FR2759293B1 - Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie - Google Patents

Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie

Info

Publication number
FR2759293B1
FR2759293B1 FR9701545A FR9701545A FR2759293B1 FR 2759293 B1 FR2759293 B1 FR 2759293B1 FR 9701545 A FR9701545 A FR 9701545A FR 9701545 A FR9701545 A FR 9701545A FR 2759293 B1 FR2759293 B1 FR 2759293B1
Authority
FR
France
Prior art keywords
polychemotherapy
radiotherapy
cisplatin
association
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9701545A
Other languages
English (en)
French (fr)
Other versions
FR2759293A1 (fr
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9701545A priority Critical patent/FR2759293B1/fr
Application filed by Ethypharm SAS filed Critical Ethypharm SAS
Priority to CA002282082A priority patent/CA2282082C/fr
Priority to PCT/FR1998/000251 priority patent/WO1998034599A1/fr
Priority to IN337DE1998 priority patent/IN187998B/en
Priority to ES98908157T priority patent/ES2210726T3/es
Priority to PT98908157T priority patent/PT971702E/pt
Priority to NZ337216A priority patent/NZ337216A/xx
Priority to BR9807319-2A priority patent/BR9807319A/pt
Priority to JP53389798A priority patent/JP4549445B2/ja
Priority to AU66267/98A priority patent/AU744001C/en
Priority to DK98908157T priority patent/DK0971702T3/da
Priority to IL13132698A priority patent/IL131326A/xx
Priority to US09/367,270 priority patent/US6458389B1/en
Priority to DE69820239T priority patent/DE69820239T2/de
Priority to PL335107A priority patent/PL191631B1/pl
Priority to EP98908157A priority patent/EP0971702B1/fr
Priority to HU0001719A priority patent/HU225425B1/hu
Priority to TW087101722A priority patent/TW561055B/zh
Priority to AT98908157T priority patent/ATE255409T1/de
Priority to EA199900734A priority patent/EA001760B1/ru
Priority to KR10-1999-7007263A priority patent/KR100471672B1/ko
Priority to ZA981123A priority patent/ZA981123B/xx
Priority to ARP980100613A priority patent/AR011133A1/es
Publication of FR2759293A1 publication Critical patent/FR2759293A1/fr
Application granted granted Critical
Publication of FR2759293B1 publication Critical patent/FR2759293B1/fr
Priority to BG103647A priority patent/BG64247B1/bg
Priority to NO19993881A priority patent/NO323230B1/no
Priority to US10/200,998 priority patent/US20030017210A1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR9701545A 1997-02-11 1997-02-11 Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie Expired - Lifetime FR2759293B1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR9701545A FR2759293B1 (fr) 1997-02-11 1997-02-11 Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie
EP98908157A EP0971702B1 (fr) 1997-02-11 1998-02-10 Microgranules contenant du cisplatine
IN337DE1998 IN187998B (enExample) 1997-02-11 1998-02-10
ES98908157T ES2210726T3 (es) 1997-02-11 1998-02-10 Microgranulos que contienen cisplatina.
PT98908157T PT971702E (pt) 1997-02-11 1998-02-10 Microgranulos contendo cis-platina
NZ337216A NZ337216A (en) 1997-02-11 1998-02-10 controlled-release microgranules containing cisplatin having a mean particle size of 0.4-1.5mm
BR9807319-2A BR9807319A (pt) 1997-02-11 1998-02-10 Microgrânulos com liberação controlada, para administração oral, contendo cisplatina, processo de preparação dos mesmos, preparação farmacêutica, e, utilização dos microgrânulos.
JP53389798A JP4549445B2 (ja) 1997-02-11 1998-02-10 シスプラチン含有マイクロ顆粒
AU66267/98A AU744001C (en) 1997-02-11 1998-02-10 Microgranules containing cisplatin
DK98908157T DK0971702T3 (da) 1997-02-11 1998-02-10 Mikrogranula indeholdende cisplatin
IL13132698A IL131326A (en) 1997-02-11 1998-02-10 Microgranules containing cisplatin
US09/367,270 US6458389B1 (en) 1997-02-11 1998-02-10 Microgranules containing cisplatin
DE69820239T DE69820239T2 (de) 1997-02-11 1998-02-10 Cisplatinhaltige mikrogranulate
PL335107A PL191631B1 (pl) 1997-02-11 1998-02-10 Mikrogranulki o kontrolowanym uwalnianiu do podawania doustnego, sposób ich wytwarzania, preparat farmaceutyczny je zawierający oraz ich zastosowanie
CA002282082A CA2282082C (fr) 1997-02-11 1998-02-10 Microgranules contenant du cisplatine
TW087101722A TW561055B (en) 1997-02-11 1998-02-10 Microgranules containing cisplatin and it's pharmaceutical preparation
HU0001719A HU225425B1 (en) 1997-02-11 1998-02-10 Microgranules containing cisplatin
AT98908157T ATE255409T1 (de) 1997-02-11 1998-02-10 Cisplatinhaltige mikrogranulate
EA199900734A EA001760B1 (ru) 1997-02-11 1998-02-10 Микрокапсулы, содержащие цис-платину
KR10-1999-7007263A KR100471672B1 (ko) 1997-02-11 1998-02-10 시스플라틴을 함유하는 마이크로그래뉼
PCT/FR1998/000251 WO1998034599A1 (fr) 1997-02-11 1998-02-10 Microgranules contenant du cisplatine
ARP980100613A AR011133A1 (es) 1997-02-11 1998-02-11 MICROGRÁNULOS DE LIBERACIoN CONTROLADA QUE CONTIENEN CISPLATINO , PROCEDIMIENTO DE SU PREPARACIoN, COMPOSICIoN FARMACÉUTICA Y UTILIZACIoN EN LA FABRICACIoN DE UN MEDICAMENTO POLIQUIMIOTERAPIA O EN ASOCIACIoN CON UNA RADIOTERAPIA.
ZA981123A ZA981123B (en) 1997-02-11 1998-02-11 Microgranules containing cisplastin manufacturing process pharmaceutical preparation and use in polychemotherapy or in combination with a radiotherapy
BG103647A BG64247B1 (bg) 1997-02-11 1999-08-10 Микрогранули, съдържащи цисплатина
NO19993881A NO323230B1 (no) 1997-02-11 1999-08-11 Mikrogranulater for kontrollert frigjoring for oral administrering som inneholder cisplatin, farmasoytiske preparater derav og anvendelse derav.
US10/200,998 US20030017210A1 (en) 1997-02-11 2002-07-25 Microgranules containing cisplatin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9701545A FR2759293B1 (fr) 1997-02-11 1997-02-11 Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie

