FR2786188B1 - Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments - Google Patents
Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicamentsInfo
- Publication number
- FR2786188B1 FR2786188B1 FR9814782A FR9814782A FR2786188B1 FR 2786188 B1 FR2786188 B1 FR 2786188B1 FR 9814782 A FR9814782 A FR 9814782A FR 9814782 A FR9814782 A FR 9814782A FR 2786188 B1 FR2786188 B1 FR 2786188B1
- Authority
- FR
- France
- Prior art keywords
- alkenyl
- alkyl
- alkynyl
- radicals
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- -1 CF3 radicals Chemical class 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9814782A FR2786188B1 (fr) | 1998-11-24 | 1998-11-24 | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
| TW088119939A TWI247747B (en) | 1998-11-24 | 1999-11-16 | New derivatives of erythromycin, their preparation process and their use as medicaments |
| AU59522/99A AU772171B2 (en) | 1998-11-24 | 1999-11-17 | New derivatives of erythromycin, their preparation process and their use as medicaments |
| CA2290136A CA2290136C (fr) | 1998-11-24 | 1999-11-18 | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US09/442,681 US6440941B1 (en) | 1998-11-24 | 1999-11-18 | Derivatives of erythromycin, their preparation process and their use as medicaments |
| ZA9907176A ZA997176B (en) | 1998-11-24 | 1999-11-18 | Derivatives of erythromycin, their preparation process and their use as medicaments. |
| JP11331141A JP2000159790A (ja) | 1998-11-24 | 1999-11-22 | 新規のエリスロマイシン誘導体、それらの製造方法及びそれらの薬剤としての使用 |
| DK99402907T DK1004592T3 (da) | 1998-11-24 | 1999-11-23 | Nye erythromycinderivater, deres fremstilling og deres anvendelse som medikamenter |
| KR1019990052014A KR100587445B1 (ko) | 1998-11-24 | 1999-11-23 | 에리트로마이신의 신규한 유도체, 그의 제조 방법 및약제로서의 그의 용도 |
| NO19995745A NO314729B1 (no) | 1998-11-24 | 1999-11-23 | Nye derivater av erytromycin, fremgangsmåte for fremstilling av disse, medikamenter som inneholder disse, samt nye forbindelser som ermellomprodukter vedfremstillingen av derivatene |
| PT99402907T PT1004592E (pt) | 1998-11-24 | 1999-11-23 | Novos derivados da eritromicina seu processo de preparacao e sua aplicacao como medicamentos |
| AT99402907T ATE245160T1 (de) | 1998-11-24 | 1999-11-23 | Derivate von erythromycin, ihr verfahren zur herstellung, und ihre verwendung als arzneimittel |
| ES99402907T ES2198867T3 (es) | 1998-11-24 | 1999-11-23 | Nuevos derivados de eritromicina, su procedimiento de fabricacion, y su aplicacion como medicamentos. |
| RU99125547A RU2237672C2 (ru) | 1998-11-24 | 1999-11-23 | Новые производные эритромицина, способ их получения и применение в качестве медикаментов |
| MXPA99010813A MXPA99010813A (es) | 1998-11-24 | 1999-11-23 | Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamento. |
| HU9904392A HUP9904392A3 (en) | 1998-11-24 | 1999-11-23 | New derivatives of erythromycin, process for their production and their use as medicament |
| CNB99127394XA CN1165546C (zh) | 1998-11-24 | 1999-11-23 | 红霉素的新衍生物,其制备方法及其制备药物的用途 |
| IL133101A IL133101A (en) | 1998-11-24 | 1999-11-23 | History of erythromycin, the process of preparation and pharmaceutical preparations containing them |
| EP99402907A EP1004592B1 (fr) | 1998-11-24 | 1999-11-23 | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments |
| DE69909577T DE69909577T2 (de) | 1998-11-24 | 1999-11-23 | Derivate von Erythromycin, ihr Verfahren zur Herstellung, und ihre Verwendung als Arzneimittel |
