FR2444669A1 - Acetals et thioacetals de mercap - Google Patents

Acetals et thioacetals de mercap

Info

Publication number
FR2444669A1
FR2444669A1 FR7931132A FR7931132A FR2444669A1 FR 2444669 A1 FR2444669 A1 FR 2444669A1 FR 7931132 A FR7931132 A FR 7931132A FR 7931132 A FR7931132 A FR 7931132A FR 2444669 A1 FR2444669 A1 FR 2444669A1
Authority
FR
France
Prior art keywords
thioacetals
mercap
acetals
compounds
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7931132A
Other languages
English (en)
French (fr)
Other versions
FR2444669B1 (de
Inventor
John Krapcho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2444669A1 publication Critical patent/FR2444669A1/fr
Application granted granted Critical
Publication of FR2444669B1 publication Critical patent/FR2444669B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
FR7931132A 1978-12-22 1979-12-19 Acetals et thioacetals de mercap Granted FR2444669A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97231478A 1978-12-22 1978-12-22

Publications (2)

Publication Number Publication Date
FR2444669A1 true FR2444669A1 (fr) 1980-07-18
FR2444669B1 FR2444669B1 (de) 1983-06-03

Family

ID=25519507

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7931132A Granted FR2444669A1 (fr) 1978-12-22 1979-12-19 Acetals et thioacetals de mercap

Country Status (31)

Country Link
JP (1) JPS5594357A (de)
AT (1) AT374174B (de)
AU (1) AU533149B2 (de)
BE (1) BE880815A (de)
CA (1) CA1132985A (de)
CH (1) CH642065A5 (de)
CS (1) CS215036B2 (de)
DD (1) DD148338A5 (de)
DE (1) DE2951200A1 (de)
DK (1) DK159115C (de)
ES (2) ES8102094A1 (de)
FI (1) FI70886C (de)
FR (1) FR2444669A1 (de)
GB (1) GB2039478B (de)
GR (1) GR78384B (de)
HK (1) HK15684A (de)
HU (1) HU179644B (de)
IE (1) IE49321B1 (de)
IL (1) IL58930A (de)
IT (1) IT1126841B (de)
LU (1) LU82023A1 (de)
NL (1) NL7909246A (de)
NO (1) NO153569C (de)
NZ (1) NZ192449A (de)
PH (1) PH19213A (de)
PL (1) PL133414B1 (de)
PT (1) PT70620A (de)
SE (1) SE451839B (de)
SU (1) SU1115668A3 (de)
YU (1) YU314879A (de)
ZA (1) ZA796720B (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462428A1 (fr) * 1979-07-30 1981-02-13 Squibb & Sons Inc Derives d'acide dithioacyldihydropyrazole carboxylique, derives de dithioacylproline, et composes apparentes, a action antihypertensive
FR2467845A1 (fr) * 1979-10-22 1981-04-30 Squibb & Sons Inc Nouveaux derives mercapto-acyles de prolines 4,4-disubstituees et de dehydroprolines 4-substituees, utiles notamment comme medicaments hypotenseurs, compositions therapeutiques et formes pharmaceutiques les contenant, et intermediaires utiles pour leur synthese
EP0095584A2 (de) * 1982-04-30 1983-12-07 E.R. Squibb & Sons, Inc. Substituierte 4-Phenoxy und 4-Phenylthio-Proline
FR2552087A1 (fr) * 1983-05-09 1985-03-22 Squibb & Sons Inc Nouveaux composes spiranniques acylmercapto-alcanoyliques et mercapto-alcanoyliques utiles notamment comme medicaments antihypertenseurs

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2455585A1 (fr) * 1979-05-04 1980-11-28 Ono Pharmaceutical Co Derives d'oxoaminoacides, procede de fabrication et composition pharmaceutique
US4356182A (en) * 1979-10-22 1982-10-26 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
CA2021409A1 (en) * 1989-08-21 1991-02-22 Donald S. Karanewsky Phosphonate substituted amino or imino acids useful as antihypertensives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372804A1 (fr) * 1976-12-03 1978-06-30 Squibb & Sons Inc Derives d'amino-acides, en tant qu'agents anti-hypertension
FR2407204A1 (fr) * 1977-10-28 1979-05-25 Sandoz Sa Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments
LU80946A1 (fr) * 1978-02-21 1979-06-18 Squibb & Sons Inc Mercaptoacylamino-acides substitues par des halogenes
FR2435469A1 (fr) * 1978-08-11 1980-04-04 Squibb & Sons Inc Derives mercaptoacyles de prolines substituees a action hypotensive

