CN100563653C - 具有β-内酰胺酶抑制剂活性的杂环化合物 - Google Patents

具有β-内酰胺酶抑制剂活性的杂环化合物 Download PDF

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Publication number
CN100563653C
CN100563653C CNB2007100015952A CN200710001595A CN100563653C CN 100563653 C CN100563653 C CN 100563653C CN B2007100015952 A CNB2007100015952 A CN B2007100015952A CN 200710001595 A CN200710001595 A CN 200710001595A CN 100563653 C CN100563653 C CN 100563653C
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Prior art keywords
oxo
octane
diazabicyclo
oxygen base
dichloromethane
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Expired - Lifetime
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CNB2007100015952A
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Chinese (zh)
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CN1994301A (zh
Inventor
J·奥索迪
C·弗罗芒坦
M·兰皮拉斯
D·A·罗兰兹
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AstraZeneca SAS
Wyeth Research Ireland Ltd
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Aventis Pharma SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB2007100015952A 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的杂环化合物 Expired - Lifetime CN100563653C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0200951A FR2835186B1 (fr) 2002-01-28 2002-01-28 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR02/00951 2002-01-28

Related Parent Applications (1)

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CNB038028786A Division CN100482225C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物

Publications (2)

Publication Number Publication Date
CN1994301A CN1994301A (zh) 2007-07-11
CN100563653C true CN100563653C (zh) 2009-12-02

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ID=27619669

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB2007100015952A Expired - Lifetime CN100563653C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的杂环化合物
CNB038028786A Expired - Lifetime CN100482225C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物
CNA2008101667591A Pending CN101406471A (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物

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CNB038028786A Expired - Lifetime CN100482225C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物
CNA2008101667591A Pending CN101406471A (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物

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EP (2) EP2279737B1 (enExample)
JP (1) JP4472346B2 (enExample)
KR (1) KR100979079B1 (enExample)
CN (3) CN100563653C (enExample)
AR (2) AR038234A1 (enExample)
AT (1) ATE484281T1 (enExample)
AU (1) AU2003214335B2 (enExample)
BE (1) BE2016C069I2 (enExample)
BR (1) BRPI0307267B8 (enExample)
CA (1) CA2474043C (enExample)
CL (1) CL2011000009A1 (enExample)
CO (1) CO5601014A2 (enExample)
CR (2) CR7387A (enExample)
CY (3) CY1111061T1 (enExample)
DE (1) DE60334527D1 (enExample)
DK (2) DK2279737T3 (enExample)
EA (1) EA007220B1 (enExample)
EC (1) ECSP045193A (enExample)
ES (2) ES2401855T3 (enExample)
FR (2) FR2835186B1 (enExample)
HR (1) HRP20040686B1 (enExample)
HU (1) HUS1600055I1 (enExample)
IL (1) IL163167A (enExample)
JO (1) JO2646B1 (enExample)
LT (1) LTC1480644I2 (enExample)
MA (1) MA26351A1 (enExample)
MX (1) MXPA04006621A (enExample)
MY (1) MY140638A (enExample)
NL (1) NL300847I2 (enExample)
NO (3) NO335195B1 (enExample)
NZ (1) NZ533936A (enExample)
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PL (1) PL220725B1 (enExample)
PT (2) PT1480644E (enExample)
RS (1) RS52137B (enExample)
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TN (1) TNSN04137A1 (enExample)
TW (1) TWI293071B (enExample)
UA (1) UA80271C2 (enExample)
UY (1) UY27626A1 (enExample)
WO (1) WO2003063864A2 (enExample)
ZA (1) ZA200405607B (enExample)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
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FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
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