| PL99336736A PL336736A1 (en) | 1998-11-24 | 1999-11-24 | Novel derivatives of erythromycin and method of obtaining them as well as their application as a drug |
| BR9905735-2A BR9905735A (pt) | 1998-11-24 | 1999-11-24 | Derivados da eritromicina, seu processo de preparação e sua aplicação como medicamentos |
| ARP990105985A AR021388A1 (es) | 1998-11-24 | 1999-11-24 | Derivados de la eritromicina, su procedimiento de preparacion y su aplicacion como medicamento |
| TR1999/02888A TR199902888A3 (tr) | 1998-11-24 | 1999-11-24 | Yeni eritromisin türevleri, hazirlanmalari, ilaç olarak kullanimlari. |
| US10/188,394 US6664398B2 (en) | 1998-11-24 | 2002-07-02 | Derivatives of erythromycin, their preparation process and their use as medicaments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9814782A FR2786188B1 (fr) | 1998-11-24 | 1998-11-24 | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2786188A1 FR2786188A1 (fr) | 2000-05-26 |
| FR2786188B1 true FR2786188B1 (fr) | 2002-10-31 |
Family
ID=9533122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9814782A Expired - Fee Related FR2786188B1 (fr) | 1998-11-24 | 1998-11-24 | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6440941B1 (enExample) |
| EP (1) | EP1004592B1 (enExample) |
| JP (1) | JP2000159790A (enExample) |
| KR (1) | KR100587445B1 (enExample) |
| CN (1) | CN1165546C (enExample) |
| AR (1) | AR021388A1 (enExample) |
| AT (1) | ATE245160T1 (enExample) |
| AU (1) | AU772171B2 (enExample) |
| BR (1) | BR9905735A (enExample) |
| CA (1) | CA2290136C (enExample) |
| DE (1) | DE69909577T2 (enExample) |
| DK (1) | DK1004592T3 (enExample) |
| ES (1) | ES2198867T3 (enExample) |
| FR (1) | FR2786188B1 (enExample) |
| HU (1) | HUP9904392A3 (enExample) |
| IL (1) | IL133101A (enExample) |
| MX (1) | MXPA99010813A (enExample) |
| NO (1) | NO314729B1 (enExample) |
| PL (1) | PL336736A1 (enExample) |
| PT (1) | PT1004592E (enExample) |
| RU (1) | RU2237672C2 (enExample) |
| TR (1) | TR199902888A3 (enExample) |
| TW (1) | TWI247747B (enExample) |
| ZA (1) | ZA997176B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
| DK1147121T3 (da) * | 1999-01-27 | 2004-04-13 | Pfizer Prod Inc | Ketolidantibiotika |
| EE200100613A (et) | 1999-05-24 | 2003-02-17 | Pfizer Products Inc. | 13-metüülerütromütsiini derivaadid |
| EP1167376B1 (en) | 2000-06-30 | 2004-07-14 | Pfizer Products Inc. | Macrolide antibiotics |
| US7601695B2 (en) | 2003-03-10 | 2009-10-13 | Optimer Pharmaceuticals, Inc. | Antibacterial agents |
| FR2862647B1 (fr) * | 2003-11-25 | 2008-07-04 | Aventis Pharma Sa | Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant |
| WO2006080954A1 (en) * | 2004-07-28 | 2006-08-03 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
| AU2008316830B2 (en) | 2007-10-25 | 2016-03-17 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| US8552162B2 (en) * | 2008-05-09 | 2013-10-08 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives |
| CN107854477A (zh) | 2008-10-24 | 2018-03-30 | 森普拉制药公司 | 使用含三唑的大环内酯治疗抗性疾病的方法 |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| US9480679B2 (en) | 2009-09-10 | 2016-11-01 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
| HRP20160168T1 (hr) | 2010-03-22 | 2016-03-25 | Cempra Pharmaceuticals Inc | Kristalne forme makrolida i njihova uporaba |
