AU533149B2 - Mercapto-acyl prolines and their pharmaceutical compositions - Google Patents

Mercapto-acyl prolines and their pharmaceutical compositions

Info

Publication number
AU533149B2
AU533149B2 AU53714/79A AU5371479A AU533149B2 AU 533149 B2 AU533149 B2 AU 533149B2 AU 53714/79 A AU53714/79 A AU 53714/79A AU 5371479 A AU5371479 A AU 5371479A AU 533149 B2 AU533149 B2 AU 533149B2
Authority
AU
Australia
Prior art keywords
prolines
mercapto
acyl
pharmaceutical compositions
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU53714/79A
Other versions
AU5371479A (en
Inventor
John Krapcho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of AU5371479A publication Critical patent/AU5371479A/en
Application granted granted Critical
Publication of AU533149B2 publication Critical patent/AU533149B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10Spiro-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AU53714/79A 1978-12-22 1979-12-11 Mercapto-acyl prolines and their pharmaceutical compositions Ceased AU533149B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97231478A 1978-12-22 1978-12-22
US972314 1978-12-22

Publications (2)

Publication Number Publication Date
AU5371479A AU5371479A (en) 1980-06-26
AU533149B2 true AU533149B2 (en) 1983-11-03

Family

ID=25519507

Family Applications (1)

Application Number Title Priority Date Filing Date
AU53714/79A Ceased AU533149B2 (en) 1978-12-22 1979-12-11 Mercapto-acyl prolines and their pharmaceutical compositions

Country Status (31)

Country Link
JP (1) JPS5594357A (en)
AT (1) AT374174B (en)
AU (1) AU533149B2 (en)
BE (1) BE880815A (en)
CA (1) CA1132985A (en)
CH (1) CH642065A5 (en)
CS (1) CS215036B2 (en)
DD (1) DD148338A5 (en)
DE (1) DE2951200A1 (en)
DK (1) DK159115C (en)
ES (2) ES8102094A1 (en)
FI (1) FI70886C (en)
FR (1) FR2444669A1 (en)
GB (1) GB2039478B (en)
GR (1) GR78384B (en)
HK (1) HK15684A (en)
HU (1) HU179644B (en)
IE (1) IE49321B1 (en)
IL (1) IL58930A (en)
IT (1) IT1126841B (en)
LU (1) LU82023A1 (en)
NL (1) NL7909246A (en)
NO (1) NO153569C (en)
NZ (1) NZ192449A (en)
PH (1) PH19213A (en)
PL (1) PL133414B1 (en)
PT (1) PT70620A (en)
SE (1) SE451839B (en)
SU (1) SU1115668A3 (en)
YU (1) YU314879A (en)
ZA (1) ZA796720B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2455585A1 (en) * 1979-05-04 1980-11-28 Ono Pharmaceutical Co OXOAMINOACID DERIVATIVES, MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITION
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4356182A (en) * 1979-10-22 1982-10-26 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
CA1258853A (en) * 1982-04-30 1989-08-29 Rudiger D. Haugwitz Substituted 4-phenoxy prolines
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
US4709046A (en) * 1983-05-09 1987-11-24 E. R. Squibb & Sons, Inc. Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds
CA2021409A1 (en) * 1989-08-21 1991-02-22 Donald S. Karanewsky Phosphonate substituted amino or imino acids useful as antihypertensives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
IT7851510A0 (en) * 1977-10-28 1978-10-16 Sandoz Ag AMIDES OF CYCLIC AMINO ACIDS THEIR PREPARATION AND THEIR APPLICATION AS MEDICINES
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines

Also Published As

Publication number Publication date
ZA796720B (en) 1980-11-26
AT374174B (en) 1984-03-26
IT1126841B (en) 1986-05-21
ES487180A0 (en) 1980-12-16
IL58930A (en) 1983-07-31
GB2039478A (en) 1980-08-13
IL58930A0 (en) 1980-03-31
SE7910550L (en) 1980-06-23
FI794027A (en) 1980-06-23
DK550079A (en) 1980-06-23
FR2444669A1 (en) 1980-07-18
HU179644B (en) 1982-11-29
AU5371479A (en) 1980-06-26
PL133414B1 (en) 1985-05-31
CA1132985A (en) 1982-10-05
CH642065A5 (en) 1984-03-30
FR2444669B1 (en) 1983-06-03
ATA805479A (en) 1983-08-15
FI70886C (en) 1986-10-27
IE792468L (en) 1980-06-22
HK15684A (en) 1984-03-02
SU1115668A3 (en) 1984-09-23
GB2039478B (en) 1983-02-16
NO794181L (en) 1980-06-24
DD148338A5 (en) 1981-05-20
PL220609A1 (en) 1980-12-01
IT7951167A0 (en) 1979-12-21
NO153569C (en) 1986-05-21
NL7909246A (en) 1980-06-24
PH19213A (en) 1986-02-04
NO153569B (en) 1986-01-06
ES488752A0 (en) 1981-02-16
YU314879A (en) 1983-04-30
BE880815A (en) 1980-06-23
ES8102094A1 (en) 1980-12-16
CS215036B2 (en) 1982-06-25
ES8103039A1 (en) 1981-02-16
LU82023A1 (en) 1980-04-23
GR78384B (en) 1984-09-26
NZ192449A (en) 1984-05-31
JPS5594357A (en) 1980-07-17
SE451839B (en) 1987-11-02
IE49321B1 (en) 1985-09-18
PT70620A (en) 1980-01-01
DK159115C (en) 1991-02-11
DK159115B (en) 1990-09-03
FI70886B (en) 1986-07-18
DE2951200A1 (en) 1980-07-10

Similar Documents

Publication Publication Date Title
AU528641B2 (en) Pharmaceutical and dietary composition
AU524655B2 (en) Pharmaceutical and dietary compositions
AU535604B2 (en) Pharmaceutical compositions
AU533149B2 (en) Mercapto-acyl prolines and their pharmaceutical compositions
AU525089B2 (en) Pharmaceutical compositions
NZ189378A (en) 4-amino-5-alkylsulphonyl-ortho-anisamdes and pharmaceutical compositions
NZ190784A (en) Benzofuranyl-piperidines and pharmaceutical compositions
NZ193798A (en) 3-thiovinyl-cephalosporin derivatives and pharmaceutical compositions
IL56407A (en) 4-amino-3-sulfamoylpyridyl derivatives and pharmaceutical compositions containing them
AU526912B2 (en) Pharmaceutical composition
IL57268A0 (en) Di-o-n-alkyl clycerol derivatives and pharmaceutical compositions containing them
AU535605B2 (en) Pharmaceutical compositions
AU526239B2 (en) Pharmaceutical compositions
AU519836B2 (en) Phenylurea compounds and pharmaceutical compositions
NZ189899A (en) Dilignols and dilignol-type compounds pharmaceutical compositions
AU6501980A (en) Pharmaceutical compositions
NZ189279A (en) Arylaminoimidazolines and pharmaceutical compositions
NZ190293A (en) Benzimidoyl-piperazines and pharmaceutical compositions
AU523405B2 (en) Pharmaceutical compositions
IL57882A (en) 2-thiophenecarboxamido-alkyl-mercaptans and pharmaceutical compositions containing them
NZ190007A (en) Steroid-spiro-oxazolidinone derivatives and pharmaceutical compositions
NZ190665A (en) S-benzylcysteine derivatives and pharmaceutical compositions
PH15436A (en) 4-amino-2-piperidinoquinazoline derivatives and pharmaceutical compositions thereof
NZ189856A (en) 6-azido-decahydro-isoquinolines and pharmaceutical compositions
GB2017096B (en) 8-hydrazinomethylergoline derivatives and pharmaceutical compositions containing them