Publications (2)

Publication Number Publication Date
FR2759293A1 FR2759293A1 (fr) 1998-08-14
FR2759293B1 true FR2759293B1 (fr) 1999-04-30

Family

ID=9503556

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9701545A Expired - Lifetime FR2759293B1 (fr) 1997-02-11 1997-02-11 Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie

Country Status (24)

Country Link
US (2) US6458389B1 (enExample)
EP (1) EP0971702B1 (enExample)
JP (1) JP4549445B2 (enExample)
KR (1) KR100471672B1 (enExample)
AR (1) AR011133A1 (enExample)
AT (1) ATE255409T1 (enExample)
BG (1) BG64247B1 (enExample)
BR (1) BR9807319A (enExample)
CA (1) CA2282082C (enExample)
DE (1) DE69820239T2 (enExample)
DK (1) DK0971702T3 (enExample)
EA (1) EA001760B1 (enExample)
ES (1) ES2210726T3 (enExample)
FR (1) FR2759293B1 (enExample)
HU (1) HU225425B1 (enExample)
IL (1) IL131326A (enExample)
IN (1) IN187998B (enExample)
NO (1) NO323230B1 (enExample)
NZ (1) NZ337216A (enExample)
PL (1) PL191631B1 (enExample)
PT (1) PT971702E (enExample)
TW (1) TW561055B (enExample)
WO (1) WO1998034599A1 (enExample)
ZA (1) ZA981123B (enExample)

