FR2422651A1 - Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde a usage therapeutique - Google Patents

Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde a usage therapeutique

Info

Publication number
FR2422651A1
FR2422651A1 FR7909362A FR7909362A FR2422651A1 FR 2422651 A1 FR2422651 A1 FR 2422651A1 FR 7909362 A FR7909362 A FR 7909362A FR 7909362 A FR7909362 A FR 7909362A FR 2422651 A1 FR2422651 A1 FR 2422651A1
Authority
FR
France
Prior art keywords
pyrrolidinecarboxaldehyde
piperidinecarboxaldehyde
derivatives
therapeutic use
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7909362A
Other languages
English (en)
Other versions
FR2422651B1 (fr
Inventor
Sesha Iyer Natarajan
Miguel Angel Ondetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2422651A1 publication Critical patent/FR2422651A1/fr
Application granted granted Critical
Publication of FR2422651B1 publication Critical patent/FR2422651B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5

Abstract

Composés de formule :
FR7909362A 1978-04-14 1979-04-12 Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde a usage therapeutique Granted FR2422651A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/896,420 US4206122A (en) 1978-04-14 1978-04-14 Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor

Publications (2)

Publication Number Publication Date
FR2422651A1 true FR2422651A1 (fr) 1979-11-09
FR2422651B1 FR2422651B1 (fr) 1982-05-21

Family

ID=25406179

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7909362A Granted FR2422651A1 (fr) 1978-04-14 1979-04-12 Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde a usage therapeutique

Country Status (27)

Country Link
US (1) US4206122A (fr)
JP (1) JPS54145662A (fr)
AT (1) AT373237B (fr)
AU (1) AU528337B2 (fr)
BE (1) BE875592A (fr)
CA (1) CA1124726A (fr)
CH (1) CH638183A5 (fr)
DD (1) DD142876A5 (fr)
DE (1) DE2914793A1 (fr)
DK (1) DK153579A (fr)
ES (1) ES479444A1 (fr)
FR (1) FR2422651A1 (fr)
GB (1) GB2020648B (fr)
HU (1) HU178357B (fr)
IE (1) IE48497B1 (fr)
IL (1) IL57071A (fr)
IT (1) IT1120407B (fr)
LU (1) LU81150A1 (fr)
NL (1) NL7902852A (fr)
NO (1) NO791236L (fr)
NZ (1) NZ190090A (fr)
PH (1) PH14438A (fr)
PL (1) PL214887A1 (fr)
PT (1) PT69483A (fr)
SU (1) SU791227A3 (fr)
YU (1) YU85979A (fr)
ZA (1) ZA791584B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
DD154444A3 (de) * 1980-07-11 1982-03-24 Roland Ohme Verfahren zur herstellung neuer sulfobetaine
US4626545A (en) * 1984-08-27 1986-12-02 Merck & Co., Inc. Amino acid derivatives as enzyme inhibitors
JPH0764834B2 (ja) * 1985-11-29 1995-07-12 サントリー株式会社 プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途
JP2691442B2 (ja) * 1989-02-20 1997-12-17 株式会社ヤクルト本社 新規なプロリン誘導体
PT861233E (pt) * 1995-11-16 2000-09-29 Searle & Co Beta-amino-hidroxissulfonatos n-protegidos/n-substituidos
JP5041219B2 (ja) * 2006-07-14 2012-10-03 ナガセケムテックス株式会社 光学活性ビスオキサゾリン−銅錯体を不斉触媒とするｎ−保護アミノアルコール化合物の不斉エステル化反応

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340932A1 (fr) * 1976-02-13 1977-09-09 Squibb & Sons Inc Derives de proline et composes apparentes, utiles pour reduire la tension sanguine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340932A1 (fr) * 1976-02-13 1977-09-09 Squibb & Sons Inc Derives de proline et composes apparentes, utiles pour reduire la tension sanguine

Also Published As

Publication number Publication date
NO791236L (no) 1979-10-16
BE875592A (fr) 1979-10-15
NZ190090A (en) 1982-03-09
YU85979A (en) 1983-02-28
IE48497B1 (en) 1985-02-06
AU528337B2 (en) 1983-04-28
ES479444A1 (es) 1979-11-16
IL57071A (en) 1982-04-30
NL7902852A (nl) 1979-10-16
IE790771L (en) 1979-10-14
ZA791584B (en) 1980-08-27
PH14438A (en) 1981-07-16
DK153579A (da) 1979-10-15
US4206122A (en) 1980-06-03
JPS54145662A (en) 1979-11-14
CA1124726A (fr) 1982-06-01
GB2020648B (en) 1982-07-21
IT7948727A0 (it) 1979-04-13
AT373237B (de) 1983-12-27
PL214887A1 (fr) 1980-01-28
CH638183A5 (fr) 1983-09-15
FR2422651B1 (fr) 1982-05-21
AU4566779A (en) 1979-10-18
GB2020648A (en) 1979-11-21
PT69483A (en) 1979-05-01
DD142876A5 (de) 1980-07-16
IL57071A0 (en) 1979-07-25
SU791227A3 (ru) 1980-12-23
ATA286579A (de) 1983-05-15
LU81150A1 (fr) 1979-07-20
IT1120407B (it) 1986-03-26
HU178357B (en) 1982-04-28
DE2914793A1 (de) 1979-10-18

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