FR2835186B1 - Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases - Google Patents

Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

Info

Publication number
FR2835186B1
FR2835186B1 FR0200951A FR0200951A FR2835186B1 FR 2835186 B1 FR2835186 B1 FR 2835186B1 FR 0200951 A FR0200951 A FR 0200951A FR 0200951 A FR0200951 A FR 0200951A FR 2835186 B1 FR2835186 B1 FR 2835186B1
Authority
FR
France
Prior art keywords
beta
heterocyclic compounds
novel heterocyclic
compounds active
lactamases inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0200951A
Other languages
English (en)
French (fr)
Other versions
FR2835186A1 (fr
Inventor
Jozsef Aszodi
Maxime Lampilas
Claude Fromentin
David Alan Rowlands
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ireland Pharmaceuticals
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27619669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2835186(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to FR0200951A priority Critical patent/FR2835186B1/fr
Priority to JO2002138A priority patent/JO2646B1/en
Priority to TW092101133A priority patent/TWI293071B/zh
Priority to EP10177533A priority patent/EP2279737B1/fr
Priority to PL371601A priority patent/PL220725B1/pl
Priority to PE2003000080A priority patent/PE20030969A1/es
Priority to CNA2008101667591A priority patent/CN101406471A/zh
Priority to SI200331935T priority patent/SI1480644T1/sl
Priority to CNB038028786A priority patent/CN100482225C/zh
Priority to NZ533936A priority patent/NZ533936A/en
Priority to PCT/FR2003/000243 priority patent/WO2003063864A2/fr
Priority to AU2003214335A priority patent/AU2003214335B2/en
Priority to MYPI20030260A priority patent/MY140638A/en
Priority to EP03709903A priority patent/EP1480644B1/fr
Priority to CNB2007100015952A priority patent/CN100563653C/zh
Priority to BRPI0307267A priority patent/BRPI0307267B8/pt
Priority to KR1020047011594A priority patent/KR100979079B1/ko
Priority to BR122015020406A priority patent/BR122015020406B8/pt
Priority to OA1200400200A priority patent/OA12761A/fr
Priority to UY27626A priority patent/UY27626A1/es
Priority to SI200332240T priority patent/SI2279737T1/sl
Priority to AT03709903T priority patent/ATE484281T1/de
Priority to ES10177533T priority patent/ES2401855T3/es
Priority to HK05109272.5A priority patent/HK1077205B/xx
Priority to HRP20040686AA priority patent/HRP20040686B1/hr
Priority to EA200400981A priority patent/EA007220B1/ru
Priority to PT101775336T priority patent/PT2279737E/pt
Priority to DK10177533.6T priority patent/DK2279737T3/da
Priority to MXPA04006621A priority patent/MXPA04006621A/es
Priority to JP2003563554A priority patent/JP4472346B2/ja
Priority to ARP030100226A priority patent/AR038234A1/es
Priority to ES03709903T priority patent/ES2356813T3/es
Priority to PT03709903T priority patent/PT1480644E/pt
Priority to PY200300301561A priority patent/PY0301561A/es
Priority to CA2474043A priority patent/CA2474043C/fr
Priority to UA20040807144A priority patent/UA80271C2/uk
Priority to DE60334527T priority patent/DE60334527D1/de
Priority to DK03709903.3T priority patent/DK1480644T3/da
Priority to YU65804A priority patent/RS52137B/sr
Publication of FR2835186A1 publication Critical patent/FR2835186A1/fr
Priority to MA27777A priority patent/MA26351A1/fr
Priority to CR7387A priority patent/CR7387A/es
Priority to ZA2004/05607A priority patent/ZA200405607B/en
Priority to EC2004005193A priority patent/ECSP045193A/es
Priority to IL163167A priority patent/IL163167A/en
Priority to TNP2004000137A priority patent/TNSN04137A1/fr
Priority to CO04071440A priority patent/CO5601014A2/es
Priority to US10/898,754 priority patent/US7612087B2/en
Priority to NO20043587A priority patent/NO335195B1/no
Application granted granted Critical
Publication of FR2835186B1 publication Critical patent/FR2835186B1/fr
Priority to HK07111190.8A priority patent/HK1105864B/xx
Priority to US12/434,270 priority patent/US20090215747A1/en
Priority to US12/610,562 priority patent/US20100048528A1/en
Priority to CY20101101192T priority patent/CY1111061T1/el
Priority to CL2011000009A priority patent/CL2011000009A1/es
Priority to US13/161,783 priority patent/US20110245254A1/en
Priority to CR20120356A priority patent/CR20120356A/es
Priority to CY20131100090T priority patent/CY1114417T1/el
Priority to ARP150101838A priority patent/AR100790A2/es
Priority to CY2016042C priority patent/CY2016042I2/el
Priority to NL300847C priority patent/NL300847I2/nl
Priority to BE2016C069C priority patent/BE2016C069I2/fr
Priority to HUS1600055C priority patent/HUS1600055I1/hu
Priority to LTPA2016037C priority patent/LTC1480644I2/lt
Priority to FR16C1019C priority patent/FR16C1019I2/fr
Priority to NO2016024C priority patent/NO2016024I2/no
Anticipated expiration legal-status Critical
Priority to NO2025027C priority patent/NO2025027I1/no
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0200951A 2002-01-28 2002-01-28 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases Expired - Lifetime FR2835186B1 (fr)