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372804A1 (fr) * 1976-12-03 1978-06-30 Squibb & Sons Inc Derives d'amino-acides, en tant qu'agents anti-hypertension
FR2407204A1 (fr) * 1977-10-28 1979-05-25 Sandoz Sa Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments
LU80946A1 (fr) * 1978-02-21 1979-06-18 Squibb & Sons Inc Mercaptoacylamino-acides substitues par des halogenes
FR2435469A1 (fr) * 1978-08-11 1980-04-04 Squibb & Sons Inc Derives mercaptoacyles de prolines substituees a action hypotensive

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462428A1 (fr) * 1979-07-30 1981-02-13 Squibb & Sons Inc Derives d'acide dithioacyldihydropyrazole carboxylique, derives de dithioacylproline, et composes apparentes, a action antihypertensive
FR2467845A1 (fr) * 1979-10-22 1981-04-30 Squibb & Sons Inc Nouveaux derives mercapto-acyles de prolines 4,4-disubstituees et de dehydroprolines 4-substituees, utiles notamment comme medicaments hypotenseurs, compositions therapeutiques et formes pharmaceutiques les contenant, et intermediaires utiles pour leur synthese
EP0095584A2 (de) * 1982-04-30 1983-12-07 E.R. Squibb & Sons, Inc. Substituierte 4-Phenoxy und 4-Phenylthio-Proline
EP0095584A3 (en) * 1982-04-30 1984-03-28 E.R. Squibb & Sons, Inc. Substituted 4-phenoxy and 4-phenylthio prolines
FR2552087A1 (fr) * 1983-05-09 1985-03-22 Squibb & Sons Inc Nouveaux composes spiranniques acylmercapto-alcanoyliques et mercapto-alcanoyliques utiles notamment comme medicaments antihypertenseurs

Also Published As

Publication number Publication date
ZA796720B (en) 1980-11-26
AT374174B (de) 1984-03-26
IT1126841B (it) 1986-05-21
ES487180A0 (es) 1980-12-16
IL58930A (en) 1983-07-31
GB2039478A (en) 1980-08-13
IL58930A0 (en) 1980-03-31
SE7910550L (sv) 1980-06-23
FI794027A (fi) 1980-06-23
DK550079A (da) 1980-06-23
HU179644B (en) 1982-11-29
AU5371479A (en) 1980-06-26
PL133414B1 (en) 1985-05-31
AU533149B2 (en) 1983-11-03
CA1132985A (en) 1982-10-05
CH642065A5 (de) 1984-03-30
FR2444669B1 (de) 1983-06-03
ATA805479A (de) 1983-08-15
FI70886C (fi) 1986-10-27
IE792468L (en) 1980-06-22
HK15684A (en) 1984-03-02
SU1115668A3 (ru) 1984-09-23
GB2039478B (en) 1983-02-16
NO794181L (no) 1980-06-24
DD148338A5 (de) 1981-05-20
PL220609A1 (de) 1980-12-01
IT7951167A0 (it) 1979-12-21
NO153569C (no) 1986-05-21
NL7909246A (nl) 1980-06-24
PH19213A (en) 1986-02-04
NO153569B (no) 1986-01-06
ES488752A0 (es) 1981-02-16
YU314879A (en) 1983-04-30
BE880815A (fr) 1980-06-23
ES8102094A1 (es) 1980-12-16
CS215036B2 (en) 1982-06-25
ES8103039A1 (es) 1981-02-16
LU82023A1 (de) 1980-04-23
GR78384B (de) 1984-09-26
NZ192449A (en) 1984-05-31
JPS5594357A (en) 1980-07-17
SE451839B (sv) 1987-11-02
IE49321B1 (en) 1985-09-18
PT70620A (en) 1980-01-01
DK159115C (da) 1991-02-11
DK159115B (da) 1990-09-03
FI70886B (fi) 1986-07-18
DE2951200A1 (de) 1980-07-10

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Legal Events

Date Code Title Description
ST Notification of lapse