ghrelin receptor agonists
JP2016510749A (ja) 2013-03-05 2016-04-11 ユニヴァーシティー オブ ノートル ダム デュ ラック キナゾリノン抗生物質
US10016425B2 (en) 2016-11-03 2018-07-10 King Saud University Anti-ulcerative colitis compound
US11203591B2 (en) 2018-10-31 2021-12-21 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
KR20210129677A (ko) * 2019-02-15 2021-10-28 노파르티스 아게 안구 표면 통증의 치료 방법
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤
EP4431497A1 (en) 2019-02-15 2024-09-18 Bausch + Lomb Ireland Limited Crystalline forms of 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrile and formulations thereof
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе
WO2022029656A1 (en) 2020-08-06 2022-02-10 Novartis Ag Crystalline forms of 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrile and formulations thereof
WO2022105792A1 (zh) * 2020-11-17 2022-05-27 苏州晶云药物科技股份有限公司 一种喹唑啉酮衍生物的新晶型及其制备方法
UY39681A (es) 2021-03-26 2022-10-31 Novartis Ag Derivados de ciclobutilo 1,3–sustituidos y sus usos
JP2025531367A (ja) 2022-09-21 2025-09-19 ボシュ ＋ ロム アイルランド リミテッド Ｔｒｐｖ１アンタゴニストの結晶多形形態およびその製剤
KR20250030194A (ko) 2023-08-24 2025-03-05 코웨이 주식회사 출수 장치

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US82365A (en) * 1868-09-22 thompson
US49728A (en) * 1865-09-05 Improvement
US95650A (en) * 1869-10-12 Improvement in machines for bending sheet-metal for cornices
US220227A (en) * 1879-10-07 Improvement in stri klng-movements for clocks
DE239090C (https=) 1906-11-01
US2749344A (en) * 1953-01-02 1956-06-05 Burroughs Wellcome Co Pyrimidine compounds
DE1224316B (de) 1961-03-18 1966-09-08 Beiersdorf & Co Ag P Verfahren zur Herstellung von 2-Methyl-3-(o-aethylphenyl)-4-oxo-3, 4-dihydrochinazolin und dessen Salzen
US3515787A (en) * 1962-06-27 1970-06-02 Squibb & Sons Inc Compositions and methods for producing a muscle relaxing effect in an animal with 2,3 - substituted - 6 - amino-4-quinazolones
DE1232152B (de) 1962-06-27 1967-01-12 Heyden Chem Fab Verfahren zur Herstellung von 3-Phenylchinazolinon-(4)-derivaten
GB1003802A (en) 1963-06-04 1965-09-08 Searle & Co Pyrimidinone derivatives
DE1280874B (de) 1963-10-09 1968-10-24 Boehringer Sohn Ingelheim 2-Methyl-3-(2-dimethylaminophenyl)-8-amino-3H-chinazolon-(4)
US3317388A (en) * 1964-11-20 1967-05-02 Wallace & Tiernan Inc Methods for treating pain
US3864362A (en) * 1970-05-27 1975-02-04 Chinoin Gyogyszer Es Vegyeszet Iso flavones
BE793594A (fr) * 1972-01-03 1973-07-02 Pfizer Nouvelles 6,7-dimethoxyquinazolines utiles comme analgesiques et tranquillisants
GB1495305A (en) 1975-09-12 1977-12-14 Pfizer Ltd 3-phenyl-4-oxo-4h-benzopyran derivatives
US4501755A (en) * 1981-05-01 1985-02-26 Pennwalt Corporation Isoflavones useful as anti-inflammatory agents
JPS59128376A (ja) * 1983-01-13 1984-07-24 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
SU1262927A1 (ru) 1985-01-09 1997-11-20 Институт физико-органической химии и углехимии АН УССР Способ получения 6-бром-5-метилимидазо(4,5-в)пиридина
JPS62201882A (ja) * 1985-11-18 1987-09-05 Yamanouchi Pharmaceut Co Ltd イソフラボン誘導体
JPS62193605A (ja) 1986-02-20 1987-08-25 Toray Ind Inc 半透性複合膜の製造方法
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
WO1992013535A1 (en) * 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Anticonvulsant substituted quinazolones
US5958930A (en) * 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US5284853A (en) * 1993-04-23 1994-02-08 American Cyanamid Company Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
US5294617A (en) * 1993-04-23 1994-03-15 American Cyanamid Company Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
EP0635263A3 (en) * 1993-06-28 1995-09-27 American Cyanamid Co Angiotensin II antagonists (AII) as inhibitors of the growth of adipose tissue.