Priority Applications (65)

Application Number Priority Date Filing Date Title
FR0200951A FR2835186B1 (fr) 2002-01-28 2002-01-28 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
JO2002138A JO2646B1 (en) 2002-01-28 2002-12-29 New differentiated cyclic compounds as beta - lactam inhibitors
TW092101133A TWI293071B (en) 2002-01-28 2003-01-20 New heterocyclic compounds, which are active as inhibitors of beta-lactamases
EP10177533A EP2279737B1 (fr) 2002-01-28 2003-01-27 Composés hétérocycliques, actifs comme inhibiteurs de béta-lactamases
PL371601A PL220725B1 (pl) 2002-01-28 2003-01-27 Zastosowanie związków heterocyklicznych aktywnych jako inhibitor β-laktamazy do wytwarzania leku do leczenia infekcji bakteryjnych u człowieka lub zwierząt, oraz zawierająca je kompozycja farmaceutyczna
PE2003000080A PE20030969A1 (es) 2002-01-28 2003-01-27 Compuestos heterociclicos, activos inhibidores de beta-lactamasas
CNA2008101667591A CN101406471A (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物
SI200331935T SI1480644T1 (sl) 2002-01-28 2003-01-27 Heterociklične spojine, učinkovite kot inhibitorji beta-laktamaz
CNB038028786A CN100482225C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物
NZ533936A NZ533936A (en) 2002-01-28 2003-01-27 Novel heterocyclic compounds, which are active as inhibitors of beta-lactamases
PCT/FR2003/000243 WO2003063864A2 (fr) 2002-01-28 2003-01-27 Composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
AU2003214335A AU2003214335B2 (en) 2002-01-28 2003-01-27 Heterocyclic compounds which are active as inhibitors of beta lactamases
MYPI20030260A MY140638A (en) 2002-01-28 2003-01-27 New heterocyclic compounds, which are active as inhibitors of beta-lactamases
EP03709903A EP1480644B1 (fr) 2002-01-28 2003-01-27 Composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
CNB2007100015952A CN100563653C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的杂环化合物
BRPI0307267A BRPI0307267B8 (pt) 2002-01-28 2003-01-27 uso de compostos inibidores de beta-lactamases e composições farmacêuticas para terapia antibacteriana
KR1020047011594A KR100979079B1 (ko) 2002-01-28 2003-01-27 베타 락타마제의 억제제로서 활성인 헤테로사이클릭 화합물을 함유하는 약제학적 조성물
BR122015020406A BR122015020406B8 (pt) 2002-01-28 2003-01-27 uso de compostos de formula i como inibidores de beta-lactamases e composições farmaceuticas
OA1200400200A OA12761A (fr) 2002-01-28 2003-01-27 Nouveaux composés héterocycliques, actifs comme inhibiteurs de béta-lactamases.
UY27626A UY27626A1 (es) 2002-01-28 2003-01-27 Nuevos compuestos heterocíclos, activos como inhibidores de beta-lactamasas
SI200332240T SI2279737T1 (sl) 2002-01-28 2003-01-27 Heterociklične spojine, učinkovite kot inhibitorji beta-laktamaz
AT03709903T ATE484281T1 (de) 2002-01-28 2003-01-27 Heterocyclische verbindungen die als beta- lactamasehemmer aktiv sind
ES10177533T ES2401855T3 (es) 2002-01-28 2003-01-27 Compuestos heterocíclicos, activos como inhibidores de beta-lactamasas
HK05109272.5A HK1077205B (en) 2002-01-28 2003-01-27 Novel heterocyclic compounds which are active as inhibitors of beta+lactamases
HRP20040686AA HRP20040686B1 (hr) 2002-01-28 2003-01-27 Novi heterocikliäśki spojevi koji djeluju kao inhibitori beta-laktamaza
EA200400981A EA007220B1 (ru) 2002-01-28 2003-01-27 Новое применение гетероциклических соединений, активных в качестве ингибиторов бета-лактамаз, и содержащие их фармацевтические композиции
PT101775336T PT2279737E (pt) 2002-01-28 2003-01-27 Compostos heterocíclicos, activos como inibidores de beta-lactamases
DK10177533.6T DK2279737T3 (da) 2002-01-28 2003-01-27 Heterocycliske forbindelser, der er aktive som beta-lactamaseinhibitorer
MXPA04006621A MXPA04006621A (es) 2002-01-28 2003-01-27 Nuevos compuestos heterociclicos, activos como inhibidores de beta-lactamasas.
JP2003563554A JP4472346B2 (ja) 2002-01-28 2003-01-27 ベータ−ラクタマーゼの阻害剤として活性である新規な複素環化合物
ARP030100226A AR038234A1 (es) 2002-01-28 2003-01-27 Compuestos heterociclicos, activos como inhibidores de beta-lactamasas
ES03709903T ES2356813T3 (es) 2002-01-28 2003-01-27 Nuevos compuestos heterocíclicos, activos como inhibidores de beta-lactamasas.
PT03709903T PT1480644E (pt) 2002-01-28 2003-01-27 Compostos heterociclícos, activos como inibidores de beta-lactamases
PY200300301561A PY0301561A (es) 2002-01-28 2003-01-27 Compuestos heterociclicos, inhibidores de beta-lactamasas