| BR112012029586A2 (pt) | 2010-05-20 | 2016-08-02 | Cempra Pharmaceuticals Inc | processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos |
| KR20130120458A (ko) * | 2010-09-10 | 2013-11-04 | 셈프라 파마슈티컬스, 인크. | 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드 |
| BR112013009823A2 (pt) | 2010-10-22 | 2016-07-05 | Bayer Ip Gmbh | novos compostos heterocíclicos como pesticidas |
| WO2013148891A1 (en) | 2012-03-27 | 2013-10-03 | Cempra Pharmaceuticals, Inc. | Parenteral formulations for administering macrolide antibiotics |
| WO2014152326A1 (en) | 2013-03-14 | 2014-09-25 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| AU2014233240B2 (en) | 2013-03-15 | 2018-08-09 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
| CN106432383A (zh) * | 2016-09-14 | 2017-02-22 | 重庆两江药物研发中心有限公司 | 索利霉素及其中间体的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4182895A (en) * | 1976-12-20 | 1980-01-08 | Sterling Drug Inc. | 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles |
| CA1098527A (en) * | 1976-12-20 | 1981-03-31 | Denis M. Bailey | 1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles |
| JPH04234891A (ja) * | 1990-03-05 | 1992-08-24 | Fujisawa Pharmaceut Co Ltd | 新規セフェム化合物およびその塩 |
| FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| KR20010013660A (ko) * | 1997-06-11 | 2001-02-26 | 실버스타인 아써 에이. | 9-옥심 에리트로마이신 유도체 |
| FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
-
1998
- 1998-11-24 FR FR9814782A patent/FR2786188B1/fr not_active Expired - Fee Related
-
1999
- 1999-11-16 TW TW088119939A patent/TWI247747B/zh not_active IP Right Cessation
- 1999-11-17 AU AU59522/99A patent/AU772171B2/en not_active Expired
- 1999-11-18 ZA ZA9907176A patent/ZA997176B/xx unknown
- 1999-11-18 CA CA2290136A patent/CA2290136C/fr not_active Expired - Lifetime
- 1999-11-18 US US09/442,681 patent/US6440941B1/en not_active Expired - Lifetime
- 1999-11-22 JP JP11331141A patent/JP2000159790A/ja active Pending
- 1999-11-23 IL IL133101A patent/IL133101A/en not_active IP Right Cessation
- 1999-11-23 NO NO19995745A patent/NO314729B1/no unknown
- 1999-11-23 PT PT99402907T patent/PT1004592E/pt unknown
- 1999-11-23 DE DE69909577T patent/DE69909577T2/de not_active Expired - Lifetime
- 1999-11-23 MX MXPA99010813A patent/MXPA99010813A/es active IP Right Grant
- 1999-11-23 CN CNB99127394XA patent/CN1165546C/zh not_active Expired - Lifetime
- 1999-11-23 AT AT99402907T patent/ATE245160T1/de active
- 1999-11-23 KR KR1019990052014A patent/KR100587445B1/ko not_active Expired - Lifetime
- 1999-11-23 HU HU9904392A patent/HUP9904392A3/hu unknown
- 1999-11-23 RU RU99125547A patent/RU2237672C2/ru not_active IP Right Cessation
- 1999-11-23 EP EP99402907A patent/EP1004592B1/fr not_active Expired - Lifetime
- 1999-11-23 DK DK99402907T patent/DK1004592T3/da active
- 1999-11-23 ES ES99402907T patent/ES2198867T3/es not_active Expired - Lifetime
- 1999-11-24 TR TR1999/02888A patent/TR199902888A3/tr unknown
- 1999-11-24 BR BR9905735-2A patent/BR9905735A/pt active Search and Examination
- 1999-11-24 AR ARP990105985A patent/AR021388A1/es not_active Application Discontinuation
- 1999-11-24 PL PL99336736A patent/PL336736A1/xx not_active Application Discontinuation
-
2002
- 2002-07-02 US US10/188,394 patent/US6664398B2/en not_active Expired - Lifetime
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