HUT68558A (en) 1993-07-20 1995-06-28 Chinoin Gyogyszer Es Vegyeszet Method for preparing isoflavon derivatives
EP0743855A1 (en) 1994-01-03 1996-11-27 Acea Pharmaceuticals, Inc. 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor
JPH07258224A (ja) 1994-03-24 1995-10-09 Dai Ichi Seiyaku Co Ltd 二環性化合物
US5756502A (en) * 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
RU2164224C2 (ru) * 1995-03-14 2001-03-20 Новартис Аг Трехзамещенные фенильные производные и фармацевтическая композиция
US5783577A (en) 1995-09-15 1998-07-21 Trega Biosciences, Inc. Synthesis of quinazolinone libraries and derivatives thereof
WO1997028118A1 (en) 1996-02-05 1997-08-07 Hoechst Celanese Corporation Process for preparing anthranilic acids
WO1997044041A1 (en) 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
FR2750862B1 (fr) 1996-07-12 1998-10-16 Dupin Jean Pierre Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques
WO1998018781A2 (en) 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
IT1289154B1 (it) 1997-01-03 1998-09-29 Chiesi Farma Spa Derivati di isoflavone loro preparazione e loro impiego terapeutico
JPH10259176A (ja) 1997-03-17 1998-09-29 Japan Tobacco Inc 血管新生阻害作用を有する新規アミド誘導体及びその用途
US5948775A (en) 1997-03-19 1999-09-07 American Home Products Corporation 2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones
WO1999009140A1 (en) * 1997-08-20 1999-02-25 The Regents Of The University Of California Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof
CA2309903C (en) 1998-01-22 2012-03-27 The Regents Of The University Of California Nucleic acid sequences encoding capsaicin receptor
SK12752000A3 (sk) 1998-02-25 2001-03-12 Genetics Institute, Inc. Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie
US6500853B1 (en) * 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
WO2000050387A1 (en) * 1999-02-22 2000-08-31 Pacific Corporation Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
GB9920912D0 (en) 1999-09-03 1999-11-10 Indena Spa Novel derivatives of flavones,xanthones and coumarins
AU4742101A (en) 2000-03-17 2001-10-03 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP1301484A2 (en) * 2000-07-20 2003-04-16 Neurogen Corporation Capsaicin receptor ligands
CA2417507A1 (en) * 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
FR2815033B1 (fr) 2000-10-06 2003-09-05 Negma Lab Derives de 7-carboxy-flavones, porcede pour leur preparation et leur application en therapeutique
NZ526622A (en) 2000-12-11 2006-07-28 Amgen Sf Llc CXCR3 antagonists
PL363907A1 (en) 2001-03-26 2004-11-29 Novartis Ag Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain.
WO2003014064A1 (en) * 2001-07-31 2003-02-20 Bayer Healthcare Ag Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists
GB0128499D0 (en) 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
IL147416A (en) * 2001-12-31 2008-11-26 Israel State Combined modalities for improved cancer treatment
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7381730B2 (en) 2002-03-15 2008-06-03 Bristol-Myers Squibb Company 3-arylquinazoline derivatives as selective estrogen receptor beta modulators
TW200401770A (en) † 2002-06-18 2004-02-01 Sankyo Co Fused-ring pyrimidin-4(3H)-one derivatives, processes for the preparation and uses thereof
EP1560816A1 (en) 2002-07-05 2005-08-10 F. Hoffmann-La Roche Ag Quinazoline derivatives
EP1398032A1 (en) 2002-09-10 2004-03-17 PheneX Pharmaceuticals AG 4-Oxo-quinazolines as LXR nuclear receptor binding compounds
GB0223730D0 (en) * 2002-10-11 2002-11-20 Novartis Ag Organic compounds
MXPA05004328A (es) 2002-11-04 2005-08-02 Nps Pharma Inc Compuestos de quinazolinona como calciliticos.
SI1611112T1 (sl) 2003-02-11 2012-12-31 Vernalis (R&D) Limited Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
JPWO2004078719A1 (ja) 2003-03-06 2006-06-08 小野薬品工業株式会社 インドール誘導体化合物およびその化合物を有効成分とする薬剤
JP2006193426A (ja) 2003-09-05 2006-07-27 Sankyo Co Ltd 置換された縮環ピリミジン−４（３ｈ）−オン化合物
WO2005040112A1 (en) 2003-10-14 2005-05-06 Oxagen Limited Compounds with pgd2 antagonist activity
CA2545725A1 (en) 2003-11-14 2005-06-02 Merck Sharp & Dohme Limited Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1)
RU2358969C2 (ru) 2004-02-13 2009-06-20 Баниу Фармасьютикал Ко., Лтд. Конденсированное 4-оксопиримидиновое производное
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
GB0412768D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
US20090298856A1 (en) 2005-05-11 2009-12-03 Rebecca Elizabeth Brown 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1)
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
KR20100039410A (ko) 2007-07-18 2010-04-15 노파르티스 아게 Ｖｒ－１ 길항제 및 ｃｏｘ－２ 억제제의 상승적 조합물
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists

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