CA2474043A CA2474043C (fr) 2002-01-28 2003-01-27 Composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
UA20040807144A UA80271C2 (uk) 2002-01-28 2003-01-27 Застосування гетероциклічних сполук як інгібіторів бета-лактамази
DE60334527T DE60334527D1 (de) 2002-01-28 2003-01-27 Heterocyclische verbindungen die als beta-lactamasehemmer aktiv sind
DK03709903.3T DK1480644T3 (da) 2002-01-28 2003-01-27 Heterocykliske forbindelser, der er aktive som inhibitorer af beta-lactamaser
YU65804A RS52137B (sr) 2002-01-28 2003-01-27 Nova heterociklična jedinjenja aktivna kao inhibitori beta-laktamaze
MA27777A MA26351A1 (fr) 2002-01-28 2004-07-12 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta+lactamases
CR7387A CR7387A (es) 2002-01-28 2004-07-13 Nuevos compuestos heterociclicos activos como inhibidores de las beta- lactamasas
ZA2004/05607A ZA200405607B (en) 2002-01-28 2004-07-14 Heterocyclic compounds which are active as inhibitors of beta-lactamases
EC2004005193A ECSP045193A (es) 2002-01-28 2004-07-15 "nuevos compuestos heterociclicos, activos como inhibidores de beta-lactamasas"
IL163167A IL163167A (en) 2002-01-28 2004-07-22 Heterocyclic compounds which are active as inhibitors of beta lactamases
TNP2004000137A TNSN04137A1 (fr) 2002-01-28 2004-07-23 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
CO04071440A CO5601014A2 (es) 2002-01-28 2004-07-26 Nuevos compuestos heterociclicos, activos como inhibidores de beta-lactamasas
US10/898,754 US7612087B2 (en) 2002-01-28 2004-07-26 Heterocyclic compounds as inhibitors of beta-lactamases
NO20043587A NO335195B1 (no) 2002-01-28 2004-08-27 Anvendelse av heterocykliske forbindelser som er aktive som inhibitorer av betalaktamaser samt farmasøytisk blanding derav.
HK07111190.8A HK1105864B (en) 2002-01-28 2007-10-17 Heterocyclic compounds which are active as inhibitors of beta-lactamases
US12/434,270 US20090215747A1 (en) 2002-01-28 2009-05-01 Heterocyclic compounds as inhibitors of beta-lactamases
US12/610,562 US20100048528A1 (en) 2002-01-28 2009-11-02 Heterocyclic compounds as inhibitors of beta-lactamases
CY20101101192T CY1111061T1 (el) 2002-01-28 2010-12-23 Νεες ετεροκυκλικες ενωσεις δραστικες ως αναστολεις των βητα-λακταμασων
CL2011000009A CL2011000009A1 (es) 2002-01-28 2011-01-05 Composicion farmaceutica que comprende un compuesto derivado de (diaza)- u (oxa-aza)-biciclo-octano en combinacion con un antibiotico de beta-lactamina; y el uso de la composicion para inhibir la produccion de beta-lactamasa en una terapia antibacteriana. (divisional de la solicitud 134-2003)
US13/161,783 US20110245254A1 (en) 2002-01-28 2011-06-16 Heterocyclic compounds as inhibitors of beta-lactamases
CR20120356A CR20120356A (es) 2002-01-28 2012-06-28 Nuevos compuestos heterocíclicos activos como inhibidores de beta-lactamasas
CY20131100090T CY1114417T1 (el) 2002-01-28 2013-01-31 Ετεροκυκλικες ενωσεις, δραστικες ως αναστολεις των βητα-λακταμασων
ARP150101838A AR100790A2 (es) 2002-01-28 2015-06-10 COMPUESTOS HETEROCÍCLICOS, ACTIVOS COMO INHIBIDORES DE b-LACTAMAS
CY2016042C CY2016042I2 (el) 2002-01-28 2016-12-06 Νεες ετεροκυκλικες ενωσεις δραστικες ως αναστολεις των βητα-λακταμασων
NL300847C NL300847I2 (enExample) 2002-01-28 2016-12-08
BE2016C069C BE2016C069I2 (enExample) 2002-01-28 2016-12-12
HUS1600055C HUS1600055I1 (hu) 2002-01-28 2016-12-13 Béta-laktamáz-inhibitor aktivitással rendelkezõ új heterociklusos vegyületek
LTPA2016037C LTC1480644I2 (lt) 2002-01-28 2016-12-13 Nauji heterocikliniai junginiai, veiksmingi kaip beta-laktamazės slopikliai
FR16C1019C FR16C1019I2 (fr) 2002-01-28 2016-12-13 Composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
NO2016024C NO2016024I2 (no) 2002-01-28 2016-12-15 Farmasøytisk blanding eller assosisjon som inneholder som aktive ingredienser: (1) ceftazidim eller et salt derav, og (2) avibaktam eller et farmasøytisk akseptabelt salt derav
NO2025027C NO2025027I1 (no) 2002-01-28 2025-06-13 Pharmaceutical mixture or association that includes as active ingredients: (1) ceftazidime or a salt thereof, and (2) avibactam or a pharmaceutically acceptable salt thereof - forlenget.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0200951A FR2835186B1 (fr) 2002-01-28 2002-01-28 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

