ES8103039A1 - Un procedimiento para preparar derivados cetalicos y tioce- talicos de mercaptoacil-prolinas - Google Patents

Un procedimiento para preparar derivados cetalicos y tioce- talicos de mercaptoacil-prolinas

Info

Publication number
ES8103039A1
ES8103039A1 ES488752A ES488752A ES8103039A1 ES 8103039 A1 ES8103039 A1 ES 8103039A1 ES 488752 A ES488752 A ES 488752A ES 488752 A ES488752 A ES 488752A ES 8103039 A1 ES8103039 A1 ES 8103039A1
Authority
ES
Spain
Prior art keywords
lower alkyl
hydrogen
mercaptoacyl
pyrrolidines
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488752A
Other languages
English (en)
Other versions
ES488752A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES8103039A1 publication Critical patent/ES8103039A1/es
Publication of ES488752A0 publication Critical patent/ES488752A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS CETALICOS Y TIOCETALICOS DE MERCAPTOACIL-PROLINAS DE FORMULA (I), O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS, EN LA QUE R ES HIDROGENO O ALCOHILO INFERIOR, R1,R2,R3,R4,R5, Y R6 PUEDEN SER DIVERSOS RADICALES,X1,X2 Y X3 SE SELECCIONAN INDEPENDIENTEMENTE DE ENTRE EL GRUPO CONSTITUIDO POR OXIGENO Y AZUFRE. SE OBTIENEN LOS DERIVADOS TRATANDO UN COMPUESTO DE FORMULA (II): CON ALCOHOLES O TIOLES. ESTOS COMPUESTOS SE EMPLEAN COMO AGENTESS ANTIHIPERSENSITIVOS. *FORMULA*. O
ES488752A 1978-12-22 1980-02-20 Un procedimiento para preparar derivados cetalicos y tioce- talicos de mercaptoacil-prolinas Granted ES488752A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97231478A 1978-12-22 1978-12-22

Publications (2)

Publication Number Publication Date
ES8103039A1 true ES8103039A1 (es) 1981-02-16
ES488752A0 ES488752A0 (es) 1981-02-16

Family

ID=25519507

Family Applications (2)

Application Number Title Priority Date Filing Date
ES487180A Expired ES8102094A1 (es) 1978-12-22 1979-12-21 Un procedimiento para preparar derivados cetalicos y tioce- talicos de mercaptoacil-prolinas
ES488752A Granted ES488752A0 (es) 1978-12-22 1980-02-20 Un procedimiento para preparar derivados cetalicos y tioce- talicos de mercaptoacil-prolinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES487180A Expired ES8102094A1 (es) 1978-12-22 1979-12-21 Un procedimiento para preparar derivados cetalicos y tioce- talicos de mercaptoacil-prolinas

Country Status (31)

Country Link
JP (1) JPS5594357A (es)
AT (1) AT374174B (es)
AU (1) AU533149B2 (es)
BE (1) BE880815A (es)
CA (1) CA1132985A (es)
CH (1) CH642065A5 (es)
CS (1) CS215036B2 (es)
DD (1) DD148338A5 (es)
DE (1) DE2951200A1 (es)
DK (1) DK159115C (es)
ES (2) ES8102094A1 (es)
FI (1) FI70886C (es)
FR (1) FR2444669A1 (es)
GB (1) GB2039478B (es)
GR (1) GR78384B (es)
HK (1) HK15684A (es)
HU (1) HU179644B (es)
IE (1) IE49321B1 (es)
IL (1) IL58930A (es)
IT (1) IT1126841B (es)
LU (1) LU82023A1 (es)
NL (1) NL7909246A (es)
NO (1) NO153569C (es)
NZ (1) NZ192449A (es)
PH (1) PH19213A (es)
PL (1) PL133414B1 (es)
PT (1) PT70620A (es)
SE (1) SE451839B (es)
SU (1) SU1115668A3 (es)
YU (1) YU314879A (es)
ZA (1) ZA796720B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2455585A1 (fr) * 1979-05-04 1980-11-28 Ono Pharmaceutical Co Derives d'oxoaminoacides, procede de fabrication et composition pharmaceutique
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4356182A (en) * 1979-10-22 1982-10-26 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
CA1258853A (en) * 1982-04-30 1989-08-29 Rudiger D. Haugwitz Substituted 4-phenoxy prolines
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
US4709046A (en) * 1983-05-09 1987-11-24 E. R. Squibb & Sons, Inc. Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds
AU632596B2 (en) * 1989-08-21 1993-01-07 E.R. Squibb & Sons, Inc. Phosphonate substituted amino or imino acids useful as antihypertensives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
IT7851510A0 (it) * 1977-10-28 1978-10-16 Sandoz Ag Ammidi di amminoacidi ciclici loro preparazione e loro applicazione quali medicamenti
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines

Also Published As

Publication number Publication date
AU5371479A (en) 1980-06-26
GB2039478B (en) 1983-02-16
DK159115B (da) 1990-09-03
IL58930A (en) 1983-07-31
AT374174B (de) 1984-03-26
NL7909246A (nl) 1980-06-24
ES487180A0 (es) 1980-12-16
FI794027A (fi) 1980-06-23
FR2444669B1 (es) 1983-06-03
IT7951167A0 (it) 1979-12-21
IT1126841B (it) 1986-05-21
IL58930A0 (en) 1980-03-31
ZA796720B (en) 1980-11-26
HK15684A (en) 1984-03-02
PL133414B1 (en) 1985-05-31
IE49321B1 (en) 1985-09-18
CA1132985A (en) 1982-10-05
CH642065A5 (de) 1984-03-30
PT70620A (en) 1980-01-01
YU314879A (en) 1983-04-30
GR78384B (es) 1984-09-26
DE2951200A1 (de) 1980-07-10
FI70886B (fi) 1986-07-18
DK159115C (da) 1991-02-11
IE792468L (en) 1980-06-22
FI70886C (fi) 1986-10-27
GB2039478A (en) 1980-08-13
HU179644B (en) 1982-11-29
NO794181L (no) 1980-06-24
ES8102094A1 (es) 1980-12-16
SU1115668A3 (ru) 1984-09-23
LU82023A1 (de) 1980-04-23
JPS5594357A (en) 1980-07-17
AU533149B2 (en) 1983-11-03
SE451839B (sv) 1987-11-02
CS215036B2 (en) 1982-06-25
FR2444669A1 (fr) 1980-07-18
NO153569C (no) 1986-05-21
DD148338A5 (de) 1981-05-20
NZ192449A (en) 1984-05-31
DK550079A (da) 1980-06-23
PH19213A (en) 1986-02-04
ES488752A0 (es) 1981-02-16
BE880815A (fr) 1980-06-23
ATA805479A (de) 1983-08-15
SE7910550L (sv) 1980-06-23
PL220609A1 (es) 1980-12-01
NO153569B (no) 1986-01-06

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401