KR930005972A - N-알킬-3-페닐-3-(2-알킬티오페녹시)프로필아민 - Google Patents

N-알킬-3-페닐-3-(2-알킬티오페녹시)프로필아민 Download PDF

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Publication number
KR930005972A
KR930005972A KR1019920017511A KR920017511A KR930005972A KR 930005972 A KR930005972 A KR 930005972A KR 1019920017511 A KR1019920017511 A KR 1019920017511A KR 920017511 A KR920017511 A KR 920017511A KR 930005972 A KR930005972 A KR 930005972A
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KR
South Korea
Prior art keywords
phenyl
alkyl
propylamine
pharmaceutically acceptable
alkylthiophenoxy
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KR1019920017511A
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English (en)
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KR100221180B1 (ko
Inventor
리챠드 게러트 도날드
웨인 로버트슨 데이비드
타이와이 윙 데이비드
Original Assignee
원본미기재
일라이 릴리 앤드 캄파니
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Publication of KR930005972A publication Critical patent/KR930005972A/ko
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Publication of KR100221180B1 publication Critical patent/KR100221180B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/29—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

Abstract

본 발명은 노르에피네프린 실조와 관련된 신경학적 질환을 치료하기 유용한 N-알킬-3-페닐-3-(2-치환된 페녹시)프로필아민을 제공한다.

Description

N-알킬-3-페닐-3-(2-알킬티오페녹시)프로필아민
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식(Ⅰ)의 화합물 또는 그의 약학적으로 허용가능한 산 부가염:
    상기식에서, X는 C1내지 C4알킬티오이고, Y는 C1내지 C2알킬이다.
  2. N-메틸-3-페닐-3-(2-메틸티오페녹시)프로필아민 또는 그의 약학적으로 허용가능한 산 부가염.
  3. 제1항 또는 제2항에 청구된 바와 같은 화합물 또는 그의 약학적으로 허용가능한 산 부가염을 하나 이상의 약학적으로 허용가능한 담체, 희석제 또는 부형제와 함께 포함하는 약학적 제형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920017511A 1991-09-27 1992-09-25 N-알킬-3-페닐-3-(2-알킬티오페녹시)프로필아민 KR100221180B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/766,993 US5281624A (en) 1991-09-27 1991-09-27 N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof
US766,993 1991-09-27

Publications (2)

Publication Number Publication Date
KR930005972A true KR930005972A (ko) 1993-04-20
KR100221180B1 KR100221180B1 (ko) 1999-09-15

Family

ID=25078150

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920017511A KR100221180B1 (ko) 1991-09-27 1992-09-25 N-알킬-3-페닐-3-(2-알킬티오페녹시)프로필아민

Country Status (23)

Country Link
US (1) US5281624A (ko)
EP (1) EP0534756A3 (ko)
JP (2) JP3256291B2 (ko)
KR (1) KR100221180B1 (ko)
CN (1) CN1033580C (ko)
AT (1) ATE124934T1 (ko)
AU (1) AU655075B2 (ko)
BR (2) BR9203743A (ko)
CA (2) CA2079161C (ko)
CZ (1) CZ281817B6 (ko)
DE (1) DE69203424T2 (ko)
FI (1) FI111250B (ko)
HU (1) HU215519B (ko)
IL (1) IL103277A (ko)
MX (1) MX9205433A (ko)
MY (1) MY108304A (ko)
NO (1) NO178109C (ko)
NZ (1) NZ244460A (ko)
RU (1) RU2057120C1 (ko)
SK (1) SK290892A3 (ko)
TW (1) TW249225B (ko)
YU (1) YU87192A (ko)
ZA (1) ZA927240B (ko)