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US20050096304A1 (en) * 1998-09-08 2005-05-05 David White Method of treating cancer using dithiocarbamate derivatives
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
JP2002544220A (ja) * 1999-05-17 2002-12-24 デー．ベー．エフ． 植物物質を含有する顆粒及びその製造方法
JP5171038B2 (ja) * 2003-10-10 2013-03-27 エティファルム イチョウ・エキスを含む放出持続性の微小顆粒およびそのような顆粒の製造方法
FR2861990B1 (fr) * 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
TW200631609A (en) * 2004-11-18 2006-09-16 Bristol Myers Squibb Co Enteric coated bead comprising ixabepilone, and preparation and administration thereof
US20080069901A1 (en) * 2004-12-10 2008-03-20 Tmrc Co. , Ltd. Therapeutic Agent for Metastatic Cancer and Cancer Metastasis Inhibitor
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
FR2918566B1 (fr) 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
MX2010003032A (es) * 2007-09-21 2010-04-09 Evonik R Hm Gmbh Composicion farmaceutica opioide de liberacion controlada ph dependiente con resistencia contra la influencia del etanol.
CN101801356B (zh) * 2007-09-21 2016-10-19 赢创罗姆有限公司 耐受乙醇影响的非阿片类的pH依赖性受控释放的药物组合物
CA2711475A1 (en) * 2008-01-10 2009-07-16 Evonik Roehm Gmbh Coated pharmaceutical or nutraceutical preparation with accelerated controlled active substance release
ES2626078T3 (es) * 2008-01-10 2017-07-21 Evonik Röhm Gmbh Preparación farmacéutica o nutracéutica revestida con liberación de sustancia activa mejorada en el colon
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
CA2688202C (en) * 2009-12-11 2012-11-13 Bj Services Company Viscoelastic fluids containing hydroxyethyl cellulose
EP2371356B1 (en) * 2010-03-12 2012-12-19 Phoeme GmbH Multi-particle pharmaceutical formulation for colon absorption
US8070047B1 (en) * 2010-12-02 2011-12-06 Rohm And Haas Electronic Materials Llc Flux composition and method of soldering
CA2883703C (en) 2012-09-04 2021-10-19 Eleison Pharmaceuticals, Llc Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin
CA2959414C (en) 2014-09-05 2023-03-14 Symbiomix Therapeutics, Llc Secnidazole for use in the treatment of bacterial vaginosis
WO2016169042A1 (en) * 2015-04-24 2016-10-27 Genedia Biotech Co. Ltd. Combination therapies for bladder cancer
WO2016196653A1 (en) * 2015-06-01 2016-12-08 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof
JP6912394B2 (ja) 2015-06-12 2021-08-04 バクサート インコーポレイテッド Ｒｓｖおよびノロウイルス抗原の小腸送達のための製剤
TWI795462B (zh) 2017-11-17 2023-03-11 日商鹽野義製藥股份有限公司 光安定性及溶出性優異的醫藥製劑
EP3785716A4 (en) 2018-04-24 2022-03-02 Shionogi & Co., Ltd SOLID FORMULATION WITH EXCELLENT STABILITY
WO2019208540A1 (ja) 2018-04-24 2019-10-31 塩野義製薬株式会社 安定性に優れた固形製剤
US12280037B2 (en) 2020-09-22 2025-04-22 Evofem Biosciences, Inc. Method and pharmaceutical composition for treating or preventing trichomoniasis and uses thereof

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IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
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Also Published As

Publication number Publication date
NO993881L (no) 1999-09-29
AR011133A1 (es) 2000-08-02
AU744001B2 (en) 2002-02-14
EA199900734A1 (ru) 2000-04-24
BR9807319A (pt) 2000-04-18
CA2282082C (fr) 2005-10-18
WO1998034599A1 (fr) 1998-08-13
HUP0001719A3 (en) 2005-11-28
KR100471672B1 (ko) 2005-03-07
PT971702E (pt) 2004-04-30
HU225425B1 (en) 2006-11-28
DE69820239T2 (de) 2004-10-07
DE69820239D1 (de) 2004-01-15
ES2210726T3 (es) 2004-07-01
US20030017210A1 (en) 2003-01-23
US6458389B1 (en) 2002-10-01
PL191631B1 (pl) 2006-06-30
HUP0001719A2 (hu) 2000-11-28
DK0971702T3 (da) 2004-04-13
EA001760B1 (ru) 2001-08-27
IN187998B (enExample) 2002-08-03
EP0971702A1 (fr) 2000-01-19
ZA981123B (en) 1998-08-20
AU6626798A (en) 1998-08-26
TW561055B (en) 2003-11-11
JP4549445B2 (ja) 2010-09-22
JP2001512433A (ja) 2001-08-21
PL335107A1 (en) 2000-04-10
CA2282082A1 (fr) 1998-08-13
NO323230B1 (no) 2007-02-05
IL131326A (en) 2005-03-20
NO993881D0 (no) 1999-08-11
ATE255409T1 (de) 2003-12-15
IL131326A0 (en) 2001-01-28
BG103647A (en) 2000-03-31
EP0971702B1 (fr) 2003-12-03
FR2759293A1 (fr) 1998-08-14
NZ337216A (en) 2000-09-29
BG64247B1 (bg) 2004-07-30
KR20000070997A (ko) 2000-11-25

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