Publications (2)

Publication Number Publication Date
FR2835186A1 FR2835186A1 (fr) 2003-08-01
FR2835186B1 true FR2835186B1 (fr) 2006-10-20

Family

ID=27619669

Family Applications (2)

Application Number Title Priority Date Filing Date
FR0200951A Expired - Lifetime FR2835186B1 (fr) 2002-01-28 2002-01-28 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR16C1019C Active FR16C1019I2 (fr) 2002-01-28 2016-12-13 Composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR16C1019C Active FR16C1019I2 (fr) 2002-01-28 2016-12-13 Composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

Country Status (45)

Country Link
US (4) US7612087B2 (enExample)
EP (2) EP1480644B1 (enExample)
JP (1) JP4472346B2 (enExample)
KR (1) KR100979079B1 (enExample)
CN (3) CN100563653C (enExample)
AR (2) AR038234A1 (enExample)
AT (1) ATE484281T1 (enExample)
AU (1) AU2003214335B2 (enExample)
BE (1) BE2016C069I2 (enExample)
BR (1) BRPI0307267B8 (enExample)
CA (1) CA2474043C (enExample)
CL (1) CL2011000009A1 (enExample)
CO (1) CO5601014A2 (enExample)
CR (2) CR7387A (enExample)
CY (3) CY1111061T1 (enExample)
DE (1) DE60334527D1 (enExample)
DK (2) DK1480644T3 (enExample)
EA (1) EA007220B1 (enExample)
EC (1) ECSP045193A (enExample)
ES (2) ES2356813T3 (enExample)
FR (2) FR2835186B1 (enExample)
HR (1) HRP20040686B1 (enExample)
HU (1) HUS1600055I1 (enExample)
IL (1) IL163167A (enExample)
JO (1) JO2646B1 (enExample)
LT (1) LTC1480644I2 (enExample)
MA (1) MA26351A1 (enExample)
MX (1) MXPA04006621A (enExample)
MY (1) MY140638A (enExample)
NL (1) NL300847I2 (enExample)
NO (3) NO335195B1 (enExample)
NZ (1) NZ533936A (enExample)
OA (1) OA12761A (enExample)
PE (1) PE20030969A1 (enExample)
PL (1) PL220725B1 (enExample)
PT (2) PT1480644E (enExample)
PY (1) PY0301561A (enExample)
RS (1) RS52137B (enExample)
SI (2) SI1480644T1 (enExample)
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