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Publication number Priority date Publication date Assignee Title
US6017965A (en) * 1993-02-08 2000-01-25 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7087765B2 (en) * 1995-06-07 2006-08-08 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
TW344661B (en) * 1993-11-24 1998-11-11 Lilly Co Eli Pharmaceutical composition for treatment of incontinence
MX9800589A (es) * 1995-07-24 1998-04-30 Lilly Co Eli Tratamiento de desorden de la falta de atencion/hiperactividad.
AU4421697A (en) * 1996-09-19 1998-04-14 American Home Products Corporation Method of treating urinary incontinence
US6586427B2 (en) 1998-04-09 2003-07-01 Pharmacia & Upjohn Company Treatments for nervous disorders
PT1069900E (pt) * 1998-04-09 2005-10-31 Pharmacia & Upjohn Co Llc Novos tratamentos para disturbios nervosos
US6342533B1 (en) 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
DE60039132D1 (de) * 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
AU777594B2 (en) 1999-05-24 2004-10-21 Mitsubishi Pharma Corporation Phenoxypropylamine compounds
DE60035232T2 (de) * 1999-07-01 2008-02-14 Pharmacia & Upjohn Co. Llc, Kalamazoo (S,S)-Reboxetin zur Behandlung von chronischem Müdigkeits-Syndrom
US20040034106A1 (en) * 2001-11-06 2004-02-19 Read Holly Ann Treatment of anxiety disorders
AU2002347984A1 (en) * 2001-11-30 2003-06-17 Eli Lilly And Company Use of norepinephrine reuptake inhibitors for the treatment of tic disorders
EP1458368B1 (en) * 2001-12-11 2007-11-21 Eli Lilly And Company Use of norepinephrine reuptake inhibitors for the treatment of cognitive failure
ATE365554T1 (de) * 2003-04-04 2007-07-15 Dynogen Pharmaceuticals Inc Methode zur behandlung von erkrankungen der unteren harnwege
US20060241188A1 (en) * 2003-08-27 2006-10-26 Elililly And Company Treatment of pervasive developemental disorders with norepinephrine reuptake inhibitors
WO2005060949A2 (en) * 2003-12-12 2005-07-07 Eli Lilly And Company Selective norepinephrine reuptake inhibitors for the treatment of hot flashes, impulse control disorders and personality change due to a general medical condition
ITMI20061987A1 (it) 2006-10-16 2008-04-17 Archimica Srl Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine.
WO2019076904A1 (en) * 2017-10-16 2019-04-25 Esteve Pharmaceuticals, S.A. PROPANAMINE DERIVATIVES FOR THE TREATMENT OF PAIN AND PAIN DISEASES ASSOCIATED WITH PAIN
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法

Family Cites Families (7)

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US4626549A (en) * 1974-01-10 1986-12-02 Eli Lilly And Company Treatment of obesity with aryloxyphenylpropylamines
US4018895A (en) * 1974-01-10 1977-04-19 Eli Lilly And Company Aryloxyphenylpropylamines in treating depression
US4313896A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Aryloxyphenylpropylamines
US4584404A (en) * 1974-01-10 1986-04-22 Eli Lilly And Company Substituted phenoxyphenylproply dimethylamines
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
US4194009A (en) * 1974-01-10 1980-03-18 Eli Lilly And Company Aryloxyphenylpropylamines for obtaining a psychotropic effect
ZA892517B (en) * 1988-04-08 1990-12-28 Lilly Co Eli Propanamine derivatives

Also Published As

Publication number Publication date
NO923710D0 (no) 1992-09-24
IL103277A (en) 1997-11-20
MY108304A (en) 1996-09-30
NO178109C (no) 1996-01-24
DE69203424D1 (de) 1995-08-17
CZ281817B6 (cs) 1997-02-12
AU655075B2 (en) 1994-12-01
ATE124934T1 (de) 1995-07-15
FI924305A0 (fi) 1992-09-25
HU9203051D0 (en) 1992-12-28
FI924305A (fi) 1993-03-28
BR1100384A (pt) 1999-08-31
CZ290892A3 (en) 1993-04-14
BR9203743A (pt) 1993-04-20
SK280480B6 (sk) 2000-02-14
AU2537092A (en) 1993-04-01
RU2057120C1 (ru) 1996-03-27
CN1071416A (zh) 1993-04-28
ZA927240B (en) 1994-03-22
CA2079162A1 (en) 1993-03-28
NZ244460A (en) 1994-10-26
JPH05238996A (ja) 1993-09-17
US5281624A (en) 1994-01-25
KR100221180B1 (ko) 1999-09-15
CA2079161A1 (en) 1993-03-28
JP3256291B2 (ja) 2002-02-12
DE69203424T2 (de) 1996-01-11
EP0534756A2 (en) 1993-03-31
YU87192A (sh) 1995-10-24
IL103277A0 (en) 1993-02-21
JPH05201961A (ja) 1993-08-10
NO923710L (no) 1993-03-29
CA2079161C (en) 2004-02-17
SK290892A3 (en) 2000-02-14
TW249225B (ko) 1995-06-11
MX9205433A (es) 1993-03-01
EP0534756A3 (en) 1993-06-16
HU215519B (hu) 1999-01-28
FI111250B (fi) 2003-06-30
NO178109B (no) 1995-10-16
HUT65375A (en) 1994-05-02
CN1033580C (zh) 1996-12-18

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